Células - tronco
Os inibidores de células-tronco são compostos que atuam especificamente nas células-tronco e em suas vias de sinalização, afetando sua capacidade de autorrenovação e diferenciação. Esses inibidores são cruciais em pesquisas focadas no controle do comportamento das células-tronco, na compreensão dos processos de desenvolvimento e no desenvolvimento de terapias para doenças como o câncer, onde se acredita que as células-tronco desempenhem um papel fundamental. Na CymitQuimica, oferecemos uma variedade de inibidores de células-tronco para apoiar sua pesquisa em medicina regenerativa, biologia do desenvolvimento e oncologia.
Foram encontrados 486 produtos de "Células - tronco"
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CMD178 TFA
<p>CMD178 (TFA) is a lead peptide that consistently reduces the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling.</p>Fórmula:C48H60F3N9O9Pureza:>99.99%Cor e Forma:SolidPeso molecular:964.05iCRT 14
CAS:<p>iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).</p>Fórmula:C21H17N3O2SPureza:99.8% - 99.97%Cor e Forma:SolidPeso molecular:375.44WDR5-0103 hydrochloride[890190-22-4(free base)]
<p>WDR5-0103 hydrochloride[890190-22-4(free base)] (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd:</p>Fórmula:C21H26ClN3O4Pureza:99.66%Cor e Forma:SolidPeso molecular:419.9KY02111
CAS:<p>KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.</p>Fórmula:C18H17ClN2O3SPureza:97.71% - 98.3%Cor e Forma:SolidPeso molecular:376.86NCC007
CAS:<p>NCC007 is a novel CKIα and CKIδ dual inhibitors by structural modification of N9 and C2 position of longdaysin.</p>Fórmula:C22H28F3N7Pureza:98.88%Cor e Forma:SolidPeso molecular:447.5Silmitasertib
CAS:<p>Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).</p>Fórmula:C19H12ClN3O2Pureza:98% - 99.90%Cor e Forma:SolidPeso molecular:349.77JAK3-IN-6
CAS:<p>JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM</p>Fórmula:C19H18N4O3Pureza:99.94% - 99.94%Cor e Forma:SolidPeso molecular:350.37β-catenin-IN-2
CAS:<p>β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.</p>Fórmula:C15H14FN3Pureza:99.93%Cor e Forma:SolidPeso molecular:255.29Afuresertib hydrochloride
CAS:<p>Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)</p>Fórmula:C18H18Cl3FN4OSPureza:99.96%Cor e Forma:SolidPeso molecular:463.8TTP 22
CAS:<p>TTP 22: ATP-competitive CK2 inhibitor; IC50/Ki: 0.1 μM/40 nM; >250x selective over JNK3, ROCK1, MET.</p>Fórmula:C16H14N2O2S2Pureza:97.08% - 97.78%Cor e Forma:SolidPeso molecular:330.42I3MT-3
CAS:<p>I3MT-3 (HMPSNE) is a selective inhibitor of 3MST, targeting active site cysteine residues and permeating cell membranes.</p>Fórmula:C17H14N2O2SPureza:99.76%Cor e Forma:SolidPeso molecular:310.37Fz7-21
CAS:<p>Fz7-21, a peptide antagonist of FZD7, inhibits Wnt/β-catenin signaling (IC50=50-100nM) in cells with WNT3A.</p>Fórmula:C83H114N18O23S2Pureza:99.8%Cor e Forma:SolidPeso molecular:1796.03AS1517499
CAS:<p>AS1517499 is a blood-brain barrier permeable inhibitor of STAT6 phosphorylation (IC50= 21 nM). High-Quality, Low-Cost!</p>Fórmula:C20H20ClN5O2Pureza:98.27% - 98.7%Cor e Forma:SolidPeso molecular:397.86exo-IWR-1
CAS:<p>exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin</p>Fórmula:C25H19N3O3Pureza:97.41%Cor e Forma:SolidPeso molecular:409.44YO-01027
CAS:<p>YO-01027 (DBZ) is a potent γ-secretase inhibitor.</p>Fórmula:C26H23F2N3O3Pureza:97.21% - 99.58%Cor e Forma:SolidPeso molecular:463.48GNF4877
CAS:<p>GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.</p>Fórmula:C25H27FN6O4Pureza:98.68% - 99.40%Cor e Forma:SolidPeso molecular:494.52WHI-P97
CAS:<p>WHI-P97 is a rationally designed potent inhibitor of JAK-3.</p>Fórmula:C16H13Br2N3O3Pureza:99.93%Cor e Forma:SolidPeso molecular:455.1Belumosudil
CAS:<p>Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).</p>Fórmula:C26H24N6O2Pureza:97.64% - 98.59%Cor e Forma:SolidPeso molecular:452.51(E/Z)-GSK-3β inhibitor 1
CAS:<p>(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.</p>Fórmula:C14H10N2OPureza:98.60%Cor e Forma:SolidPeso molecular:222.24Wnt pathway activator 1
CAS:<p>Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM.</p>Fórmula:C18H16O4Pureza:99.93%Cor e Forma:SolidPeso molecular:296.32FH535
CAS:<p>FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.</p>Fórmula:C13H10Cl2N2O4SPureza:98.25% - 99.5%Cor e Forma:SolidPeso molecular:361.2S3I-201
CAS:<p>S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.</p>Fórmula:C16H15NO7SPureza:97.83%Cor e Forma:SolidPeso molecular:365.36IHR-1
CAS:<p>IHR-1, a Smo inhibitor (IC50 7.6 nM), blocks Hedgehog pathway, not Wnt/Notch, and prevents Smo in primary cilium.</p>Fórmula:C20H12Cl4N2O2Pureza:97.02%Cor e Forma:SolidPeso molecular:454.13Avagacestat
