Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1424 produtos de "Autofagia"
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Biotin-11-dCTP
<p>Biotin-11-dCTP is a fluorescent dye for DNA labeling [1] .</p>Fórmula:C28H43Li3N7O16P3SCor e Forma:SolidPeso molecular:879.49Bacilotetrin C analogue
<p>Bacilotetrin C analogue is a variant of Bacilotetrin C. It exhibits cytotoxicity against the triple-negative breast cancer cell line MDA-MB-231, with an IC50 of 0.48 μM. This compound induces autophagy (autophagy) in tumor cells and possesses antitumor activity.</p>Fórmula:C44H76N6O10Cor e Forma:SolidPeso molecular:849.11Cy3-dCTP
<p>Cy3-dCTP, a fluorescent cyanine-dye-labeled nucleotide triphosphate, serves as a DNA imaging probe.</p>Fórmula:C43H51Li4N6O20P3S2Cor e Forma:SolidPeso molecular:1156.71(S)-Sitagliptin phosphate
CAS:<p>(S)-Sitagliptin phosphate, less active enantiomer, is a potent DPP4 inhibitor with an IC50 of 19 nM.</p>Fórmula:C16H18F6N5O5PCor e Forma:SolidPeso molecular:505.314Acetazolamide
CAS:<p>Acetazolamide (Diamox) is a Carbonic Anhydrase Inhibitor. The mechanism of action of acetazolamide is as a Carbonic Anhydrase Inhibitor. The chemical classification of acetazolamide is Sulfonamides.</p>Fórmula:C4H6N4O3S2Pureza:99.61% - 99.94%Cor e Forma:Crystals From Water 1992)Peso molecular:222.25D-CopA3
CAS:<p>D-CopA3 is an inhibitor of MDM2 and an activator of the p53 signaling pathway. It exhibits cytotoxicity in colorectal cancer cells HCT-116, LoVo, and RKO with IC50 values of 15-18 μM and induces JNK/Beclin-1 mediated autophagy. D-CopA3 downregulates the expression of the cell cycle inhibitor protein p21Cip1/Waf1, enhances mucosal barrier function, and reduces infiltration of inflammatory mediators. It shows anti-inflammatory properties in mouse models of acute enteritis induced by C. difficile toxin A and chronic colitis induced by DSS. Additionally, D-CopA3 demonstrates antitumor activity in a mouse HCT-116 xenograft model.</p>Fórmula:C96H184N30O18S2Cor e Forma:SolidPeso molecular:2110.81MeCY5-NHS ester triethylamine
<p>MeCY5-NHS ester (potassium) is a reactive dye optimized for labeling proteins and nucleic acids [1].</p>Fórmula:C42H56N4O10S2Cor e Forma:SolidPeso molecular:841.04CXCR4 antagonist 1
CAS:<p>CXCR4 antagonist 1 is a potent inhibitor of the CXCR4 receptor, with notable anti-HIV activity.</p>Fórmula:C27H43N7Cor e Forma:SolidPeso molecular:465.69MW-150 hydrochloride
CAS:<p>MW-150 hydrochloride is a selective p38α MAPK inhibitor with a 101 nM Ki, offering good CNS penetration and oral bioavailability.</p>Fórmula:C24H24ClN5Cor e Forma:SolidPeso molecular:417.93DMTr-4'-CF3-5-Me-U-CED phosphoramidite
<p>DMTr-4'-CF3-5-Me-U-CED is a dye for oligonucleotide labeling in RNA research.</p>Fórmula:C42H50F3N4O8PCor e Forma:SolidPeso molecular:826.84SJFδ
CAS:<p>SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1].</p>Fórmula:C62H63F2N7O12SPureza:98%Cor e Forma:SolidPeso molecular:1168.27KRH-3955 hydrochloride
CAS:<p>KRH-3955 hydrochloride is an orally available CXCR4 blocker with IC50 of 0.61 nM and EC50 of 0.3-1.0 nM against X4 HIV-1.</p>Fórmula:C28H48Cl3N7Cor e Forma:SolidPeso molecular:589.09(3R,5S)-Fluvastatin
CAS:<p>(3R,5S)-Fluvastatin, a synthetic HMG-CoA reductase inhibitor (IC50: 8 nM), activates Nrf2 for antioxidant defense.</p>Fórmula:C24H26FNO4Cor e Forma:SolidPeso molecular:411.47SG31
<p>SG31 is a potent activator of autophagy, exerting its effects through the AMPK/ULK1-dependent pathway.</p>Fórmula:C26H37N6O8PCor e Forma:SolidPeso molecular:592.58CXCL-CXCR1/2-IN-1
CAS:<p>CXCL-CXCR1/2-IN-1 is an ELR+CXCL-CXCR1/2 pathway inhibitor with anticancer activity and can be used in the study of cardiovascular disease.</p>Fórmula:C14H8Cl2N4O3SPureza:99.4%Cor e Forma:SoildPeso molecular:383.21Chlorotris(triphenylphosphine)copper
CAS:<p>Chlorotris (triphenylphosphine) copper (CuCl(TPP)₃) is a metal complex that targets DNA. Through non-covalent interactions of its copper (I) center, such as groove-binding, it affects DNA function and exhibits inhibitory activity against bacteria, fungi, and tumor cells. Chlorotris (triphenylphosphine) copper holds potential for research as an antimicrobial, antitumor, and antioxidant agent.</p>Fórmula:C54H45ClCuP3Cor e Forma:SolidPeso molecular:885.86Hexidium iodide
CAS:<p>Hexidium iodide fluoresces, stains mammalian cells & gram-positive bacteria, and binds to DNA with EDTA. Excitation/emission: ~518/600 nm.</p>Fórmula:C25H28IN3Cor e Forma:SolidPeso molecular:497.424CCR7 antagonist 1
<p>CCR7 antagonist1 (30c) functions as a dual antagonist, targeting CXCR2 with an IC50 of 11.02 μM and CCR7 with an IC50 of 0.43 μM.</p>Fórmula:C13H22N6OSPeso molecular:310.15758H1k
<p>H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that downregulates the expression of cell cycle protein B1.</p>Fórmula:C27H22N2OPureza:98.13%Cor e Forma:SoildPeso molecular:390.48Valproic acid sodium salt
CAS:<p>Sodium valproate is an anti-epileptic, boosting brain GABA levels and possibly affecting potassium channels for membrane stability.</p>Fórmula:C8H15NaO2Pureza:98.43% - 99.78%Cor e Forma:White PowderPeso molecular:166.2
