Receptor activado por protease
Os inibidores dos Receptores Ativados por Proteases (PAR) são compostos que têm como alvo e inibem a atividade dos PARs, uma família de receptores acoplados à proteína G que são ativados por clivagem proteolítica. Esses receptores desempenham um papel em vários processos fisiológicos, incluindo coagulação, inflamação e reparo tecidual. Os inibidores de PAR são ferramentas valiosas para estudar os mecanismos desses processos e seu envolvimento em doenças como câncer, distúrbios cardiovasculares e inflamação crônica. Na CymitQuimica, oferecemos inibidores de PAR para apoiar sua pesquisa em transdução de sinal, resposta imunológica e descoberta terapêutica.
Foram encontrados 55 produtos de "Receptor activado por protease"
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TRAP-6 amide
CAS:TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide.Fórmula:C34H57N11O8Cor e Forma:SolidPeso molecular:747.899PAR-4 Agonist Peptide, amide
CAS:PAR-4 Agonist Peptide, amide (AY-NH2) is an agonist of proteinase-activated receptor-4 (PAR-4).Fórmula:C34H48N8O7Pureza:98%Cor e Forma:SolidPeso molecular:680.79H-Ser-Phe-Leu-Leu-Arg-OH
CAS:Thrombin Receptor Activator for Peptide 5 (TRAP-5) is also called Coagulation Factor II Receptor (1-5), used in the research of coronary heart disease (CHD).Fórmula:C30H50N8O7Pureza:98%Cor e Forma:SolidPeso molecular:634.77PAR650097
PAR650097 is a humanized monoclonal antibody targeting PAR2, used in migraine research.Pureza:96.67% (SEC-HPLC) - 98.83% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:144.1 kDaPZ-128
CAS:PZ-128, a PAR1 antagonist, is used potentially for the treatment of thrombosis.Fórmula:C55H99N13O9Pureza:98%Cor e Forma:SolidPeso molecular:1086.46PAR-4 Agonist Peptide, amide acetate
PAR-4 Agonist Peptide, amide acetate is an agonist of proteinase-activated receptor-4 (PAR-4).Fórmula:C36H52N8O9Pureza:98%Cor e Forma:SolidPeso molecular:740.86Parstatin(mouse)
CAS:Peptide inhibits endothelial migration/proliferation (IC50 ~20μM), induces cell cycle arrest, triggers apoptosis, and has cardioprotective effects.Fórmula:C189H326N58O57S3Pureza:98%Cor e Forma:SolidPeso molecular:4419.19AC-264613
CAS:AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5.Fórmula:C19H18BrN3O2Pureza:98%Cor e Forma:SolidPeso molecular:400.28Parstatin(human)
CAS:Cell-permeable PAR1-derived peptide; inhibits endothelial migration, proliferation (IC50 ~3μM), induces apoptosis, and has cardioprotective effects.Fórmula:C191H330N64O53S3Pureza:98%Cor e Forma:SolidPeso molecular:4467.292-Furoyl-LIGRLO-amide
CAS:2-Furoyl-LIGRLO-amide TFA is a peptide that acts as a proteinase-activated receptor-2 (PAR2) agonist, and contains a furoyl group addition at its N-terminal.Fórmula:C36H63N11O8Pureza:98%Cor e Forma:SolidPeso molecular:777.95Parstatin(human) TFA
Parstatin(human) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, effectively inhibits angiogenesis, as indicated by studies [1] [2].Fórmula:C193H331F3N64O55S3Cor e Forma:SolidPeso molecular:4581.28RAG8 peptide
RAG8 peptide is an antagonist of protease-activated receptor 4 (PAR 4), which inhibits late-stage platelet activation and reduces thrombosis without altering hemostasis or increasing bleeding risk. It is applicable in atherosclerosis research.Fórmula:C56H98N16O11Peso molecular:1170.7601tcY-NH2
CAS:Selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.Fórmula:C40H49N7O7Pureza:98%Cor e Forma:SolidPeso molecular:739.87FSLLRY-NH2
CAS:PAR2 antagonist; counters taxol effects, PKC in mice; inhibits ERK, collagen in fibroblasts; lessens dermatophyte itch in mice.Fórmula:C39H60N10O8Pureza:98%Cor e Forma:SolidPeso molecular:796.97Protease-Activated Receptor-1, PAR-1 Agonist TFA
PAR-1 Agonist TFA: Selective peptide, mimics thrombin, activates PAR-1 receptor.Cor e Forma:LiquidAY 254
CAS:AY 254: Potent PAR2 agonist, ERK1/2 activation (EC50=2 nM), limits caspase 3/8, aids HT29 cell healing, boosts IL-8.
