Gama-secretase
Os inibidores da gama-secretase são compostos que têm como alvo o complexo enzimático gama-secretase, que está envolvido na clivagem da proteína precursora do amiloide (APP) para produzir peptídeos beta-amiloides. Esses peptídeos podem se agregar para formar placas amiloides, uma característica da doença de Alzheimer. Ao inibir a gama-secretase, esses compostos visam reduzir a produção de beta-amiloide e sua acumulação no cérebro, sendo, portanto, um foco importante na pesquisa sobre a doença de Alzheimer. Na CymitQuimica, oferecemos inibidores da gama-secretase para apoiar sua pesquisa em biologia amiloide, terapia do Alzheimer e doenças neurodegenerativas.
Foram encontrados 63 produtos de "Gama-secretase"
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CB-103
CAS:CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.Fórmula:C15H18N2OPureza:99.44%Cor e Forma:SolidPeso molecular:242.32Brontictuzumab
CAS:Brontictuzumab (OMP 52M5) is an anti-Notch1 monoclonal antibody with antitumor activity that inhibits tumor cell proliferation.Pureza:98.1% (SDS-PAGE); 97.6% (SEC-HPLC) - 98.1% (SDS-PAGE); 97.6% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:143.93 kDaDemcizumab
CAS:Demcizumab (OMP 21M18), an anti-DLL4 antibody, inhibits the Notch pathway and fights various cancers solo or with chemo.Pureza:> 95%Cor e Forma:LiquidPeso molecular:145.34 kDaRovalpituzumab
CAS:Rovalpituzumab: humanized antibody against DLL3, forms ADCs, treats small cell lung cancer.Pureza:> 95%Cor e Forma:LiquidPeso molecular:145.02 kDaNavicixizumab
CAS:Navicixizumab, a bispecific VEGF/DLL4 inhibitor, pairs with Paclitaxel in ovarian and other cancer research.Cor e Forma:LiquidRovalpituzumab MMAE
Rovalpituzumab-MMAE (Anti-DLL3 Reference Antibody), produced in CHO cells, consists of a huIgG1 heavy chain and a hukappa light chain. The molecular weight of this antibody is predicted to be 145.02 kDa.Cor e Forma:LiquidPeso molecular:145 kDaSAHM1 TFA
SAHM1 TFA inhibits the Notch pathway, stabilizes alpha helices, and blocks Notch complex formation.Fórmula:C96H163N36F3O25SCor e Forma:SolidPeso molecular:2310.6Notch 1
CAS:Notch1 (Notchhomolog 1, translocation-associated) encodes a protein that is a member of the NOTCH family. This type I transmembrane protein family is characterized by common structural features, including an extracellular domain made up of multiple epidermal growth factor-like (EGF) repeats and an intracellular domain composed of various types of domains.Fórmula:C62H97N15O22S3Cor e Forma:SolidPeso molecular:1500.72PSEN1-IN-1
PSEN1-IN-1 (Compound (+)-13b) functions as an inhibitor of PSEN1, displaying potent inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with respective IC50Fórmula:C20H19ClF3NO3SCor e Forma:SolidPeso molecular:445.88SPL-707
CAS:SPL-707 is an effective and selective signal peptide peptidase-like 2a inhibitor (IC50: 80 nM).Fórmula:C27H28FN5O4Pureza:98%Cor e Forma:SolidPeso molecular:505.54PSEN1-IN-2
PSEN1-IN-2 (Compound 13K) is a potent inhibitor of both PSEN1-APH1A and PSEN1-APH1B complexes, exhibiting IC50 values of 6.9 nM and 2.4 nM, respectively.Fórmula:C20H18ClFN2O3SCor e Forma:SolidPeso molecular:420.88SAHM1
CAS:Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.Fórmula:C94H162N36O23SPureza:98%Cor e Forma:SolidPeso molecular:2196.58γ-Secretase modulator 10
CAS:γ-Secretase modulator 10 is a novel γ-secretase modulator.Fórmula:C25H23F3N4O2Cor e Forma:SolidPeso molecular:468.48CIA-1 (Free base)
CAS:CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor growth in mouse prostate cancer.Fórmula:C17H19N3O2SPureza:99%Cor e Forma:SolidPeso molecular:329.42FRM-024
CAS:FRM-024 is a powerful gamma secretase modulator with the ability to penetrate the central nervous system (CNS), designed specifically for the treatment ofFórmula:C22H22ClN5O2Cor e Forma:SolidPeso molecular:423.9RBPJ Inhibitor-1
CAS:RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cellFórmula:C17H14FN3O2Pureza:99.79%Cor e Forma:SoildPeso molecular:311.31Ref: TM-T35566
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg130,00€25mg215,00€50mg371,00€100mg537,00€Notch 1 TFA
Notch 1 TFA encodes a member of the NOTCH family of proteins.Fórmula:C64H98N15F3O25S3Pureza:98%Cor e Forma:SolidPeso molecular:1614.81BMS-906024
CAS:BMS-906024 (Osugacestat) is a gamma secretase inhibitor, a Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity.Fórmula:C26H26F6N4O3Pureza:99.88% - >99.99%Cor e Forma:SolidPeso molecular:556.55β-Cholanic acid
CAS:5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.
