Receptor activado por protease
Os inibidores dos Receptores Ativados por Proteases (PAR) são compostos que têm como alvo e inibem a atividade dos PARs, uma família de receptores acoplados à proteína G que são ativados por clivagem proteolítica. Esses receptores desempenham um papel em vários processos fisiológicos, incluindo coagulação, inflamação e reparo tecidual. Os inibidores de PAR são ferramentas valiosas para estudar os mecanismos desses processos e seu envolvimento em doenças como câncer, distúrbios cardiovasculares e inflamação crônica. Na CymitQuimica, oferecemos inibidores de PAR para apoiar sua pesquisa em transdução de sinal, resposta imunológica e descoberta terapêutica.
Foram encontrados 55 produtos de "Receptor activado por protease"
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FLLRN
CAS:FLLRN is a biologically active peptide serving as a PAR1-specific antagonist.Fórmula:C31H51N9O7Cor e Forma:SolidPeso molecular:661.79YFLLRNP
CAS:YFLLRNP is a biologically active peptide functioning as a partial agonist of PAR-1, selectively activating the G12/13 signaling pathway.Fórmula:C45H67N11O10Cor e Forma:SolidPeso molecular:922.08TRAP-5 amide
CAS:TRAP-5 amide is a peptide agonist for protease-activated receptor 1 (PAR 1) [1].Fórmula:C30H51N9O6Cor e Forma:SolidPeso molecular:633.78PAR 4 (1-6) (TFA)
PAR 4 (1-6) TFA (GYPGQV TFA), a hexapeptide derived from protease-activated receptor 4 (PAR 4), serves as a specific agonist for PAR 4.Fórmula:C28H41N7O9·xC2HF3O2Cor e Forma:SolidP4pal10 TFA
P4pal10 TFA, the TFA salt form of P4pal10, serves as an antagonist of the protease-activated receptor 4 (PAR4). This compound inhibits platelet aggregation and thrombin generation induced by tissue factor (TF), exhibiting anticoagulant and antithrombotic activities. Additionally, P4pal10 TFA alleviates carrageenan-induced edema and neutrophil infiltration, and ameliorates damage in rat myocardial ischemia/reperfusion (I/R) models.Cor e Forma:Odour SolidTRAP-6 amide TFA
CAS:TRAP-6 amide TFA is a PAR-1 thrombin receptor agonist peptide.Fórmula:C36H58F3N11O10Cor e Forma:SolidPeso molecular:861.922TFLLR-NH2(TFA)
CAS:TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM. EC50: 1.9 μM (PAR1)Fórmula:C33H54F3N9O8Pureza:98%Cor e Forma:SolidPeso molecular:761.83SLIGRL-NH2
CAS:SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is a PAR-2 agonist that induces non-histaminergic pruritus.Fórmula:C29H56N10O7Pureza:98.29%Cor e Forma:SolidPeso molecular:656.82AZ3451
CAS:AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).Fórmula:C30H27BrN4O3Pureza:98.12%Cor e Forma:SolidPeso molecular:571.46PAR-2-IN-1
CAS:PAR-2-IN-1 (IUN76750) is a PAR- 2 signaling pathway inhibitor with anti-inflammatory and anticancer effects.Fórmula:C12H14ClN3O2Pureza:99.75%Cor e Forma:SolidPeso molecular:267.71Ref: TM-T8917
2mg34,00€5mg50,00€1mL*10mM (DMSO)52,00€10mg86,00€25mg161,00€50mg243,00€100mg355,00€200mg502,00€Vorapaxar
CAS:Vorapaxar (MK-5348) (SCH 530348) is an effective and orally active thrombin receptor (PAR-1) antagonist (Ki: 8.1 nM).Fórmula:C29H33FN2O4Pureza:98.77% - 99.93%Cor e Forma:SolidPeso molecular:492.58Ref: TM-T7013
1mg71,00€5mg138,00€1mL*10mM (DMSO)152,00€10mg192,00€25mg326,00€50mg447,00€100mg642,00€200mg888,00€Vorapaxar sulfate
CAS:Vorapaxar sulfate (Zontivity) is a potent and orally active thrombin receptor (PAR-1) antagonist.Fórmula:C29H35FN2O8SPureza:99.9% - >99.99%Cor e Forma:SolidPeso molecular:590.66Ref: TM-T3098
1mg35,00€2mg50,00€5mg74,00€1mL*10mM (DMSO)94,00€10mg113,00€25mg200,00€50mg334,00€100mg500,00€500mg1.099,00€TFLLR-NH2 2TFA(197794-83-5(free base))
TFLLR-NH2 2TFA(197794-83-5(free base)) is an agonist of PAR1 (EC50 :1.9 μM).Fórmula:C35H55F6N9O10Pureza:99.56%Cor e Forma:SolidPeso molecular:875.87I-191
CAS:I-191 is a potent antagonist of protease-activated receptor 2 (PAR2), inhibits multiple signaling functions in human cancer cells.Fórmula:C23H26FN5O2Pureza:99.8%Cor e Forma:SolidPeso molecular:423.48TRAP-6
CAS:TRAP-6 (Thrombin Receptor Activator Peptide 6)(2TFA) is an agonist of protease-activated receptor 1 (PAR1).Fórmula:C34H56N10O9Pureza:>99.99%Cor e Forma:SolidPeso molecular:748.87Ref: TM-T7625
1mg40,00€2mg52,00€5mg88,00€10mg126,00€1mL*10mM (DMSO)126,00€25mg274,00€50mg411,00€100mg550,00€200mg785,00€TRAP-6 amide acetate
TRAP-6 amide acetate is a PAR-1 thrombin receptor agonist peptide[1].Fórmula:C36H61N11O10Pureza:98.55%Cor e Forma:SolidPeso molecular:807.94PAR-4 Agonist Peptide, amide TFA
CAS:PAR-4 agonist peptide doesn't affect PAR-1/PAR-2; blocked by PAR-4 antagonist.Fórmula:C36H49F3N8O9Pureza:99.72%Cor e Forma:SolidPeso molecular:794.82Ref: TM-TP1065
1mg34,00€5mg92,00€1mL*10mM (DMSO)131,00€10mg138,00€25mg225,00€50mg323,00€100mg467,00€200mg643,00€Protease-Activated Receptor-1, PAR-1 Agonist acetate
PAR-1 Agonist acetate is a selective PAR-1 agonist that mimics thrombin action.Fórmula:C37H62N10O11Pureza:98.1800%Cor e Forma:SolidPeso molecular:822.95PAR-2 Activating Peptide acetate
PAR-2 Activating Peptide acetate (SLIGRL-NH2 acetate) is an agonist of Protease-Activated Receptor-2 (PAR-2).Fórmula:C31H60N10O9Pureza:98.5% - 99.92%Cor e Forma:SolidPeso molecular:716.88AC-55541
CAS:AC-55541 (AOB2796), a PAR2 agonist, activates PAR2 in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays.
Fórmula:C25H20BrN5O3Pureza:98% - 99.33%Cor e Forma:SolidPeso molecular:518.36