Fórmula:C30H49N9O6Cor e Forma:SolidPeso molecular:631.779Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2
CAS:Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biologically active peptide functioning as a selective agonist for Protease Activated Receptor 1 (PAR-1), a subtypeFórmula:C42H63FN12O8Cor e Forma:SolidPeso molecular:883.02PAR-2 (1-6) (human)
CAS:PAR-2 (1-6) (human) (SLIGKV), a peptide ligand, is a PAR-2 agonist [1] .Fórmula:C28H53N7O8Cor e Forma:SolidPeso molecular:615.76SFNGGP-NH2
CAS:SFNGGP-NH2 is a biologically active peptide that interacts with Protease-Activated Receptor 3 (PAR-3), a high-affinity thrombin receptor.Fórmula:C25H36N8O8Cor e Forma:SolidPeso molecular:576.6Protease-Activated Receptor-1, PAR-1 Agonist
CAS:Selective peptide agonist that mimics thrombin to activate PAR-1 receptor, enabling targeted receptor activation.Fórmula:C35H58N10O9Cor e Forma:SolidPeso molecular:762.91FLLRN
CAS:FLLRN is a biologically active peptide serving as a PAR1-specific antagonist.Fórmula:C31H51N9O7Cor e Forma:SolidPeso molecular:661.79YFLLRNP
CAS:YFLLRNP is a biologically active peptide functioning as a partial agonist of PAR-1, selectively activating the G12/13 signaling pathway.Fórmula:C45H67N11O10Cor e Forma:SolidPeso molecular:922.08TRAP-5 amide
CAS:TRAP-5 amide is a peptide agonist for protease-activated receptor 1 (PAR 1) [1].Fórmula:C30H51N9O6Cor e Forma:SolidPeso molecular:633.78PAR 4 (1-6) (TFA)
PAR 4 (1-6) TFA (GYPGQV TFA), a hexapeptide derived from protease-activated receptor 4 (PAR 4), serves as a specific agonist for PAR 4.Fórmula:C28H41N7O9·xC2HF3O2Cor e Forma:SolidP4pal10 TFA
P4pal10 TFA, the TFA salt form of P4pal10, serves as an antagonist of the protease-activated receptor 4 (PAR4). This compound inhibits platelet aggregation and thrombin generation induced by tissue factor (TF), exhibiting anticoagulant and antithrombotic activities. Additionally, P4pal10 TFA alleviates carrageenan-induced edema and neutrophil infiltration, and ameliorates damage in rat myocardial ischemia/reperfusion (I/R) models.Cor e Forma:Odour SolidTRAP-6 amide TFA
CAS:TRAP-6 amide TFA is a PAR-1 thrombin receptor agonist peptide.Fórmula:C36H58F3N11O10Cor e Forma:SolidPeso molecular:861.922TFLLR-NH2(TFA)
CAS:TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM. EC50: 1.9 μM (PAR1)Fórmula:C33H54F3N9O8Pureza:98%Cor e Forma:SolidPeso molecular:761.83SLIGRL-NH2
CAS:SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is a PAR-2 agonist that induces non-histaminergic pruritus.Fórmula:C29H56N10O7Pureza:98.29%Cor e Forma:SolidPeso molecular:656.82AZ3451
CAS:AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).Fórmula:C30H27BrN4O3Pureza:98.12%Cor e Forma:SolidPeso molecular:571.46PAR-2-IN-1
