Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1523 produtos de "Autofagia"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Diquat dibromide
CAS:Diquat dibromide is a water-soluble herbicide that causes rapid and profound systemic toxicity.Diquat dibromide induces acute kidney injury with high lethality.Fórmula:C12H12Br2N2Pureza:97.11% - 99%Cor e Forma:SolidPeso molecular:344.05Bacilotetrin C analogue
Bacilotetrin C analogue is a variant of Bacilotetrin C. It exhibits cytotoxicity against the triple-negative breast cancer cell line MDA-MB-231, with an IC50 of 0.48 μM. This compound induces autophagy (autophagy) in tumor cells and possesses antitumor activity.Fórmula:C44H76N6O10Cor e Forma:SolidPeso molecular:849.11Mito-fisetin mF3
Mito-fisetin mF3 (compund mito-fisetin mF3) is a potent anticancer and anti-aging therapeutic agent that targets mitochondria.Fórmula:C52H42IO7PCor e Forma:SolidPeso molecular:936.76PTX80
CAS:PTX80 is an antagonist of p62, with an IC50 value of 31.18 nM. It has been shown to reduce tumor volume in a HCT116 colorectal cancer mouse xenograft model.Fórmula:C26H26N4O3SCor e Forma:SolidPeso molecular:474.58TH152
CAS:TH152 is a general reversible ligand for LC3/GABARAP with a dissociation constant (KD) of 2 µM. LC3/GABARAP is a protein associated with autophagy.Fórmula:C22H23ClN4O4S2Cor e Forma:SolidPeso molecular:507.03DB1113
CAS:DB1113 is a bifunctional kinase degrader, targeting ABL1, ABL2, CDK4, MAPKs, and more for disease research.Fórmula:C59H68F3N13O6SCor e Forma:SolidPeso molecular:1144.31OsMo
OsMo is a lysosomal-targeting hNEU1 inhibitor utilized in the study of myocardial injury.Cor e Forma:Odour SolidcGMP-HTL
cGMP-HTL, an AUTAC, promotes K63-linked mitochondrial ubiquitination with a Cys-S-cGMP tag and target-specific warhead.Fórmula:C31H51ClN7O14PSCor e Forma:SolidPeso molecular:844.27YTK-105
CAS:YTK-105 is a ligand targeting autophagy that binds to p62.Fórmula:C16H19NO2Pureza:98.31%Cor e Forma:SoildPeso molecular:257.33PF-543
CAS:PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.Fórmula:C27H31NO4SPureza:99.02%Cor e Forma:SolidPeso molecular:465.6FDW028
CAS:FDW028 is a FUT8 inhibitor with antitumor activity that works by promoting B7-H3 lysosomal degradation through defucosylation and CMA pathways.Fórmula:C22H24N6OPureza:98.73% - 99.55%Cor e Forma:SoildPeso molecular:388.47Ref: TM-T77809
1mg66,00€5mg142,00€1mL*10mM (DMSO)158,00€10mg215,00€25mg358,00€50mg517,00€100mg707,00€HDAC6-IN-58
HDAC6-IN-58 (compound 24c) is a selective HDAC6 inhibitor with IC50 values of 9.5 nM for HDAC6 and 7374.5 nM for HDAC1. It enhances tubulin acetylation, exhibits antiproliferative effects, and induces autophagy (autophagy).Cor e Forma:Odour SolidTigecycline mesylate
CAS:Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.Fórmula:C30H43N5O11SPureza:98%Cor e Forma:SolidPeso molecular:681.75(1R)-cis-Bifenthrin
CAS:kappa-Bifenthrin is a pyrethroid insecticide.Fórmula:C23H22ClF3O2Pureza:98%Cor e Forma:SolidPeso molecular:422.87(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH
(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), consisting of Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit the CRBN protein and serves as a crucial intermediate for synthesizing complete PROTAC molecules.Fórmula:C27H32N8O5Peso molecular:548.24957Flavopiridol
CAS:Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.Fórmula:C21H20ClNO5Pureza:97.74% - 99.99%Cor e Forma:SolidPeso molecular:401.84BRD4 degrader-5
