Glutaminase
Os inibidores de glutaminase são compostos que inibem a glutaminase, uma enzima que catalisa a conversão de glutamina em glutamato, um passo crítico no metabolismo celular, especialmente em células cancerosas. A glutaminase desempenha um papel fundamental na provisão de energia e precursores biossintéticos para células em rápida proliferação. Os inibidores de glutaminase são importantes para explorar dependências metabólicas em células cancerosas e desenvolver potenciais estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores de glutaminase para apoiar sua pesquisa em metabolismo do câncer, bioenergética celular e descoberta terapêutica.
Foram encontrados 45 produtos de "Glutaminase"
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BJJF078
CAS:BJJF078, an aminopiperidine, inhibits human/mouse TG2 (IC50: 41/54 nM) and TG1 (IC50: 0.16 μM), may be used in MS studies.Fórmula:C27H29N3O6SPureza:99.56%Cor e Forma:SoildPeso molecular:523.6LDN-27219
CAS:LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.Fórmula:C20H16N4O2S2Pureza:99.01% - 99.38%Cor e Forma:SolidPeso molecular:408.5Ref: TM-T11831
1mg35,00€5mg66,00€10mg92,00€25mg160,00€50mg234,00€100mg351,00€200mg515,00€1mL*10mM (DMSO)71,00€Glutaminase C-IN-2
<p>Glutaminase C-IN-2 (compound 11), an allosteric inhibitor of glutaminase C (GAC), exhibits potent inhibitory activity with an IC50 of 10.64 nM.</p>Fórmula:C24H23N7O2SPureza:98%Cor e Forma:SolidPeso molecular:473.55GLS1 Inhibitor-7
GLS1 Inhibitor-7 (compound 4d) serves as a GLS1 antagonist with an IC50 value of 46.7 μM, demonstrating potential applications in anticancer, antiaging, andFórmula:C20H17F3N4O3S2Pureza:98%Cor e Forma:SolidPeso molecular:482.56-Diazo-5-oxo-L-nor-Leucine
CAS:6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) is an antagonist of glutaminases (Ki : 6 μM).Fórmula:C6H9N3O3Pureza:98.04% - 98.93%Cor e Forma:SolidPeso molecular:171.15HB-2-30
CAS:HB-2-30 is a far-red fluorescent transglutaminase 2 (TG2) probe for in vitro and in vivo endocytosis imaging. HB-2-30 complexes with TG2 and α2-macroglobulin for efficient endocytosis via the LRP1 pathway.Fórmula:C66H86N10O14S2Peso molecular:1307.58Trivalent hydroxyarsinothricn
Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible inhibitor of kidney-type glutaminase (KGA). It binds to the glutamine binding site and forms a covalent bond with the cysteine residue at the active site. This compound selectively kills triple-negative breast cancer (TNBC) cells without being cytotoxic to control cell lines. KGA is an enzyme that regulates glutamine metabolism and is associated with tumor malignancy.Fórmula:C4H10AsNO4Peso molecular:210.98258LM11
<p>LM11 is a transglutaminase 2 (TG2) inhibitor that exhibits activity against glioblastoma cells by maintaining TG2 in a cytotoxic conformational state.</p>Fórmula:C26H18Cl2N4O5Peso molecular:536.06543L-Methionine-DL-sulfoximine
CAS:MSO blocks glutamine synthetase, impacts astroglia, and is used in convulsant research.Fórmula:C5H12N2O3SPureza:99.56% - ≥98%Cor e Forma:White Crystalline PowderPeso molecular:180.23PROTAC TG2 degrader-1
PROTAC TG2 Degrader-1 (Compound 11) is a VHL-based PROTAC that targets tissue transglutaminase (TG2) and exhibits a binding affinity with a K D of 68.9 μM.Fórmula:C55H73N9O10SPureza:98%Cor e Forma:SolidPeso molecular:1052.29PROTAC TG2 degrader-2
PROTAC TG2 degrader-2 (compound 7) is a selective competitive degrader of Transglutaminase 2 (TG2), exhibiting a dissociation constant (Kd) greater than 100 μM.Fórmula:C47H57N9O6SPureza:98%Cor e Forma:SolidPeso molecular:876.08Glutaminase-IN-1
