ALK
Os inibidores de ALK são compostos que especificamente visam e inibem a quinase do linfoma anaplásico (ALK), uma tirosina quinase receptora envolvida no desenvolvimento e progressão de certos cânceres, incluindo o câncer de pulmão de células não pequenas e o neuroblastoma. Ao inibir ALK, esses compostos bloqueiam vias de sinalização que promovem o crescimento e a sobrevivência das células tumorais. Na CymitQuimica, oferecemos inibidores de ALK para apoiar sua pesquisa em oncologia, terapias direcionadas contra o câncer e transdução de sinal.
Foram encontrados 112 produtos de "ALK"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
ZX-29
CAS:<p>ZX-29: Strong ALK inhibitor; IC50 - ALK 2.1 nM, L1196M 1.3 nM, G1202R 3.9 nM; triggers autophagy; anti-cancer.</p>Fórmula:C23H28ClN7O3SPureza:98.32%Cor e Forma:SolidPeso molecular:518.03CEP-28122 mesylate salt (1022958-60-6 free base)
<p>CEP-28122 mesylate salt (1022958-60-6 free base) is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).</p>Fórmula:C29H39ClN6O6SPureza:99.79%Cor e Forma:SolidPeso molecular:635.17ALK-IN-26
CAS:<p>ALK-IN-26 is an ALK inhibitor with potential anticancer activity.ALK-IN-26 shows antiproliferative activity against glioblastoma.</p>Fórmula:C24H23NO3SPureza:99.91%Cor e Forma:SoildPeso molecular:405.51Ascrinvacumab
CAS:<p>Ascrinvacumab (PF-03446962): humanized IgG2 anti-ALK-1 antibody, Kd 7 nM, inhibits TGF-β, for HCC research.</p>Pureza:SDS-PAGE:95% SEC-HPLC:98.18%Cor e Forma:LiquidPeso molecular:150 kDaSIAIS164018 hydrochloride
<p>SIAIS164018 hydrochloride is a PROTAC-based degrader targeting ALK and EGFR, exhibiting IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R.</p>Fórmula:C43H49Cl2N10O7PPureza:98%Cor e Forma:SolidPeso molecular:919.79CPD-1224
CAS:<p>CPD-1224, an oral ALK inhibitor derivative, binds cereblon, targets EML4-ALK fusions, and degrades ALK plus L1196M/G1202R mutants.</p>Fórmula:C43H47ClN8O7SCor e Forma:SolidPeso molecular:855.4dALK-3
<p>dALK-3 is a degrader of anaplastic lymphoma kinase (ALK) that effectively induces the degradation of EML4-ALK with a DC50 of 0.182 μM. It exhibits significant antiproliferative activity against H3122 cells and is applicable for tumor research.</p>Fórmula:C39H45ClN7O5PCor e Forma:SolidPeso molecular:758.245M4K2234
CAS:<p>M4K2234 (26b) inhibits ALK2/ALK5 (IC50: 5/2144 nM), used as a probe for ALK1/2 kinases in cancer research.</p>Fórmula:C27H31FN4O2Cor e Forma:SolidPeso molecular:462.56LAE-102
<p>LAE-102 is a monoclonal antibody that acts as an antagonist of activin receptor II-A (ACTRIIA/ACVR2). It shows potential for research in the fields of endocrine and metabolic disorders, oncology, and respiratory diseases.</p>Cor e Forma:Odour LiquidFDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Cor e Forma:LiquidALK-IN-9
CAS:<p>ALK-IN-9 effectively inhibits cell growth with IC50 <0.2 nM for Ba/F3-EML4-ALK, KM12, KG-1.</p>Fórmula:C20H21FN6O3Cor e Forma:SolidPeso molecular:412.425Multi-kinase-IN-6
<p>Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2.</p>Pureza:98%Cor e Forma:Odour SolidTL13-112
CAS:<p>TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).</p>Fórmula:C49H60ClN9O10SPureza:98%Cor e Forma:SolidPeso molecular:1002.57Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Cor e Forma:Odour SolidLDN-193189 2HCl