CAS:<p>Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM,</p>Fórmula:C20H17ClF4N4O4SPureza:98.87% - 99.73%Cor e Forma:SolidPeso molecular:520.89MRT-14
CAS:<p>MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies.</p>Fórmula:C24H24N4O5Pureza:99.54%Cor e Forma:SolidPeso molecular:448.47BDP5290
CAS:<p>BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)</p>Fórmula:C17H18ClN7OPureza:97.22%Cor e Forma:SolidPeso molecular:371.82Lats-IN-1
CAS:<p>Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.</p>Fórmula:C18H14N4OSPureza:97.54% - 99.79%Cor e Forma:SolidPeso molecular:334.39LY3200882
CAS:<p>LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).</p>Fórmula:C24H29N5O3Pureza:99.46% - 99.63%Cor e Forma:SolidPeso molecular:435.52WAY 316606
CAS:<p>WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.</p>Fórmula:C18H19F3N2O4S2Pureza:99.65%Cor e Forma:SolidPeso molecular:448.48XMU-MP-1
CAS:<p>XMU-MP-1 is a reversible and selective MST1/2 kinase inhibitor, IC50 values for MST1 and MST2 are 71.1 nM and 38.1 nM, respectively. High-Quality, Low-Cost!</p>Fórmula:C17H16N6O3S2Pureza:99.68% - 99.79%Cor e Forma:SolidPeso molecular:416.48AS-252424
CAS:<p>AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.</p>Fórmula:C14H8FNO4SPureza:99.06% - 99.09%Cor e Forma:SolidPeso molecular:305.28Crenigacestat
CAS:<p>Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested.</p>Fórmula:C22H23F3N4O4Pureza:97.27% - 98.99%Cor e Forma:SolidPeso molecular:464.44Fosciclopirox
CAS:<p>Fosciclopirox (CPX-POM), the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entire</p>Fórmula:C13H20NO6PPureza:99.83%Cor e Forma:SolidPeso molecular:317.27Jagged-1 (188-204) TFA(219127-21-6 free base)
<p>Jagged-1 (188-204) TFA, a JAG-1 skin protein fragment, induces epidermal maturation and keratinocyte stratification.</p>Fórmula:C95H128F3N25O28S3Pureza:99.48%Cor e Forma:SolidPeso molecular:2221.37SKL2001
CAS:<p>SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.</p>Fórmula:C14H14N4O3Pureza:97.46% - 99.5%Cor e Forma:SolidPeso molecular:286.29AR-A014418
CAS:<p>AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.</p>Fórmula:C12H12N4O4SPureza:>99.99% - ≥95%Cor e Forma:SolidPeso molecular:308.31KYA1797K
CAS:<p>KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.</p>Fórmula:C17H11N2O6S2·KPureza:97.57% - 99.33%Cor e Forma:SolidPeso molecular:442.51AZD2858
CAS:<p>AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.</p>Fórmula:C21H23N7O3SPureza:98% - 99.25%Cor e Forma:SolidPeso molecular:453.52SB 216763
CAS:<p>SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).</p>Fórmula:C19H12Cl2N2O2Pureza:98.9% - 99.13%Cor e Forma:SolidPeso molecular:371.22JANEX-1
CAS:<p>JANEX-1: cell-permeable, reversible Jak3 inhibitor (IC50: 78 μM), ATP-competitive, selective; weak on JAK1/2, Zap/Syk, SRC.</p>Fórmula:C16H15N3O3Pureza:98% - 99.81%Cor e Forma:SolidPeso molecular:297.31Pyrvinium pamoate
CAS:<p>Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug</p>Fórmula:C26H28N3C23H14O6Pureza:99.76% - >99.99%Cor e Forma:SolidPeso molecular:575.71KY19382
CAS:<p>KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.</p>Fórmula:C17H11Cl2N3O2Pureza:98.06%Cor e Forma:SolidPeso molecular:360.19MYF-01-37
CAS:<p>MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.</p>Fórmula:C15H17F3N2OPureza:99.46% - 99.5%Cor e Forma:SolidPeso molecular:298.3CKI-7
CAS:<p>CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.</p>Fórmula:C11H14Cl3N3O2SPureza:>99.99%Cor e Forma:SolidPeso molecular:358.67AT13148
CAS:<p>AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.</p>Fórmula:C17H16ClN3OPureza:98.04% - ≥95%Cor e Forma:SolidPeso molecular:313.78CP21R7
CAS:<p>CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.</p>Fórmula:C19H15N3O2Pureza:96.14% - 99.16%Cor e Forma:SolidPeso molecular:317.34Upadacitinib
CAS:<p>Upadacitinib (ABT-494), a selective JAK1 inhibitor, is researched for autoimmune diseases; IC50: 43 nM.</p>Fórmula:C17H19F3N6OPureza:98.96% - 99.94%Cor e Forma:SolidPeso molecular:380.37BD750
CAS:<p>BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in</p>Fórmula:C14H13N3OSPureza:99.02%Cor e Forma:SolidPeso molecular:271.34VP3.15 dihydrobromide
CAS:<p>VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.</p>Fórmula:C20H24Br2N4OSPureza:99.67% - ≥95%Cor e Forma:SolidPeso molecular:528.3LGK974
CAS:<p>LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal and head/neck cancer trials. IC50: 0.4 nM.</p>Fórmula:C23H20N6OPureza:98.8% - >99.99%Cor e Forma:SolidPeso molecular:396.44
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