CAS:Glutaminase-IN-1 (CB839 derivative), a glutaminase (KGA) inhibitor, has antitumor activity in an aggressive H22 hepatocellular carcinoma xenograft model.Fórmula:C26H24F3N7O3SePureza:98.65% - 98.65%Cor e Forma:SolidPeso molecular:618.47Glutaminase-IN-3
CAS:Glutaminase-IN-3 is a potent Glutaminase 1 inhibitor with potential antitumor activity and inhibits GLS1 for cancer research.Fórmula:C19H19F3N6O2SPureza:98.51%Cor e Forma:SolidPeso molecular:452.45Glutaminase C-IN-1
CAS:Glutaminase C-IN-1 (Compound 968) is a Glutaminase C allosteric inhibitor.Fórmula:C27H27BrN2OPureza:99.68% - >99.99%Cor e Forma:SolidPeso molecular:475.42Ref: TM-T3964
2mg42,00€5mg60,00€10mg87,00€25mg162,00€50mg273,00€100mg378,00€200mg557,00€1mL*10mM (DMSO)67,00€BPTES
CAS:BPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.Fórmula:C24H24N6O2S3Pureza:95.83% - 99.64%Cor e Forma:SolidPeso molecular:524.68Ref: TM-T6791
1mg37,00€2mg52,00€5mg69,00€10mg88,00€25mg150,00€50mg217,00€100mg324,00€200mg472,00€500mg772,00€1mL*10mM (DMSO)88,00€Telaglenastat
CAS:Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.Fórmula:C26H24F3N7O3SPureza:97.57% - 99.89%Cor e Forma:SolidPeso molecular:571.57Ref: TM-T6797
1g1.130,00€2mg38,00€5mg51,00€10mg79,00€25mg126,00€50mg210,00€100mg350,00€500mg825,00€1mL*10mM (DMSO)65,00€GK921
CAS:GK921 is a transglutaminase 2 (TGase) inhibitor.Fórmula:C21H20N4OPureza:97.44% - 99.49%Cor e Forma:SolidPeso molecular:344.41L-Albizziin
CAS:L-Albizziin (L-beta-Ureidoalanine) is a glutamase inhibitor and is a glutaminyl-tRNA synthetase inhibitor.Fórmula:C4H9N3O3Pureza:99.98%Cor e Forma:White PowderPeso molecular:147.13Zampilimab
CAS:Zampilimab (UCB-7858) is a humanised monoclonal antibody targeting TGM2, inhibits the cross-linking transamidase activity of TG2, renal fibrosis.Pureza:95%Cor e Forma:LiquidIrbesartan-d4
CAS:Irbesartan-d4 (Irbesartan D4), a deuterated compound of Irbesartan, is an angiotensin receptor blocker and is used in the study of cardiovascular disease.Fórmula:C25H28N6OPureza:>99.99%Cor e Forma:SolidPeso molecular:432.55NC9 TG2 inhibitor
CAS:NC9 is an irreversible inhibitor of transglutaminase 2 (TG2) and also inhibits Factor XIIIA (FXIIIA).Fórmula:C35H47N5O8SPureza:98%Cor e Forma:SolidPeso molecular:697.84α-Glucosidase-IN-5
CAS:α-Glucosidase-IN-5 (compound 8) is isolated from a twig extract of Polyalthia cinnamomea which is a potent α-glucosidase inhibitor with an IC50 of 57.9 µM.Fórmula:C15H13NO3Cor e Forma:SolidPeso molecular:255.27Glutaminase-IN-4
CAS:Glutaminase-IN-4 (compound 2a) is a glutaminase (GLS) inhibitor (IC50: 2.3 μM).Fórmula:C23H22N6O2S2Cor e Forma:SolidPeso molecular:478.59AA10 TG2 inhibitor
CAS:AA10 is an irreversible inhibitor of transglutaminase 2 (TG2).Fórmula:C32H36N4O5Cor e Forma:SolidPeso molecular:556.65VA4 TG2 inhibitor
CAS:VA4 is a novel irreversible TG2 transamidase site-specific inhibitor.Fórmula:C33H41N5O6SCor e Forma:SolidPeso molecular:635.77Duazomycin
CAS:Duazomycin, an antitumor substance and glutamine antagonist, is used as a chemotherapeutic agent.Fórmula:C8H11N3O4Cor e Forma:SolidPeso molecular:213.19GLS1 Inhibitor
CAS:GLS1 inhibitor blocks glutaminase 1 (IC50=0.021 μM), hinders NCI H1703 NSCLC cell growth in vitro (GI50=0.011 μM), and suppresses tumors in mice.Fórmula:C19H21N7O2SCor e Forma:SolidPeso molecular:411.48CP4d inhibitor
CAS:CP4d is a novel reversible tg2 transamidase site-specific inhibitorFórmula:C18H13N5O5Cor e Forma:SolidPeso molecular:379.33JHU-083
CAS:JHU-083 is a glutaminase antagonist that improves cognition and normalizes aberrant hippocampal glutaminase activity in APOE4 mice.Fórmula:C14H24N4O4Pureza:97.89% - 99.53%Cor e Forma:SolidPeso molecular:312.37THDP-17
