FLT
Os inibidores de FLT (Fms-like tyrosine kinase) são compostos que têm como alvo os receptores FLT, que estão envolvidos na regulação da angiogênese através da via do VEGF (fator de crescimento endotelial vascular). Os receptores FLT desempenham um papel crucial no desenvolvimento de novos vasos sanguíneos em tumores. Inibir os receptores FLT pode reduzir efetivamente a angiogênese e o crescimento tumoral, tornando esses inibidores importantes na terapia contra o câncer. Na CymitQuimica, oferecemos uma seleção de inibidores de FLT de alta qualidade para apoiar sua pesquisa em oncologia, biologia vascular e angiogênese.
Foram encontrados 87 produtos para "FLT".
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Lomonitinib
CAS:Lomonitinib is a potent and selective pan-FLT3/IRAK4 inhibitor with antitumor properties. It shows promise for research in myeloid leukemia.Fórmula:C27H24N4O2Cor e Forma:SolidPeso molecular:436.505Multi-kinase inhibitor 3
CAS:Multi-kinase inhibitor 3 (compound 12) is an orally active and effective multikinase (multikinase) inhibitor, demonstrating potent IC50 values against FLT1/VEGFR1, KDR/VEGFR2, FLT4/VEGFR3, FLT3, PDGFRα, and PDGFRβ, at 1.59, 1.23, 1.19, 0.59, 0.22, and 1.15 nM respectively. This compound exhibits anti-proliferative and anticancer activities.Fórmula:C26H26N6O2Cor e Forma:SolidPeso molecular:454.52FLT3-IN-38
CAS:FLT3-IN-38 (Flt-3 Inhibitor II) is a compound that acts as an FLT3 inhibitor. It also exhibits off-target effects by inhibiting the serine/threonine kinase haspin, a mitotic signaling coordinator. FLT3-IN-38 has potential applications in cancer research.Fórmula:C17H12N2O3Peso molecular:292.29LT-850-166
LT-850-166 is a potent inhibitor of FLT3 and has shown efficacy in overcoming a wide range of FLT3 mutations.Fórmula:C30H29Cl2N7OCor e Forma:SolidPeso molecular:574.5JNJ-47117096
CAS:JNJ-47117096 is a potent and selective MELK inhibitor with an IC50 of 23 nM, and it also exhibits strong activity against Flt3 with an IC50 of 18 nM.Fórmula:C21H22N4O2Cor e Forma:SolidPeso molecular:362.425Multi-kinase inhibitor 4
CAS:Multi-kinase inhibitor 4 (compound 14) serves as an orally effective inhibitor targeting FLT1, KDR, FLT3, FLT4, PDGFRα, and PDGFRβ, exhibiting IC50 values of 1.97 nM, 1.04 nM, 0.33 nM, 1.44 nM, 0.18 nM, and 0.89 nM respectively. This compound plays a crucial role in cancer research.Fórmula:C25H24N6O2Cor e Forma:SolidPeso molecular:440.50FLT3/ITD-IN-1
FLT3/ITD-IN-1 inhibits FLT3-ITD with IC50s: 38.2 nM (FLT3) and 144.1 nM (ITD), and fights acute myeloid leukemia.Fórmula:C19H22N6O2Cor e Forma:SolidPeso molecular:366.42