BRD4 degrader-5 (Compound 23) is a protein degrader utilizing a hydrophobic tag (HyTag) that targets BRD4 for degradation through endoplasmic reticulum stress and the autophagy-lysosome pathway (DC50 = 24.7 μM). It also inhibits the proliferation of 4T1 cancer cells, with an IC50 of 20.6 μM.Fórmula:C35H42ClN7O2SCor e Forma:SolidPeso molecular:660.27PDEδ autophagic degrader 1
PDEδ autophagic degrader 1 (compound 12c) is an autophagosome-tethering compound (ATTEC) and a potent autophagic degrader of PDEδ. This compound effectively reduces PDEδ protein levels through lysosome-mediated autophagy without affecting PDEδ mRNA expression. Additionally, PDEδ autophagic degrader 1 inhibits the growth of KRAS mutant pancreatic cancer cells.Fórmula:C41H42Br2IN7O5Peso molecular:997.06589STO-609 acetate
CAS:STO-609 acetate is selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki: 80/15 ng/ml, for CaM-KKα/KKβ); competes for theFórmula:C19H10N2O3·C2H4O2Pureza:99.75%Cor e Forma:SolidPeso molecular:374.35Autophagy/REV-ERB-IN-1 hydrochloride
Autophagy/REV-ERB-IN-1 hydrochloride (Compound 24) is a dual inhibitor of autophagy and REV-ERB with anticancer properties. It enhances the efficacy of autophagy blockade and increases cytotoxicity against cancer cells. Autophagy/REV-ERB-IN-1 (hydrochloride) is applicable in melanoma research.Fórmula:C24H32Cl2F2N2Peso molecular:456.19106Insecticidal agent 364
CAS:Insecticidal agent 364 is a selective small molecule inhibitor of rapamycin kinase target protein.
Fórmula:C23H18N4O3SPureza:99.81%Cor e Forma:SolidPeso molecular:430.48Biotin-11-dCTP
Biotin-11-dCTP is a fluorescent dye for DNA labeling [1] .Fórmula:C28H43Li3N7O16P3SCor e Forma:SolidPeso molecular:879.49(1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-(1R,4r)-cyclohexane-NH-Boc
(1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. This compound serves as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in the synthesis of complete PROTAC molecules.Fórmula:C31H41N5O6Peso molecular:579.30568BVT173187
CAS:BVT173187 is a neutrophil formyl peptide receptors (FPR1) inhibitor.Fórmula:C14H10Cl3NO2Cor e Forma:SolidPeso molecular:330.59Manzamine A hydrochloride
CAS:Manzamine A hydrochloride: oral beta-carboline inhibiting GSK-3β & CDK-5; blocks autophagy in cancer; antimalarial; fights HSV-1.Fórmula:C36H45ClN4OCor e Forma:SolidPeso molecular:585.23Cy3-dCTP
Cy3-dCTP, a fluorescent cyanine-dye-labeled nucleotide triphosphate, serves as a DNA imaging probe.Fórmula:C43H51Li4N6O20P3S2Cor e Forma:SolidPeso molecular:1156.71ALX 40-4C
CAS:ALX40-4C is a small peptide inhibitor of the chemokine receptor CXCR4 that can inhibit X4 strains of HIV-1.Fórmula:C56H113N37O10Pureza:98%Cor e Forma:SolidPeso molecular:1464.74Autocamtide 2, amide
Autocamtide-2, an amide, is a selective CaMKII substrate for CAMK family assays at 100 μM.Fórmula:C65H119N23O19Pureza:98%Cor e Forma:SolidPeso molecular:1526.79(S)-Sitagliptin phosphate
CAS:(S)-Sitagliptin phosphate, less active enantiomer, is a potent DPP4 inhibitor with an IC50 of 19 nM.Fórmula:C16H18F6N5O5PCor e Forma:SolidPeso molecular:505.314Cytochalasin E
CAS:Cytochalasin E, from Aspergillus, disrupts actin, inhibits angiogenesis, and halts tumor growth.Fórmula:C28H33NO7Pureza:98%Cor e Forma:Crystals From Acetone-Hexane White PowderPeso molecular:495.56Cisatracurium besylate
CAS:Cisatracurium besylate (51W89) is a nondepolarizing skeletal muscle relaxant for intravenous administration.Fórmula:C53H72N2O12·2C6H5O3SPureza:97.89% - 99.85%Cor e Forma:White Or White Powder CategoryPeso molecular:1243.48Ref: TM-T1459
10mg44,00€1mL*10mM (DMSO)57,00€25mg66,00€50mg105,00€100mg170,00€200mg250,00€500mg427,00€Autophagy/REV-ERB-IN-1
Autophagy/REV-ERB-IN-1 is a dual inhibitor of autophagy and REV-ERB. It exhibits antitumor activity, with a CC50 value of 2.3 μM in BTB-474 cells.Fórmula:C24H30F2N2Peso molecular:384.23771D-CopA3
