Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1424 produtos de "Autofagia"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
SHP2-IN-35
<p>SHP2-IN-35 (Compound 3f) functions as an inhibitor of SHP2. It exhibits antiproliferative activity in cancer cell lines RKO, SW480, and CT26, with IC50 values of 5.72 μM, 3.71 μM, and 1.42 μM, respectively. SHP2-IN-35 inhibits the PI3K-Akt signaling pathway, regulates the expression of cell cycle-related genes, and induces mitochondrial autophagy (autophagy). Within the tumor microenvironment (TME), SHP2-IN-35 suppresses the expression of certain cytokines and chemokines, thereby modulating tumor progression.</p>Fórmula:C34H32FeO6Cor e Forma:SolidPeso molecular:592.46VUF-11222
CAS:<p>VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).</p>Fórmula:C25H31BrINPureza:99.82%Cor e Forma:SolidPeso molecular:552.33(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3
<p>(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3 is an E3 ligase ligand-linker conjugate (E3LigaseLigand-Linker Conjugates) composed of thalidomide and its corresponding linker. This compound functions as a Cereblon ligand, facilitating the recruitment of CRBN protein, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.</p>Fórmula:C33H42N8O7Peso molecular:662.31765Bacilotetrin C analogue
<p>Bacilotetrin C analogue is a variant of Bacilotetrin C. It exhibits cytotoxicity against the triple-negative breast cancer cell line MDA-MB-231, with an IC50 of 0.48 μM. This compound induces autophagy (autophagy) in tumor cells and possesses antitumor activity.</p>Fórmula:C44H76N6O10Cor e Forma:SolidPeso molecular:849.11Deoxy-thalidomide-Pip-C-PIP-boc
CAS:<p>Deoxy-thalidomide-Pip-C-PIP-boc, a conjugate of E3 ligase ligand and linker, comprises Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in synthesizing complete PROTAC molecules.</p>Fórmula:C28H39N5O5Cor e Forma:SolidPeso molecular:525.64p62-ZZ Ligand-Linker Conjugate 1
CAS:<p>p62-ZZ Ligand-Linker Conjugate 1 is a conjugate of the p62-ZZ domain ligand and linker. This compound is utilized in the synthesis of AUTOTACVinclozolinM2-2204.</p>Fórmula:C31H42N2O6Cor e Forma:SolidPeso molecular:538.68JH-XII-03-02
CAS:<p>JH-XII-03-02 is a potent and selective leucine-rich repeat kinase 2 (LRRK2) proteolysis targeting chimera (PROTAC) degrader, utilized in Parkinson's Disease (PD</p>Fórmula:C43H51N9O10Pureza:98%Cor e Forma:SolidPeso molecular:853.92Polyphyllin G
CAS:<p>Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas.</p>Fórmula:C51H84O22Pureza:98%Cor e Forma:SolidPeso molecular:1049.21CXCR4 antagonist 2
CAS:<p>CXCR4 antagonist 2 is a CXCR4 antagonist with an IC 50 value of 47 nM.</p>Fórmula:C25H36N6Cor e Forma:SolidPeso molecular:420.605N6-Isopentenyladenosine
CAS:<p>N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity.</p>Fórmula:C15H21N5O4Pureza:97.13% - 99.69%Cor e Forma:SolidPeso molecular:335.36Fumagilin-105
CAS:<p>Fumagilin-105, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62 and exhibits a DC50 of 0.7 μM against MetAP2 in HEK293 cells.</p>Fórmula:C46H60N2O9Cor e Forma:SolidPeso molecular:784.98TRAF6 peptide
