Cisteína Protease
Os inibidores de protease de cisteína são compostos que visam e inibem as proteases de cisteína, uma classe de enzimas que degradam proteínas ao clivar ligações peptídicas nas quais um resíduo de cisteína atua como nucleófilo. Essas enzimas estão envolvidas em vários processos fisiológicos, incluindo apoptose, resposta imune e renovação proteica. Os inibidores de protease de cisteína são cruciais para o estudo de doenças como câncer, distúrbios neurodegenerativos e infecções parasitárias. Na CymitQuimica, oferecemos inibidores de protease de cisteína para apoiar sua pesquisa em proteólise, regulação celular e descoberta de medicamentos.
Foram encontrados 110 produtos de "Cisteína Protease"
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CatD-IN-1
CAS:CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM, and it shows potential for research in the field of osteoarthritis.Fórmula:C18H18Cl2N4O5Cor e Forma:SolidPeso molecular:441.265GB111-NH2
CAS:GB111-NH2, a cysteine cathepsin inhibitor, is applicable in cancer research [1].Fórmula:C33H39N3O6Cor e Forma:SolidPeso molecular:573.68Verducatib
CAS:Verducatib is an inhibitor of cathepsins (cathepsin).Fórmula:C31H35FN4O3Cor e Forma:SolidPeso molecular:530.633Z-FY-CHO
CAS:Pyridoxal (Pyridoxaldehyde), a component of vitamin B6, is an aldehyde obtained by oxidizing pyridoxine and is widely found in plants and animals.Fórmula:C26H26N2O5Pureza:95.88%Cor e Forma:SolidPeso molecular:446.5Cathepsin C-IN-5
CAS:<p>Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.</p>Fórmula:C21H17ClN6OSCor e Forma:SolidPeso molecular:436.92Dual Cathepsin L/JAK-IN-1
CAS:DualCathepsinL/JAK-IN-1 (Compound A8) serves as a dual inhibitor of Cathepsin L (CTSL) and JAK, exhibiting IC50 values of 0.68 μM for CTSL and 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for JAK1/2/3 and TYK2, respectively. This compound effectively prevents the activation of MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. DualCathepsinL/JAK-IN-1 is applicable in research on acute lung injury (ALI).Fórmula:C19H18ClN5Cor e Forma:SolidPeso molecular:351.833Z-Val-Val-Nle-diazomethylketone
CAS:Z-Val-Val-Nle-diazomethylketone is an inhibitor of cathepsin S (CATS). It significantly suppresses the upregulation of IFNg-induced MHCII molecules, specifically HLA-DR and Ii-p33/35, while increasing the protein level of Ii-p10. This compound can be utilized for research into skin disorders such as psoriasis, atopic dermatitis, and actinic keratosis.Fórmula:C25H37N5O5Cor e Forma:SolidPeso molecular:487.59MIV-247
CAS:MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.Fórmula:C17H24F3N3O4Pureza:99.27%Cor e Forma:SolidPeso molecular:391.39PD 151746
CAS:PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.Fórmula:C11H8FNO2SPureza:98.63% - ≥95%Cor e Forma:SolidPeso molecular:237.25ALLM
CAS:ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].Fórmula:C19H35N3O4SPureza:98%Cor e Forma:White PowderPeso molecular:401.56