CAS:THDP-17 is a inhibitor of glutaminase. THDP-17 shows a partial uncompetitive inhibition in vitro.Fórmula:C12H16N2SPureza:98%Cor e Forma:SolidPeso molecular:220.33AA9 TG2 inhibitor
CAS:AA9 is a novel transglutaminase (TG2) inhibitor.Fórmula:C32H36N4O5Cor e Forma:SolidPeso molecular:556.65GLS1 Inhibitor-3
CAS:GLS1 Inhibitor-3 (compound C147) is a potent inhibitor of GLS1 (IC50: 27.98 nM) and exhibits anti-proliferative effects.Fórmula:C30H32N10O2SCor e Forma:SolidPeso molecular:596.71TG-2-IN-1
CAS:TG-2-IN-1 (Compound D003) is a transglutaminase-2 ( TGM-2 ) inhibitor. TG-2-IN-1 can be used in myopia research[1].Fórmula:C8H13ClN2OSPureza:98.43%Cor e Forma:SolidPeso molecular:220.72Sirpiglenastat
CAS:Sirpiglenastat (DRP-104) is a glutamine antagonist, a prodrug of DON, with antitumor activity that acts by suppressing the adaptive immune system.Fórmula:C22H27N5O5Pureza:98.01% - 98.37%Cor e Forma:SolidPeso molecular:441.48IPN60090
CAS:IPN60090: potent oral GLS1 inhibitor, IC50 of 31 nM, potential for anticancer and immunomodulation.Fórmula:C24H27F3N8O3Pureza:99.76%Cor e Forma:SolidPeso molecular:532.52Ref: TM-T11412
1mg105,00€5mg250,00€10mg393,00€25mg635,00€50mg944,00€100mg1.254,00€1mL*10mM (DMSO)283,00€UPGL00004
CAS:UPGL00004: potent GAC inhibitor, IC50=29 nM, Kd=27 nM, suppresses triple-negative breast cancer cell growth.Fórmula:C25H26N8O2S2Pureza:97.93%Cor e Forma:SolidPeso molecular:534.66TG2-IN-3h
CAS:TG2-IN-3h is a highly selective, potent, cell-permeable fluorescent irreversible tissue transglutaminase (tg2) inhibitorFórmula:C21H26N4O4SPureza:99.34% - 99.76%Cor e Forma:SolidPeso molecular:430.52KCC009
CAS:KCC009 is a potent and selective Transglutaminase 2 Inhibitor.Fórmula:C21H22BrN3O5Cor e Forma:SolidPeso molecular:476.32ZED-1227
CAS:<p>ZED-1227 (TAK-227) is a TG2 inhibitor with anticancer activity that blocks inflammation-induced TG2 expression and activation for the treatment of Celiac Diseas</p>Fórmula:C26H36N6O6Pureza:99.04%Cor e Forma:SolidPeso molecular:528.6TGase2-IN-1
CAS:TGase2-IN-1 (Compound 22) is an orally effective TGase2 inhibitor with an IC50 of 1.12 µM. It inhibits TGase2 in human retinal microvascular endothelial cells with a strikingly lower IC50 of 0.07 µM. The oral bioavailability of TGase2-IN-1 is 74.6%. Additionally, it can suppress retinal vascular leakage in a mouse model of diabetes induced by Streptozotocin.Fórmula:C23H25N3O3Cor e Forma:SolidPeso molecular:391.46GLS-1-IN-1
GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.Fórmula:C26H25FN4OSCor e Forma:SolidPeso molecular:460.57TG-2-IN-4
CAS:TG-2-IN-4 (compound 8), an inhibitor of transglutaminase 2 (TG2) with an IC 50 value of less than 0.5 mM, is utilized in the study of inflammatory disorders [1].Fórmula:C34H40N6O5Cor e Forma:SolidPeso molecular:612.723-Aminobenzene-1,2-diol
CAS:3-Aminobenzene-1,2-diol (compound C8) is an inhibitor of matrix metalloproteinases (MMP), with IC50 values of 20, 26, 16, and 16.3 μM against MMP-2, MMP-8, MMP-9, and MMP-14, respectively.Fórmula:C6H7NO2Cor e Forma:SolidPeso molecular:125.13Duazomycin sodium
CAS:Duazomycin (Duazomycin A) sodium acts as a glutamine antagonist. It significantly enhances the efficacy of 6-Mercaptopurine (6-MP) in treating experimental autoimmune encephalomyelitis (EAE) without increasing toxicity.Fórmula:C8H10N3NaO4Cor e Forma:SolidPeso molecular:235.17IPN60090 dihydrochloride
CAS:IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.Fórmula:C24H29Cl2F3N8O3Cor e Forma:SolidPeso molecular:605.44
