Glutaminase
Os inibidores de glutaminase são compostos que inibem a glutaminase, uma enzima que catalisa a conversão de glutamina em glutamato, um passo crítico no metabolismo celular, especialmente em células cancerosas. A glutaminase desempenha um papel fundamental na provisão de energia e precursores biossintéticos para células em rápida proliferação. Os inibidores de glutaminase são importantes para explorar dependências metabólicas em células cancerosas e desenvolver potenciais estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores de glutaminase para apoiar sua pesquisa em metabolismo do câncer, bioenergética celular e descoberta terapêutica.
Foram encontrados 45 produtos para "Glutaminase".
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GLS1 Inhibitor-3
CAS:GLS1 Inhibitor-3 (compound C147) is a potent inhibitor of GLS1 (IC50: 27.98 nM) and exhibits anti-proliferative effects.Fórmula:C30H32N10O2SCor e Forma:SolidPeso molecular:596.71JHU-083
CAS:JHU-083 is a glutaminase antagonist that improves cognition and normalizes aberrant hippocampal glutaminase activity in APOE4 mice.Fórmula:C14H24N4O4Pureza:97.89% - 99.53%Cor e Forma:SolidPeso molecular:312.37GLS1 Inhibitor
CAS:GLS1 inhibitor blocks glutaminase 1 (IC50=0.021 μM), hinders NCI H1703 NSCLC cell growth in vitro (GI50=0.011 μM), and suppresses tumors in mice.Fórmula:C19H21N7O2SCor e Forma:SolidPeso molecular:411.48NC9 TG2 inhibitor
CAS:NC9 is an irreversible inhibitor of transglutaminase 2 (TG2) and also inhibits Factor XIIIA (FXIIIA).Fórmula:C35H47N5O8SPureza:98%Cor e Forma:SolidPeso molecular:697.84AA9 TG2 inhibitor
CAS:AA9 is a novel transglutaminase (TG2) inhibitor.Fórmula:C32H36N4O5Cor e Forma:SolidPeso molecular:556.65AA10 TG2 inhibitor
CAS:AA10 is an irreversible inhibitor of transglutaminase 2 (TG2).Fórmula:C32H36N4O5Cor e Forma:SolidPeso molecular:556.65VA4 TG2 inhibitor
CAS:VA4 is a novel irreversible TG2 transamidase site-specific inhibitor.Fórmula:C33H41N5O6SCor e Forma:SolidPeso molecular:635.77α-Glucosidase-IN-5
CAS:α-Glucosidase-IN-5 (compound 8) is isolated from a twig extract of Polyalthia cinnamomea which is a potent α-glucosidase inhibitor with an IC50 of 57.9 µM.Fórmula:C15H13NO3Cor e Forma:SolidPeso molecular:255.27Glutaminase-IN-4
CAS:Glutaminase-IN-4 (compound 2a) is a glutaminase (GLS) inhibitor (IC50: 2.3 μM).Fórmula:C23H22N6O2S2Cor e Forma:SolidPeso molecular:478.59Duazomycin
CAS:Duazomycin, an antitumor substance and glutamine antagonist, is used as a chemotherapeutic agent.Fórmula:C8H11N3O4Cor e Forma:SolidPeso molecular:213.19CP4d inhibitor
CAS:CP4d is a novel reversible tg2 transamidase site-specific inhibitorFórmula:C18H13N5O5Cor e Forma:SolidPeso molecular:379.33THDP-17
CAS:THDP-17 is a inhibitor of glutaminase. THDP-17 shows a partial uncompetitive inhibition in vitro.Fórmula:C12H16N2SPureza:98%Cor e Forma:SolidPeso molecular:220.33TG2-IN-3h
CAS:TG2-IN-3h is a highly selective, potent, cell-permeable fluorescent irreversible tissue transglutaminase (tg2) inhibitorFórmula:C21H26N4O4SPureza:99.34% - 99.76%Cor e Forma:Yellow SolidPeso molecular:430.52Sirpiglenastat
CAS:Sirpiglenastat (DRP-104) is a glutamine antagonist, a prodrug of DON, with antitumor activity that acts by suppressing the adaptive immune system.Fórmula:C22H27N5O5Pureza:98.01% - 98.37%Cor e Forma:SolidPeso molecular:441.48IPN60090
CAS:IPN60090: potent oral GLS1 inhibitor, IC50 of 31 nM, potential for anticancer and immunomodulation.Fórmula:C24H27F3N8O3Pureza:99.76%Cor e Forma:SolidPeso molecular:532.52Ref: TM-T11412
1mg100,00€5mg236,00€1mL*10mM (DMSO)268,00€10mg371,00€25mg602,00€50mg893,00€100mg1.189,00€UPGL00004
CAS:UPGL00004: potent GAC inhibitor, IC50=29 nM, Kd=27 nM, suppresses triple-negative breast cancer cell growth.Fórmula:C25H26N8O2S2Pureza:97.93%Cor e Forma:Red SolidPeso molecular:534.66TG-2-IN-1
CAS:TG-2-IN-1 (Compound D003) is a transglutaminase-2 ( TGM-2 ) inhibitor. TG-2-IN-1 can be used in myopia research[1].Fórmula:C8H13ClN2OSPureza:98.43%Cor e Forma:White SolidPeso molecular:220.72KCC009
CAS:KCC009 is a TG2 inhibitor; IC50=20 μM; blocks survival signaling; cancer chemotherapy sensitization; glioblastoma research.Fórmula:C21H22BrN3O5Pureza:98.68%Cor e Forma:White SolidPeso molecular:476.32ZED-1227
CAS:ZED-1227 (TAK-227) is a TG2 inhibitor with anticancer activity that blocks inflammation-induced TG2 expression and activation for the treatment of Celiac DiseasFórmula:C26H36N6O6Pureza:99.04%Cor e Forma:SolidPeso molecular:528.6Ref: TM-T17289
1mg235,00€2mg331,00€5mg482,00€1mL*10mM (DMSO)560,00€10mg735,00€25mg1.431,00€50mg2.322,00€3-Aminobenzene-1,2-diol
CAS:3-Aminobenzene-1,2-diol (compound C8) is an inhibitor of matrix metalloproteinases (MMP), with IC50 values of 20, 26, 16, and 16.3 μM against MMP-2, MMP-8, MMP-9, and MMP-14, respectively.Fórmula:C6H7NO2Cor e Forma:SolidPeso molecular:125.13