CAS:<p>LDN-193189 2HCl inhibits BMP signaling (ALK1/2/3/6), IC50: 0.8-16.7 nM; selective over TGF-β by 200-fold in C2C12 cells.</p>Fórmula:C25H24Cl2N6Pureza:99.78%Cor e Forma:SolidPeso molecular:479.4INCB-000928
CAS:<p>Zilurgisertib (INCB-000928) is a selective and potent ALK 2 inhibitor for the study of cancer and MF anemia.</p>Fórmula:C30H38N4O3Pureza:98.93%Cor e Forma:SolidPeso molecular:502.65ALK protein ligand-1
CAS:<p>ALK protein ligand-1 (Compound A1) is an ALK protein ligand, acting as a ligand for the target protein in PROTACs, demonstrating inhibitory effects on ALK. It is also useful in the synthesis of AP-1.</p>Fórmula:C24H29ClN6O3SCor e Forma:SolidPeso molecular:517.043ALK-IN-29
ALK-IN-29 (compound 4c) exhibits inhibitory effects on tyrosine protein kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, displaying a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is applicable in cancer research.Fórmula:C29H32FN3OCor e Forma:SolidPeso molecular:457.58ALK/ROS1-IN-3
<p>ALK/ROS1-IN-3 (compound C01) is a dual inhibitor targeting ROS1 and ALK, with IC50 values of 42.3 nM for ROS1G2032R and 49.1 nM for ALKG1202R.</p>Fórmula:C32H32N4O2Peso molecular:504.25253LDN 193688
CAS:<p>LDN 193688 is a BMP kinase inhibitor preferential for the ALK2 site, acting by binding to the ALK site,progressive osseous fibrodysplasia.</p>Fórmula:C22H16N4OPureza:99.16%Cor e Forma:SoildPeso molecular:352.39ALK/ROS1-IN-5
<p>ALK/ROS1-IN-5 (compound X4) is a selective inhibitor of ALK and ROS1 kinases, with IC50 values of 0.512 μM for ALK and 0.766 μM for ROS1. It inhibits H2228 cells with an IC50 of 0.034 μM and induces apoptosis in cancer cells in a dose-dependent manner. Additionally, ALK/ROS1-IN-5 effectively suppresses the expression of p-ALK and p-ERK in cancer cells.</p>Fórmula:C32H28F2N4O3Cor e Forma:SolidPeso molecular:554.586ALK-IN-12
CAS:<p>ALK-IN-12: potent ALK inhibitor (IC50: 0.18 nM), affects IGF1R and InsR (IC50: 20.3/90.6 nM), potential for cancer therapy.</p>Fórmula:C24H30ClN6O2PCor e Forma:SolidPeso molecular:500.97PROTAC ALK degrader-3
<p>PROTAC ALK degrader-3 (4B) is an orally active PROTAC-based ALK degrader, efficiently inducing sustained degradation of ALK fusion protein and significant inhibition of downstream pathways in Karpas 299 cells with an IC50 of 119.33 nM. This compound exhibits antitumor activity.</p>Fórmula:C50H60ClN9O7SCor e Forma:SolidPeso molecular:966.59ALK-IN-13
CAS:<p>ALK-IN-13 is an ALK inhibitor.</p>Fórmula:C29H39ClN7O2PCor e Forma:SolidPeso molecular:584.12-Keto Crizotinib
CAS:<p>2-Keto Crizotinib is an active lactam metabolite of crizotinib.</p>Fórmula:C21H20Cl2FN5O2Pureza:98%Cor e Forma:SolidPeso molecular:464.32TL13-12
CAS:<p>TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).</p>Fórmula:C45H53ClN10O10SPureza:98%Cor e Forma:SolidPeso molecular:961.49TL13-110
CAS:<p>Negative control for TL 13-112 . Displays no degradation of ALK in cell lines. Highly potent ALK inhibitor (IC50 = 0.34 nM).</p>Fórmula:C49H62ClN9O9SCor e Forma:SolidPeso molecular:988.59ALKBH5-IN-5
CAS:<p>ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor that alters m6A levels on mRNA, induces apoptosis, antitumo.</p>Fórmula:C13H13NO3Pureza:99.54%Cor e Forma:SoildPeso molecular:231.25ALK5 Inhibitor II (hydrochloride)
CAS:<p>ALK5 Inhibitor II has IC50s: 4 nM (auto), 18 nM (TGF-β assay), 23 nM (binding, HepG2).</p>Fórmula:C17H13N5·HClPureza:98%Cor e Forma:SolidPeso molecular:323.8TL13-22