Fórmula:C24H40O2Pureza:98.91% - 99.89%Cor e Forma:SoildPeso molecular:360.57Jagged-1 (188-204)
CAS:Jagged-1 （188-204）is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin.Fórmula:C93H127N25O26S3Pureza:98%Cor e Forma:SolidPeso molecular:2107.4Legumain inhibitor 1
CAS:Legumain inhibitor 1 is a highly potent and specific Legumain inhibitor with potential anticancer activity for cancer research.Fórmula:C23H25N5O4SPureza:98.14%Cor e Forma:SolidPeso molecular:467.54Enoticumab
CAS:Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits cancer cell growth.Pureza:98.2% (SDS-PAGE); 98.9% (SEC-HPLC) - 98.2% (SDS-PAGE); 98.9% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:146.22 kDaγ-secretase modulator 3
CAS:Gamma-secretase modulator 3 (γ-secretase modulator 3) is a γ-secretase modulator that reduces Aβ production.Fórmula:C24H23FN4OSPureza:98%Cor e Forma:SolidPeso molecular:434.53JI130
CAS:JI130 hinders Hes1 transcription repression; notably shrinks pancreatic tumor volume in mice.Fórmula:C23H24N2O3Pureza:99.61%Cor e Forma:SolidPeso molecular:376.45Jagged-1 (188-204) TFA(219127-21-6 free base)
Jagged-1 (188-204) TFA, a JAG-1 skin protein fragment, induces epidermal maturation and keratinocyte stratification.Fórmula:C95H128F3N25O28S3Pureza:99.48%Cor e Forma:SolidPeso molecular:2221.37IMR-1
CAS:IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Fórmula:C15H15NO5S2Pureza:97.96% - 98.38%Cor e Forma:SolidPeso molecular:353.41FLI-06
CAS:FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).Fórmula:C25H30N2O5Pureza:99.81% - ≥98%Cor e Forma:SolidPeso molecular:438.52Ref: TM-T3075
1mg34,00€2mg49,00€5mg71,00€1mL*10mM (DMSO)78,00€10mg94,00€25mg168,00€50mg295,00€100mg513,00€500mg1.125,00€γ-secretase modulator 1 hydrochloride
CAS:gamma-secretase inhibitior-1 is a gamma-secretase modulator that is useful to Alzheimer's disease [1].Fórmula:C24H25ClN4OSPureza:98%Cor e Forma:SolidPeso molecular:453MK-0752 Sodium
CAS:Sodium MK-0752 is a novel and potent gamma-secretase inhibitor that has been evaluated in clinical trials for the treatment of various types of cancer.Fórmula:C21H21ClF2NaO4SCor e Forma:SolidPeso molecular:465.89LY900009
CAS:LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.Fórmula:C23H27N3O4Pureza:97.07%Cor e Forma:SolidPeso molecular:409.48Ref: TM-T9015
1mg35,00€5mg80,00€1mL*10mM (DMSO)87,00€10mg112,00€25mg197,00€50mg290,00€100mg420,00€200mg590,00€RO7185876
CAS:RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.Fórmula:C25H28F3N7Pureza:99.50%Cor e Forma:SolidPeso molecular:483.532Sulindac EP Impurity C-d3
CAS:Sulindac EP Impurity C-d3 is a deuterated compound of Sulindac EP Impurity C. Sulindac EP Impurity C has a CAS number of 32004-67-4. (E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer's disease [1].Fórmula:C20H14D3FO2SCor e Forma:SolidPeso molecular:343.43Tarextumab
