Cisteína Protease
Os inibidores de protease de cisteína são compostos que visam e inibem as proteases de cisteína, uma classe de enzimas que degradam proteínas ao clivar ligações peptídicas nas quais um resíduo de cisteína atua como nucleófilo. Essas enzimas estão envolvidas em vários processos fisiológicos, incluindo apoptose, resposta imune e renovação proteica. Os inibidores de protease de cisteína são cruciais para o estudo de doenças como câncer, distúrbios neurodegenerativos e infecções parasitárias. Na CymitQuimica, oferecemos inibidores de protease de cisteína para apoiar sua pesquisa em proteólise, regulação celular e descoberta de medicamentos.
Foram encontrados 96 produtos de "Cisteína Protease"
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GB111-NH2
CAS:GB111-NH2, a cysteine cathepsin inhibitor, is applicable in cancer research [1].Fórmula:C33H39N3O6Cor e Forma:SolidPeso molecular:573.68Verducatib
CAS:<p>Verducatib is an inhibitor of cathepsins (cathepsin).</p>Fórmula:C31H35FN4O3Cor e Forma:SolidPeso molecular:530.633Cathepsin K inhibitor 2
CAS:<p>Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.</p>Fórmula:C30H33F4N5O3Cor e Forma:SolidPeso molecular:587.61BI-1915
CAS:<p>BI-1915 is a selective inhibitor of Cathepsin S, with an IC50 of 17 nM. It is utilized in the research of autoimmune diseases.</p>Fórmula:C21H37N5O3Cor e Forma:SolidPeso molecular:407.55Cathepsin C-IN-3
<p>Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).</p>Fórmula:C28H21F3N6OSCor e Forma:SolidPeso molecular:546.57RO5461111
CAS:<p>RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) & 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation & lupus nephritis.</p>Fórmula:C27H24F6N4O4SCor e Forma:SolidPeso molecular:614.56SID 26681509 quarterhydrate
<p>SID 26681509 is a selective inhibitor of cathepsin L (IC50: 56 nM) and blocks Plasmodium falciparum (IC50: 15.4 μM) and Leishmania major (IC50: 12.5 μM).</p>Fórmula:C27H35N5O6SCor e Forma:SolidPeso molecular:544.16Dual Cathepsin L/JAK-IN-1
CAS:<p>DualCathepsinL/JAK-IN-1 (Compound A8) serves as a dual inhibitor of Cathepsin L (CTSL) and JAK, exhibiting IC50 values of 0.68 μM for CTSL and 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for JAK1/2/3 and TYK2, respectively. This compound effectively prevents the activation of MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. DualCathepsinL/JAK-IN-1 is applicable in research on acute lung injury (ALI).</p>Fórmula:C19H18ClN5Cor e Forma:SolidPeso molecular:351.833Cathepsin C-IN-5
CAS:<p>Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.</p>Fórmula:C21H17ClN6OSCor e Forma:SolidPeso molecular:436.92Z-FY-CHO
CAS:<p>Pyridoxal (Pyridoxaldehyde), a component of vitamin B6, is an aldehyde obtained by oxidizing pyridoxine and is widely found in plants and animals.</p>Fórmula:C26H26N2O5Pureza:95.88%Cor e Forma:SolidPeso molecular:446.5CTSL/CAPN1-IN-2
CAS:<p>CTSL/CAPN1-IN-2 (Compound 14b) serves as an orally active inhibitor targeting both CTSL and CAPN1, manifesting IC50 values of 6.88 nM for CTSL and 347.6 nM for CAPN1 respectively. This compound not only displays anti-inflammatory attributes but also features favorable pharmacokinetic properties. Moreover, CTSL/CAPN1-IN-2 shows extensive antiviral effects against coronaviruses by inhibiting viral entry [1].</p>Fórmula:C34H40N4O6Cor e Forma:SolidPeso molecular:600.7CatD-IN-1
CAS:<p>CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM, and it shows potential for research in the field of osteoarthritis.</p>Fórmula:C18H18Cl2N4O5Cor e Forma:SolidPeso molecular:441.265Cathepsin C-IN-4
<p>Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM).</p>Fórmula:C21H14ClF3N4SCor e Forma:SolidPeso molecular:446.88MIV-247
CAS:<p>MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.</p>Fórmula:C17H24F3N3O4Pureza:99.27%Cor e Forma:SolidPeso molecular:391.39PD 151746
CAS:<p>PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.</p>Fórmula:C11H8FNO2SPureza:98.63% - ≥95%Cor e Forma:SolidPeso molecular:237.25ALLM
CAS:<p>ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].</p>Fórmula:C19H35N3O4SPureza:98%Cor e Forma:White PowderPeso molecular:401.56