CAS:D-CopA3 is an inhibitor of MDM2 and an activator of the p53 signaling pathway. It exhibits cytotoxicity in colorectal cancer cells HCT-116, LoVo, and RKO with IC50 values of 15-18 μM and induces JNK/Beclin-1 mediated autophagy. D-CopA3 downregulates the expression of the cell cycle inhibitor protein p21Cip1/Waf1, enhances mucosal barrier function, and reduces infiltration of inflammatory mediators. It shows anti-inflammatory properties in mouse models of acute enteritis induced by C. difficile toxin A and chronic colitis induced by DSS. Additionally, D-CopA3 demonstrates antitumor activity in a mouse HCT-116 xenograft model.Fórmula:C96H184N30O18S2Cor e Forma:SolidPeso molecular:2110.81(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH
(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH is a conjugate combining an E3 ligase ligand with a linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding Linker. This compound functions as a Cereblon ligand, recruiting the CRBN protein and serving as a crucial intermediate in the synthesis of complete PROTAC molecules.Fórmula:C29H36N8O6Peso molecular:592.27578(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc
(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. It acts as a Cereblon ligand, recruiting CRBN proteins, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.
Fórmula:C30H39N5O6Peso molecular:565.29003CXCR4-IN-3
CXCR4-IN-3 (compound XVI) is an orally active inhibitor targeting the inflammation-related receptor CXCR4, with an IC50 of 3.2 nM. It exhibits potent anti-chemotactic effects, with an inhibition rate of 79.19±2.33%. Additionally, CXCR4-IN-3 possesses anti-inflammatory properties and can be utilized in research on IBD (inflammatory bowel disease).
CXCL8 (54-72)
CXCL8 (54-72) is a C-terminal peptide segment of the chemokine CXCL8. This peptide features a long, highly positively charged C-terminal region that interacts with the negative charges on glycosaminoglycans (GAG) to facilitate binding. CXCL8 (54-72) inhibits neutrophil adhesion and migration, as well as adhesion to endothelial cells. It is useful in studying the role of chemokines in inflammatory responses.Fórmula:C107H173N33O30Peso molecular:2400.30261Balixafortide TFA (1051366-32-5 free base)
Balixafortide TFA is a selective CXCR4 antagonist with IC50 < 10nM, over 1000x preference for CXCR4, and blocks β-arrestin and calcium flux.Fórmula:C82H113N22F3O23S2Pureza:98%Cor e Forma:SolidPeso molecular:1896.05Desethyl chloroquine
CAS:Desethyl chloroquine (Monodesethylchloroquine) is a major metabolite of Chloroquine which is a TLR inhibitor. Desethyl chloroquine shows antiplasmodic activity.Fórmula:C16H22ClN3Pureza:99.56%Cor e Forma:SolidPeso molecular:291.82(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3
(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3 is an E3 ligase ligand-linker conjugate (E3LigaseLigand-Linker Conjugates) composed of thalidomide and its corresponding linker. This compound functions as a Cereblon ligand, facilitating the recruitment of CRBN protein, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.Fórmula:C33H42N8O7Peso molecular:662.31765Antitumor agent-133
Antitumor agent-133 (compound 4d) is a bis-santine derivative that demonstrates activity against Huh1 (IC50 = 17.13 μM) and Huh7 (IC50 = 8.27 μM). It induces autophagy and inhibits tumor growth by modulating the levels of the LC3BII, ATG5, and p62 proteins.Fórmula:C27H24Br2N4O8Peso molecular:689.99609Valproic acid sodium salt
CAS:Sodium valproate is an anti-epileptic, boosting brain GABA levels and possibly affecting potassium channels for membrane stability.Fórmula:C8H15NaO2Pureza:98% - 99.78%Cor e Forma:White PowderPeso molecular:166.2Hoechst 33342 analog trihydrochloride
