Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1522 produtos de "Autofagia"
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meta-Fluoxetine (hydrochloride)
CAS:meta-Fluoxetine (hydrochloride) can be used in related research in the field of life sciences. Its product number is T37474 and CAS number is 79088-29-2.Fórmula:C17H19ClF3NOCor e Forma:SolidPeso molecular:345.79Elaiophylin
CAS:Elaiophylin exhibits anti-Plasmodium falciparum and anti-Trypanosoma brucei activity; IC50: 0.36 μM & 0.45 μM, respectively.Fórmula:C54H88O18Pureza:98%Cor e Forma:SolidPeso molecular:1025.27ML-SA5
CAS:ML-SA5 is a MCOLN1 agonist that blocks autophagic flux by disrupting fusion between autophagosomes and lysosomes.Cost-effective and quality-assured.Fórmula:C19H24ClN3O4S2Pureza:99.16% - >99.99%Cor e Forma:SoildPeso molecular:457.99Chromomycin A2
CAS:Chromomycin A2, from marine actinomycetes, halts B. subtilis and various cancer cells; promotes autophagy in melanoma.Fórmula:C59H86O26Cor e Forma:SolidPeso molecular:1211.31HuMax-IL8
HuMax-IL8 (MDX 018) is a humanized anti-IL-8 monoclonal antibody for the study of metastatic or unresectable solid tumors.Pureza:98.8% (SDS-PAGE); 97.4% (SEC-HPLC) - 98.8% (SDS-PAGE); 97.4% (SEC-HPLC)Cor e Forma:Odour LiquidPeso molecular:144.82 kDaAzithromycin-13C,d3
Azithromycin-13C,d3 is the deuterated form of Azithromycin labeled with 13C.Cor e Forma:Odour SolidGefitinib-d3
CAS:Gefitinib-d3 is the deuterated form of Gefitinib. Gefitinib (ZD1839) is a potent, selective, and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. It selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and blocks EGFR autophosphorylation in EGF-stimulated tumor cells. Additionally, Gefitinib can induce autophagy (autophagy) and exhibits antitumor activity.Fórmula:C22H24ClFN4O3Cor e Forma:SolidPeso molecular:449.92Ambroxol-d5 hydrochloride
CAS:Ambroxol-d5 (hydrochloride) is the deuterated variant of Ambroxol hydrochloride. Ambroxol hydrochloride (NA-872 hydrochloride) is the active metabolite of the precursor bromhexine and exhibits potent expectorant properties. It acts as a glucocerebrosidase (GCase) chaperone, enhancing the enzyme's activity. Additionally, Ambroxol hydrochloride can induce autophagy in the lungs and holds potential for research in Parkinson's disease and neuronopathic Gaucher's disease.Fórmula:C13H19Br2ClN2OCor e Forma:SolidPeso molecular:419.60Retinoic acid-d5
CAS:Retinoic acid-d5: deuterium-labeled, natural RAR agonist (IC50: 14 nM), affects cell growth and development, inhibits Nrf2.Fórmula:C20H28O2Pureza:98%Cor e Forma:SoildPeso molecular:305.47SJFα
CAS:SJFα (SJF alpha) degrades p38α and p38δ and can be used in cancer research.Fórmula:C59H67F2N7O11SPureza:95.25%Cor e Forma:SolidPeso molecular:1120.27BRD4 degrader-5
BRD4 degrader-5 (Compound 23) is a protein degrader utilizing a hydrophobic tag (HyTag) that targets BRD4 for degradation through endoplasmic reticulum stress and the autophagy-lysosome pathway (DC50 = 24.7 μM). It also inhibits the proliferation of 4T1 cancer cells, with an IC50 of 20.6 μM.Fórmula:C35H42ClN7O2SCor e Forma:SolidPeso molecular:660.27Diquat dibromide
CAS:Diquat dibromide is a water-soluble herbicide that causes rapid and profound systemic toxicity.Diquat dibromide induces acute kidney injury with high lethality.Fórmula:C12H12Br2N2Pureza:97.11% - 99%Cor e Forma:SolidPeso molecular:344.05Ezurpimtrostat
CAS:Ezurpimtrostat targets fibrosis, cancer, autophagy, CTSB, CTSL, CTSD. (From patent WO2020048694 A1)Fórmula:C25H31ClN4Cor e Forma:SolidPeso molecular:423.06-Mercaptopurine-13C2,15N
CAS:6-Mercaptopurine-13C2,15N is a 6-Mercaptopurine labeled with 13C and 15N. This compound is a purine analog that acts as an antagonist to endogenous purines and is widely used for its anti-leukemic and immunosuppressive properties.Fórmula:C5H4N4SCor e Forma:SolidPeso molecular:155.16Dusquetide TFA
