Células - tronco
Os inibidores de células-tronco são compostos que atuam especificamente nas células-tronco e em suas vias de sinalização, afetando sua capacidade de autorrenovação e diferenciação. Esses inibidores são cruciais em pesquisas focadas no controle do comportamento das células-tronco, na compreensão dos processos de desenvolvimento e no desenvolvimento de terapias para doenças como o câncer, onde se acredita que as células-tronco desempenhem um papel fundamental. Na CymitQuimica, oferecemos uma variedade de inibidores de células-tronco para apoiar sua pesquisa em medicina regenerativa, biologia do desenvolvimento e oncologia.
Foram encontrados 486 produtos de "Células - tronco"
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SR-1277
CAS:<p>SR-1277 is a potent, highly selective and ATP-competitive CK1δ/ε inhibitor, regulating Wee1 activity at the G2/M cell-cycle interface, and antiproliferative.</p>Fórmula:C21H19N9O3SCor e Forma:SolidPeso molecular:477.5TEAD-IN-6
CAS:<p>TEAD-IN-6 (Example 11-1) is a TEAD modulator that inhibits the YAP1/TAZ-TEAD interaction, and has applications in cancer research [1].</p>Fórmula:C19H17F3N4O3SPureza:98%Cor e Forma:SolidPeso molecular:438.42PI-828
CAS:<p>PI-828 (LY 294002), a PI3K inhibitor, researches PI3K function and aids stem cell differentiation into mesoderm.</p>Fórmula:C19H18N2O3Pureza:99.95%Cor e Forma:SolidPeso molecular:322.36JAK-STAT-IN-1
CAS:<p>JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.</p>Fórmula:C21H21N5O2Pureza:99.59%Cor e Forma:SolidPeso molecular:375.42GSK-3 Inhibitor XIII
CAS:<p>GSK-3 InhibitorXIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.</p>Fórmula:C18H15N5Pureza:99.85% - 99.86%Cor e Forma:SolidPeso molecular:301.35GSK-3β inhibitor 11
CAS:<p>GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM.</p>Fórmula:C20H15N3O4SPureza:97.33%Cor e Forma:SolidPeso molecular:393.42AS 1892802
CAS:<p>AS 1892802, a ROCK inhibitor: IC50 - 52nM (hROCK2), 57nM (rROCK2), 122nM (hROCK1). Fast antinociceptive effect similar to Tramadol, Diclofenac.</p>Fórmula:C20H19N3O2Pureza:99.86%Cor e Forma:SolidPeso molecular:333.38IHMT-MST1-58
CAS:<p>IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity.</p>Fórmula:C21H22N6O3SPureza:98.31% - 99.92%Cor e Forma:SolidPeso molecular:438.5FzM1.8
CAS:<p>FzM1.8: allosteric FZD4 agonist, pEC50=6.4; boosts TCF/LEF, activates WNT/β-catenin with no WNT needed.</p>Fórmula:C18H14N2O4Pureza:99.89%Cor e Forma:SolidPeso molecular:322.31ABC1183
CAS:<p>ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.</p>Fórmula:C18H14N4OSPureza:98.92%Cor e Forma:SolidPeso molecular:334.39GSK-3β inhibitor 2
CAS:<p>GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50</p>Fórmula:C14H14N4O3SPureza:99.08%Cor e Forma:SolidPeso molecular:318.35LM-41
CAS:<p>LM-41 is a TEAD binding agent with potential anticancer activity for the study of breast cancer.</p>Fórmula:C19H14FNO2Pureza:99.73%Cor e Forma:SolidPeso molecular:307.32BIP-135
CAS:<p>BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.</p>Fórmula:C21H13BrN2O3Pureza:99.93%Cor e Forma:SolidPeso molecular:421.24XL413 xHCl
CAS:<p>BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215</p>Fórmula:C14H12ClN3O2·xHClPureza:99.37% - 99.67%Cor e Forma:SolidPeso molecular:326.18SJ000063181
