Gama-secretase
Os inibidores da gama-secretase são compostos que têm como alvo o complexo enzimático gama-secretase, que está envolvido na clivagem da proteína precursora do amiloide (APP) para produzir peptídeos beta-amiloides. Esses peptídeos podem se agregar para formar placas amiloides, uma característica da doença de Alzheimer. Ao inibir a gama-secretase, esses compostos visam reduzir a produção de beta-amiloide e sua acumulação no cérebro, sendo, portanto, um foco importante na pesquisa sobre a doença de Alzheimer. Na CymitQuimica, oferecemos inibidores da gama-secretase para apoiar sua pesquisa em biologia amiloide, terapia do Alzheimer e doenças neurodegenerativas.
Foram encontrados 59 produtos de "Gama-secretase"
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LY900009
CAS:<p>LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.</p>Fórmula:C23H27N3O4Pureza:97.07%Cor e Forma:SolidPeso molecular:409.48JI130
CAS:<p>JI130 hinders Hes1 transcription repression; notably shrinks pancreatic tumor volume in mice.</p>Fórmula:C23H24N2O3Pureza:99.61%Cor e Forma:SolidPeso molecular:376.45FLI-06
CAS:<p>FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).</p>Fórmula:C25H30N2O5Pureza:99.81% - ≥98%Cor e Forma:SolidPeso molecular:438.52γ-secretase modulator 1 hydrochloride
CAS:<p>gamma-secretase inhibitior-1 is a gamma-secretase modulator that is useful to Alzheimer's disease [1].</p>Fórmula:C24H25ClN4OSPureza:98%Cor e Forma:SolidPeso molecular:453IMR-1A
CAS:<p>IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.</p>Fórmula:C13H11NO5S2Pureza:97.1% - 99.76%Cor e Forma:SolidPeso molecular:325.36MK-0752 Sodium
CAS:<p>Sodium MK-0752 is a novel and potent gamma-secretase inhibitor that has been evaluated in clinical trials for the treatment of various types of cancer.</p>Fórmula:C21H21ClF2NaO4SCor e Forma:SolidPeso molecular:465.89RO7185876
CAS:<p>RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.</p>Fórmula:C25H28F3N7Pureza:99.50%Cor e Forma:SolidPeso molecular:483.532Dilpacimab
CAS:<p>Dilpacimab (ABT165) is a dual-variable antibody that targets DLL4 and VEGF pathways, showing potential in cancer research by blocking angiogenesis and Notch.</p>Pureza:95% - 95%Cor e Forma:LiquidTarlatamab
CAS:<p>"Tarlatamab (AMG-757), a BiTE antibody, targets DLL3, prevalent in SCLC tumors with scant normal tissue expression, and shows promise for SCLC research."</p>Cor e Forma:LiquidTarextumab
CAS:<p>Tarextumab is an anti-Notch2/3 mAb, a promising candidate for breast, lung, ovarian, and pancreatic cancers.</p>Pureza:95%Cor e Forma:Liquidγ-secretase modulator 1
CAS:<p>gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.</p>Fórmula:C24H24N4OSPureza:99.75% - 99.96%Cor e Forma:SolidPeso molecular:416.54JI051
CAS:<p>JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 cells and pancreatic cancer cells.</p>Fórmula:C22H24N2O3Pureza:≥98% - ≥98.0%Cor e Forma:SolidPeso molecular:364.44BPN-15606
CAS:<p>BPN-15606, an oral γ-secretase modulator, reduces Aβ42/Aβ40 with IC50 of 7/17 nM; promising PK/PD, lowers Aβ in rodent CNS.</p>Fórmula:C23H23FN6OCor e Forma:SolidPeso molecular:418.47Yhhu-3792
CAS:<p>Yhhu-3792 activates Notch, boosts Hes3/Hes5, enhances NSC renewal, expands NSC pool, and may improve memory.</p>Fórmula:C24H24N4O2Cor e Forma:SolidPeso molecular:400.47ELN318463 racemate
CAS:<p>ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.</p>Fórmula:C19H20BrClN2O3SPureza:99.69%Cor e Forma:SolidPeso molecular:471.8γ-secretase modulator 2
CAS:<p>Gamma-secretase modulator 2 selectively targets Alzheimer's by reducing Aβ(1-42), aiding in prevention and treatment.</p>Fórmula:C25H22F4N6O2Pureza:98%Cor e Forma:SolidPeso molecular:514.47Aβ42-IN-2
CAS:<p>Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].</p>Fórmula:C24H26N6O2Pureza:98.09% - 99.87%Cor e Forma:SolidPeso molecular:430.5ELN318463
CAS:<p>ELN 318463 selectively inhibits γ-secretase; EC50: 12 nM (PS1), 656 nM (PS2); 51x more selective for PS1; targets APP.</p>Fórmula:C19H20BrClN2O3SPureza:98%Cor e Forma:SolidPeso molecular:471.8CIA-1 hcl(452087-38-6 Free base)
CAS:<p>CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety of</p>Fórmula:C17H20ClN3O2SPureza:99.02%Cor e Forma:SolidPeso molecular:365.88γ-Secretase modulator 4
CAS:<p>γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively.</p>Fórmula:C23H19FN4O2Pureza:98%Cor e Forma:SolidPeso molecular:402.42
