Receptor de Efrina
Os inibidores dos receptores de efrina têm como alvo os receptores Eph, uma família de tirosina quinases receptoras que interagem com ligantes de efrina ligados à membrana. A sinalização de efrina é crucial para o posicionamento celular, a padronização dos tecidos e a angiogênese. A desregulação dessa via está implicada no câncer, em doenças neurodegenerativas e em distúrbios do desenvolvimento. Na CymitQuimica, oferecemos inibidores dos receptores de efrina para apoiar sua pesquisa em biologia do desenvolvimento, oncologia e neurobiologia.
Foram encontrados 27 produtos para "Receptor de Efrina".
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ALW-II-49-7
CAS:ALW-II-49-7 is a selective and potent inhibitor of EphB2 kinase with an EC50 value of 40 nM in cell.Fórmula:C21H17F3N4O2Pureza:99.72%Cor e Forma:SolidPeso molecular:414.38Ref: TM-T67736
1mg67,00€5mg158,00€1mL*10mM (DMSO)167,00€10mg230,00€25mg416,00€50mg613,00€100mg873,00€500mg1.755,00€EphA2 agonist 1
CAS:Compound 7bg is a potent, selective EphA2 agonist targeting overexpressed glioblastoma cells.Fórmula:C50H58N12O12Cor e Forma:SolidPeso molecular:1019.07AWL-II-38.3
CAS:AWL-II-38.3 is a highly potent EphA3 inhibitor with potent kinase inhibitory activity against EphA3.Cost-effective and quality-assured.Fórmula:C23H18F3N5O3Pureza:99.03% - 99.57%Cor e Forma:SolidPeso molecular:469.42Ref: TM-T38511
1mg77,00€5mg166,00€1mL*10mM (DMSO)167,00€10mg250,00€25mg515,00€50mg740,00€100mg1.018,00€500mg2.052,00€Nuzefatide
CAS:Nuzefatide is a peptide that binds to liver protein receptors.Fórmula:C105H162N32O27S3Cor e Forma:SolidPeso molecular:2400.80(123B9)2-L2-PTX
(123B9)2-L2-PTX is an EphA2 agonist peptide-drug conjugate (PDC). It consists of dimer 123B9 and Paclitaxel. This compound significantly reduces circulating tumor cells and inhibits lung metastasis in a breast cancer metastasis mouse model. (123B9)2-L2-PTX is applicable in cancer research, including studies on melanoma, ovarian cancer, and breast cancer.Cor e Forma:Odour SolidPKMYT1-IN-8
PKMYT1-IN-8 (Compound 137) is an inhibitor of PKMYT1, with an IC50 value of 9 nM. It also inhibits EPHB3, EPHA1, KIT, EPHB1, EPHA2, EPHA3, and EPHB2, exhibiting IC50 values of 1.79, 3.17, 4.29, 6.32, 6.83, 8.10, and 10.9 μM, respectively. Additionally, PKMYT1-IN-8 suppresses the proliferation of cancer cells OVCAR3 with a GI50 of 2.02 μM.Fórmula:C17H16F3N5O2Cor e Forma:SolidPeso molecular:379.336SA-PA
SA-PA, a self-assembled intracellular PROTAC leveraging azide-alkyne click chemistry, selectively degrades VEGFR-2, PDGFR-β, and EphB4 proteins within U87 cellsFórmula:C40H32ClF3N10O8Pureza:98%Cor e Forma:SolidPeso molecular:873.19AZ12672857
CAS:AZ12672857 is an inhibitor of EphB4 with IC50 of 1.3 nM.Fórmula:C26H30N8O2Pureza:98.99%Cor e Forma:Red SolidPeso molecular:486.57Ref: TM-T9650
1mg66,00€2mg87,00€5mg146,00€1mL*10mM (DMSO)158,00€10mg245,00€25mg403,00€50mg627,00€100mg847,00€UniPR1449