Dusquetide TFA (SGX942) is an IDR that modulates immunity by targeting p62, reducing inflammation, and enhancing bacterial clearance.Fórmula:C27H48F3N9O7Cor e Forma:SolidPeso molecular:667.72CXCR7 modulator 1
CAS:CXCR7 modulator 1 is an effective and orally bioavailable peptoid hybrid CXCR7 modulator with Ki of 9 nM.Fórmula:C48H57F2N7O7SPureza:98%Cor e Forma:SolidPeso molecular:914.07Mito-fisetin mF3
Mito-fisetin mF3 (compund mito-fisetin mF3) is a potent anticancer and anti-aging therapeutic agent that targets mitochondria.Fórmula:C52H42IO7PCor e Forma:SolidPeso molecular:936.76TH152
CAS:TH152 is a general reversible ligand for LC3/GABARAP with a dissociation constant (KD) of 2 µM. LC3/GABARAP is a protein associated with autophagy.Fórmula:C22H23ClN4O4S2Cor e Forma:SolidPeso molecular:507.03PTX80
CAS:PTX80 is an antagonist of p62, with an IC50 value of 31.18 nM. It has been shown to reduce tumor volume in a HCT116 colorectal cancer mouse xenograft model.Fórmula:C26H26N4O3SCor e Forma:SolidPeso molecular:474.58TSPO ligand-1
CAS:TSPO ligand-1 binds benzodiazepine receptors and AUTAC4, induces mitochondrial autophagy, aids cholesterol transport, and marks brain injury.Fórmula:C16H10ClNO2Pureza:≥98%Cor e Forma:SolidPeso molecular:283.71OsMo
OsMo is a lysosomal-targeting hNEU1 inhibitor utilized in the study of myocardial injury.Cor e Forma:Odour SolidRimantadine
CAS:Rimantadine (1-Rimantadine) (Flumadine) is an anti-influenza virus drug for T. brucei with IC50 of 7 μM.Fórmula:C12H21NPureza:98%Cor e Forma:SolidPeso molecular:179.3Basic Blue 20
CAS:Basic Blue 20: Red-emitting DNA stain, peaks at 633/677 nm, high photobleaching resistance.Fórmula:C26H33Cl2N3Cor e Forma:SolidPeso molecular:458.47CX4338
CAS:CX4338 is a CXCL8-mediated chemotaxis inhibitor.Fórmula:C22H24N2OSCor e Forma:SolidPeso molecular:364.50Cyclic MKEY
CAS:MKEY peptide inhibits CXCL4-CCL5, reduces atherosclerosis and aneurysm, neuroinflammatory effects unknown.Fórmula:C113H174N28O34S2Pureza:98%Cor e Forma:SolidPeso molecular:2532.89CLK1-IN-3
CAS:Clk1-in-3 is a + selective and highly potent sexual Clk1 inhibitor with an IC50 of 5 nM and 300 pairs higher affinity than Dyrk1A.Fórmula:C24H23FN6OPureza:98.46% - 99.76%Cor e Forma:SoildPeso molecular:430.48Obeticholic acid-d5
CAS:Obeticholic acid-d5 is the deuterated form of Obeticholic acid. Obeticholic acid (INT-747) acts as a potent, selective, and orally active FXR agonist with an EC50 of 99 nM, exhibiting both anticholeretic and anti-inflammatory properties. Additionally, Obeticholic acid can induce autophagy (autophagy).Fórmula:C26H44O4Cor e Forma:SolidPeso molecular:425.66(R)-Hydroxychloroquine phosphate
CAS:(R)-Hydroxychloroquine ((R)-HCQ) phosphate is an isomer of Hydroxychloroquine. It inhibits insulin-metabolizing enzymes in the cytosolic fraction of liver homogenates in both healthy and diabetic rats.Fórmula:C18H28ClN3O5SCor e Forma:SolidPeso molecular:433.95Fluvastatin-d6 sodium
Fluvastatin-d6(sodium) is the deuterium-labeled analogue of Fluvastatin sodium. Fluvastatin sodium (XU 62320) is the first fully synthetic and competitive HMG-CoA reductase inhibitor, with an IC50 of 8 nM.Cor e Forma:Odour SolidSJFδ
CAS:SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1].Fórmula:C62H63F2N7O12SPureza:98%Cor e Forma:SolidPeso molecular:1168.27Tigecycline hydrochloride
CAS:Tigecycline hydrochloride is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.Fórmula:C29H40ClN5O8Pureza:98%Cor e Forma:SolidPeso molecular:622.11E70K
E70K, a CXCL8 C-terminal peptide, features a lysine (K) substitution for glutamic acid (E) at position 70 and has demonstrated the ability to attenuateFórmula:C108H178N34O28Pureza:98%Cor e Forma:SolidPeso molecular:2400.78Nictide