CAS:<p>TL13-22 is a potent inhibitor of ALK and does not lead to degradation of ALK proteins.TL13-22 is often used as a negative control for TL13-12 .</p>Fórmula:C45H55ClN10O9SPureza:99.13%Cor e Forma:SolidPeso molecular:947.5LDN-193189 Tetrahydrochloride
CAS:<p>LDN193189 is a BMPI receptor inhibitor, blocking ALK2 and ALK3 effectively, while weak on ALK4, ALK5, ALK7.</p>Fórmula:C25H26Cl4N6Pureza:98.21%Cor e Forma:SolidPeso molecular:552.33EW-7195
CAS:<p>EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.</p>Fórmula:C23H18N8Pureza:98.76%Cor e Forma:SolidPeso molecular:406.44R-268712
CAS:<p>R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.</p>Fórmula:C20H18FN5OPureza:99.61%Cor e Forma:SolidPeso molecular:363.39A 77-01
CAS:<p>A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.</p>Fórmula:C18H14N4Pureza:98.82% - ≥95%Cor e Forma:SolidPeso molecular:286.33GW788388
CAS:<p>GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.</p>Fórmula:C25H23N5O2Pureza:98.03% - 99.58%Cor e Forma:SolidPeso molecular:425.48ML347
CAS:<p>ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.</p>Fórmula:C22H16N4OPureza:99.30% - ≥95%Cor e Forma:SolidPeso molecular:352.395-phenylthieno[2,3-d]pyrimidin-4-amine
CAS:<p>5-phenylthieno[2,3-d]pyrimidin-4-amine is a heterocycle that inhibits enzymes like kinases, may treat diseases.</p>Fórmula:C12H9N3SPureza:97%Cor e Forma:SolidPeso molecular:227.29RepSox
CAS:<p>RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).</p>Fórmula:C17H13N5Pureza:98.8% - 99.73%Cor e Forma:SolidPeso molecular:287.32Brigatinib
CAS:<p>Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.</p>Fórmula:C29H39ClN7O2PPureza:97.18% - >99.99%Cor e Forma:SolidPeso molecular:584.09SM 16
CAS:<p>SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).</p>Fórmula:C25H26N4O3Pureza:99.72%Cor e Forma:SolidPeso molecular:430.5N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline
CAS:<p>Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.</p>Fórmula:C22H18BrN7Pureza:99.935%Cor e Forma:SolidPeso molecular:460.33CH5424802 analog
CAS:<p>CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.</p>Fórmula:C28H30N4O2Pureza:98.96%Cor e Forma:SolidPeso molecular:454.56DMH-1
CAS:<p>DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.</p>Fórmula:C24H20N4OPureza:98% - 99.92%Cor e Forma:SolidPeso molecular:380.44ALK kinase inhibitor-1
CAS:<p>SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase.</p>Fórmula:C28H32FN5O3SPureza:99.84%Cor e Forma:SolidPeso molecular:537.65CEP-28122 mesylate salt
<p>CEP-28122 mesylate, a diaminopyrimidine, selectively inhibits ALK with IC50 of 1.9 nM and exhibits antitumor effects.</p>Fórmula:C29H39ClN6O6SCor e Forma:SolidPeso molecular:635.17AZD-3463
CAS:<p>AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.</p>Fórmula:C24H25ClN6OPureza:99.13%Cor e Forma:SolidPeso molecular:448.95Crizotinib acetate
CAS:<p>Crizotinib is an oral c-met/HGFR tyrosine kinase inhibitor with potential cancer-fighting properties.</p>Fórmula:C23H26Cl2FN5O3Cor e Forma:SolidPeso molecular:510.39K02288
CAS:<p>K 02288 is a novel small molecule inhibitor of ALK1/2/3/6.</p>Fórmula:C20H20N2O4Pureza:98% - 99.83%Cor e Forma:SolidPeso molecular:352.38CEP-28122