CAS:<p>TRAF6 peptide inhibits TRAF6-p62, blocks TrkA ubiquitination, and shows promise for neurological disease research.</p>Fórmula:C145H238N34O44Cor e Forma:SolidPeso molecular:3161.64SQA1
CAS:<p>SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.</p>Fórmula:C22H26N4O5Cor e Forma:SolidPeso molecular:426.47Microcolin H
CAS:<p>Microcolin H, a marine lipopeptide and phosphatidylinositol transfer protein ligand, targets PITPα/β. It enhances the conversion of LC3I to LC3II and decreases p62 levels in cancer cells, inducing autophagy cell death (Autophagy). Furthermore, Microcolin H effectively inhibits tumor growth and exhibits anti-proliferative activity in nude mouse subcutaneous tumor models [1].</p>Fórmula:C38H63N5O9Cor e Forma:SolidPeso molecular:733.93PBA-1105b
CAS:<p>PBA-1105b, a longer PEGylated derivative of PBA-1105, is an autophagy-targeting chimeric compound (AUTOTAC) that can induce self-oligomerization of p62. It enhances the autophagic flux of Ub-bound aggregates.</p>Fórmula:C47H64N2O10Cor e Forma:SolidPeso molecular:817.02Episilvestrol
CAS:<p>Episilvestrol is a derivative of silvestrol with eIF4A-targeted antitumor properties, found in Aglaia silvestris fruits and twigs.</p>Fórmula:C34H38O13Pureza:98%Cor e Forma:SolidPeso molecular:654.66Polyphemusin II-Derived Peptide
CAS:<p>T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.</p>Fórmula:C90H141N33O18S2Cor e Forma:SolidPeso molecular:2037.42LC3in-C42
<p>LC3in-C42 is a covalent inhibitor of LC3A/B and autophagy active within cells. Selectively inhibiting the binding of P62 to LC3A/B both in vitro and at the cellular level, LC3in-C42 functions similarly to D5 and is effective at lower concentrations.</p>Cor e Forma:Odour SolidPeptide R
CAS:<p>Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.</p>Fórmula:C39H59N13O8S2Cor e Forma:SolidPeso molecular:902.1PI3K-AKT-mTOR Compound Library
<p>A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with</p>Cor e Forma:Odour SolidErlotinib-13C6
CAS:<p>Erlotinib-13C6 (CP-358774-13C6), a 13C-labeled direct EGFR inhibitor, IC50: 2 nM.</p>Fórmula:C22H23N3O4Cor e Forma:SolidPeso molecular:399.397Fe-TMPyP
CAS:<p>Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.</p>Fórmula:C44H36Cl5FeN8Cor e Forma:SolidPeso molecular:909.92Acridine homodimer
CAS:<p>Acridine homodimer (NSC 219743), a blue-green fluorescent dye, binds DNA, preferring AT-rich areas, useful for chromosome banding.</p>Fórmula:C38H42Cl2N6O2Cor e Forma:SolidPeso molecular:685.69cGMP-HTL
<p>cGMP-HTL, an AUTAC, promotes K63-linked mitochondrial ubiquitination with a Cys-S-cGMP tag and target-specific warhead.</p>Fórmula:C31H51ClN7O14PSCor e Forma:SolidPeso molecular:844.27Beclin1-Bcl-2 interaction inhibitor 1
<p>Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].</p>Cor e Forma:Odour SolidPHTPP-1304
CAS:<p>PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ERβ (DC50: ~2 nM, HEK293T). Additionally, PHTPP-1304 facilitates the formation of p62+ERβ+ puncta in a dose-dependent manner, influencing autophagic flux.</p>Fórmula:C51H50F6N4O7Cor e Forma:SolidPeso molecular:944.96Imatinib D4