CAS:<p>SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.</p>Fórmula:C14H14ClFN2O2Pureza:99.94%Cor e Forma:SolidPeso molecular:296.72Rhodblock 6
CAS:<p>Rhodblock 6 is a Rho kinase inhibitor, blocking phosphorylated MRLC localization by targeting ROCK activity.</p>Fórmula:C12H13N3OPureza:98.27%Cor e Forma:SolidPeso molecular:215.25FzM1
CAS:<p>FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2)</p>Fórmula:C21H16N2O2SPureza:99.37% - 99.89%Cor e Forma:SolidPeso molecular:360.43Casein kinase 1δ-IN-1
CAS:<p>Casein kinase 1δ-IN-1 (WAY-643895) is an inhibitor of casein kinase 1δ (CK1δ), which inhibits CK1δ.</p>Fórmula:C11H7N3OSPureza:99.46%Cor e Forma:SolidPeso molecular:229.26TT-10
CAS:<p>TT-10 (TAZ-K) activates YAP-TEAD; useful in heart disease with cardiomyocyte loss research.</p>Fórmula:C11H10FN3OS2Pureza:99.29%Cor e Forma:SolidPeso molecular:283.35JAK1-IN-8
CAS:<p>JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).</p>Fórmula:C22H23FN4O3SPureza:98.4%Cor e Forma:SolidPeso molecular:442.51Izencitinib
CAS:<p>Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.</p>Fórmula:C22H26N8Pureza:99.82%Cor e Forma:SolidPeso molecular:402.50MSC-4106
CAS:<p>MSC-4106, an oral YAP/TAZ-TEAD inhibitor, blocks TEAD1/3 auto-palmitoylation and suppresses NCI-H226 tumors.</p>Fórmula:C18H12F3N3O2Pureza:99.89%Cor e Forma:SoildPeso molecular:359.3DIF-3
CAS:<p>DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.</p>Fórmula:C13H17ClO4Pureza:99.57%Cor e Forma:SolidPeso molecular:272.72CID-5056270
CAS:<p>CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma</p>Fórmula:C17H13N3O3SPureza:99.6%Cor e Forma:SolidPeso molecular:339.37EHT 1610
CAS:<p>EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively.</p>Fórmula:C18H14FN5O2SPureza:98.59%Cor e Forma:SolidPeso molecular:383.4CRT0066854 hydrochloride
CAS:<p>CRT0066854 HCl inhibits atypical PKCs; IC50: PKCι 132 nM, PKCζ 639 nM, ROCK-II 620 nM.</p>Fórmula:C24H27Cl2N5SPureza:99.63%Cor e Forma:SolidPeso molecular:488.48Rho-Kinase-IN-1
CAS:<p>Rho-Kinase-IN-1: ROCK inhibitor, Ki of 30.5 nM (ROCK1) & 3.9 nM (ROCK2), used in research for diseases linked to cell overgrowth and inflammation.</p>Fórmula:C20H24N4SPureza:99.8%Cor e Forma:SolidPeso molecular:352.5Miclxin
CAS:<p>Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potent</p>Fórmula:C26H27N5O2Pureza:99.17% - 99.99%Cor e Forma:SolidPeso molecular:441.52ARN25068
CAS:<p>ARN25068 inhibits GSK-3β, FYN, DYRK1A kinases; acts in sub-micromolar range; combats tau hyperphosphorylation.</p>Fórmula:C19H18N6SPureza:99.75%Cor e Forma:SolidPeso molecular:362.45Wnt/β-catenin agonist 4
CAS:<p>Wnt/β-catenin agonist 4 is an agonist of Wnt that activates Wnt/β-catenin signaling and directs signaling.</p>Fórmula:C16H15FN4O2Pureza:99.61%Cor e Forma:SolidPeso molecular:314.31LEQ506
CAS:<p>LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.</p>Fórmula:C25H32N6OPureza:99.76%Cor e Forma:SolidPeso molecular:432.56ROCK-IN-8
CAS:<p>ROCK-IN-8 (Example 4), a ROCK inhibitor, exhibits anti-inflammatory properties and is suitable for respiratory and gastro-intestinal disease research,</p>Fórmula:C30H25FN4O4SPureza:98%Cor e Forma:SolidPeso molecular:556.61Casein kinase 1δ-IN-10