CAS:<p>CEP-28122 is a highly potent and selective orally active ALK inhibitor.</p>Fórmula:C28H35ClN6O3Pureza:99.87% - >99.99%Cor e Forma:SolidPeso molecular:539.07Vactosertib
CAS:<p>Vactosertib (EW-7197) is an oral TGFBR1/ALK5 inhibitor with potential cancer-fighting properties.</p>Fórmula:C22H18FN7Pureza:98.85% - 99.81%Cor e Forma:SolidPeso molecular:399.42CAY10594
CAS:<p>CAY10594, a PLD2 inhibitor, mitigates acetaminophen liver damage via the p-GSK-3β/JNK pathway.</p>Fórmula:C26H28N4O2Pureza:98%Cor e Forma:SolidPeso molecular:428.53LDN-214117
CAS:<p>LDN-214117 is a potent and selective ALK2 inhibitor.</p>Fórmula:C25H29N3O3Pureza:98% - 99.82%Cor e Forma:SolidPeso molecular:419.52LDN193189
CAS:<p>LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.</p>Fórmula:C25H22N6Pureza:98% - 99.86%Cor e Forma:SolidPeso molecular:406.48BIBF0775
CAS:<p>BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).</p>Fórmula:C31H34N4O2Pureza:99.45% - 99.79%Cor e Forma:SolidPeso molecular:494.63A 83-01
CAS:<p>A 83-01 (ALK5 Inhibitor IV) is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7.</p>Fórmula:C25H19N5SPureza:97% - 98.2%Cor e Forma:SolidPeso molecular:421.52SB-505124
CAS:<p>SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.</p>Fórmula:C20H21N3O2Pureza:97.19% - 99.92%Cor e Forma:SolidPeso molecular:335.4Alectinib hydrochloride
CAS:<p>Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)</p>Fórmula:C30H35ClN4O2Pureza:99.61% - 99.96%Cor e Forma:SolidPeso molecular:519.08Ensartinib
CAS:<p>Ensartinib (X-396) is a potent and orally active dual ALK/MET inhibitor for the treatment of ALK-positive non-small cell lung cancer (NSCLC).</p>Fórmula:C26H27Cl2FN6O3Pureza:99.92%Cor e Forma:SolidPeso molecular:561.44HG-14-10-04
CAS:<p>HG-14-10-04 is a potent and specific ALK inhibitor.</p>Fórmula:C29H34ClN7OPureza:99.75% - >99.99%Cor e Forma:SolidPeso molecular:532.08SB-431542
CAS:<p>SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective.</p>Fórmula:C22H16N4O3Pureza:99.035% - >99.99%Cor e Forma:SolidPeso molecular:384.39LDN-212854
CAS:<p>LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors.</p>Fórmula:C25H22N6Pureza:98% - 98.71%Cor e Forma:SolidPeso molecular:406.48Blu-782
CAS:<p>Blu-782 (ALK2-IN-1) is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)</p>Fórmula:C31H42N6O4Pureza:99.51%Cor e Forma:SolidPeso molecular:562.7SB 525334
CAS:<p>SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).</p>Fórmula:C21H21N5Pureza:98.39% - ≥95%Cor e Forma:SolidPeso molecular:343.42LDN-193189 HCl
CAS:<p>LDN-193189 HCl (LDN193189 Hydrochloride) is a selective BMP type I receptor kinases inhibitor.</p>Fórmula:C25H22N6·HClPureza:99.49% - 99.53%Cor e Forma:SolidPeso molecular:442.94Vactosertib Hydrochloride
CAS:<p>Vactosertib Hydrochloride (EW-7197 Hydrochloride) is an ALK5 inhibitor, a TGF-β receptor I inhibitor with antimetastatic and anticancer effects.</p>Fórmula:C22H19ClFN7Pureza:98.03%Cor e Forma:SolidPeso molecular:435.89A 83-01 sodium salt
CAS:<p>A 83-01 sodium salt inhibits ALK5, ALK4, and ALK7 kinases with IC50s: 12, 45, 7.5 nM.</p>Fórmula:C25H19N5NaSCor e Forma:SolidPeso molecular:444.51AZ 12799734
CAS:<p>AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.</p>Fórmula:C18H18N4O3SPureza:98.23%Cor e Forma:SolidPeso molecular:370.43SB-505124 hydrochloride
CAS:<p>SB-505124 hydrochloride (SB505124 hydrochloride) is a TGF-β type I receptor (ALK4, ALK5, ALK7) inhibitor for the study of colorectal cancer.</p>Fórmula:C20H22ClN3O2Pureza:98.71%Cor e Forma:SolidPeso molecular:371.86Itacnosertib