CAS:PAR-2-IN-1 (IUN76750) is a PAR- 2 signaling pathway inhibitor with anti-inflammatory and anticancer effects.Fórmula:C12H14ClN3O2Pureza:99.75%Cor e Forma:SolidPeso molecular:267.71Ref: TM-T8917
2mg34,00€5mg50,00€1mL*10mM (DMSO)52,00€10mg86,00€25mg161,00€50mg243,00€100mg355,00€200mg502,00€Vorapaxar
CAS:Vorapaxar (MK-5348) (SCH 530348) is an effective and orally active thrombin receptor (PAR-1) antagonist (Ki: 8.1 nM).Fórmula:C29H33FN2O4Pureza:98.77% - 99.93%Cor e Forma:SolidPeso molecular:492.58Ref: TM-T7013
1mg71,00€5mg138,00€1mL*10mM (DMSO)152,00€10mg192,00€25mg326,00€50mg447,00€100mg642,00€200mg888,00€Vorapaxar sulfate
CAS:Vorapaxar sulfate (Zontivity) is a potent and orally active thrombin receptor (PAR-1) antagonist.Fórmula:C29H35FN2O8SPureza:99.9% - >99.99%Cor e Forma:SolidPeso molecular:590.66Ref: TM-T3098
1mg35,00€2mg50,00€5mg74,00€1mL*10mM (DMSO)94,00€10mg113,00€25mg200,00€50mg334,00€100mg500,00€500mg1.099,00€TFLLR-NH2 2TFA(197794-83-5(free base))
TFLLR-NH2 2TFA(197794-83-5(free base)) is an agonist of PAR1 (EC50 :1.9 μM).Fórmula:C35H55F6N9O10Pureza:99.56%Cor e Forma:SolidPeso molecular:875.87I-191
CAS:I-191 is a potent antagonist of protease-activated receptor 2 (PAR2), inhibits multiple signaling functions in human cancer cells.Fórmula:C23H26FN5O2Pureza:99.8%Cor e Forma:SolidPeso molecular:423.48TRAP-6
CAS:TRAP-6 (Thrombin Receptor Activator Peptide 6)(2TFA) is an agonist of protease-activated receptor 1 (PAR1).Fórmula:C34H56N10O9Pureza:>99.99%Cor e Forma:SolidPeso molecular:748.87Ref: TM-T7625
1mg40,00€2mg52,00€5mg88,00€10mg126,00€1mL*10mM (DMSO)126,00€25mg274,00€50mg411,00€100mg550,00€200mg785,00€TRAP-6 amide acetate
TRAP-6 amide acetate is a PAR-1 thrombin receptor agonist peptide[1].Fórmula:C36H61N11O10Pureza:98.55%Cor e Forma:SolidPeso molecular:807.94PAR-4 Agonist Peptide, amide TFA
CAS:PAR-4 agonist peptide doesn't affect PAR-1/PAR-2; blocked by PAR-4 antagonist.Fórmula:C36H49F3N8O9Pureza:99.72%Cor e Forma:SolidPeso molecular:794.82Ref: TM-TP1065
1mg34,00€5mg92,00€1mL*10mM (DMSO)131,00€10mg138,00€25mg225,00€50mg323,00€100mg467,00€200mg643,00€Protease-Activated Receptor-1, PAR-1 Agonist acetate
PAR-1 Agonist acetate is a selective PAR-1 agonist that mimics thrombin action.Fórmula:C37H62N10O11Pureza:98.1800%Cor e Forma:SolidPeso molecular:822.95PAR-2 Activating Peptide acetate
PAR-2 Activating Peptide acetate (SLIGRL-NH2 acetate) is an agonist of Protease-Activated Receptor-2 (PAR-2).Fórmula:C31H60N10O9Pureza:98.5% - 99.92%Cor e Forma:SolidPeso molecular:716.88AC-55541
CAS:AC-55541 (AOB2796), a PAR2 agonist, activates PAR2 in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays.