CAS:<p>Imatinib D4 is a deuterium-labeled Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, PDGFR, v-Abl, and c-kit kinase activity.</p>Fórmula:C29H31N7OPureza:98%Cor e Forma:SolidPeso molecular:497.63Cilengitide TFA
CAS:<p>Cilengitide, αvβ3/αvβ5 inhibitor, IC50: 4.1/79 nM in vitro. 10x selectivity vs. gpIIbIIIa. Phase 2.</p>Fórmula:C29H41F3N8O9Cor e Forma:SolidPeso molecular:702.68Olaparib-d5
CAS:<p>Olaparib D5 is a deuterium labeled Olaparib. Olaparib is a potent and oral inhibitor of PARP.</p>Fórmula:C24H23FN4O3Pureza:98%Cor e Forma:SolidPeso molecular:439.49Gemcitabine elaidate
CAS:<p>Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with</p>Fórmula:C27H43F2N3O5Cor e Forma:SolidPeso molecular:527.64R1487 Hydrochloride
CAS:<p>R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38α.</p>Fórmula:C19H19ClF2N4O3Pureza:99.42%Cor e Forma:SolidPeso molecular:424.83Saquinavir mesylate
CAS:<p>Saquinavir mesylate (Ro 31-8959/003) is an Inhibitor of HIV Proteaseused in antiretroviral therapy</p>Fórmula:C39H54N6O8SPureza:99.19%Cor e Forma:White Or Pale Yellow PowderPeso molecular:766.9Heparin Lithium
CAS:<p>Heparin Lithium salt is an anticoagulant that reversibly binds to ATIII and enhances its inhibitory effect on coagulation factor(thrombin and factor Xa).</p>Fórmula:C14H25NO20S3Cor e Forma:SolidPeso molecular:623.01321GW406108X
CAS:<p>GW406108X is a Kif15 and ULK1 inhibitor; IC50: 0.82 µM (ATPase), pIC50: 6.37; blocks autophagy.</p>Fórmula:C20H11Cl2NO4Pureza:98%Cor e Forma:SolidPeso molecular:400.21Bexarotene D4
CAS:<p>Bexarotene D4 is a deuterium-labeled Bexarotene (LGD1069). Bexarotene is a selective RXR agonist used in the treatment of cutaneous T-cell lymphoma.</p>Fórmula:C24H28O2Pureza:98%Cor e Forma:SolidPeso molecular:352.5Trimetazidine
CAS:<p>Trimetazidine is a antianginal agent that selectively inhibits the mitochondrial enzyme LC 3-KAT, thereby preventing β-oxidation of free fatty acids.</p>Fórmula:C14H22N2O3Pureza:99.9%Cor e Forma:Hite Or Off-White Crystalline PowderPeso molecular:266.34Binimetinib-13C-d3
<p>Binimetinib-13C-d3 (MEK162) is an isotopically labelled compound of Binimetinib.Binimetinib (ARRY-162) is a selective MEK1/2 inhibitor melanoma.</p>Fórmula:C17H15BrF2N4O3Cor e Forma:SolidPeso molecular:445.24Gefitinib-d8
CAS:<p>Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib D8 is a deuterium labeled Gefitinib.</p>Fórmula:C22H24ClFN4O3Pureza:98%Cor e Forma:SolidPeso molecular:454.95LG100268
CAS:<p>LG100268 is a selective, and oral RXR agonist，inducing transcriptional activation in adipocytes; inhibits keratin 17 increases PD-L1 expression.</p>Fórmula:C24H29NO2Pureza:99.83%Cor e Forma:SolidPeso molecular:363.49Enzalutamide-d3
CAS:<p>Enzalutamide D3 is a deuterium labeled Enzalutamide . Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells.</p>Fórmula:C21H16F4N4O2SCor e Forma:SolidPeso molecular:467.45TRAF6 peptide TFA
<p>TRAF6 peptide TFA, a specific inhibitor of the TRAF6-p62 interaction, significantly inhibits NGF-dependent ubiquitination of TrkA.</p>Fórmula:C145H238N34O44·xC2HF3O2Pureza:98%Cor e Forma:SolidPeso molecular:3161.64 (free acid)Isoniazid-d4
CAS:<p>Isoniazid-d4 is a deuterium isotope marker for Isoniazid.Isoniazid is a prodrug that must be activated by the bacterial peroxidase KatG, and is bactericidal.</p>Fórmula:C6H3D4N3OCor e Forma:SolidPeso molecular:141.16KN-93 hydrochloride