CAS:<p>Itacnosertib (TP-0184) is an orally available ACRV1 (ALK-2), FLT3 and JAK2 inhibitor that inhibits the growth of tumor cells,antitumor and antileukemic.</p>Fórmula:C26H28N8OPureza:99.38%Cor e Forma:SolidPeso molecular:468.55ALK5-IN-79
CAS:<p>ALK5-IN-79 (compound 57), an ALK inhibitor, exhibits anticancer activity by inhibiting the TGF-β1/SMAD signaling pathway. It effectively reduces the production of extracellular matrix (ECM) and collagen deposition. Moreover, ALK5-IN-79 demonstrates satisfactory pharmacokinetic (PK) properties and favorable in vivo tolerance.</p>Fórmula:C23H27N7OCor e Forma:SolidPeso molecular:417.51KRCA-0713
CAS:<p>KRCA-0713 is a ALK inhibitor.</p>Fórmula:C26H32ClN5O3SPureza:98%Cor e Forma:SolidPeso molecular:530.08WY-135
CAS:<p>WY-135 is a dual inhibitor of ALK and ROS1 (IC50 of 1.4 nM and 1.1 nM, respectively).</p>Fórmula:C28H34ClN9O3SPureza:98%Cor e Forma:SolidPeso molecular:612.15ALK2-IN-5
CAS:<p>ALK2-IN-5, a pyrazolopyrimidine compound, serves as an inhibitor of ALK2 and FGFR, targeting disorders linked with their activity, including cancer [1].</p>Fórmula:C24H32N8O2Cor e Forma:SolidPeso molecular:464.56ALK-IN-5
CAS:<p>ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).</p>Fórmula:C24H25FN6O3Pureza:98%Cor e Forma:SolidPeso molecular:464.49TGFBR1-IN-1
CAS:<p>TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).</p>Fórmula:C23H17N5O2SPureza:98%Cor e Forma:SolidPeso molecular:427.48EML4-ALK kinase inhibitor 1
CAS:<p>Potent oral EML4-ALK inhibitor with a 1 nM IC50.</p>Fórmula:C31H48N8O3Pureza:99.62%Cor e Forma:SolidPeso molecular:580.76ALK2-IN-2
CAS:<p>ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.</p>Fórmula:C28H27N5O2SPureza:99.55%Cor e Forma:SolidPeso molecular:497.61OD36
CAS:<p>OD36: Potent RIPK2 inhibitor, IC50=5.3 nM; hinders ALK2 signaling and osteogenesis, KD=37 nM; targets ALK2 ATP pocket.</p>Fórmula:C16H15ClN4O2Pureza:99.89%Cor e Forma:SolidPeso molecular:330.77OD36 hydrochloride
CAS:<p>OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently</p>Fórmula:C16H16Cl2N4O2Pureza:99.85%Cor e Forma:SolidPeso molecular:367.23J-1048
CAS:<p>J-1048, an activin receptor-like kinase 5 (ALK5) inhibitor, effectively suppresses TAA-induced liver fibrosis in mice through specific inhibition of the TGF-β/</p>Fórmula:C23H17FN6S2Cor e Forma:SolidPeso molecular:460.55CJ-2360
CAS:<p>CJ-2360 is a potent ALK inhibitor, effective on wild-type and various mutants, with IC50 values ranging from 2.2 to 8.9 nM, also targeting 468 kinases.</p>Fórmula:C27H30FN5O2Cor e Forma:SolidPeso molecular:475.56ALK-IN-22
CAS:<p>ALK-IN-22 suppresses ALK and mutants (IC50: 2.3-3.7 nM), hinders phosphorylation, and induces apoptosis in tumor studies.</p>Fórmula:C24H24ClN7O2Cor e Forma:SolidPeso molecular:477.95RIPK2-IN-1
CAS:<p>RIPK2-IN-1 (compound 18f) is a potent inhibitor of RIPK2 (IC50: 51 nM) and also inhibits ALK2 (IC50: 5 nM).</p>Fórmula:C23H27N5O3SCor e Forma:SolidPeso molecular:453.56ALK-IN-21
CAS:<p>ALK-IN-21 (B10) inhibits ALK WT (IC50: 4.59nM), L1196M (2.07nM), G1202R (5.95nM); curbs Karpas299, H2228 cell growth; for ALCL research.</p>Fórmula:C35H45ClN6O6S4Cor e Forma:SolidPeso molecular:809.48Con B-1
