Células - tronco
Os inibidores de células-tronco são compostos que atuam especificamente nas células-tronco e em suas vias de sinalização, afetando sua capacidade de autorrenovação e diferenciação. Esses inibidores são cruciais em pesquisas focadas no controle do comportamento das células-tronco, na compreensão dos processos de desenvolvimento e no desenvolvimento de terapias para doenças como o câncer, onde se acredita que as células-tronco desempenhem um papel fundamental. Na CymitQuimica, oferecemos uma variedade de inibidores de células-tronco para apoiar sua pesquisa em medicina regenerativa, biologia do desenvolvimento e oncologia.
Foram encontrados 129 produtos para "Células - tronco".
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TEAD-IN-24
CAS:TEAD-IN-24 (Example 65) is a TEAD inhibitor with anticancer activity against non-small cell lung cancer.Fórmula:C23H22F3N3O4Peso molecular:461.44LATS-IN-2
CAS:LATS-IN-2 is a potent inhibitor of LATS, demonstrating significant inhibitory activity against LATS1 with an IC50 value of 1.3 nM. By inhibiting LATS kinase activity, LATS-IN-2 reduces the phosphorylation of YAP. Additionally, LATS-IN-2 increases the thickness of mouse epidermis and can be used in research on ocular diseases, such as limbal stem cell deficiency and corneal endothelial dysfunction.Fórmula:C15H16N6Peso molecular:280.34VS3
CAS:VS3 is an inhibitor of the YAP-TEAD interaction. By directly binding to the TEAD4 Interface 3 (Kd = 6 μM), VS3 disrupts the interaction between YAP and TEAD. It exhibits antiproliferative activity against HT29, HCT116, and A2780 cells. VS3 is useful for studying colorectal adenocarcinoma and ovarian cancer.Fórmula:C21H21N3O3Peso molecular:363.42TGFβ1-IN-1
CAS:TGFβ1-IN-1 is a TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in cancer research.Fórmula:C22H24N2O3Pureza:99.89% - 99.89%Cor e Forma:White SolidPeso molecular:364.438Ref: TM-T61389
1mg50,00€5mg105,00€1mL*10mM (DMSO)117,00€10mg170,00€25mg340,00€50mg557,00€100mg893,00€200mg1.198,00€CDD-1431
CAS:CDD-1431 is a highly selective BMPR2 kinase inhibitor with a Kiapp of 20.6 nM. It inhibits BRE reporter gene activity, exhibiting an IC50 of 4.87 μM. BMPs regulate cellular processes across various tissue types such as the kidneys, skeletal muscle, heart, and reproductive organs, and can induce ectopic bone formation.Fórmula:C33H38N8O5SCor e Forma:SolidPeso molecular:658.77M3686
CAS:M3686 (Compound 29) is a potent and selective TEAD1 inhibitor with an IC50 value of 51 nM. It exhibits weaker binding activity toward TEAD3. M3686 significantly inhibits the cellular activity of YAP-dependent NCI-H226 cell lines, with an IC50 value of 0.06 μM, and demonstrates strong antitumor effects in the NCI-H226 xenograft model.Fórmula:C21H18F3N5O2Cor e Forma:SolidPeso molecular:429.395YAP/TAZ inhibitor-3
CAS:YAP/TAZ inhibitor-3 (Compound 24) is a YAP/TAZ inhibitor applicable for relevant research within the life sciences field.Fórmula:C21H18F3NO3Pureza:99.63%Cor e Forma:White SolidPeso molecular:389.37Ref: TM-T87651
10mgA consultar25mgA consultar50mgA consultar100mgA consultar1mg90,00€5mg215,00€1mL*10mM (DMSO)236,00€TEAD-IN-10
CAS:TEAD-IN-10 (compound 15), a covalent inhibitor, exhibits selective and potent inhibitory activity against TEAD1 (IC 50 =14 nM), TEAD2 (IC 50 =179 nM), and TEAD3 (IC 50 =4 nM). This compound is utilized in cancer research [1].Fórmula:C15H14F3NOCor e Forma:SolidPeso molecular:281.27TGFβRI-IN-3
CAS:TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4.Fórmula:C28H23N3O2SPureza:99.85%Cor e Forma:SolidPeso molecular:465.57Ref: TM-T9523
1mg84,00€5mg177,00€1mL*10mM (DMSO)177,00€10mg281,00€25mg552,00€50mg859,00€100mg1.234,00€500mg2.457,00€
