Cisteína Protease
Os inibidores de protease de cisteína são compostos que visam e inibem as proteases de cisteína, uma classe de enzimas que degradam proteínas ao clivar ligações peptídicas nas quais um resíduo de cisteína atua como nucleófilo. Essas enzimas estão envolvidas em vários processos fisiológicos, incluindo apoptose, resposta imune e renovação proteica. Os inibidores de protease de cisteína são cruciais para o estudo de doenças como câncer, distúrbios neurodegenerativos e infecções parasitárias. Na CymitQuimica, oferecemos inibidores de protease de cisteína para apoiar sua pesquisa em proteólise, regulação celular e descoberta de medicamentos.
Foram encontrados 117 produtos para "Cisteína Protease".
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Calpain Inhibitor XII
CAS:Calpain Inhibitor XII (Z-L-Nva-CONH-CH2-2-Py) is a calpain I inhibitor that inhibits calpain II and cathepsin B.Fórmula:C26H34N4O5Pureza:99.24%Cor e Forma:Yellow SolidPeso molecular:482.57LmCPB-IN-1
CAS:LmCPB-IN-1, compound 35, is a reversible inhibitor of LmCPB with strong binding (pKi 9.7).Fórmula:C18H30N6O2Cor e Forma:SolidPeso molecular:362.47DTS
CAS:DTS is a selective and isoform-specific RSK1 kinase inhibitor. It also has broad cancer therapeutic potential.Fórmula:C14H14S3Pureza:98%Cor e Forma:SolidPeso molecular:278.46Cathepsin L/S-IN-1
Cathepsin L/S-IN-1 inhibits Cathepsin L & S (IC50: 4.10 & 1.79 μM) and reduces metastasis in pancreatic cancer cells.Fórmula:C29H33BrN4O4SCor e Forma:SolidPeso molecular:613.57JPM-OEt
CAS:JPM-OEt: broad-spectrum, covalent cysteine cathepsin inhibitor with antitumor effects.Fórmula:C20H28N2O6Pureza:98%Cor e Forma:SolidPeso molecular:392.45GSK-2793660
CAS:GSK-2793660, an oral, irreversible CTSC inhibitor, aids bronchiectasis research.Fórmula:C20H27N3O3Pureza:98%Cor e Forma:SolidPeso molecular:357.45Gü1303
CAS:Gü1303 is a highly potent and reversible inhibitor of Cathepsin K (CatK), with a Ki value of 0.91 nM for mature CatK (mCatK).Fórmula:C20H22N4O3Cor e Forma:SolidPeso molecular:366.41Cysteine Protease inhibitor
CAS:Cysteine protease inhibitors are inhibitors of cysteine proteases. Target: Cysteine ProteaseFórmula:C18H14N4OPureza:98%Cor e Forma:SolidPeso molecular:302.33GSK2793660 HCl
CAS:GSK2793660 is a irreversible covalent α,β-unsaturated amide based DPP1 inhibitor.Fórmula:C22H32ClN3O3Cor e Forma:SolidPeso molecular:421.96JNJ-10329670
CAS:JNJ 10329670 is a highly potent (Ki of approximately 30 nM), nonpeptidic, noncovalent inhibitor of human cathepsin S with immunosuppressive activity.Fórmula:C30H34ClF3N6O3SCor e Forma:SolidPeso molecular:651.14Gü2602
CAS:Gü2602 inhibits the cathepsin K zymogen autocatalytic activation that is a potent, reversible inhibitor of cathepsin K (CatK) with a Ki of 0.013 nM for matureFórmula:C16H22N4O3Cor e Forma:SolidPeso molecular:318.37VEL-0230
CAS:VEL-0230 (NC-2300) is a cathespin K inhibitor boosting bone growth and reducing loss, targeting bone diseases and developed by Velcura Therapeutics.Fórmula:C14H24NNaO5Cor e Forma:SolidPeso molecular:309.33ASPER-29
CAS:ASPER-29, an Asperphenamate analog, inhibits cathepsins L/S with IC50s of 6.03/5.02 μM, useful in cancer migration/invasion research.Fórmula:C31H29BrN2O5SCor e Forma:SolidPeso molecular:621.54L-873724
CAS:L-873724: Selective, reversible cathepsin K inhibitor; IC50s—cat K: 0.2 nM, cat S: 178 nM, cat L: 264 nM, cat B: 5239 nM; inhibits bone resorption.Fórmula:C23H26F3N3O3SPureza:98%Cor e Forma:SolidPeso molecular:481.53CAA0225
