Receptor TAM
Os inibidores dos receptores TAM têm como alvo a família de receptores tirosina quinase TAM, que inclui Tyro3, Axl e Mer. Estes receptores estão envolvidos na regulação das respostas imunológicas, na sobrevivência celular e na eliminação de células apoptóticas. A desregulação dos receptores TAM está implicada no câncer, em doenças autoimunes e na inflamação crônica. Na CymitQuimica, oferecemos inibidores dos receptores TAM para apoiar sua pesquisa em imunologia, oncologia e inflamação.
Foram encontrados 30 produtos para "Receptor TAM".
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DS-1205
CAS:DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.Fórmula:C41H42FN5O7Pureza:99.75%Cor e Forma:SolidPeso molecular:735.8Dubermatinib
CAS:Dubermatinib (TP0903) is a potent and selective Axl kinase inhibitor.Fórmula:C24H30ClN7O2SPureza:98.65% - 99.58%Cor e Forma:SolidPeso molecular:516.06Anticancer agent 109
CAS:Anticancer agent 109 (compound 6-15) acts as an inhibitor targeting the Gas6-Axl axis, demonstrating significant anti-cancer properties. This compound suppresses the expression of Gas6, Axl, p-PI3K, and p-AKT in cancer cells, thereby inducing G1 phase arrest and promoting apoptosis of cancer cells. Additionally, Anticancer agent 109 effectively inhibits tumor growth in nude mouse tumor-bearing models [1].Fórmula:C19H15N3O2Cor e Forma:SolidPeso molecular:317.34R916562
CAS:R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis.Fórmula:C26H30ClN9SPureza:98%Cor e Forma:SolidPeso molecular:536.09AXL-IN-15
CAS:AXL-IN-15 (cpd391) is a potent inhibitor of Axl, exhibiting both a dissociation constant (K i) and a half-maximal inhibitory concentration (IC50) of less than 1Fórmula:C26H32F3N9O3Pureza:98%Cor e Forma:SolidPeso molecular:575.59AXL-IN-14
CAS:AXL-IN-14: orally active, potent AXL inhibitor (IC50=0.8 nM); hinders Gas6/AXL migration, invasion; lowers p-AXL, p-AKT; anti-tumor.Fórmula:C32H24F2N4O4Pureza:98%Cor e Forma:SolidPeso molecular:566.55MerTK-IN-1
CAS:MerTK-IN-1 (compound 31) serves as an inhibitor of MerTK, with the capability to bind to the target in vivo.Fórmula:C23H26N8O4Cor e Forma:SolidPeso molecular:478.50Ligritinib
CAS:Ligritinib (AB801) is an orally active inhibitor of the AXL receptor tyrosine kinase. By inhibiting the kinase activity of AXL, Ligritinib blocks its downstream signaling pathways. It is utilized in cancer research, particularly in studies involving non-small cell lung cancer (NSCLC) in combination with chemotherapy.Fórmula:C33H32N6OCor e Forma:SolidPeso molecular:528.65MerTK-IN-3
CAS:MerTK-IN-3 (compound 11) is an orally active, selective inhibitor of MerTK, exhibiting IC50 values of 21.5 nM for MerTK and 991.3 nM for Tyro3. It is applicable in colon cancer research.Fórmula:C36H31FN8O4Cor e Forma:SolidPeso molecular:658.68MerTK/Axl-IN-1
CAS:MerTK/Axl-IN-1 (Compound A-910) is a potent and selective dual inhibitor of MerTK/Axl, exhibiting IC50 values of 4.2 nM and 8.8 nM in Ba/F3 cells, and 0.2 nM and 0.9 nM in HTRF cells, respectively. It effectively inhibits pMerTK in vivo and possesses a long half-life and high oral bioavailability.Fórmula:C40H47FN6O4Cor e Forma:SolidPeso molecular:694.84