CAS:Tarextumab is an anti-Notch2/3 mAb, a promising candidate for breast, lung, ovarian, and pancreatic cancers.Pureza:95%Cor e Forma:LiquidPeso molecular:~150 kDaDilpacimab
CAS:Dilpacimab (ABT165) is a dual-variable antibody that targets DLL4 and VEGF pathways, showing potential in cancer research by blocking angiogenesis and Notch.Pureza:95% - 97.7% (SDS-PAGE); 95.6% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:199.37 kDatCFA15
CAS:tCFA15: A trimethylated long-chain fatty alcohol with a 15-carbon side chain; may regulate Notch signaling and neuron differentiation.Fórmula:C24H44O2Pureza:98%Cor e Forma:SolidPeso molecular:364.61LY-411575 isomer 1
CAS:LY-411575 isomer 1 is a potent γ-secretase inhibitor. LY-411575 isomer 1 is an isomer of LY411575.Fórmula:C26H23F2N3O4Pureza:98%Cor e Forma:SolidPeso molecular:479.48ELN318463
CAS:ELN 318463 selectively inhibits γ-secretase; EC50: 12 nM (PS1), 656 nM (PS2); 51x more selective for PS1; targets APP.Fórmula:C19H20BrClN2O3SPureza:98%Cor e Forma:SolidPeso molecular:471.8RR-11a analog
CAS:RR-11a (aza-peptide) inhibits asparaginyl endopeptidase: IC50 - 4.5 nM (T. Vaginalis, I. ricinus), 31 nM (S. mansoni).Fórmula:C22H29N5O8Pureza:98.80%Cor e Forma:SolidPeso molecular:491.49Ref: TM-T12770
1mg152,00€5mg364,00€1mL*10mM (DMSO)394,00€10mg565,00€25mg1.044,00€50mg1.773,00€100mg2.602,00€ELN318463 racemate
CAS:ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.Fórmula:C19H20BrClN2O3SPureza:99.69%Cor e Forma:SolidPeso molecular:471.8Ref: TM-T11178L
1mg154,00€5mg370,00€1mL*10mM (DMSO)424,00€10mg583,00€25mg858,00€50mg1.170,00€100mg1.575,00€Yhhu-3792
CAS:Yhhu-3792 activates Notch, boosts Hes3/Hes5, enhances NSC renewal, expands NSC pool, and may improve memory.Fórmula:C24H24N4O2Cor e Forma:SolidPeso molecular:400.47BPN-15606
CAS:BPN-15606, an oral γ-secretase modulator, reduces Aβ42/Aβ40 with IC50 of 7/17 nM; promising PK/PD, lowers Aβ in rodent CNS.Fórmula:C23H23FN6OCor e Forma:SolidPeso molecular:418.47JI051
CAS:JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 cells and pancreatic cancer cells.Fórmula:C22H24N2O3Pureza:≥98% - ≥98.0%Cor e Forma:SolidPeso molecular:364.44Aβ42-IN-1 free base
CAS:Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels, exhibiting an IC 50 of 0.091Fórmula:C29H26N4O2Pureza:98%Cor e Forma:SolidPeso molecular:462.54Aβ42-IN-2
CAS:Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].Fórmula:C24H26N6O2Pureza:98.09% - 99.87%Cor e Forma:SolidPeso molecular:430.5Ref: TM-T9641
1mg42,00€1mL*10mM (DMSO)93,00€5mg94,00€10mg134,00€25mg215,00€50mg304,00€100mg420,00€200mg582,00€γ-secretase modulator 2
CAS:Gamma-secretase modulator 2 selectively targets Alzheimer's by reducing Aβ(1-42), aiding in prevention and treatment.Fórmula:C25H22F4N6O2Pureza:98%Cor e Forma:SolidPeso molecular:514.47RR-11a
CAS:RR-11a is a synthetic enzyme Legumain inhibitor.