CAS:Nictide, a peptide substrate for LRRK2 (leucine-rich repeat protein kinase-2), undergoes phosphorylation by the activated form of LRRK2[G2019S], exhibiting a Km value of 10 μM.Fórmula:C123H193N45O28Cor e Forma:SolidPeso molecular:2750.13DOTA-CXCR4-L
DOTA-CXCR4-L, a peptide targeting the CXCR4 receptor, is utilized in cancer research, notably in the contexts of glioblastoma and triple-negative breast cancerFórmula:C58H78N16O14Pureza:98%Cor e Forma:SolidPeso molecular:1223.34CXCL-CXCR1/2-IN-1
CAS:CXCL-CXCR1/2-IN-1 is an ELR+CXCL-CXCR1/2 pathway inhibitor with anticancer activity and can be used in the study of cardiovascular disease.Fórmula:C14H8Cl2N4O3SPureza:99.4%Cor e Forma:SoildPeso molecular:383.21(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH
(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), consisting of Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit the CRBN protein and serves as a crucial intermediate for synthesizing complete PROTAC molecules.Fórmula:C27H32N8O5Peso molecular:548.24957Cytochalasin E
CAS:Cytochalasin E, from Aspergillus, disrupts actin, inhibits angiogenesis, and halts tumor growth.Fórmula:C28H33NO7Pureza:98%Cor e Forma:Crystals From Acetone-Hexane White PowderPeso molecular:495.56Autophagy/REV-ERB-IN-1 hydrochloride
Autophagy/REV-ERB-IN-1 hydrochloride (Compound 24) is a dual inhibitor of autophagy and REV-ERB with anticancer properties. It enhances the efficacy of autophagy blockade and increases cytotoxicity against cancer cells. Autophagy/REV-ERB-IN-1 (hydrochloride) is applicable in melanoma research.Fórmula:C24H32Cl2F2N2Peso molecular:456.19106PDEδ autophagic degrader 1
PDEδ autophagic degrader 1 (compound 12c) is an autophagosome-tethering compound (ATTEC) and a potent autophagic degrader of PDEδ. This compound effectively reduces PDEδ protein levels through lysosome-mediated autophagy without affecting PDEδ mRNA expression. Additionally, PDEδ autophagic degrader 1 inhibits the growth of KRAS mutant pancreatic cancer cells.Fórmula:C41H42Br2IN7O5Peso molecular:997.065894-Amino-D-phenylalanine
CAS:4-Amino-D-phenylalanine ([D-Phe(4-NH2)]) is a cyclic pentapeptide that inhibits the binding of CXCL12 to CXCR4 in FC131, with an IC50 value of 0.1 μM.Fórmula:C9H12N2O2Cor e Forma:SolidPeso molecular:180.2SDF-1α (human)
CAS:SDF-1α (human) serves as a chemotactic agent for mononuclear cells through its interaction with the CXCR4 receptor, facilitating critical biological processesFórmula:C356H578N106O93S4Pureza:98%Cor e Forma:SolidPeso molecular:7959.34(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3
(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3 is an E3 ligase ligand-linker conjugate (E3LigaseLigand-Linker Conjugates) composed of thalidomide and its corresponding linker. This compound functions as a Cereblon ligand, facilitating the recruitment of CRBN protein, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.Fórmula:C33H42N8O7Peso molecular:662.31765RCP168
RCP168 is a highly selective and potent CXCR4 receptor antagonist with an IC50 of 5 nM. It exhibits superior capacity to inhibit HIV-1 (Human Immunodeficiency Virus type 1) from entering host cells via the CXCR4 receptor compared to natural chemokines. RCP168 suppresses HIV-1 infection by blocking viral binding sites or inducing receptor internalization. It can be utilized in research to study interactions between the CXCR4 receptor and other chemokine receptors.Fórmula:C365H585N105O95S5Peso molecular:8119.27766VUF-11222
CAS:VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).Fórmula:C25H31BrINPureza:99.82%Cor e Forma:SolidPeso molecular:552.33(1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-(1R,4r)-cyclohexane-NH-Boc
(1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. This compound serves as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in the synthesis of complete PROTAC molecules.Fórmula:C31H41N5O6Peso molecular:579.30568CXCL8 (54-72)