CAS:<p>KN-93 hydrochloride is a cell-permeable, reversible and competitive calmodulin-dependent kinase type II ( CaMKII ) inhibitor with a K i of 370 nM.</p>Fórmula:C26H30Cl2N2O4SCor e Forma:SolidPeso molecular:537.5Rosuvastatin D3 Sodium
CAS:<p>Rosuvastatin D3 Sodium is deuterium labeled Rosuvastatin, which is a competitive HMG-CoA reductase inhibitor(IC50 of 11 nM).</p>Fórmula:C22H24D3FN3NaO6SPureza:98%Cor e Forma:SolidPeso molecular:506.54Regorafenib-d3
CAS:<p>Regorafenib D3 is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor inhibitor of tyrosine kinase.</p>Fórmula:C21H15ClF4N4O3Pureza:98%Cor e Forma:SolidPeso molecular:485.83LY2510924
CAS:<p>LY2510924 is an effective and selective CXCR4 antagonist. It blocks SDF-1 binding to CXCR4 (IC50: 0.079 nM).</p>Fórmula:C62H88N14O10Cor e Forma:SolidPeso molecular:1189.45Rapalink-1
CAS:<p>Rapalink-1 is an mTOR inhibitor that inhibits the mTORC1-4E-BP1 pathway in mice.</p>Fórmula:C91H138N12O24Pureza:98%Cor e Forma:SolidPeso molecular:1784.14Rapamycin-d3
CAS:<p>Rapamycin-d3 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific inhibitor of mTOR(IC50 of 0.1 nM in HEK293 cells).</p>Fórmula:C51H79NO13Pureza:98%Cor e Forma:SolidPeso molecular:917.19Erlotinib-d6 hydrochloride
CAS:<p>Erlotinib Hydrochloride inhibits purified EGFR kinase with an IC50 of 2 nM. Erlotinib D6 hydrochloride a deuterium labeled Erlotinib Hydrochloride.</p>Fórmula:C22H24ClN3O4Pureza:98%Cor e Forma:SolidPeso molecular:435.93Ezetimibe-d4
CAS:<p>Ezetimibe D4, a deuterium-labeled variant of Ezetimibe, functions as an inhibitor of Niemann-Pick C1-like1 (NPC1L1) and is recognized for its potent activation</p>Fórmula:C24H21F2NO3Pureza:98%Cor e Forma:White SolidPeso molecular:413.45Ponatinib-d8
CAS:<p>Ponatinib D8 is a deuterium-enriched, oral multi-kinase inhibitor (Abl, PDGFRα, VEGFR2, FGFR1, Src; IC50s: 0.37-5.4 nM).</p>Fórmula:C29H27F3N6OPureza:98%Cor e Forma:SolidPeso molecular:540.61Anti-LRRK2 Antibody (1C773)
<p>Anti-LRRK2 Antibody (1C773) is an antibody targeting LRRK2. Anti-LRRK2 Antibody (1C773) can be used in ELISA, IHC.</p>Cor e Forma:Odour LiquidTetrahydrocurcumin D6
CAS:<p>Tetrahydrocurcumin D6 is a deuterium labeled Tetrahydrocurcumin. Tetrahydrocurcumin displays inhibitory activity for CYP2C9 and CYP3A4.</p>Fórmula:C21H24O6Pureza:98%Cor e Forma:SolidPeso molecular:378.45Manzamine A
CAS:<p>Manzamine A, from marine sponges, blocks GSK-3, halts cancer growth, prevents bacterial infections, and reduces tau phosphorylation.</p>Fórmula:C36H44N4OPureza:98%Cor e Forma:SolidPeso molecular:548.775PS372424 hydrochloride
CAS:<p>PS372424 hydrochloride,CXCR3 agonist. Anti-inflammatory. Inhibits T-cell migration.</p>Fórmula:C33H45ClN6O4Pureza:95.03%Cor e Forma:SolidPeso molecular:625.2Idelalisib D5
CAS:<p>Idelalisib D5, a version of Idelalisib marked with deuterium, is an orally bioavailable and highly selective inhibitor of p110δ.</p>Fórmula:C22H18FN7OPureza:98%Cor e Forma:SolidPeso molecular:420.45Ladarixin
