Gama-secretase
Os inibidores da gama-secretase são compostos que têm como alvo o complexo enzimático gama-secretase, que está envolvido na clivagem da proteína precursora do amiloide (APP) para produzir peptídeos beta-amiloides. Esses peptídeos podem se agregar para formar placas amiloides, uma característica da doença de Alzheimer. Ao inibir a gama-secretase, esses compostos visam reduzir a produção de beta-amiloide e sua acumulação no cérebro, sendo, portanto, um foco importante na pesquisa sobre a doença de Alzheimer. Na CymitQuimica, oferecemos inibidores da gama-secretase para apoiar sua pesquisa em biologia amiloide, terapia do Alzheimer e doenças neurodegenerativas.
Foram encontrados 59 produtos de "Gama-secretase"
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tCFA15
CAS:<p>tCFA15: A trimethylated long-chain fatty alcohol with a 15-carbon side chain; may regulate Notch signaling and neuron differentiation.</p>Fórmula:C24H44O2Pureza:98%Cor e Forma:SolidPeso molecular:364.61RR-11a analog
CAS:<p>RR-11a (aza-peptide) inhibits asparaginyl endopeptidase: IC50 - 4.5 nM (T. Vaginalis, I. ricinus), 31 nM (S. mansoni).</p>Fórmula:C22H29N5O8Pureza:98.80%Cor e Forma:SolidPeso molecular:491.49γ-Secretase modulator 11
CAS:<p>5-{8-[(3,4'-Difluoro[1,1'-biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency and</p>Fórmula:C28H22F2N4O2Cor e Forma:SolidPeso molecular:484.5LY-411575 isomer 1
CAS:<p>LY-411575 isomer 1 is a potent γ-secretase inhibitor. LY-411575 isomer 1 is an isomer of LY411575.</p>Fórmula:C26H23F2N3O4Pureza:98%Cor e Forma:SolidPeso molecular:479.48Aβ42-IN-1 free base
CAS:<p>Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels, exhibiting an IC 50 of 0.091</p>Fórmula:C29H26N4O2Pureza:98%Cor e Forma:SolidPeso molecular:462.54RR-11a
CAS:<p>RR-11a is a synthetic enzyme Legumain inhibitor.</p>Fórmula:C24H28N6O10Pureza:98%Cor e Forma:SolidPeso molecular:560.51BMS-983970
CAS:<p>BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.</p>Fórmula:C26H26F4N4O3Cor e Forma:SolidPeso molecular:518.5BT-GSI
<p>BT-GSI: γ-secretase inhibitor targeting Notch, anti-myeloma & anti-resorptive for multiple myeloma/bone disease research.</p>Fórmula:C26H46BrN5O10P2Cor e Forma:SolidPeso molecular:730.52Yhhu-3792 hydrochloride
CAS:<p>Yhhu-3792 hydrochloride is a compound that bolsters the self-renewal capacity of neural stem cells (NSCs), catalyzes the Notch signaling pathway, and upregulates expression of Hes3 and Hes5. It augments the NSC pool, stimulates endogenous neurogenesis in the mouse hippocampal dentate gyrus (DG), and enhances mice's spatial and episodic memory skills. This compound shows promise for researching learning and memory impairments linked to DG dysfunction [1].</p>Fórmula:C24H25ClN4O2Cor e Forma:SolidPeso molecular:436.93BMS-932481
CAS:<p>BMS-932481 is a γ-secretase modulator.</p>Fórmula:C24H24FN7OCor e Forma:SolidPeso molecular:445.49GSM-1
CAS:<p>GSM-1 is a modulator of γ-Secretase.</p>Fórmula:C26H31ClF3NO2Cor e Forma:SolidPeso molecular:481.98Gossypolone
CAS:<p>Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.</p>Fórmula:C30H26O10Pureza:96.66%Cor e Forma:SolidPeso molecular:546.52γ-Secretase modulator 11 hydrochloride
CAS:<p>γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM).</p>Fórmula:C28H23ClF2N4O2Cor e Forma:SolidPeso molecular:520.96PF-06648671
CAS:<p>PF-06648671 is a γ-secretase modulator for the treatment of neurodegenerative and/or neurological disorders.</p>Fórmula:C25H23ClF4N4O3Pureza:98%Cor e Forma:SolidPeso molecular:538.92DAPM
CAS:<p>DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects.</p>Fórmula:C20H20F2N2O4Pureza:99.76%Cor e Forma:SolidPeso molecular:390.38BPN-15606 besylate
<p>BPN-15606 besylate is a potent oral γ-secretase regulator reducing Aβ42 and Aβ40 with good pharmacokinetics. IC50: 7 nM (Aβ42), 17 nM (Aβ40).</p>Fórmula:C29H29FN6O4SCor e Forma:SolidPeso molecular:576.64Notch inhibitor 1
CAS:<p>Notch inhibitor 1 blocks Notch 1/3 (IC50: 7.8/8.5 nM) and aids cancer research.</p>Fórmula:C26H25F7N4O3Pureza:98%Cor e Forma:SolidPeso molecular:574.49Aβ42-IN-1
CAS:<p>Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).</p>Fórmula:C29H27ClN4O2Pureza:98%Cor e Forma:SolidPeso molecular:499HDAC6-IN-9
CAS:<p>HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.</p>Fórmula:C19H16N2O3Pureza:98.84%Cor e Forma:SolidPeso molecular:320.34