CXCL8 (54-72) is a C-terminal peptide segment of the chemokine CXCL8. This peptide features a long, highly positively charged C-terminal region that interacts with the negative charges on glycosaminoglycans (GAG) to facilitate binding. CXCL8 (54-72) inhibits neutrophil adhesion and migration, as well as adhesion to endothelial cells. It is useful in studying the role of chemokines in inflammatory responses.Fórmula:C107H173N33O30Peso molecular:2400.30261(1R)-cis-Bifenthrin
CAS:kappa-Bifenthrin is a pyrethroid insecticide.Fórmula:C23H22ClF3O2Pureza:98%Cor e Forma:SolidPeso molecular:422.87ITIC
CAS:"ITIC, a non-fullerene acceptor with high Tg of 180°C, shows excellent thermal stability and a low glass-crystal transition, plus unique crystallization."Fórmula:C94H82N4O2S4Pureza:98%Cor e Forma:SolidPeso molecular:1427.96Antitumor agent-133
Antitumor agent-133 (compound 4d) is a bis-santine derivative that demonstrates activity against Huh1 (IC50 = 17.13 μM) and Huh7 (IC50 = 8.27 μM). It induces autophagy and inhibits tumor growth by modulating the levels of the LC3BII, ATG5, and p62 proteins.Fórmula:C27H24Br2N4O8Peso molecular:689.99609CCR7 antagonist 1
CCR7 antagonist1 (30c) functions as a dual antagonist, targeting CXCR2 with an IC50 of 11.02 μM and CCR7 with an IC50 of 0.43 μM.Fórmula:C13H22N6OSPeso molecular:310.15758ALX 40-4C Trifluoroacetate
Alx40-4C trifluoroacetate inhibits CXCR4 and is an APJ antagonist with IC50 of 2.9M.Fórmula:C58H114F3N37O12Pureza:98%Cor e Forma:SolidPeso molecular:1578.76Tigecycline hydrate
CAS:Tigecycline hydrate: broad-spectrum, glycylcycline antibiotic, bacteriostatic, inhibits protein synthesis, effective against resistant bacteria.Fórmula:C29H39N5O8·xH2OCor e Forma:SolidATRA-biotin
CAS:ATRA-biotin is a biotin-conjugated form of all-trans retinoic acid (ATRA). It is utilized for the purpose of tracking ATRA within cells or specific tissues.Fórmula:C36H55N3O4SCor e Forma:SolidPeso molecular:625.91(S)-Sitagliptin phosphate
CAS:(S)-Sitagliptin phosphate, less active enantiomer, is a potent DPP4 inhibitor with an IC50 of 19 nM.Fórmula:C16H18F6N5O5PCor e Forma:SolidPeso molecular:505.314Manzamine A hydrochloride
CAS:Manzamine A hydrochloride: oral beta-carboline inhibiting GSK-3β & CDK-5; blocks autophagy in cancer; antimalarial; fights HSV-1.Fórmula:C36H45ClN4OCor e Forma:SolidPeso molecular:585.23AUTAC1
CAS:AUTAC1 is a MetAP2-targeted autophagy-mediated degradator (AUTAC) that degrades MetAP2 and FKBP12 proteins and can be used to synthesize PROTAC.Fórmula:C44H63FN8O11SPureza:99.45% - 99.45%Cor e Forma:SolidPeso molecular:931.08Syntide 2
CAS:Syntide-2 is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII; Km = 12 µM).Fórmula:C68H122N20O18Pureza:98%Cor e Forma:Lyophilized SolidPeso molecular:1507.82Deoxy-thalidomide-Pip-C-PIP-boc
CAS:Deoxy-thalidomide-Pip-C-PIP-boc, a conjugate of E3 ligase ligand and linker, comprises Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in synthesizing complete PROTAC molecules.Fórmula:C28H39N5O5Cor e Forma:SolidPeso molecular:525.64Cabergoline
CAS:Cabergoline (FCE-21336), an ergot-derived dopamine D2-like agonist, targets D2/D3/5-HT2B, normalizes prolactin, controls pituitary tumors.Fórmula:C26H37N5O2Pureza:97.69% - 99.86%Cor e Forma:White Crystalline SolidPeso molecular:451.6MRL828
MRL828 is a compound that combines a Tau pathology-binding ligand with a guanine group modified by ATTEC technology, allowing it to selectively target aggregated tau proteins for clearance via the autophagy-lysosome pathway (ALP). MRL828 reduces intracellular Tau aggregates and facilitates the secretion of Tau.Fórmula:C46H51FN14O5SCor e Forma:SolidPeso molecular:930.38716(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc
(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. It acts as a Cereblon ligand, recruiting CRBN proteins, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.
