Cisteína Protease
Os inibidores de protease de cisteína são compostos que visam e inibem as proteases de cisteína, uma classe de enzimas que degradam proteínas ao clivar ligações peptídicas nas quais um resíduo de cisteína atua como nucleófilo. Essas enzimas estão envolvidas em vários processos fisiológicos, incluindo apoptose, resposta imune e renovação proteica. Os inibidores de protease de cisteína são cruciais para o estudo de doenças como câncer, distúrbios neurodegenerativos e infecções parasitárias. Na CymitQuimica, oferecemos inibidores de protease de cisteína para apoiar sua pesquisa em proteólise, regulação celular e descoberta de medicamentos.
Foram encontrados 117 produtos para "Cisteína Protease".
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PMSF
CAS:PMSF (Phenylmethylsulfonyl fluoride) is an irreversible inhibitor of serine/cysteine protease , preparation of cell lysates. High-Quality, Low-Cost!Fórmula:C7H7FO2SPureza:97.75% - 99.88%Cor e Forma:White SolidPeso molecular:174.19Acetyl-Calpastatin (184-210)(human) acetate
Acetyl-Calpastatin acetate inhibits µ-calpain (Ki=0.2nM) and cathepsin L (Ki=6μM) selectively and reversibly.Fórmula:C144H234N36O46SPureza:97.84% - 98.16%Cor e Forma:SolidPeso molecular:3237.68Z-Leu-Tyr-Chloromethylketone
CAS:Z-Leu-Tyr-Chloromethylketone is a calpain inhibitor [1].Fórmula:C24H29ClN2O5Cor e Forma:SolidPeso molecular:460.95N-CBZ-Phe-Arg-AMC
CAS:Z-FR-AMC substrate for serine proteases; cathepsins, kallikrein, plasmin. Substrate: 330/390 nm; Product: 342/441 nm.Fórmula:C33H36N6O6Pureza:98%Cor e Forma:SolidPeso molecular:612.68Dazcapistat
CAS:Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.Fórmula:C21H18FN3O4Pureza:99.11%Cor e Forma:SolidPeso molecular:395.38Ref: TM-T9710
1mg92,00€5mg192,00€1mL*10mM (DMSO)212,00€10mg289,00€25mg522,00€50mg732,00€100mg1.018,00€Leupeptin
CAS:Leupeptin, from actinomycetes, inhibits various proteases (e.g., trypsin, plasmin, kallikrein, papain, cathepsin B) but not α-chymotrypsin/thrombin.Fórmula:C20H38N6O4Pureza:98%Cor e Forma:SolidPeso molecular:426.562Z-FG-NHO-Bz
CAS:Z-FG-NHO-Bz is a selective inhibitor of cathepsin [1].Fórmula:C26H25N3O6Cor e Forma:SolidPeso molecular:475.49Mpro/Cathepsin L-IN-1
Mpro/Cathepsin L-IN-1 (Compound 4d) is an inhibitor of SARS-CoV-2 Mpro and hCatL, with Ki values of 5.54 μM and 0.701 μM, respectively.Fórmula:C24H32FN3O4Cor e Forma:SolidPeso molecular:445.23768FGA139
FGA139 is an inhibitor of cysteine proteases, specifically targeting cathepsin B and L with IC50 values of 4.98 μM and 3.14 μM, respectively. It reduces the production of NO in LPS-induced RAW264.7 cells and lowers TNFα levels in microglia, demonstrating antioxidant and anti-inflammatory properties. Additionally, FGA139 enhances the secretion of neuroprotective metabolites such as purines and linoleic acid in LPS-stimulated microglia. This compound is applicable in the study of neuroinflammatory diseases.Fórmula:C48H58BF2N7O5Cor e Forma:SolidPeso molecular:861.45605Tacalcitol monohydrate
