Glutaminase
Os inibidores de glutaminase são compostos que inibem a glutaminase, uma enzima que catalisa a conversão de glutamina em glutamato, um passo crítico no metabolismo celular, especialmente em células cancerosas. A glutaminase desempenha um papel fundamental na provisão de energia e precursores biossintéticos para células em rápida proliferação. Os inibidores de glutaminase são importantes para explorar dependências metabólicas em células cancerosas e desenvolver potenciais estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores de glutaminase para apoiar sua pesquisa em metabolismo do câncer, bioenergética celular e descoberta terapêutica.
Foram encontrados 40 produtos de "Glutaminase"
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GLS1 Inhibitor-3
CAS:<p>GLS1 Inhibitor-3 (compound C147) is a potent inhibitor of GLS1 (IC50: 27.98 nM) and exhibits anti-proliferative effects.</p>Fórmula:C30H32N10O2SCor e Forma:SolidPeso molecular:596.71α-Glucosidase-IN-5
CAS:<p>α-Glucosidase-IN-5 (compound 8) is isolated from a twig extract of Polyalthia cinnamomea which is a potent α-glucosidase inhibitor with an IC50 of 57.9 µM.</p>Fórmula:C15H13NO3Cor e Forma:SolidPeso molecular:255.27Glutaminase-IN-4
CAS:<p>Glutaminase-IN-4 (compound 2a) is a glutaminase (GLS) inhibitor (IC50: 2.3 μM).</p>Fórmula:C23H22N6O2S2Cor e Forma:SolidPeso molecular:478.59AA10 TG2 inhibitor
CAS:<p>AA10 is an irreversible inhibitor of transglutaminase 2 (TG2).</p>Fórmula:C32H36N4O5Cor e Forma:SolidPeso molecular:556.65Duazomycin
CAS:<p>Duazomycin, an antitumor substance and glutamine antagonist, is used as a chemotherapeutic agent.</p>Fórmula:C8H11N3O4Cor e Forma:SolidPeso molecular:213.19AA9 TG2 inhibitor
CAS:<p>AA9 is a novel transglutaminase (TG2) inhibitor.</p>Fórmula:C32H36N4O5Cor e Forma:SolidPeso molecular:556.65JHU-083
CAS:<p>JHU-083 is a glutaminase antagonist that improves cognition and normalizes aberrant hippocampal glutaminase activity in APOE4 mice.</p>Fórmula:C14H24N4O4Pureza:97.89% - 99.53%Cor e Forma:SolidPeso molecular:312.37GLS1 Inhibitor
CAS:<p>GLS1 inhibitor blocks glutaminase 1 (IC50=0.021 μM), hinders NCI H1703 NSCLC cell growth in vitro (GI50=0.011 μM), and suppresses tumors in mice.</p>Fórmula:C19H21N7O2SCor e Forma:SolidPeso molecular:411.48NC9 TG2 inhibitor
CAS:<p>NC9 is an irreversible inhibitor of transglutaminase 2 (TG2) and also inhibits Factor XIIIA (FXIIIA).</p>Fórmula:C35H47N5O8SPureza:98%Cor e Forma:SolidPeso molecular:697.84IPN60090
CAS:<p>IPN60090: potent oral GLS1 inhibitor, IC50 of 31 nM, potential for anticancer and immunomodulation.</p>Fórmula:C24H27F3N8O3Pureza:99.76%Cor e Forma:SolidPeso molecular:532.52UPGL00004
CAS:<p>UPGL00004: potent GAC inhibitor, IC50=29 nM, Kd=27 nM, suppresses triple-negative breast cancer cell growth.</p>Fórmula:C25H26N8O2S2Pureza:97.93%Cor e Forma:SolidPeso molecular:534.66Sirpiglenastat
CAS:<p>Sirpiglenastat (DRP-104) is a glutamine antagonist, a prodrug of DON, with antitumor activity that acts by suppressing the adaptive immune system.</p>Fórmula:C22H27N5O5Pureza:98.01% - 98.37%Cor e Forma:SolidPeso molecular:441.48TG2-IN-3h
CAS:<p>TG2-IN-3h is a highly selective, potent, cell-permeable fluorescent irreversible tissue transglutaminase (tg2) inhibitor</p>Fórmula:C21H26N4O4SPureza:99.34% - 99.76%Cor e Forma:SolidPeso molecular:430.52TG-2-IN-1
CAS:<p>TG-2-IN-1 (Compound D003) is a transglutaminase-2 ( TGM-2 ) inhibitor. TG-2-IN-1 can be used in myopia research[1].</p>Fórmula:C8H13ClN2OSPureza:98.43%Cor e Forma:SolidPeso molecular:220.72KCC009
CAS:<p>KCC009 is a potent and selective Transglutaminase 2 Inhibitor.</p>Fórmula:C21H22BrN3O5Cor e Forma:SolidPeso molecular:476.32ZED-1227
CAS:<p>ZED-1227 (TAK-227) is a TG2 inhibitor with anticancer activity that blocks inflammation-induced TG2 expression and activation for the treatment of Celiac Diseas</p>Fórmula:C26H36N6O6Pureza:99.04%Cor e Forma:SolidPeso molecular:528.6TG-2-IN-4
CAS:<p>TG-2-IN-4 (compound 8), an inhibitor of transglutaminase 2 (TG2) with an IC 50 value of less than 0.5 mM, is utilized in the study of inflammatory disorders [1].</p>Fórmula:C34H40N6O5Cor e Forma:SolidPeso molecular:612.72TGase2-IN-1
CAS:<p>TGase2-IN-1 (Compound 22) is an orally effective TGase2 inhibitor with an IC50 of 1.12 µM. It inhibits TGase2 in human retinal microvascular endothelial cells with a strikingly lower IC50 of 0.07 µM. The oral bioavailability of TGase2-IN-1 is 74.6%. Additionally, it can suppress retinal vascular leakage in a mouse model of diabetes induced by Streptozotocin.</p>Fórmula:C23H25N3O3Cor e Forma:SolidPeso molecular:391.46GLS-1-IN-1
<p>GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.</p>Fórmula:C26H25FN4OSCor e Forma:SolidPeso molecular:460.57IPN60090 dihydrochloride
CAS:<p>IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.</p>Fórmula:C24H29Cl2F3N8O3Cor e Forma:SolidPeso molecular:605.44