Fórmula:C25H20BrN5O3Pureza:98% - 99.33%Cor e Forma:SolidPeso molecular:518.36LRGILS-NH2 acetate
LRGILS-NH2 acetate is a PAR-2-inactive reversed peptide.Fórmula:C29H56N10O7Pureza:96.65%Cor e Forma:SolidPeso molecular:656.82FSLLRY-NH2 TFA(245329-02-6 free base)
FSLLRY-NH2 TFA inhibits PAR2, reverses taxol-induced pain, and reduces itch in mice; blocks ERK and collagen in fibroblasts.Fórmula:C41H61F3N10O10Pureza:99.32%Cor e Forma:SolidPeso molecular:910.99tcY-NH2 TFA(327177-34-4 free base)
tcY-NH2 TFA is a selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.Fórmula:C42H50F3N7O9Pureza:>99.99%Cor e Forma:SolidPeso molecular:853.9Thrombin Receptor Activator for Peptide
Thrombin Receptor Activator (TRAP) or Coagulation Factor II (1-5), used in CHD research.Fórmula:C32H51F3N8O9Pureza:99.88%Cor e Forma:SolidPeso molecular:748.79Parmodulin 2
CAS:ML161 (Parmodulin 2) inhibits PAR1, blocking platelet activation and thrombin-induced activity (IC50: 0.26μM).Fórmula:C17H17BrN2O2Pureza:97.35% - 99.95%Cor e Forma:SolidPeso molecular:361.23Protease-Activated Receptor-4 diTFA
Protease-Activated Receptor-4 diTFA,2454 is the proteinase-activated receptor-4 (PAR4)agonistFórmula:C37H48F6N8O11Pureza:98.54%Cor e Forma:SolidPeso molecular:894.81Ref: TM-T7740
1mg46,00€2mg57,00€5mg81,00€10mg131,00€1mL*10mM (DMSO)161,00€25mg259,00€50mg389,00€100mg575,00€Protease-Activated Receptor-2, amide
CAS:Protease-Activated Receptor-2, amide (SLIGKV-NH2) is an agonist of PAR2 (IC50 : 10.4 M)Fórmula:C28H54N8O7Pureza:>99.99%Cor e Forma:SolidPeso molecular:614.782-Furoyl-LIGRLO-amide TFA(729589-58-6 free base)
2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base) is a potent and selective protease-activated receptor 2 (PAR2) agonist.Fórmula:C38H64F3N11O10Pureza:>99.99%Cor e Forma:SolidPeso molecular:891.98VKGILS-NH2 Acetate
VKGILS-NH2 Acetate is a reversed amino acid sequence control peptide for SLIGKV-NH2, a protease-activated receptor 2 (PAR2) agonist.Fórmula:C30H58N8O9Pureza:98.83%Cor e Forma:SolidPeso molecular:674.83Ref: TM-T21699L
1mg33,00€2mg49,00€5mg62,00€10mg92,00€1mL*10mM (DMSO)92,00€25mg155,00€50mg224,00€100mg331,00€200mg470,00€ML-354
CAS:ML354 is a selective antagonist of PAR4 with an IC 50 of 140 nM [1].Fórmula:C16H14N2O3Pureza:99.44%Cor e Forma:SolidPeso molecular:282.29iso-TRAP-6
CAS:iso-TRAP-6 (iso-SFLLRN), a hexapeptide made from isoserine instead of serine, is a PAR1 agonist that activates platelets via PAR-1.Fórmula:C34H56N10O9Pureza:98.55%Cor e Forma:SolidPeso molecular:748.87PAR4 antagonist 3
CAS:PAR4 antagonist3 (Compound 36) is a selective antagonist of protease-activated receptor 4 (PAR4). It exhibits antiplatelet activity with an IC50 of 26.1 nM and enhances metabolic stability in human liver microsomes, with a half-life (T1/2) of 97.6 minutes.Fórmula:C22H16FN3O5SPeso molecular:453.44PAR-2-IN-2
CAS:PAR-2-IN-2 (compound P-596) is an inhibitor of protease-activated receptor 2 (PAR-2), with an IC50 of 10.79 μM for SLIGKV and an IC50 greater than 200 μM for trypsin.Fórmula:C25H20F3N5O2Cor e Forma:SolidPeso molecular:479.454BMS-986141
CAS:BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614Fórmula:C27H23N5O5S2Pureza:98.43% - 99.26%Cor e Forma:SolidPeso molecular:561.63Protease-Activated Receptor-4
CAS:Protease-Activated Receptor-4 (PAR4) is a proteinase-activated receptor-4 agonist used in antiplatelet therapy.Fórmula:C33H46N8O7Pureza:98%Cor e Forma:SolidPeso molecular:666.77