CAS:Tacalcitol monohydrate(Curatoderm monohydrate), a vitamin D3 analog that promotes bone development by regulating calcium ions, can be used to study psoriasis.Fórmula:C27H46O4Pureza:99.28%Cor e Forma:SolidPeso molecular:434.65SmCB1-IN-1
SmCB1-IN-1 (Compound 2h) is an inhibitor of the Schistosoma mansoni cathepsin B1 (SmCB1) with a Ki of 0.05 μM. It demonstrates selectivity towards non-target human proteases, showing inhibition rates of 29% for CatB and 37% for CatL at 20 μM. At 1 μM, SmCB1-IN-1 inhibits 68% of Schistosoma mansoni.Fórmula:C26H25NO6SCor e Forma:SolidPeso molecular:479.14026Cathepsin L-IN-5
CathepsinL-IN-5 (D6-3) is a potent inhibitor of Cathepsin L (CatL) with an IC50 value of 0.27 nM. It effectively blocks the function of CatL and significantly impedes the entry of SARS-CoV-2 pseudovirus into cells by inhibiting the cleavage of the spike protein. CathepsinL-IN-5 is applicable for research on infections.Cor e Forma:Odour SolidPD150606
CAS:PD150606 is a calpain inhibitor with neuroprotective activity that inhibits μ-calpains and interferes with excitotoxicity-dependent motor neuron death.Fórmula:C9H7IO2SPureza:98.19%Cor e Forma:SolidPeso molecular:306.12Cathepsin K inhibitor 7
Cathepsin K Inhibitor7 (compound 7) is an inhibitor of Cathepsin K, exhibiting a pKi value of 7.3. It is utilized in research on osteoporosis.Cor e Forma:Odour SolidProtease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Cor e Forma:Odour SolidRef: TM-L1100
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarCathepsin D and E FRET Substrate acetate
Fluorogenic substrate for cathepsins D & E, not B/H/L; useful in their mechanistic studies.Fórmula:C86H124N22O21Pureza:96.47%Cor e Forma:Yellow SolidPeso molecular:1802.04Cathepsin L-IN-3
CAS:Cathepsin L-IN-3, a tripeptide-sized inhibitor of cathepsin L, effectively targets this specific enzyme.Fórmula:C41H49N7O4SCor e Forma:SolidPeso molecular:735.94Cathepsin Inhibitor 4
Cathepsin Inhibitor 4 (Compound 45) is a selective inhibitor of Cathepsin S, with a Ki value of 0.04 nM.
Fórmula:C24H35N3O5Peso molecular:445.257676,6′-Dihydroxythiobinupharidine
CAS:6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-foldFórmula:C30H42N2O4SCor e Forma:SolidPeso molecular:526.73Hepcidin-1 (mouse)
CAS:Hepcidin-1 (mouse) is a peptide hormone that regulates iron balance, elevates mRNA for TRAP, cathepsin K, and MMP-9, and promotes TRAP-5b protein secretion.Fórmula:C111H169N31O35S8Cor e Forma:SolidPeso molecular:2754.24Cathepsin C-IN-6
Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastaseFórmula:C24H35N5O4·xC2HF3O2Cor e Forma:SolidMpro/Cathepsin L-IN-2
Mpro/Cathepsin L-IN-2 (Compound 1) is an irreversible dual inhibitor targeting the main protease of SARS-CoV-2 (Mpro, pIC50=8.61) and human cathepsin L (hCTSL, pIC50=7.64). Mpro/Cathepsin L-IN-2 shows potential for use in research related to COVID-19 and other coronavirus infections.Cor e Forma:Odour SolidZ-Arg-Arg-βNA acetate
CAS:Z-Arg-Arg-βNA acetate serves as a sensitive dipeptide substrate for Cathepsin B protease, while demonstrating resistance to proteases H and L. This compound is crucial for differentiating non-Cathepsin B type proteins.Fórmula:C32H43N9O6Cor e Forma:SolidPeso molecular:649.74Cathepsin D and E FRET Substrate