CAS:<p>Casein kinase 1δ-IN-10 is an inhibitor of casein kinase 1δ (CK1δ).</p>Fórmula:C21H17N3O3Pureza:98%Cor e Forma:SolidPeso molecular:359.38inS3-54A18
CAS:<p>inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.</p>Fórmula:C23H16ClNO2Pureza:99.68%Cor e Forma:SolidPeso molecular:373.83BMS-983970
CAS:<p>BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.</p>Fórmula:C26H26F4N4O3Cor e Forma:SolidPeso molecular:518.5ROCK2-IN-6 hydrochloride
CAS:<p>ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。</p>Fórmula:C26H22ClF2N7OPureza:98%Cor e Forma:SolidPeso molecular:521.95BRD5648
CAS:<p>BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.</p>Fórmula:C20H23N3OPureza:99.89%Cor e Forma:SolidPeso molecular:321.42Casein kinase 1δ-IN-5
CAS:<p>Casein kinase 1δ-IN-5 is a potent and selective CK-1δ inhibitor, exhibiting an IC50 of 47 nM, and demonstrates neuroprotective and anti-inflammatory effects in</p>Fórmula:C16H11F3N2OSPureza:98%Cor e Forma:SolidPeso molecular:336.33STAT6-IN-3
CAS:<p>STAT6-IN-3 (Compound 18a) serves as an inhibitor of STAT6 with an IC50 value of 44 nM, specifically targeting the Src Homology 2 (SH2) domain.</p>Fórmula:C32H35IN3O7PPureza:98%Cor e Forma:SolidPeso molecular:731.51Stafib-2
CAS:<p>Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,</p>Fórmula:C28H26N2O12P2Pureza:98.48%Cor e Forma:SolidPeso molecular:644.46JAK2-IN-4
CAS:<p>JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.</p>Fórmula:C23H27N5O4SPureza:98%Cor e Forma:SolidPeso molecular:469.56Antitumor agent-73
CAS:<p>Antitumor Agent-73, derived from Diosgenin, blocks STAT3 and activates Pdia3, showing strong cancer cell line efficacy.</p>Fórmula:C50H82BrO4PPureza:98%Cor e Forma:SolidPeso molecular:858.06JW 67
CAS:<p>JW 67 is an inhibitor of canonical Wnt pathway signaling.</p>Fórmula:C21H18N2O6Pureza:99.02%Cor e Forma:SolidPeso molecular:394.38YAP-TEAD-IN-2
CAS:<p>YAP-TEAD-IN-2 (compound 6) serves as a potent inhibitor of the YAP-TEAD protein-protein interaction (PPI), demonstrating an inhibitory concentration 50 (IC50)</p>Fórmula:C25H24ClFN2O4Pureza:98%Cor e Forma:SolidPeso molecular:470.92ROCK2-IN-2
CAS:<p>ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).</p>Fórmula:C18H12N6OSPureza:99.65%Cor e Forma:SolidPeso molecular:360.39Myristoyl tetrapeptide-12
CAS:<p>Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].</p>Fórmula:C32H63N7O5Pureza:98%Cor e Forma:SolidPeso molecular:625.89A 1070722
CAS:<p>A 1070722: potent GSK-3 inhibitor, Ki = 0.6 nM for both α/β isoforms, crosses BBB, potential brain GSK-3 PET radiotracer.</p>Fórmula:C17H13F3N4O2Pureza:99.9%Cor e Forma:SolidPeso molecular:362.31STAT3-IN-20
CAS:<p>STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclear</p>Fórmula:C30H27F4N7SPureza:98%Cor e Forma:SolidPeso molecular:593.64JAK kinase-IN-1
CAS:<p>JAK kinase-IN-1 (Example 1) functions as a potent inhibitor targeting the JAK family, which includes TYK2, JAK1, JAK2, and JAK3, with IC50 values of 4.2 nM, 32</p>Fórmula:C17H19F2N7OSPureza:98%Cor e Forma:SolidPeso molecular:407.44Casein Kinase II Inhibitor IV
CAS:<p>Casein kinase II inhibitor IV is an effective small molecule inducer, which can be used to induce epidermal keratinocyte differentiation.</p>Fórmula:C24H23N5O3Pureza:99.65% - 99.75%Cor e Forma:SolidPeso molecular:429.47
