c-Fms

<p>ARRY-382 is a highly selective oral inhibitor of CSF-1R with an IC50 of 9 nM.</p>

<p>Pimicotinib hydrochloride is an inhibitor of CSF1R, displaying antitumor activity.</p>

<p>Enrupatinib is an inhibitor of the colony stimulating factor 1 receptor (CSF1R), exhibiting antitumor activity.</p>

<p>c-Fms-IN-15 (compound 8g) is a potent inhibitor of FMS kinase, with an IC50 of 563 nM.</p>

<p>SJ-C1044 is an orally effective pan-RAF inhibitor demonstrating immunomodulatory and antitumor activities. It targets wild-type BRAF, wild-type CRAF, and BRAF(V600E) with IC50 values of 331, 257, and 187 nM, respectively. SJ-C1044 suppresses tumor cell proliferation by inhibiting kras activation and MEK-ERK phosphorylation. Additionally, it shows inhibition of VEGFR2, TIE2, and CSF1R, with IC50 values of 100, 23, and 235 nM respectively. The compound enhances the tumor immune microenvironment through inhibition of angiogenesis and modulation of macrophage function. SJ-C1044 is applicable for research in colorectal cancer.</p>

<p>GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor.</p>

<p>Leustroducsin B is a novel colony-stimulating factor (CSF) inducer extracted from Streptomyces platensis SANK 60191.</p>

<p>JNJ-6204 is a deuterated compound that efficiently inhibits CSNK1D and CSNK1E.</p>