Fórmula:C24H28N6O10Pureza:98%Cor e Forma:SolidPeso molecular:560.51CIA-1 hcl(452087-38-6 Free base)
CAS:CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety ofFórmula:C17H20ClN3O2SPureza:99.02%Cor e Forma:SolidPeso molecular:365.88γ-Secretase modulator 4
CAS:γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively.Fórmula:C23H19FN4O2Pureza:98%Cor e Forma:SolidPeso molecular:402.42γ-secretase modulator 1
CAS:gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.Fórmula:C24H24N4OSPureza:99.75% - 99.96%Cor e Forma:SolidPeso molecular:416.54γ-Secretase modulator 11
CAS:5-{8-[(3,4'-Difluoro[1,1'-biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency andFórmula:C28H22F2N4O2Cor e Forma:SolidPeso molecular:484.5Yhhu-3792 hydrochloride
CAS:Yhhu-3792 hydrochloride is a compound that bolsters the self-renewal capacity of neural stem cells (NSCs), catalyzes the Notch signaling pathway, and upregulates expression of Hes3 and Hes5. It augments the NSC pool, stimulates endogenous neurogenesis in the mouse hippocampal dentate gyrus (DG), and enhances mice's spatial and episodic memory skills. This compound shows promise for researching learning and memory impairments linked to DG dysfunction [1].Fórmula:C24H25ClN4O2Cor e Forma:SolidPeso molecular:436.93BMS-932481
CAS:BMS-932481 is a γ-secretase modulator.Fórmula:C24H24FN7OCor e Forma:SolidPeso molecular:445.49BT-GSI
BT-GSI: γ-secretase inhibitor targeting Notch, anti-myeloma & anti-resorptive for multiple myeloma/bone disease research.Fórmula:C26H46BrN5O10P2Cor e Forma:SolidPeso molecular:730.52BMS-983970
CAS:BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.Fórmula:C26H26F4N4O3Cor e Forma:SolidPeso molecular:518.5GSM-1
CAS:GSM-1 is a modulator of γ-Secretase.Fórmula:C26H31ClF3NO2Cor e Forma:SolidPeso molecular:481.98γ-Secretase modulator 11 hydrochloride
CAS:γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM).Fórmula:C28H23ClF2N4O2Cor e Forma:SolidPeso molecular:520.96BPN-15606 besylate
BPN-15606 besylate is a potent oral γ-secretase regulator reducing Aβ42 and Aβ40 with good pharmacokinetics. IC50: 7 nM (Aβ42), 17 nM (Aβ40).Fórmula:C29H29FN6O4SCor e Forma:SolidPeso molecular:576.64PF-06648671
CAS:PF-06648671 is a γ-secretase modulator for the treatment of neurodegenerative and/or neurological disorders.Fórmula:C25H23ClF4N4O3Pureza:98%Cor e Forma:SolidPeso molecular:538.92Aβ42-IN-1
CAS:Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).Fórmula:C29H27ClN4O2Pureza:98%Cor e Forma:SolidPeso molecular:499Notch inhibitor 1
CAS:Notch inhibitor 1 blocks Notch 1/3 (IC50: 7.8/8.5 nM) and aids cancer research.Fórmula:C26H25F7N4O3Pureza:98%Cor e Forma:SolidPeso molecular:574.49HDAC6-IN-9
CAS:HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.Fórmula:C19H16N2O3Pureza:98.84%Cor e Forma:SolidPeso molecular:320.34DAPM
CAS:DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects.Fórmula:C20H20F2N2O4Pureza:99.76%Cor e Forma:SolidPeso molecular:390.38PF-06442609
CAS:PF-06442609 is an orally active γ-secretase modulator with an IC50 value of 6 nM for Aβ42. It exhibits good CNS permeability.Fórmula:C24H24F4N4O3Peso molecular:492.47