CAS:<p>Ladarixin (DF 2156A free base) is an orally active, non-competitive CXCR1/CXCR2 allosteric inhibitor that suppresses AKT, NF-κB, and angiogenesis.</p>Fórmula:C11H12F3NO6S2Pureza:99.36%Cor e Forma:SolidPeso molecular:375.34ACT-1004-1239
CAS:<p>ACT-1004-1239 is a CXCR7 antagonist with immunomodulatory and myelination-promoting effects, used for research on inflammatory demyelinating diseases.</p>Fórmula:C27H28F2N6O3Pureza:98.31%Cor e Forma:SolidPeso molecular:522.55Curcumin-d6
CAS:<p>Curcumin D6 (difluoroformylmethane D6) is deuterium-labeled curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with various pharmacological effects, including anti-inflammatory, antioxidant, anti-proliferative and anti-a</p>Fórmula:C21H20O6Pureza:98%Cor e Forma:SolidPeso molecular:374.422Levomepromazine
CAS:<p>Levomepromazine (Methotrimeprazine) is a Ca2+ release inducer with antiviral, anti-inflammatory, neuroprotective, sedative, and anti-nociceptive activities.</p>Fórmula:C19H24N2OSPureza:99.15%Cor e Forma:SolidPeso molecular:328.47ATI-2341
CAS:<p>ATI-2341, pepducin targeting the CXCR4, is an allosteric agonist activating the Gi to promote inhibition of cAMP production and induce calcium mobilization.</p>Fórmula:C104H178N26O25S2Cor e Forma:SolidPeso molecular:2256.82Motixafortide
CAS:<p>Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).</p>Fórmula:C97H144FN33O19S2Pureza:98%Cor e Forma:SolidPeso molecular:2159.52CXCR2 antagonist 8
CAS:<p>CXCR2 antagonist 8 is a selective CXCR2 antagonist, which can be used for the treatment and prevention of insulin resistance.</p>Fórmula:C14H13N3O5Cor e Forma:SolidPeso molecular:303.27THZ-P1-2
CAS:<p>THZ-P1-2 is a PI5P4K inhibitor with anti-leukemic activity and can be used in the study of leukemia.</p>Fórmula:C31H29N7O2Cor e Forma:SolidPeso molecular:531.61Rosuvastatin Sodium
CAS:<p>Rosuvastatin Sodium: HMGCR inhibitor, blocks hERG (IC50: 11 nM, 195 nM), reduces hERG expression, hinders Hsp70-hERG interaction.</p>Fórmula:C22H27FN3NaO6SCor e Forma:SolidPeso molecular:503.52Loperamide-d6 hydrochloride
CAS:<p>Loperamide D6 HCl: Deuterium-enriched opioid for diarrhea.</p>Fórmula:C29H34Cl2N2O2Pureza:98%Cor e Forma:SolidPeso molecular:519.54Br-DAPI
CAS:<p>IST5-002 (N6-Benzyladenosine-5'-phosphate) is a Stat5a/b inhibitor with anticancer activity and is used in cancer research.</p>Fórmula:C16H14BrN5Pureza:100%Cor e Forma:SolidPeso molecular:356.22OR-1855
CAS:<p>OR-1855 is an active Levosimendan metabolite, has effect on human myometrial contractility.</p>Fórmula:C11H13N3OPureza:98%Cor e Forma:Pale Yellow SolidPeso molecular:203.24Aliskiren
CAS:<p>Aliskiren (CGP 60536) is a renin inhibitor (IC50: 1.5 nM) with antihypertensive activity and is used in the treatment of various cardiovascular diseases.</p>Fórmula:C30H53N3O6Pureza:97.02%Cor e Forma:SolidPeso molecular:551.76Peptide R TFA
<p>Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It demonstrates excellent tumor stroma remodeling capabilities and is applicable in research on solid tumors, such as glioblastoma.</p>Fórmula:C39H57N13O8S2·xC2HF3O2Cor e Forma:SolidPeso molecular:900.08 (free base)Omeprazole-d3
CAS:<p>Omeprazole D3 is deuterium labeled Omeprazole. Omeprazole is a proton pump inhibitor (PPI)</p>Fórmula:C17H19N3O3SPureza:98%Cor e Forma:SolidPeso molecular:348.44IKK 16 hydrochloride