CAS:Hoechst 33342 analog trihydrochloride, an analog of Hoechst 33342, serves as a fluorochrome by binding to the minor groove of DNA, facilitating theFórmula:C32H38Cl3N7Cor e Forma:SolidPeso molecular:627.05CCR7 antagonist 1
CCR7 antagonist1 (30c) functions as a dual antagonist, targeting CXCR2 with an IC50 of 11.02 μM and CCR7 with an IC50 of 0.43 μM.Fórmula:C13H22N6OSPeso molecular:310.15758RCP168
RCP168 is a highly selective and potent CXCR4 receptor antagonist with an IC50 of 5 nM. It exhibits superior capacity to inhibit HIV-1 (Human Immunodeficiency Virus type 1) from entering host cells via the CXCR4 receptor compared to natural chemokines. RCP168 suppresses HIV-1 infection by blocking viral binding sites or inducing receptor internalization. It can be utilized in research to study interactions between the CXCR4 receptor and other chemokine receptors.Fórmula:C365H585N105O95S5Peso molecular:8119.27766Deoxy-thalidomide-Pip-C-PIP-boc
CAS:Deoxy-thalidomide-Pip-C-PIP-boc, a conjugate of E3 ligase ligand and linker, comprises Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in synthesizing complete PROTAC molecules.Fórmula:C28H39N5O5Cor e Forma:SolidPeso molecular:525.64Desfluoro-ezetimibe
CAS:Desfluoro-ezetimibe: a defluorinated ezetimibe impurity; a stable, potent cholesterol blocker and Nrf2 activator.Fórmula:C24H22FNO3Pureza:98%Cor e Forma:SolidPeso molecular:391.43Polyphyllin G
CAS:Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas.Fórmula:C51H84O22Pureza:98%Cor e Forma:SolidPeso molecular:1049.21EB-42486
CAS:EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.Fórmula:C22H22N8OPureza:99.53%Cor e Forma:SolidPeso molecular:414.46Ref: TM-T39972
1mg66,00€2mg87,00€5mg147,00€1mL*10mM (DMSO)161,00€10mg215,00€25mg388,00€50mg577,00€100mg820,00€200mg1.099,00€N6-Isopentenyladenosine
CAS:N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity.Fórmula:C15H21N5O4Pureza:97.13% - 99.69%Cor e Forma:SolidPeso molecular:335.36ACKR3 agonist 1
ACKR3 agonist 1 (compound 27), exhibiting selective agonistic properties for ACKR3 (EC 50 =69 nM, E max =82%), demonstrates the capability to inhibit platelet aggregation and shows potential in mitigating platelet-mediated thrombosis. This compound is characterized by its metabolic stability and non-cytotoxic nature.Fórmula:C25H30N2OSCor e Forma:SolidPeso molecular:406.58CXCR4 antagonist 2
CAS:CXCR4 antagonist 2 is a CXCR4 antagonist with an IC 50 value of 47 nM.Fórmula:C25H36N6Cor e Forma:SolidPeso molecular:420.605Fumagilin-105
CAS:Fumagilin-105, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62 and exhibits a DC50 of 0.7 μM against MetAP2 in HEK293 cells.Fórmula:C46H60N2O9Cor e Forma:SolidPeso molecular:784.98CXCL-CXCR1/2-IN-1
CAS:CXCL-CXCR1/2-IN-1 is an ELR+CXCL-CXCR1/2 pathway inhibitor with anticancer activity and can be used in the study of cardiovascular disease.Fórmula:C14H8Cl2N4O3SPureza:99.4%Cor e Forma:SoildPeso molecular:383.21Bam 12P
CAS:Bam 12P is a Pro-Met-enkephalin precursor that is isolated from the bovine adrenal medulla.Fórmula:C62H97N21O16SPureza:98%Cor e Forma:SolidPeso molecular:1424.64SDF-1α (human)
CAS:SDF-1α (human) serves as a chemotactic agent for mononuclear cells through its interaction with the CXCR4 receptor, facilitating critical biological processesFórmula:C356H578N106O93S4Pureza:98%Cor e Forma:SolidPeso molecular:7959.34TRAF6 peptide
CAS:TRAF6 peptide inhibits TRAF6-p62, blocks TrkA ubiquitination, and shows promise for neurological disease research.Fórmula:C145H238N34O44Cor e Forma:SolidPeso molecular:3161.64LC3in-C42