Fórmula:C30H39N5O6Peso molecular:565.29003CXCR4-IN-3
CXCR4-IN-3 (compound XVI) is an orally active inhibitor targeting the inflammation-related receptor CXCR4, with an IC50 of 3.2 nM. It exhibits potent anti-chemotactic effects, with an inhibition rate of 79.19±2.33%. Additionally, CXCR4-IN-3 possesses anti-inflammatory properties and can be utilized in research on IBD (inflammatory bowel disease).
Autocamtide 2, amide
Autocamtide-2, an amide, is a selective CaMKII substrate for CAMK family assays at 100 μM.Fórmula:C65H119N23O19Pureza:98%Cor e Forma:SolidPeso molecular:1526.79Autophagy/REV-ERB-IN-1
Autophagy/REV-ERB-IN-1 is a dual inhibitor of autophagy and REV-ERB. It exhibits antitumor activity, with a CC50 value of 2.3 μM in BTB-474 cells.Fórmula:C24H30F2N2Peso molecular:384.23771Polyphyllin G
CAS:Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas.Fórmula:C51H84O22Pureza:98%Cor e Forma:SolidPeso molecular:1049.21(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH
(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH is a conjugate combining an E3 ligase ligand with a linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding Linker. This compound functions as a Cereblon ligand, recruiting the CRBN protein and serving as a crucial intermediate in the synthesis of complete PROTAC molecules.Fórmula:C29H36N8O6Peso molecular:592.27578Indomethacin-D4
CAS:Indomethacin-D4 is a deuterium labeled Indomethacin.Fórmula:C19H16ClNO4Pureza:98%Cor e Forma:SolidPeso molecular:361.81Atorvastatin Sodium
CAS:Atorvastatin Sodium (Lipitor) is a competitive inhibitor of HMG-CoA reductase and increases the expression of low density lipoprotein (LDL) receptors onFórmula:C33H34FN2NaO5Pureza:99.88% - >99.99%Cor e Forma:SolidPeso molecular:580.63ALX 40-4C
CAS:ALX40-4C is a small peptide inhibitor of the chemokine receptor CXCR4 that can inhibit X4 strains of HIV-1.Fórmula:C56H113N37O10Pureza:98%Cor e Forma:SolidPeso molecular:1464.74LC3B recruiter 2
CAS:LC3B recruiter 2 (34R) is an LC3B recruiting agent incorporated into the autophagy-lysosome pathway degradation system (ATTEC, Autophagy-Tethering Compounds), with a direct binding affinity for LC3B. It connects via a linker to the CDK9 inhibitor SNS-032, creating an ATTEC capable of targeting and degrading the CDK9 and Cyclin T1 complex, while also inhibiting them. Consequently, LC3B recruiter 2 exerts its function through an LC3B-dependent autophagy-lysosome pathway, interfering with the cancer cell cycle progression, thereby demonstrating antitumor activity.Fórmula:C10H9ClN2O2Cor e Forma:SolidPeso molecular:224.644MLCK inhibitor peptide 18
CAS:Myosin light chain kinase inhibitor; IC50=50 nM; 4000x more selective over CaM kinase II; no PKA inhibition; cell-permeable.Fórmula:C60H105N23O11Pureza:98%Cor e Forma:SolidPeso molecular:1324.64Autophagy agonist-1
Autophagyagonist-1 (compound 22) is an autophagy agonist. It exhibits significant anticancer activity against HepG2 cells and normal cells, with IC50 values of 8.8 μM and > 50 μM, respectively. The compound induces G1/S phase cell cycle arrest, suppresses the expression of CDK4 and CyclinD1, and upregulates P21. Additionally, Autophagyagonist-1 enhances autophagosome, LC3, and PINK1 accumulation, thereby promoting autophagy and mitophagy in HepG2 cells.Fórmula:C33H41N3O5Cor e Forma:SolidPeso molecular:559.7CXM102