CAS:<p>IKK 16 hydrochloride, a potent IKK1/2 and LRRK2 inhibitor, IC50s: 40-200 nM and 50 nM respectively.</p>Fórmula:C28H30ClN5OSCor e Forma:SolidPeso molecular:520.09Pemetrexed disodium heptahydrate
CAS:<p>Pemetrexed disodium heptahydrate (LY231514) is an antifolate that inhibits TS, DHFR and GARFT, inhibits precursor purine and pyrimidine nucleotides.</p>Fórmula:C20H33N5Na2O13Pureza:99.783%Cor e Forma:SolidPeso molecular:597.49Brivanib
CAS:<p>Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against</p>Fórmula:C19H19FN4O3Pureza:98.87%Cor e Forma:SolidPeso molecular:370.38Cediranib maleate
CAS:<p>Cediranib maleate (AZD2171 maleate) is a VEGFR2 inhibitor that inhibits Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit.</p>Fórmula:C29H31FN4O7Cor e Forma:SolidPeso molecular:566.58Resveratrol analog 1
CAS:<p>Resveratrol analog 1 is a natural product analog of resveratrol, which has more significant anti-leukemic activity than resveratrol.</p>Fórmula:C14H11FO2Pureza:98.42%Cor e Forma:SolidPeso molecular:230.23Rupatadine
CAS:<p>Rupatadine (UR-12592, rupatadine) is a potent and orally available dual antagonist of PAF and histamine H1 receptors ,allergic and anti-inflammatory.</p>Fórmula:C26H26ClN3Pureza:99.87%Cor e Forma:SolidPeso molecular:415.96Metformin-d6 hydrochloride
CAS:<p>Metformin-d6 hydrochloride (Metformin-d6 hydrochloride) is a deuteride of Metformin, which can be used to study Metformin metabolism in vivo.</p>Fórmula:C4H12ClN5Pureza:98.1%Cor e Forma:SolidPeso molecular:171.66Pyrazinamide-d3
CAS:<p>Pyrazinamide-d3 is a deuterated compound of Pyrazinamide. Pyrazinamide has a CAS number of 98-96-4. Pyrazinamide, an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amide derivative.</p>Fórmula:C5D3H2N3OCor e Forma:SolidPeso molecular:126.13Dexamethasone-d5
CAS:<p>Dexamethasone-d5 is a deuterated compound of Dexamethasone.</p>Fórmula:C22H24D5FO5Cor e Forma:SolidPeso molecular:397.49Afatinib D6
CAS:<p>Afatinib D6 (BIBW 2992 D6) is a deuterium-labeled Afatinib. Afatinib is an irreversible EGFR family inhibitor.</p>Fórmula:C24H25ClFN5O3Cor e Forma:SolidPeso molecular:491.98V-9302 hydrochloride
CAS:<p>V-9302 hydrochloride is a competitive transmembrane glutamine flux antagonist that selectively targets the amino acid transporter ASCT2/SLC1A5.</p>Fórmula:C34H39ClN2O4Pureza:97.31%Cor e Forma:SolidPeso molecular:575.14Nilotinib-d6
CAS:<p>Nilotinib D6 is a deuterium labeled Nilotinib which is an orally available inhibitor of Bcr-Abl tyrosine kinase ,and with antineoplastic activity.</p>Fórmula:C28H22F3N7OPureza:98%Cor e Forma:SolidPeso molecular:535.55Megestrol Acetate-d3
CAS:<p>Megestrol Acetate-d3 is a deuterated compound of Megestrol Acetate. Megestrol Acetate has a CAS number of 595-33-5. Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia.</p>Fórmula:C24H29D3O4Cor e Forma:SolidPeso molecular:387.53Silibinin-d3
<p>Silibinin-d3 is the deuterium-labelled compound of silibinin, used for isotope tracing. Silibinin inhibit cancer cell proliferation and migration.</p>Fórmula:C25H22O10Cor e Forma:SolidPeso molecular:485.46Isorhapontigenin