CAS:Mca-GKPILFFRL-Dpa-r-amide, FRET substrate for cathepsin D and E. Also cleaved by napsin A.Fórmula:C85H122N22O19Cor e Forma:SolidPeso molecular:1756.046Cathepsin D/E Substrate, Fluorogenic
CathepsinD/E Substrate, Fluorogenic, is an 11-amino acid peptide specifically designed as a substrate for cathepsins D and E, demonstrating selectivity by not acting as a substrate for cathepsins B, H, or L.Fórmula:C83H119N21O18Cor e Forma:SolidPeso molecular:1697.9042VK13
VK13 (Compound 6) is a potent inhibitor of human cathepsin L (hCatL) and SARS-CoV-2 3CLpro (3CL-PR), with Ki values of 2.6 nM and 0.55 nM, respectively. It also exhibits activity against CoV-2, with an EC50 value of 1.25 μM.Fórmula:C24H28N4O5Cor e Forma:SolidPeso molecular:452.503CTSL/CAPN1-IN-1
CTSL/CAPN1-IN-1 (compound 14a) is an orally active inhibitor targeting CTSL and CAPN1, with IC50 values of 3.34 nM and 375.1 nM, respectively. It exhibits both anti-coronavirus and anti-inflammatory activities.Fórmula:C34H33FN4O6Cor e Forma:SolidPeso molecular:612.23841Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)
Fluorogenic substrate for cathepsins D & E; cleaves at Phe-Phe bond; not for B, H, L. Useful for assays and studies.Cor e Forma:Odour SolidZ-Phe-Tyr(tBu)-diazomethylketone
CAS:Irreversible cathepsin L inhibitor which is ca 10'000 times more effective in inactivating cathepsin L than cathepsin S.Fórmula:C31H34N4O5Cor e Forma:SolidPeso molecular:542.636Z-L(D-Val)G-CHN2
Z-L(D-Val)G-CHN2, an isoform of Z-LVG-CHN2, serves as a cell-permeable and irreversible inhibitor of cysteine proteinase.Fórmula:C22H31N5O5Pureza:98%Cor e Forma:SolidPeso molecular:445.51Relacatib
CAS:Relacatib (SB-462795) is a potent cathepsins K, L, V inhibitor with high affinity (Ki: 41-68 pM) and reduces bone resorption effectively.Fórmula:C27H32N4O6SCor e Forma:SolidPeso molecular:540.64N-CBZ-Phe-Arg-AMC TFA
N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.Fórmula:C35H37F3N6O8Pureza:99.88%Cor e Forma:White SolidPeso molecular:726.7Gallinamide A TFA
CAS:Gallinamide A TFA is a peptide that exhibits linear deposition and serves as a potent inhibitor of cathepsin L (CatL) with an IC50 of 17.6 pM. It inhibits SARS-CoV-2 infection by targeting CatL (EC50: 28 nM) and also inhibits Plasmodium falciparum with an IC50 of 50 nM [1] [2].Fórmula:C33H53F3N4O9Cor e Forma:SolidPeso molecular:706.79Ac-PLVE-FMK
CAS:Ac-PLVE-FMK (Ac-Pro-Leu-Val-Glu(OMe)-CH2F), a tetrapeptidyl fluoromethylketone (FMKs), serves as a cathepsin inhibitor. It is utilized in cancer research [1].Fórmula:C25H41FN4O7Pureza:98%Cor e Forma:SolidPeso molecular:528.61LN5P45
LN5P45, an OTUB2 inhibitor (IC50: 2.3 μM), promotes monoubiquitination of OTUB2 at lysine 31 and is utilized in the study of tumor progression and metastasis [1Fórmula:C13H15ClN2O2Cor e Forma:SolidPeso molecular:266.72Odanacatib
CAS:Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.Fórmula:C25H27F4N3O3SPureza:98.53% - 99.53%Cor e Forma:SolidPeso molecular:525.56JTE-607