CAS:<p>ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells .</p>Fórmula:C38H52ClN7O6SCor e Forma:SolidPeso molecular:770.38SMU-B
CAS:<p>SMU-B is a well-tolerated c-Met/ALK dual inhibitor.</p>Fórmula:C26H25Cl2FN4O2Pureza:98%Cor e Forma:SolidPeso molecular:515.41Ficonalkib
CAS:<p>Ficonalkib is a potent antineoplastic agent that inhibits the Anaplastic Lymphoma Kinase (ALK) tyrosine kinase receptor.</p>Fórmula:C29H39N7O3SCor e Forma:SolidPeso molecular:565.73ALK5-IN-30
CAS:<p>ALK5-IN-30 (EX-07) is a potent inhibitor of ALK with inhibitory effects on ALK5 (IC50< 10 nM) and TGFβ-R1 (IC50< 10 nM).</p>Fórmula:C24H25FN8Cor e Forma:SolidPeso molecular:444.51XST-14
CAS:<p>XST-14 is a ULK1 inhibitor.XST-14 induces apoptosis and inhibits the growth of HCC cells.</p>Fórmula:C16H21NO4Pureza:99.84% - 99.84%Cor e Forma:SolidPeso molecular:291.34TRK/ALK-IN-1
<p>TRK/ALK-IN-1: Potent dual TRK & ALK inhibitor; IC50s: 2.2nM (TRKA), 9.3nM (ALK WT), 38nM (ALK L1196M); cancer research potential.</p>Fórmula:C31H35ClF2N8O2SCor e Forma:SolidPeso molecular:657.18ALK5-IN-29
CAS:<p>ALK5-IN-29: selective ALK inhibitor, IC50 ≤ 10 nM, curbs tumor growth, aids in cancer research.</p>Fórmula:C24H25FN8Cor e Forma:SolidPeso molecular:444.51TP0427736 hydrochloride
CAS:<p>TP0427736 hydrochloride is a novel and selective ALK5 inhibitor, capable of inhibiting Smad2/3 phosphorylation in A549 cells.</p>Fórmula:C14H11ClN4S2Pureza:98.99%Cor e Forma:SolidPeso molecular:334.85UNC5293
CAS:<p>UNC5293: potent oral MERTK inhibitor, Ki=190 pM, IC50=0.9 nM; selective vs Axl/Tyro3/Flt3; good mouse PK; used in leukemia research.</p>Fórmula:C30H42N6O2Cor e Forma:SolidPeso molecular:518.69ALK-IN-6
CAS:<p>ALK-IN-6 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50s: 71 nM, 18.72 nM, and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L).</p>Fórmula:C26H29ClD3N5O3SPureza:98%Cor e Forma:SolidPeso molecular:533.1ALK/EGFR-IN-3
CAS:<p>ALK/EGFR-IN-3 is a dual ALK and EGFR inhibitor that demonstrates potent anti-proliferative effects on various cancer cell lines, including H1975, PC9, and Baf3-</p>Fórmula:C27H34ClN7O3SCor e Forma:SolidPeso molecular:572.12ALK/ROS1-IN-1
CAS:<p>ALK/ROS1-IN-1 is a potent and selective anti-crizotinib-resistant ALK/ROS1 dual inhibitor (IC50s: 0.530 μM and 0.174 μM for ROS1 and ALK enzyme).</p>Fórmula:C30H35F3N6O3Pureza:98%Cor e Forma:SolidPeso molecular:584.63ALK/EGFR-IN-1
CAS:<p>ALK/EGFR-IN-1 (Compound 8l) is a dual inhibitor targeting both ALK and EGFR, effectively blocking their phosphorylation.</p>Fórmula:C27H34ClN7O3SPureza:98%Cor e Forma:SolidPeso molecular:572.12ALK/EGFR-IN-2
CAS:<p>ALK/EGFR-IN-2 is a potent dual inhibitor targeting ALK and EGFR, promoting apoptosis and G0/G1 cell cycle arrest in cancer cells.</p>Fórmula:C27H34ClN7O3SCor e Forma:SolidPeso molecular:572.12ALK-IN-27
CAS:<p>Neladalkib (NVL-655) is an ALK inhibitor with antitumor activity for the study of non-small cell cancers.</p>Fórmula:C23H22ClFN6OPureza:99.71%Cor e Forma:SolidPeso molecular:452.91KER047
CAS:<p>ALK2-IN-4, a highly effective ALK2 inhibitor.</p>Fórmula:C26H30FN7OPureza:98.49% - >99.99%Cor e Forma:SolidPeso molecular:475.56
![5-phenylthieno[2,3-d]pyrimidin-4-amine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT50042.webp&w=3840&q=75)
![N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bro…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT9837.webp&w=3840&q=75)
