Células - tronco
Os inibidores de células-tronco são compostos que atuam especificamente nas células-tronco e em suas vias de sinalização, afetando sua capacidade de autorrenovação e diferenciação. Esses inibidores são cruciais em pesquisas focadas no controle do comportamento das células-tronco, na compreensão dos processos de desenvolvimento e no desenvolvimento de terapias para doenças como o câncer, onde se acredita que as células-tronco desempenhem um papel fundamental. Na CymitQuimica, oferecemos uma variedade de inibidores de células-tronco para apoiar sua pesquisa em medicina regenerativa, biologia do desenvolvimento e oncologia.
Foram encontrados 224 produtos de "Células - tronco"
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Porcn-IN-1
CAS:Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).Fórmula:C25H19FN4OPureza:99.15%Cor e Forma:SolidPeso molecular:410.44BIO-013077-01
CAS:BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.Fórmula:C17H13N5Pureza:99.87%Cor e Forma:SolidPeso molecular:287.32Ref: TM-T8330
1mg50,00€5mg92,00€10mg140,00€25mg273,00€50mg393,00€100mg557,00€200mg753,00€1mL*10mM (DMSO)138,00€IWP-O1
CAS:IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.Fórmula:C26H20N6OPureza:99.12%Cor e Forma:SolidPeso molecular:432.48Ref: TM-T5342
2mg39,00€5mg64,00€10mg101,00€25mg163,00€50mg226,00€100mg320,00€200mg459,00€1mL*10mM (DMSO)70,00€Tegatrabetan
CAS:Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.Fórmula:C28H36N4O6S2Pureza:98.01% - 99.18%Cor e Forma:SolidPeso molecular:588.74Ref: TM-T5642
1mg40,00€2mg52,00€5mg85,00€10mg124,00€25mg210,00€50mg334,00€100mg565,00€1mL*10mM (DMSO)96,00€AZD1080
CAS:AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.Fórmula:C19H18N4O2Pureza:97.72% - 99.75%Cor e Forma:SolidPeso molecular:334.37Ref: TM-T1741
1mg43,00€2mg56,00€5mg85,00€10mg124,00€25mg219,00€50mg350,00€100mg429,00€1mL*10mM (DMSO)63,00€β-catenin-IN-2
CAS:β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.Fórmula:C15H14FN3Pureza:99.93%Cor e Forma:SolidPeso molecular:255.29Ref: TM-T9696
1mg96,00€5mg227,00€10mg359,00€25mg607,00€50mg868,00€100mg1.169,00€500mg2.365,00€1mL*10mM (DMSO)264,00€Afuresertib hydrochloride
CAS:Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
Fórmula:C18H18Cl3FN4OSPureza:99.96%Cor e Forma:SolidPeso molecular:463.8I3MT-3
CAS:I3MT-3 (HMPSNE) is a selective inhibitor of 3MST, targeting active site cysteine residues and permeating cell membranes.Fórmula:C17H14N2O2SPureza:99.76%Cor e Forma:SolidPeso molecular:310.37exo-IWR-1
CAS:exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin
Fórmula:C25H19N3O3Pureza:97.41%Cor e Forma:SolidPeso molecular:409.44YO-01027
CAS:YO-01027 (DBZ) is a potent γ-secretase inhibitor.
Fórmula:C26H23F2N3O3Pureza:97.21% - 99.58%Cor e Forma:SolidPeso molecular:463.48Belumosudil
CAS:Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).Fórmula:C26H24N6O2Pureza:97.64% - 98.59%Cor e Forma:SolidPeso molecular:452.51Ref: TM-T6867
2mg48,00€5mg73,00€10mg90,00€25mg166,00€50mg250,00€100mg376,00€500mg895,00€1mL*10mM (DMSO)79,00€IHR-1
CAS:IHR-1, a Smo inhibitor (IC50 7.6 nM), blocks Hedgehog pathway, not Wnt/Notch, and prevents Smo in primary cilium.Fórmula:C20H12Cl4N2O2Pureza:97.02%Cor e Forma:SolidPeso molecular:454.13Ref: TM-T24159
2mg33,00€5mg50,00€10mg80,00€25mg131,00€50mg193,00€100mg290,00€200mg416,00€1mL*10mM (DMSO)55,00€MRT-14
CAS:MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies.Fórmula:C24H24N4O5Pureza:99.54%Cor e Forma:SolidPeso molecular:448.47Lats-IN-1
CAS:Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.Fórmula:C18H14N4OSPureza:97.54% - 99.79%Cor e Forma:SolidPeso molecular:334.39Ref: TM-T9053