LC3in-C42 is a covalent inhibitor of LC3A/B and autophagy active within cells. Selectively inhibiting the binding of P62 to LC3A/B both in vitro and at the cellular level, LC3in-C42 functions similarly to D5 and is effective at lower concentrations.Cor e Forma:Odour SolidSQA1
CAS:SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.Fórmula:C22H26N4O5Cor e Forma:SolidPeso molecular:426.47Syntide 2
CAS:Syntide-2 is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII; Km = 12 µM).Fórmula:C68H122N20O18Pureza:98%Cor e Forma:Lyophilized SolidPeso molecular:1507.82EthD-III
EthD-III: red fluorescent nucleic acid probe; stains dead cells; binds to DNA in cells with damaged membranes; Ex/Em=530/645 nm.Fórmula:C51H62Cl5N9Cor e Forma:SolidPeso molecular:978.36PHTPP-1304
CAS:PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ERβ (DC50: ~2 nM, HEK293T). Additionally, PHTPP-1304 facilitates the formation of p62+ERβ+ puncta in a dose-dependent manner, influencing autophagic flux.Fórmula:C51H50F6N4O7Cor e Forma:SolidPeso molecular:944.96Polyphemusin II-Derived Peptide
CAS:T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.Fórmula:C90H141N33O18S2Cor e Forma:SolidPeso molecular:2037.42Peptide R
CAS:Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.Fórmula:C39H59N13O8S2Cor e Forma:SolidPeso molecular:902.1Erlotinib-13C6
CAS:Erlotinib-13C6 (CP-358774-13C6), a 13C-labeled direct EGFR inhibitor, IC50: 2 nM.Fórmula:C22H23N3O4Cor e Forma:SolidPeso molecular:399.397(R)-Hydroxychloroquine phosphate
CAS:(R)-Hydroxychloroquine ((R)-HCQ) phosphate is an isomer of Hydroxychloroquine. It inhibits insulin-metabolizing enzymes in the cytosolic fraction of liver homogenates in both healthy and diabetic rats.Fórmula:C18H28ClN3O5SCor e Forma:SolidPeso molecular:433.95Microcolin H
CAS:Microcolin H, a marine lipopeptide and phosphatidylinositol transfer protein ligand, targets PITPα/β. It enhances the conversion of LC3I to LC3II and decreases p62 levels in cancer cells, inducing autophagy cell death (Autophagy). Furthermore, Microcolin H effectively inhibits tumor growth and exhibits anti-proliferative activity in nude mouse subcutaneous tumor models [1].Fórmula:C38H63N5O9Cor e Forma:SolidPeso molecular:733.93PI3K-AKT-mTOR Compound Library
A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved withCor e Forma:Odour SolidRef: TM-L1300
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarOleanolic acid-d3
CAS:Oleanolic acid-d3 is the deuterated form of Oleanolic Acid. Oleanolic Acid (Oleanic acid) is a natural compound known for its anticancer properties.Fórmula:C30H48O3Cor e Forma:SolidPeso molecular:459.72Atorvastatin Sodium
CAS:Atorvastatin Sodium (Lipitor) is a competitive inhibitor of HMG-CoA reductase and increases the expression of low density lipoprotein (LDL) receptors onFórmula:C33H34FN2NaO5Pureza:99.88% - >99.99%Cor e Forma:SolidPeso molecular:580.63Beclin1-Bcl-2 interaction inhibitor 1
Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].Cor e Forma:Odour SolidPBA-1105b
CAS:PBA-1105b, a longer PEGylated derivative of PBA-1105, is an autophagy-targeting chimeric compound (AUTOTAC) that can induce self-oligomerization of p62. It enhances the autophagic flux of Ub-bound aggregates.Fórmula:C47H64N2O10Cor e Forma:SolidPeso molecular:817.02CX4338
CAS:CX4338 is a CXCL8-mediated chemotaxis inhibitor.Fórmula:C22H24N2OSCor e Forma:SolidPeso molecular:364.50Olaparib-d5
CAS:Olaparib D5 is a deuterium labeled Olaparib. Olaparib is a potent and oral inhibitor of PARP.Fórmula:C24H23FN4O3Pureza:98%Cor e Forma:SolidPeso molecular:439.49Aliskiren
