Gama-secretase
Os inibidores da gama-secretase são compostos que têm como alvo o complexo enzimático gama-secretase, que está envolvido na clivagem da proteína precursora do amiloide (APP) para produzir peptídeos beta-amiloides. Esses peptídeos podem se agregar para formar placas amiloides, uma característica da doença de Alzheimer. Ao inibir a gama-secretase, esses compostos visam reduzir a produção de beta-amiloide e sua acumulação no cérebro, sendo, portanto, um foco importante na pesquisa sobre a doença de Alzheimer. Na CymitQuimica, oferecemos inibidores da gama-secretase para apoiar sua pesquisa em biologia amiloide, terapia do Alzheimer e doenças neurodegenerativas.
Foram encontrados 68 produtos para "Gama-secretase".
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γ-Secretase modulator 4
CAS:γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively.Fórmula:C23H19FN4O2Pureza:98%Cor e Forma:SolidPeso molecular:402.42tCFA15
CAS:tCFA15: A trimethylated long-chain fatty alcohol with a 15-carbon side chain; may regulate Notch signaling and neuron differentiation.Fórmula:C24H44O2Pureza:98%Cor e Forma:SolidPeso molecular:364.61γ-secretase modulator 2
CAS:Gamma-secretase modulator 2 selectively targets Alzheimer's by reducing Aβ(1-42), aiding in prevention and treatment.Fórmula:C25H22F4N6O2Pureza:98%Cor e Forma:SolidPeso molecular:514.47CIA-1 hcl(452087-38-6 Free base)
CAS:CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety ofFórmula:C17H20ClN3O2SPureza:99.02%Cor e Forma:SolidPeso molecular:365.88ELN318463
CAS:ELN 318463 selectively inhibits γ-secretase; EC50: 12 nM (PS1), 656 nM (PS2); 51x more selective for PS1; targets APP.Fórmula:C19H20BrClN2O3SPureza:98%Cor e Forma:SolidPeso molecular:471.8RR-11a analog
CAS:RR-11a (aza-peptide) inhibits asparaginyl endopeptidase: IC50 - 4.5 nM (T. Vaginalis, I. ricinus), 31 nM (S. mansoni).Fórmula:C22H29N5O8Pureza:98.80%Cor e Forma:White SolidPeso molecular:491.49Ref: TM-T12770
1mg152,00€5mg364,00€1mL*10mM (DMSO)394,00€10mg565,00€25mg1.044,00€50mg1.773,00€100mg2.602,00€RR-11a
CAS:RR-11a is a synthetic enzyme Legumain inhibitor.Fórmula:C24H28N6O10Pureza:98%Cor e Forma:SolidPeso molecular:560.51Aβ42-IN-1 free base
CAS:Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels, exhibiting an IC 50 of 0.091Fórmula:C29H26N4O2Pureza:98%Cor e Forma:SolidPeso molecular:462.54BPN-15606
CAS:BPN-15606, an oral γ-secretase modulator, reduces Aβ42/Aβ40 with IC50 of 7/17 nM; promising PK/PD, lowers Aβ in rodent CNS.Fórmula:C23H23FN6OCor e Forma:SolidPeso molecular:418.47γ-Secretase modulator 11
CAS:5-{8-[(3,4'-Difluoro[1,1'-biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency andFórmula:C28H22F2N4O2Cor e Forma:SolidPeso molecular:484.5PSEN1-IN-1
PSEN1-IN-1 (Compound (+)-13b) functions as an inhibitor of PSEN1, displaying potent inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with respective IC50Fórmula:C20H19ClF3NO3SCor e Forma:SolidPeso molecular:445.88Aβ42-IN-2
CAS:Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].Fórmula:C24H26N6O2Pureza:99.87% - 99.90%Cor e Forma:Purple SolidPeso molecular:430.5Ref: TM-T9641
1mg39,00€1mL*10mM (DMSO)87,00€5mg89,00€10mg127,00€25mg203,00€50mg289,00€100mg399,00€200mg552,00€JI051
CAS:JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 cells and pancreatic cancer cells.Fórmula:C22H24N2O3Pureza:≥98% - ≥98.0%Cor e Forma:SolidPeso molecular:364.44GSM-1
CAS:GSM-1 is a modulator of γ-Secretase.Fórmula:C26H31ClF3NO2Cor e Forma:SolidPeso molecular:481.98BT-GSI
BT-GSI: γ-secretase inhibitor targeting Notch, anti-myeloma & anti-resorptive for multiple myeloma/bone disease research.Fórmula:C26H46BrN5O10P2Cor e Forma:SolidPeso molecular:730.52Yhhu-3792 hydrochloride
CAS:Yhhu-3792 hydrochloride is a compound that bolsters the self-renewal capacity of neural stem cells (NSCs), catalyzes the Notch signaling pathway, and upregulates expression of Hes3 and Hes5. It augments the NSC pool, stimulates endogenous neurogenesis in the mouse hippocampal dentate gyrus (DG), and enhances mice's spatial and episodic memory skills. This compound shows promise for researching learning and memory impairments linked to DG dysfunction [1].Fórmula:C24H25ClN4O2Cor e Forma:SolidPeso molecular:436.93BMS-932481
CAS:BMS-932481 is a γ-secretase modulator.Fórmula:C24H24FN7OCor e Forma:SolidPeso molecular:445.49Nirogacestat dihydrobromide
CAS:Potent γ-secretase inhibitor; IC50: 1.2 nM (cell), 6.2 nM (cell-free); lowers Aβ in mice/guinea pigs' brain, CSF, plasma.Fórmula:C27H43Br2F2N5OPureza:99.07%Cor e Forma:SolidPeso molecular:651.47Ref: TM-T38266
1mgA consultar5mgA consultar25mgA consultar100mgA consultar1mL*10mM (DMSO)A consultar10mg126,00€50mg492,00€BMS-983970
CAS:BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.Fórmula:C26H26F4N4O3Cor e Forma:SolidPeso molecular:518.5Aβ42-IN-1
CAS:Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).Fórmula:C29H27ClN4O2Pureza:98%Cor e Forma:SolidPeso molecular:499