CXM102 is an activator of autophagy. This compound induces autophagy in aged BMSCs, rejuvenating them and promoting their preferential differentiation into osteoblasts. CXM102 enhances the nuclear translocation of transcription factor EB (TFEB) and the formation of osteoblasts. In middle-aged male mice, it stimulates bone anabolic metabolism, reduces marrow adipocytes, delays bone loss, lowers serum inflammation levels, reduces organ fibrosis, and extends lifespan.Fórmula:C28H27NO3Cor e Forma:SolidPeso molecular:425.52BOLD-100 free base
CAS:BOLD-100 (NKP-1339/IT-139) is a ruthenium anticancer agent that inhibits GRP78 and disrupts ER homeostasis, affecting lysosome function and autophagy.Fórmula:C14H12Cl4N4RuCor e Forma:SolidPeso molecular:479.15ACKR3 agonist 1
ACKR3 agonist 1 (compound 27), exhibiting selective agonistic properties for ACKR3 (EC 50 =69 nM, E max =82%), demonstrates the capability to inhibit platelet aggregation and shows potential in mitigating platelet-mediated thrombosis. This compound is characterized by its metabolic stability and non-cytotoxic nature.Fórmula:C25H30N2OSCor e Forma:SolidPeso molecular:406.58N6-Isopentenyladenosine
CAS:N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity.Fórmula:C15H21N5O4Pureza:97.13% - 99.69%Cor e Forma:SolidPeso molecular:335.36BVT173187
CAS:BVT173187 is a neutrophil formyl peptide receptors (FPR1) inhibitor.Fórmula:C14H10Cl3NO2Cor e Forma:SolidPeso molecular:330.59Spiroplatin
CAS:Spiroplatin (TNO-6) is a novel platinum-containing analogue with antitumor activity that is commonly used in the study of solid tumors.Fórmula:C8H18N2O4PtSPureza:≥98%Cor e Forma:SolidPeso molecular:433.39SQA1
CAS:SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.Fórmula:C22H26N4O5Cor e Forma:SolidPeso molecular:426.47DB1113
CAS:DB1113 is a bifunctional kinase degrader, targeting ABL1, ABL2, CDK4, MAPKs, and more for disease research.Fórmula:C59H68F3N13O6SCor e Forma:SolidPeso molecular:1144.31TRAF6 peptide
CAS:TRAF6 peptide inhibits TRAF6-p62, blocks TrkA ubiquitination, and shows promise for neurological disease research.Fórmula:C145H238N34O44Cor e Forma:SolidPeso molecular:3161.64Salinomycin sodium salt
CAS:Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.Fórmula:C42H69NaO11Pureza:98.76% - 99.11%Cor e Forma:White Or Light Yellow Crystalline Powder With Special SmelPeso molecular:772.98Ch55-O-C3-NH2
CAS:Ch55-O-C3-NH2, also known as RAR ligand 1, is a ligand derived from the Ch55 compound that specifically targets RAR.Fórmula:C27H35NO4Pureza:98%Cor e Forma:SolidPeso molecular:437.57LC3in-C42
LC3in-C42 is a covalent inhibitor of LC3A/B and autophagy active within cells. Selectively inhibiting the binding of P62 to LC3A/B both in vitro and at the cellular level, LC3in-C42 functions similarly to D5 and is effective at lower concentrations.Cor e Forma:Odour SolidFumagilin-105
CAS:Fumagilin-105, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62 and exhibits a DC50 of 0.7 μM against MetAP2 in HEK293 cells.Fórmula:C46H60N2O9Cor e Forma:SolidPeso molecular:784.98Desethyl chloroquine