CAS:CAA0225 is a selective inhibitor of cathepsin L. CAA0225 is a probe for autophagic proteolysis.Fórmula:C28H29N3O5Cor e Forma:SolidPeso molecular:487.55MDL 27399
CAS:MDL 27399 suppresses human neutrophil cathepsin G.Fórmula:C26H36N4O8Cor e Forma:SolidPeso molecular:532.59AM 4299 B
CAS:AM 4299 B is a novel inhibitor of a thiol protease.Fórmula:C16H27N3O7Pureza:98%Cor e Forma:SolidPeso molecular:373.4Cysteine Protease inhibitor hydrochloride
CAS:Cysteine Protease inhibitor hydrochloride is a cysteine protease inhibitor.Fórmula:C18H15ClN4OPureza:98%Cor e Forma:SolidPeso molecular:338.79NAAA-IN-2
CAS:NAAA-IN-2, a selective inhibitor with 50 nM IC50, targets NAAA, an enzyme hydrolyzing PEA/OEA, and may aid inflammation and pain studies.Fórmula:C11H13N3O2SCor e Forma:SolidPeso molecular:251.3SSAA09E1
CAS:SSAA09E1 blocks SARS-CoV entry, lowers ACE2-mediated HEK293T cell infection (EC50 = 6.7 μM), and inhibits cathepsin L (IC50 = 5.33 μM).Fórmula:C7H9N3S2Cor e Forma:SolidPeso molecular:199.3SQ 32602
CAS:SQ 32602 is a cathepsin E inhibitor.Fórmula:C32H52N3O7PCor e Forma:SolidPeso molecular:621.74Dutacatib
CAS:Dutacatib is an inhibitor of SARS-CoV-2 3CLpro and cathepsin K, offering antiviral properties and potential benefits in treating cancer-induced bone disease.Fórmula:C23H31N7OCor e Forma:SolidPeso molecular:421.54Cysteine protease inhibitor-2
CAS:Cysteine protease inhibitor from US20070032499A1; halts DCT116 at 6.5μM, PC3 at 4.4μM.Fórmula:C13H5N5OPureza:98%Cor e Forma:SolidPeso molecular:247.21Kgp-IN-1
CAS:Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor.Fórmula:C19H24F4N4O3Pureza:98%Cor e Forma:SolidPeso molecular:432.41LHVS
CAS:LHVS effectively blocks T.Fórmula:C28H37N3O5SPureza:98%Cor e Forma:SolidPeso molecular:527.68CA 074
CAS:CA 074 is a potent inhibitor of cathepsin B with a Ki value of 2 to 5 nM.CA 074 inhibits ischemic hippocampal neuronal death in primates and attenuatesFórmula:C18H29N3O6Pureza:98.81%Cor e Forma:White SolidPeso molecular:383.44Ref: TM-T21509
1mg75,00€1mL*10mM (DMSO)168,00€5mg200,00€10mg313,00€25mg625,00€50mg868,00€100mg1.153,00€Oxocarbazate
CAS:Oxocarbazate (CID23631927) is a subnanomolar, reversible cathepsin L inhibitor, also reducing SARS-CoV and Ebola virus entry into human cells.Fórmula:C28H33N5O6Cor e Forma:SolidPeso molecular:535.59Calpain-2-IN-1
CAS:Calpain-2-IN-1 is a selective calpain-2 inhibitor with Ki values of 181 nM for calpain-1 and 7.8 nM for calpain-2, applicable for neurodegenerative diseases a.Fórmula:C28H37N3O7Pureza:98.05%Cor e Forma:White SolidPeso molecular:527.61GSK2793660 free base
CAS:GSK-2793660, a cathepsin C inhibitor, may treat cystic fibrosis and related lung conditions.Fórmula:C22H31N3O3Cor e Forma:SolidPeso molecular:385.5JNJ-10311795
CAS:JNJ-10311795 (RWJ-355871) is an inhibitor of neutrophil elastase G and mast cell chymase, demonstrating significant anti-inflammatory effects.Fórmula:C40H35N2O6PPureza:97.43%Cor e Forma:SolidPeso molecular:670.69Cathepsin X-IN-1
CAS:Cathepsin X-IN-1 (compound 25) reduces the migration of PC-3 cell with low cytotoxic that is a potent inhibitor of Cathepsin X (IC 50 = 7.13 μM) [1].Fórmula:C15H13N3O3SPureza:99.34%Cor e Forma:White SolidPeso molecular:315.35MeOSuc-AAPV-CMK
CAS:MeOSuc-AAPV-CMK (Elastase Inhibitor III) serves as an inhibitor of elastase, as well as cathepsin G and proteinase 3, and impedes leukocyte elastase-mediatedFórmula:C22H35ClN4O7Cor e Forma:SolidPeso molecular:502.99Z-LVG