UniPR1449 is an EphA2 receptor antagonist with a KD of 3.8±2.4 μM, which is significant in cancer pathophysiology [1].Pureza:98%Cor e Forma:Odour SolidUniPR1454
UniPR1454 targets the EphA2 receptor and inhibits the interaction between EphA2 and ephrin A1, with an IC50 of 2.6 μM. Furthermore, UniPR1454 suppresses the proliferation of glioblastoma U251 cells.Cor e Forma:Odour SolidKYL peptide
CAS:EphA4 inhibitor, Kd 0.8 μM, blocks EphA4-EphrinA5; avoids AβO damage, preserves spines & LTP; long half-life (8-12h), neuroprotective.Fórmula:C74H108N14O17Pureza:98%Cor e Forma:SolidPeso molecular:1465.75Ehp-inhibitor-2
CAS:Ehp-inhibitor-2 is an Eph family tyrosine kinase inhibitor targeting Eph receptors.Fórmula:C17H13N5OPureza:97.88%Cor e Forma:SolidPeso molecular:303.32Ref: TM-T5452
2mg35,00€5mg55,00€1mL*10mM (DMSO)62,00€10mg96,00€25mg146,00€50mg210,00€100mg309,00€200mg444,00€NVP-BHG712 isomer
CAS:NVP-BHG712 isomer shows conserved non-bonded binding to EPHA2 and EPHB4.Fórmula:C26H20F3N7OPureza:99.14%Cor e Forma:White SolidPeso molecular:503.48Ref: TM-T19487
1mg40,00€2mg52,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg142,00€25mg245,00€50mg356,00€100mg530,00€JI-101
CAS:JI-101 (CGI-1842) is an oral multi-kinase inhibitor that targets VEGFR-2, PDGFR-β, and EphB4.Fórmula:C22H20BrN5O2Pureza:99.41% - 99.97%Cor e Forma:SolidPeso molecular:466.33NVP-BHG712
CAS:NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src andFórmula:C26H20F3N7OPureza:97.32% - 98.63%Cor e Forma:SolidPeso molecular:503.48Ref: TM-T6348
1mg34,00€5mg74,00€1mL*10mM (DMSO)84,00€10mg105,00€25mg200,00€50mg371,00€100mg557,00€200mg790,00€Eph inhibitor 2
CAS:Eph inhibitor 2 is an Eph family tyrosine kinase inhibitor targeting Eph receptors.Fórmula:C18H15N5OPureza:99.01%Cor e Forma:White SolidPeso molecular:317.34Tesevatinib
CAS:Tesevatinib (XL-647) is an oral, multi-targeted tyrosine kinase inhibitor.Cost-effective and quality-assured.Fórmula:C24H25Cl2FN4O2Pureza:97.89% - 99.99%Cor e Forma:White SolidPeso molecular:491.39KYL acetate(676657-00-4 free base)
EphA4 inhibitor, Kd: 0.8 μM, IC50: 6.34 μM. Protects synapses and spines, maintains LTP. Long half-life: 8-12h. Neuroprotective.Fórmula:C76H112N14O19Pureza:99.75%Cor e Forma:SolidPeso molecular:1525.78Tivozanib
CAS:Tivozanib (KRN951) is an oral VEGFRs 1-3 inhibitor with potential antiangiogenic and cancer-fighting properties.Fórmula:C22H19ClN4O5Pureza:98.08% - 99.67%Cor e Forma:SolidPeso molecular:454.86Ref: TM-T2456
2mg38,00€5mg57,00€1mL*10mM (DMSO)63,00€10mg79,00€25mg135,00€50mg226,00€100mg405,00€200mg597,00€ALW-II-41-27
CAS:ALW-II-41-27 (Eph receptor tyrosine kinase inhibitor), an Eph receptor tyrosine kinase inhibitor, is used for cancer therapy.Fórmula:C32H32F3N5O2SPureza:97.01% - 99.52%Cor e Forma:Yellow SolidPeso molecular:607.69Ref: TM-T4344
1mg63,00€5mg159,00€1mL*10mM (DMSO)216,00€10mg236,00€25mg371,00€50mg522,00€100mg713,00€200mg982,00€