CAS:Desethyl chloroquine (Monodesethylchloroquine) is a major metabolite of Chloroquine which is a TLR inhibitor. Desethyl chloroquine shows antiplasmodic activity.Fórmula:C16H22ClN3Pureza:99.56%Cor e Forma:SolidPeso molecular:291.82p62-ZZ Ligand-Linker Conjugate 1
CAS:p62-ZZ Ligand-Linker Conjugate 1 is a conjugate of the p62-ZZ domain ligand and linker. This compound is utilized in the synthesis of AUTOTACVinclozolinM2-2204.Fórmula:C31H42N2O6Cor e Forma:SolidPeso molecular:538.68YTK-105
CAS:YTK-105 is a ligand targeting autophagy that binds to p62.Fórmula:C16H19NO2Pureza:98.31%Cor e Forma:SoildPeso molecular:257.33Peptide R
CAS:Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.Fórmula:C39H59N13O8S2Cor e Forma:SolidPeso molecular:902.1PF-543
CAS:PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.Fórmula:C27H31NO4SPureza:99.02%Cor e Forma:SolidPeso molecular:465.6Erlotinib-13C6
CAS:Erlotinib-13C6 (CP-358774-13C6), a 13C-labeled direct EGFR inhibitor, IC50: 2 nM.Fórmula:C22H23N3O4Cor e Forma:SolidPeso molecular:399.397FDW028
CAS:FDW028 is a FUT8 inhibitor with antitumor activity that works by promoting B7-H3 lysosomal degradation through defucosylation and CMA pathways.Fórmula:C22H24N6OPureza:98.73% - 99.55%Cor e Forma:SoildPeso molecular:388.47Ref: TM-T77809
1mg66,00€5mg142,00€1mL*10mM (DMSO)158,00€10mg215,00€25mg358,00€50mg517,00€100mg707,00€HDAC6-IN-58
HDAC6-IN-58 (compound 24c) is a selective HDAC6 inhibitor with IC50 values of 9.5 nM for HDAC6 and 7374.5 nM for HDAC1. It enhances tubulin acetylation, exhibits antiproliferative effects, and induces autophagy (autophagy).Cor e Forma:Odour SolidcGMP-HTL
cGMP-HTL, an AUTAC, promotes K63-linked mitochondrial ubiquitination with a Cys-S-cGMP tag and target-specific warhead.Fórmula:C31H51ClN7O14PSCor e Forma:SolidPeso molecular:844.27Beclin1-Bcl-2 interaction inhibitor 1
Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].Cor e Forma:Odour SolidPHTPP-1304
CAS:PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ERβ (DC50: ~2 nM, HEK293T). Additionally, PHTPP-1304 facilitates the formation of p62+ERβ+ puncta in a dose-dependent manner, influencing autophagic flux.Fórmula:C51H50F6N4O7Cor e Forma:SolidPeso molecular:944.96Corydalmine hydrochloride
CAS:Corydalmine hydrochloride: antifungal, oral analgesic, soothes neuropathic pain by blocking NF-κB/CXCL1/CXCR2.Fórmula:C20H24ClNO4Cor e Forma:SolidPeso molecular:377.86SHP2-IN-35
SHP2-IN-35 (Compound 3f) functions as an inhibitor of SHP2. It exhibits antiproliferative activity in cancer cell lines RKO, SW480, and CT26, with IC50 values of 5.72 μM, 3.71 μM, and 1.42 μM, respectively. SHP2-IN-35 inhibits the PI3K-Akt signaling pathway, regulates the expression of cell cycle-related genes, and induces mitochondrial autophagy (autophagy). Within the tumor microenvironment (TME), SHP2-IN-35 suppresses the expression of certain cytokines and chemokines, thereby modulating tumor progression.Fórmula:C34H32FeO6Cor e Forma:SolidPeso molecular:592.46Flavopiridol
CAS:Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.Fórmula:C21H20ClNO5Pureza:97.74% - 99.99%Cor e Forma:SolidPeso molecular:401.84Zn-DPA-maytansinoid conjugate 1
Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.Fórmula:C115H145ClN18O31S2Zn2Cor e Forma:SolidPeso molecular:2505.83