CAS:Z-LVG, an irreversible cysteine protease inhibitor and a tripeptide derivative of cystatin C, serves as an inhibitor of viral replication and is utilized inFórmula:C21H31N3O6Cor e Forma:SolidPeso molecular:421.49Cathepsin K inhibitor 3
CAS:Cathepsin K inhibitor 3: Selective, IC50 of 0.5 nM, good pharmacokinetics, potential for OA research.Fórmula:C30H31FN4O4SCor e Forma:SolidPeso molecular:562.65ABP 25
CAS:ABP 25 is a highly potent and selective activity-based probe (ABP) for cathepsin K imaging.Fórmula:C55H66ClN5O3Cor e Forma:SolidPeso molecular:880.6MPI8
CAS:MPI8 is a SARS-CoV-2 Protease inhibitor (IC50 = 105 nM).Fórmula:C32H48N4O7Cor e Forma:SolidPeso molecular:600.75Z-DEVD-CMK
CAS:Z-DEVD-CMK irreversibly inhibits various cathepsins in vitro [1].Fórmula:C27H35ClN4O12Cor e Forma:SolidPeso molecular:643.04Z-FG-NHO-BzOME
CAS:Z-FG-NHO-BzOME is a chemical compound functioning as a cysteine protease inhibitor, selectively targeting and inhibiting cathepsin B, cathepsin L, cathepsin S,Fórmula:C27H27N3O7Cor e Forma:SolidPeso molecular:505.52Petesicatib
CAS:Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.Fórmula:C25H23F6N5O4SPureza:99.76% - 99.86%Cor e Forma:SolidPeso molecular:603.54Ref: TM-T16474
1mg100,00€5mg236,00€1mL*10mM (DMSO)314,00€10mg371,00€25mg735,00€50mg1.134,00€100mg1.468,00€200mg1.972,00€SID 26681509
CAS:SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).Fórmula:C27H33N5O5SPureza:99.18%Cor e Forma:White SolidPeso molecular:539.65Ref: TM-T12909
1mg63,00€5mg137,00€1mL*10mM (DMSO)163,00€10mg205,00€25mg414,00€50mg618,00€100mg882,00€Cathepsin Inhibitor 2
CAS:Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).Fórmula:C19H21F6N3OPureza:98%Cor e Forma:SolidPeso molecular:421.38SPR38
SPR38: SARS-CoV-2 protease inhibitor with Ki 0.260 μM; also blocks hCatL (Ki 1.92 μM) and hCatB (Ki 11.1 μM).Fórmula:C24H33N3O5Cor e Forma:SolidPeso molecular:443.54SQ 32056
CAS:SQ 32056 is a cathepsin E inhibitor.Fórmula:C37H56N4O5Pureza:98%Cor e Forma:SolidPeso molecular:636.86(Rac)-Neurodegenerative Disorder-Targeting Compound 1
CAS:(Rac)-Neurodegenerative Disorder-Targeting Compound 1 is a calpain inhibitor.Fórmula:C28H28N4O4Cor e Forma:SolidPeso molecular:484.55MK-0674
CAS:MK-0674 is a cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S for metabolism-related diseases.Fórmula:C26H27F6N3O2Pureza:97.3% - 99.91%Cor e Forma:White SolidPeso molecular:527.5VBY-825
CAS:VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.Fórmula:C23H29F4N3O5SPureza:99.91%Cor e Forma:White SolidPeso molecular:535.55CatD-IN-1
CAS:CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM, and it shows potential for research in the field of osteoarthritis.Fórmula:C18H18Cl2N4O5Cor e Forma:SolidPeso molecular:441.265CTSL/CAPN1-IN-2
CAS:CTSL/CAPN1-IN-2 (Compound 14b) serves as an orally active inhibitor targeting both CTSL and CAPN1, manifesting IC50 values of 6.88 nM for CTSL and 347.6 nM for CAPN1 respectively. This compound not only displays anti-inflammatory attributes but also features favorable pharmacokinetic properties. Moreover, CTSL/CAPN1-IN-2 shows extensive antiviral effects against coronaviruses by inhibiting viral entry [1].Fórmula:C34H40N4O6Cor e Forma:SolidPeso molecular:600.7Cathepsin C-IN-4
Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM).Fórmula:C21H14ClF3N4SCor e Forma:SolidPeso molecular:446.88Cathepsin K inhibitor 2
CAS:Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.Fórmula:C30H33F4N5O3Cor e Forma:SolidPeso molecular:587.61