CAS:<p>Isorhapontigenin: a methoxylated stilbenoid isomer of rhapontigenin, similar to resveratrol, present in Gnetum spp. and Aiphanes aculeata seeds.</p>Fórmula:C15H14O4Pureza:98.49% - 99.85%Cor e Forma:Off White Crystals PowerPeso molecular:258.27Valproic Acid
CAS:<p>Valproic Acid (2-Propylpentanoic Acid) is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels.</p>Fórmula:C8H16O2Pureza:97.78% - 99%Cor e Forma:Colourless To Pale Yellow Liquid ViscousPeso molecular:144.21Ginkgolide K
CAS:<p>Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity.</p>Fórmula:C20H22O9Pureza:99.44% - 99.72%Cor e Forma:SolidPeso molecular:406.38Momelotinib
CAS:<p>Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.</p>Fórmula:C23H22N6O2Pureza:97.47% - 99.56%Cor e Forma:SolidPeso molecular:414.46Clematichinenoside AR
CAS:<p>Clematichinenoside AR is anti-inflammatory, immunosuppressive, and combats arthritis via PI3K/Akt and TNF-α pathways.</p>Fórmula:C82H134O43Pureza:99.04% - 99.69%Cor e Forma:SolidPeso molecular:1807.92Tanespimycin
CAS:<p>Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1. High-Quality, Low-Cost!</p>Fórmula:C31H43N3O8Pureza:99.07% - 99.83%Cor e Forma:Dark Purple SolidPeso molecular:585.69Selenomethionine
CAS:<p>DL-Selenomethionine (SeMet) is a selenium analog of methionine, substituting sulfur with selenium, and can replace methionine in proteins.</p>Fórmula:C5H11NO2SePureza:98% - 99.95%Cor e Forma:Transparent Hexagonal Sheets Or Plates; Metallic Luster Of Crystals SolidPeso molecular:196.11Dimethyl fumarate
CAS:<p>Dimethyl fumarate (DMF) is an orally Nrf2 activator. Dimethyl fumarate has antimicrobial and anti-inflammatory activities. Cost-effective and quality-assured.</p>Fórmula:C6H8O4Pureza:90.51% - >99.99%Cor e Forma:White To Off-White Powder White Crystalline PowderPeso molecular:144.13ABT-751
CAS:<p>ABT-751 (E7010) has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.</p>Fórmula:C18H17N3O4SPureza:98.84% - 99.50%Cor e Forma:SolidPeso molecular:371.41GNE0877
CAS:<p>GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).</p>Fórmula:C14H16F3N7Pureza:98.01% - 99.97%Cor e Forma:SolidPeso molecular:339.32Autophinib
CAS:<p>Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and</p>Fórmula:C14H11ClN6O3Pureza:99.25% - 99.41%Cor e Forma:SolidPeso molecular:346.73Corynoxine
CAS:<p>Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla.</p>Fórmula:C22H28N2O4Pureza:96.83% - 99.93%Cor e Forma:SolidPeso molecular:384.47STO-609
CAS:<p>STO-609 inhibits CaM-KKα/KKβ (Ki: 80/15 ng/mL), is specific, cell-permeable, and targets Ca2+/calmodulin-dependent protein kinase kinase.</p>Fórmula:C19H10N2O3Pureza:97.14% - 98.8%Cor e Forma:SolidPeso molecular:314.29CHIR-99021
CAS:<p>View and buy CHIR-99021 from TargetMol.CHIR-99021 is a GSK-3α/β inhibitor.Cited in 10 publications.</p>Fórmula:C22H18Cl2N8Pureza:97.94% - ≥95%Cor e Forma:SolidPeso molecular:465.34Bergapten
CAS:<p>Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication.</p>Fórmula:C12H8O4Pureza:99.48% - ≥95%Cor e Forma:Needles From Alcohol; Soln In Sulfuric Acid Is Yellow-Gold Physical Description Grayish-White Micr°Crystalline Powder Or Yellow Fluffy Solid (Ntp 1992)Peso molecular:216.19