CAS:JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.Fórmula:C25H33Cl4N3O5Pureza:97.88%Cor e Forma:SolidPeso molecular:597.36Ref: TM-T27695
1mg42,00€5mg93,00€1mL*10mM (DMSO)109,00€10mg150,00€25mg310,00€50mg492,00€100mg707,00€200mg973,00€Aloxistatin
CAS:Aloxistatin (E64d) inhibits cysteine proteases, blocks calpain in platelets, and prevents blood clotting.Fórmula:C17H30N2O5Pureza:99.46% - 99.69%Cor e Forma:SolidPeso molecular:342.43Balicatib
CAS:Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.Fórmula:C23H33N5O2Pureza:97.78% - 98.17%Cor e Forma:SolidPeso molecular:411.54E 64c
CAS:E 64c (EP 475) , a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.Fórmula:C15H26N2O5Pureza:98.73%Cor e Forma:SolidPeso molecular:314.382-Cyanopyrimidine
CAS:2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM)Fórmula:C5H3N3Pureza:99.27%Cor e Forma:SolidPeso molecular:105.1CA-074 methyl ester
CAS:CA-074 methyl ester (Cathepsin B Inhibitor IV) is a selective inhibitor of Cathepsin B (IC50=36.3 nM). neuroprotective effect. High-Quality, Low-Cost!Fórmula:C19H31N3O6Pureza:97.26% - 99.58%Cor e Forma:SolidPeso molecular:397.47KGP94
CAS:KGP94 is a potent, selective, and competitive inhibitor of the lysosomal endopeptidase enzyme.Fórmula:C14H12BrN3OSPureza:99.6%Cor e Forma:White SolidPeso molecular:350.23Ref: TM-T27730
1mg65,00€5mg138,00€1mL*10mM (DMSO)152,00€10mg215,00€25mg359,00€50mg510,00€100mg692,00€200mg928,00€LY 3000328
CAS:LY 3000328 (Cathepsin S inhibitor) is a selective inhibitor of cathepsin S.Cost-effective and quality-assured.Fórmula:C25H29FN4O5Pureza:97.83% - 99.54%Cor e Forma:White SolidPeso molecular:484.52Ref: TM-TQ0116
1mg90,00€2mg130,00€5mg198,00€1mL*10mM (DMSO)207,00€10mg263,00€25mg462,00€50mg672,00€100mg945,00€L-006235
CAS:L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.Fórmula:C24H30N6O2SPureza:99.37%Cor e Forma:SolidPeso molecular:466.6Ref: TM-T21616
2mg39,00€5mg60,00€1mL*10mM (DMSO)62,00€10mg92,00€25mg177,00€50mg299,00€100mg432,00€200mg602,00€MDL-28170
CAS:MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.Fórmula:C22H26N2O4Pureza:95.06%Cor e Forma:SolidPeso molecular:382.45Ref: TM-T2470
1mg34,00€2mg49,00€5mg71,00€1mL*10mM (DMSO)75,00€10mg90,00€25mg128,00€50mg167,00€100mg284,00€(1S,2R)-Alicapistat
CAS:(1S,2R)-Alicapistat inhibits calpains 1 and 2, shows promise for Alzheimer's, and has an IC50 of 395 nM.Fórmula:C25H27N3O4Pureza:99.60%Cor e Forma:White SolidPeso molecular:433.5Ref: TM-T60150
1mg64,00€5mg142,00€1mL*10mM (DMSO)167,00€10mg197,00€25mg299,00€50mg400,00€100mg537,00€ALLM
CAS:ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].Fórmula:C19H35N3O4SPureza:98%Cor e Forma:SolidPeso molecular:401.56S 2160
CAS:S 2160 is a synthetic chromogenic substrate for thrombin.Fórmula:C33H40N8O6Cor e Forma:SolidPeso molecular:644.72Cathepsin Inhibitor 1
CAS:Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.Fórmula:C20H24ClN5O2Pureza:99.78%Cor e Forma:SolidPeso molecular:401.89Ref: TM-T6015
1mg46,00€5mg90,00€1mL*10mM (DMSO)100,00€10mg144,00€25mg236,00€50mg371,00€100mg522,00€200mg743,00€