CAS:Aliskiren (CGP 60536) is a renin inhibitor (IC50: 1.5 nM) with antihypertensive activity and is used in the treatment of various cardiovascular diseases.Fórmula:C30H53N3O6Pureza:97.02%Cor e Forma:SolidPeso molecular:551.76Ref: TM-T22233
1mg34,00€5mg70,00€1mL*10mM (DMSO)85,00€10mg100,00€25mg141,00€50mg177,00€100mg268,00€200mg398,00€Heparin Lithium
CAS:Heparin Lithium salt is an anticoagulant that reversibly binds to ATIII and enhances its inhibitory effect on coagulation factor(thrombin and factor Xa).Fórmula:C14H25NO20S3Cor e Forma:SolidPeso molecular:623.01321Omeprazole-d3
CAS:Omeprazole D3 is deuterium labeled Omeprazole. Omeprazole is a proton pump inhibitor (PPI)Fórmula:C17H19N3O3SPureza:98%Cor e Forma:SolidPeso molecular:348.44Imatinib D4
CAS:Imatinib D4 is a deuterium-labeled Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, PDGFR, v-Abl, and c-kit kinase activity.Fórmula:C29H31N7OPureza:98%Cor e Forma:SolidPeso molecular:497.63Bexarotene D4
CAS:Bexarotene D4 is a deuterium-labeled Bexarotene (LGD1069). Bexarotene is a selective RXR agonist used in the treatment of cutaneous T-cell lymphoma.Fórmula:C24H28O2Pureza:98%Cor e Forma:SolidPeso molecular:352.5Trimetazidine
CAS:Trimetazidine is a antianginal agent that selectively inhibits the mitochondrial enzyme LC 3-KAT, thereby preventing β-oxidation of free fatty acids.Fórmula:C14H22N2O3Pureza:99.9%Cor e Forma:Hite Or Off-White Crystalline PowderPeso molecular:266.34Binimetinib-13C-d3
Binimetinib-13C-d3 (MEK162) is an isotopically labelled compound of Binimetinib.Binimetinib (ARRY-162) is a selective MEK1/2 inhibitor melanoma.Fórmula:C17H15BrF2N4O3Cor e Forma:SolidPeso molecular:445.24LG100268
CAS:LG100268 is a selective, and oral RXR agonist，inducing transcriptional activation in adipocytes; inhibits keratin 17 increases PD-L1 expression.Fórmula:C24H29NO2Pureza:99.83%Cor e Forma:SolidPeso molecular:363.49Enzalutamide-d3
CAS:Enzalutamide D3 is a deuterium labeled Enzalutamide . Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells.Fórmula:C21H16F4N4O2SCor e Forma:SolidPeso molecular:467.45TRAF6 peptide TFA
TRAF6 peptide TFA, a specific inhibitor of the TRAF6-p62 interaction, significantly inhibits NGF-dependent ubiquitination of TrkA.Fórmula:C145H238N34O44·xC2HF3O2Pureza:98%Cor e Forma:SolidPeso molecular:3161.64 (free acid)Isoniazid-d4
CAS:Isoniazid-d4 is a deuterium isotope marker for Isoniazid.Isoniazid is a prodrug that must be activated by the bacterial peroxidase KatG, and is bactericidal.Fórmula:C6H3D4N3OCor e Forma:SolidPeso molecular:141.16Atorvastatin hemicalcium salt (Standard)
CAS:Atorvastatin hemicalcium salt (Standard) is the standard substance of Atorvastatin hemicalcium salt, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Atorvastatin hemicalcium salt (Atorvastatin Calcium) is an HMG-CoA reductase inhibitor with oral activity. Atorvastatin hemicalcium salt is used to lower cholesterol.Fórmula:C33H34FN2O5CaCor e Forma:White Crystalline PowderPeso molecular:577.67Nilotinib-d6
CAS:Nilotinib D6 is a deuterium labeled Nilotinib which is an orally available inhibitor of Bcr-Abl tyrosine kinase ,and with antineoplastic activity.Fórmula:C28H22F3N7OPureza:98%Cor e Forma:SolidPeso molecular:535.55Rapamycin-d3
CAS:Rapamycin-d3 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific inhibitor of mTOR(IC50 of 0.1 nM in HEK293 cells).Fórmula:C51H79NO13Pureza:98%Cor e Forma:SolidPeso molecular:917.19Rapalink-1
CAS:Rapalink-1 is an mTOR inhibitor that inhibits the mTORC1-4E-BP1 pathway in mice.Fórmula:C91H138N12O24Pureza:98%Cor e Forma:SolidPeso molecular:1784.14ACT-1004-1239
CAS:ACT-1004-1239 is a CXCR7 antagonist with immunomodulatory and myelination-promoting effects, used for research on inflammatory demyelinating diseases.