1mg52,00€2mg73,00€5mg105,00€10mg167,00€25mg309,00€50mg416,00€100mg592,00€200mg842,00€1mL*10mM (DMSO)118,00€LY3200882
CAS:LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).Fórmula:C24H29N5O3Pureza:99.46% - 99.63%Cor e Forma:SolidPeso molecular:435.52XMU-MP-1
CAS:XMU-MP-1 is a reversible and selective MST1/2 kinase inhibitor, IC50 values for MST1 and MST2 are 71.1 nM and 38.1 nM, respectively. High-Quality, Low-Cost!Fórmula:C17H16N6O3S2Pureza:99.68% - 99.86%Cor e Forma:SolidPeso molecular:416.48Ref: TM-T4212
1mg52,00€2mg79,00€5mg97,00€10mg153,00€25mg305,00€50mg512,00€100mg663,00€1mL*10mM (DMSO)95,00€Fosciclopirox
CAS:Fosciclopirox (CPX-POM), the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entireFórmula:C13H20NO6PPureza:99.83%Cor e Forma:SolidPeso molecular:317.27Ref: TM-T9422
2mg35,00€5mg52,00€10mg90,00€25mg170,00€50mg259,00€100mg383,00€200mg545,00€1mL*10mM (DMSO)58,00€AR-A014418
CAS:AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.Fórmula:C12H12N4O4SPureza:>99.99% - ≥95%Cor e Forma:SolidPeso molecular:308.31SB 216763
CAS:SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).Fórmula:C19H12Cl2N2O2Pureza:98.9% - 99.13%Cor e Forma:SolidPeso molecular:371.22Ref: TM-T3077
2mg39,00€5mg52,00€10mg79,00€25mg131,00€50mg197,00€100mg334,00€500mg803,00€1mL*10mM (DMSO)52,00€MYF-01-37
CAS:MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.Fórmula:C15H17F3N2OPureza:99.46% - 99.5%Cor e Forma:SolidPeso molecular:298.3Ref: TM-T22372
2mg38,00€5mg57,00€10mg90,00€25mg166,00€50mg281,00€100mg421,00€500mg888,00€1mL*10mM (DMSO)63,00€VP3.15 dihydrobromide
CAS:VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.Fórmula:C20H24Br2N4OSPureza:99.67% - ≥95%Cor e Forma:SolidPeso molecular:528.3LGK974
CAS:LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal and head/neck cancer trials. IC50: 0.4 nM.Fórmula:C23H20N6OPureza:98.8% - >99.99%Cor e Forma:SolidPeso molecular:396.44Ref: TM-T2618
1mg46,00€2mg62,00€5mg90,00€10mg156,00€25mg288,00€50mg515,00€100mg737,00€1mL*10mM (DMSO)90,00€SJ000291942
CAS:SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.Fórmula:C16H15FN2O4Pureza:99.66%Cor e Forma:SolidPeso molecular:318.3Ref: TM-T4662
1mg34,00€2mg44,00€5mg63,00€10mg100,00€25mg205,00€50mg349,00€100mg557,00€200mg790,00€1mL*10mM (DMSO)71,00€Indirubin-3′-oxime
CAS:Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.
Fórmula:C16H11N3O2Pureza:98.34%Cor e Forma:SolidPeso molecular:277.28RKI1313
CAS:RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasionFórmula:C17H16N4O2SPureza:99.53% - ≥95%Cor e Forma:SolidPeso molecular:340.4Ref: TM-T2011
1mg70,00€5mg142,00€10mg207,00€25mg369,00€50mg540,00€100mg772,00€500µg49,00€1mL*10mM (DMSO)160,00€LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .Fórmula:C25H44F6N6O9Pureza:99.75%Cor e Forma:SolidPeso molecular:686.64Ref: TM-T7676
2mg42,00€5mg54,00€10mg84,00€25mg138,00€50mg207,00€100mg316,00€200mg442,00€1mL*10mM (DMSO)93,00€Kartogenin
CAS:Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.Fórmula:C20H15NO3Pureza:96.25% - 97.79%Cor e Forma:SolidPeso molecular:317.34TBB
CAS:TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).
Fórmula:C6HBr4N3Pureza:98.51% - 99.45%Cor e Forma:Off-White SolidPeso molecular:434.71IWP L6
CAS:IWP L6 (Porcn Inhibitor III) is an extremely effective Porcn inhibitor (EC50: 0.5 nM).
Fórmula:C25H20N4O2S2Pureza:99.51% - >99.99%Cor e Forma:SolidPeso molecular:472.58PF-4800567
CAS:PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.Fórmula:C17H18ClN5O2Pureza:99.74% - 99.76%Cor e Forma:SolidPeso molecular:359.81Solcitinib
CAS:Solcitinib (GLPG-0778), a JAK1 inhibitor, may treat psoriasis, ulcerative colitis, and lupus.
