Receptor do Factor de Crescimento Fibroblasto (FGFR)
Os inibidores de FGFR (receptores do fator de crescimento de fibroblastos) são terapias direcionadas que bloqueiam a atividade dos FGFRs, que estão envolvidos na proliferação celular, diferenciação e angiogênese. A sinalização de FGFR contribui para a formação de novos vasos sanguíneos em tumores, promovendo seu crescimento e sobrevivência. Inibir FGFR pode, portanto, reduzir a angiogênese e a progressão tumoral. Na CymitQuimica, oferecemos uma gama de inibidores de FGFR de alta qualidade para apoiar sua pesquisa em câncer, biologia do desenvolvimento e angiogênese.
Foram encontrados 170 produtos de "Receptor do Factor de Crescimento Fibroblasto (FGFR)"
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NSC 12
CAS:<p>NSC 12 is an orally active pan-FGF trap that binds FGF2 and interferes with its interaction with FGFR1 with potential FGF-dependent antitumor activity.</p>Fórmula:C24H34F6O3Pureza:99.51%Cor e Forma:SolidPeso molecular:484.52Nintedanib
CAS:Fórmula:C31H33N5O4Pureza:>95.0%(T)(HPLC)Cor e Forma:White to Yellow to Yellow green powder to crystalPeso molecular:539.64SM27
CAS:<p>SM27 is a fibroblast growth factor 2 (FGF2) inhibitor with anti-angiogenic activity and can be used to study tumours.</p>Fórmula:C21H16N2O9S2Pureza:98.83%Cor e Forma:SolidPeso molecular:504.49(Z)-Orantinib
CAS:<p>(Z)-Orantinib, oral ATP-competitive blocker for Flk-1/KDR, PDGFRβ, FGFR1 (IC50: 2.1, 0.008, 1.2 μM), is a strong antiangiogenic, antitumor drug.</p>Fórmula:C18H18N2O3Cor e Forma:SolidPeso molecular:310.35PD-161570
CAS:Fórmula:C26H35Cl2N7OPureza:>98.0%(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:532.51FIIN-3
CAS:<p>FIIN-3 is an irreversible inhibitor of FGFR.</p>Fórmula:C34H36Cl2N8O4Pureza:97.63% - 98.92%Cor e Forma:SolidPeso molecular:691.61Masitinib
CAS:<p>Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.</p>Fórmula:C28H30N6OSPureza:97.56% - >99.99%Cor e Forma:SolidPeso molecular:498.64S49076 HCl
CAS:<p>S49076 HCl (S-49076 Hydrochloride) is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3.</p>Fórmula:C22H18ClN3O5Pureza:98%Cor e Forma:SolidPeso molecular:439.85Dovitinib lactate
CAS:<p>Dovitinib lactate (TKI-258 lactate)(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).</p>Fórmula:C24H27FN6O4Pureza:99.54% - 99.77%Cor e Forma:SolidPeso molecular:482.51ON123300
CAS:<p>ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).</p>Fórmula:C24H27N7OPureza:99.22% - 99.53%Cor e Forma:SolidPeso molecular:429.52PRN1371
CAS:<p>PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).</p>Fórmula:C26H30Cl2N6O4Pureza:98.65%Cor e Forma:SolidPeso molecular:561.46KHS 101
CAS:<p>KHS101 is a novel inhibitor of transforming acidic coiled-coil protein 3 (TACC3). It is a selective inducer of neuronal differentiation.</p>Fórmula:C18H21N5SPureza:99.63%Cor e Forma:SolidPeso molecular:339.46SU4984
CAS:<p>SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).</p>Fórmula:C20H19N3O2Pureza:97.20%Cor e Forma:SolidPeso molecular:333.38PF 477736
CAS:<p>PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (</p>Fórmula:C22H25N7O2Pureza:97.58% - 99.94%Cor e Forma:SolidPeso molecular:419.48Masitinib mesylate
CAS:<p>Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;</p>Fórmula:C29H34N6O4S2Pureza:97.67% - 98.44%Cor e Forma:SolidPeso molecular:594.75Ferulic acid sodium
CAS:<p>Ferulic acid sodium (Sodium ferulic) is an agent used in the treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis.</p>Fórmula:C10H9NaO4Pureza:99.58%Cor e Forma:White Crystalline PowderPeso molecular:216.16R1530
CAS:<p>R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.</p>Fórmula:C18H14ClFN4OPureza:98.422%Cor e Forma:SolidPeso molecular:356.78Futibatinib
CAS:<p>Futibatinib (TAS-120) is an orally active, potent,and irreversible FGFR inhibitor of FGFR1, FGFR2, FGFR3, and FGFR4.Cost-effective and quality-assured.</p>Fórmula:C22H22N6O3Pureza:97.66% - 99.44%Cor e Forma:SolidPeso molecular:418.45GW786034B
CAS:<p>Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.</p>Fórmula:C21H23N7O2S·HClPureza:99.87%Cor e Forma:SolidPeso molecular:473.98Dovitinib lactate hydrate
CAS:<p>Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit).</p>Fórmula:C24H27FN6O4Pureza:99.82%Cor e Forma:SolidPeso molecular:482.51