Fórmula:C27H28F2N6O3Pureza:98.31%Cor e Forma:SolidPeso molecular:522.55Erlotinib-d6 hydrochloride
CAS:Erlotinib Hydrochloride inhibits purified EGFR kinase with an IC50 of 2 nM. Erlotinib D6 hydrochloride a deuterium labeled Erlotinib Hydrochloride.Fórmula:C22H24ClN3O4Pureza:98%Cor e Forma:SolidPeso molecular:435.93Ponatinib-d8
CAS:Ponatinib D8 is a deuterium-enriched, oral multi-kinase inhibitor (Abl, PDGFRα, VEGFR2, FGFR1, Src; IC50s: 0.37-5.4 nM).Fórmula:C29H27F3N6OPureza:98%Cor e Forma:SolidPeso molecular:540.61KN-93 hydrochloride
CAS:KN-93 hydrochloride is a reversible, competitive CaMKII inhibitor inducing reversible G1 arrest, supporting cell cycle and signaling pathway studies.Fórmula:C26H30Cl2N2O4SPureza:99.99%Cor e Forma:SolidPeso molecular:537.5Silibinin-d3
Silibinin-d3 is the deuterium-labelled compound of silibinin, used for isotope tracing. Silibinin inhibit cancer cell proliferation and migration.Fórmula:C25H22O10Cor e Forma:SolidPeso molecular:485.46Levomepromazine
CAS:Levomepromazine (Methotrimeprazine) is a Ca2+ release inducer with antiviral, anti-inflammatory, neuroprotective, sedative, and anti-nociceptive activities.Fórmula:C19H24N2OSPureza:99.15%Cor e Forma:SolidPeso molecular:328.47ATI-2341
CAS:ATI-2341, pepducin targeting the CXCR4, is an allosteric agonist activating the Gi to promote inhibition of cAMP production and induce calcium mobilization.Fórmula:C104H178N26O25S2Cor e Forma:SolidPeso molecular:2256.82Rosuvastatin D3 Sodium
CAS:Rosuvastatin D3 Sodium is deuterium labeled Rosuvastatin, which is a competitive HMG-CoA reductase inhibitor(IC50 of 11 nM).Fórmula:C22H24D3FN3NaO6SPureza:98%Cor e Forma:SolidPeso molecular:506.54Anti-LRRK2 Antibody (1C773)
Anti-LRRK2 Antibody (1C773) is an antibody targeting LRRK2. Anti-LRRK2 Antibody (1C773) can be used in ELISA, IHC.Cor e Forma:Odour LiquidMotixafortide
CAS:Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).Fórmula:C97H144FN33O19S2Pureza:98%Cor e Forma:SolidPeso molecular:2159.52PS372424 hydrochloride
CAS:PS372424 hydrochloride,CXCR3 agonist. Anti-inflammatory. Inhibits T-cell migration.Fórmula:C33H45ClN6O4Pureza:95.03%Cor e Forma:SolidPeso molecular:625.2