Fórmula:C22H23N5O2Pureza:99.61% - 99.82%Cor e Forma:SolidPeso molecular:389.45TED-347
CAS:TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.Fórmula:C15H11ClF3NOPureza:99.9%Cor e Forma:SolidPeso molecular:313.7SD-208
CAS:SD-208 (ALK5 Inhibitor V), a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.Fórmula:C17H10ClFN6Pureza:98.72% - 99.65%Cor e Forma:SolidPeso molecular:352.75PF-5274857
CAS:PF-5274857: selective hedgehog pathway inhibitor (IC50: 5.8 nM, Ki: 4.6 nM), treats brain tumors, crosses blood-brain barrier, orally stable.Fórmula:C20H25ClN4O3SPureza:98.53%Cor e Forma:SolidPeso molecular:436.96SRI-011381
CAS:SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.Fórmula:C20H31N3OPureza:98.64%Cor e Forma:SolidPeso molecular:329.48GSK269962A
CAS:GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.Fórmula:C29H30N8O5Pureza:99.14% - 99.71%Cor e Forma:SolidPeso molecular:570.6EasyStep Human Cys-C(CystatinC) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human Cys-C, and the Human Cys-C standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human Cys-C. After TMB substrate solution is added, only those wells that contain Human Cys-C and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human Cys-C in the samples is then determined by comparing the OD of the samples to the standard curve.Cor e Forma:Colourless TransparentliquidCHIR 98024
CAS:CHIR 98024: strong GSK-3α/β blocker, IC50 0.65/0.58 nM, selective over Cdc2/ERK2.Fórmula:C20H17Cl2N9O2Pureza:99.45%Cor e Forma:SolidPeso molecular:486.31Ref: TM-T3074
1mg44,00€2mg55,00€5mg96,00€10mg153,00€25mg298,00€50mg487,00€100mg705,00€1mL*10mM (DMSO)97,00€RO7185876
CAS:RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.Fórmula:C25H28F3N7Pureza:99.50%Cor e Forma:SolidPeso molecular:483.532PRI-724
CAS:PRI-724 is a second-generation, selective small molecule inhibitor of the β-catenin/CBP interaction.Cost-effective and quality-assured.
Fórmula:C33H35N6O7PPureza:98.25% - 99.11%Cor e Forma:SoildPeso molecular:658.64YAP/TAZ inhibitor-2
CAS:Potent oral TEAD-YAP/TAZ inhibitor-2 with 3 nM EC50; exhibits anti-proliferative and antitumor effects.Fórmula:C19H14F4N4OPureza:98.65%Cor e Forma:SoildPeso molecular:390.33Ref: TM-T60218
1mg87,00€2mg113,00€5mg177,00€10mg281,00€25mg475,00€50mg687,00€100mg964,00€500mg1.918,00€1mL*10mM (DMSO)197,00€VT107
CAS:VT107 is a potent pan-TEAD autopalmitoylation inhibitor. VT-107 can be used in cancer therapy research.Cost-effective and quality-assured.Fórmula:C25H20F3N3OPureza:99.72% - 99.92%Cor e Forma:SolidPeso molecular:435.44Ref: TM-T35545
1mg130,00€5mg314,00€10mg477,00€25mg768,00€50mg1.045,00€100mg1.406,00€200mg1.882,00€1mL*10mM (DMSO)343,00€Ginisortamab
CAS:Ginisortamab (UCB6114) is a fully humanized monoclonal antibody targeting Gremlin-1, IC50=8.2 nM and 9 nM against human and mouse Gremlin-1, respectively.Pureza:95% - 96.0% (SDS-PAGE); 97.0% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:147.55 kDaTrevogrumab
CAS:Trevogrumab is a human monoclonal antibody that inhibits myostatin (GDF8) to promote muscle growth, and is under research for treating age-related muscle loss (sarcopenia).Pureza:95% - 97.6% (SDS-PAGE); 95.9% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:144.02 kDaTEAD-IN-6
CAS:TEAD-IN-6 (Example 11-1) is a TEAD modulator that inhibits the YAP1/TAZ-TEAD interaction, and has applications in cancer research [1].Fórmula:C19H17F3N4O3SPureza:98%Cor e Forma:SolidPeso molecular:438.42BRD0209
CAS:BRD0209 is a highly selective and potent GSK3 inhibitor.
Fórmula:C22H25N3OPureza:99.92%Cor e Forma:SolidPeso molecular:347.45CJJ300
CAS:CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, and halts cell migration.Fórmula:C30H33N3Pureza:99.51%Cor e Forma:SolidPeso molecular:435.6Ref: TM-T62483
2mg35,00€5mg51,00€10mg90,00€25mg164,00€50mg259,00€100mg393,00€200mg552,00€1mL*10mM (DMSO)57,00€GSK-3β inhibitor 12
CAS:GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3βFórmula:C14H13N3OSPureza:98.58%Cor e Forma:SolidPeso molecular:271.34JAK3/BTK-IN-2
CAS:JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor.
Fórmula:C25H32N8O2Pureza:99.64% - 99.87%Cor e Forma:SolidPeso molecular:476.57Chromenone 1
CAS:Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).Fórmula:C18H10F3N3O2Pureza:99.83% - 99.93%Cor e Forma:SolidPeso molecular:357.29Ref: TM-T61301
1mg52,00€5mg111,00€10mg162,00€25mg235,00€50mg330,00€100mg452,00€200mg607,00€1mL*10mM (DMSO)113,00€
