Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1428 produtos de "Autofagia"
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GSK343
CAS:<p>GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against</p>Fórmula:C31H39N7O2Pureza:98% - 99.9%Cor e Forma:SolidPeso molecular:541.69Neflamapimod
CAS:<p>Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.</p>Fórmula:C19H9Cl2F2N3OSPureza:97.88% - 99.75%Cor e Forma:SolidPeso molecular:436.26Turofexorate Isopropyl
CAS:<p>Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM</p>Fórmula:C25H24F2N2O3Pureza:98.55% - 99.73%Cor e Forma:SolidPeso molecular:438.47LYN-1604 dihydrochloride
CAS:<p>LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.</p>Fórmula:C33H45Cl4N3O2Pureza:98.95% - 99.92%Cor e Forma:SolidPeso molecular:657.54Salvianolic acid B
CAS:<p>Salvianolic acid B (Dan Shen Suan B) is a water-soluble antioxidant from Salvia miltiorrhiza extract with antiplatelet aggregation and antithrombotic effects.</p>Fórmula:C36H30O16Pureza:99.75% - 99.86%Cor e Forma:Yellow SolidPeso molecular:718.61SGI-1776
CAS:<p>SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.</p>Fórmula:C20H22F3N5OPureza:99.3% - >99.99%Cor e Forma:SolidPeso molecular:405.42OSU-T315
CAS:<p>OSU-T315 (OSU-T315 (1,5-regioisomer)) (1,5-regioisomer) is a ILK inhibitor.</p>Fórmula:C30H30F3N5OPureza:98.69%Cor e Forma:SolidPeso molecular:533.59Milciclib
CAS:<p>Milciclib (PHA-848125) is a potent CDK2 inhibitor with a 45 nM IC50, selective over CDK1/2/4/5/7. In Phase 2 trials.</p>Fórmula:C25H32N8OPureza:99.28%Cor e Forma:SolidPeso molecular:460.57STF-62247
CAS:<p>STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively.</p>Fórmula:C15H13N3SPureza:99.6% - 99.67%Cor e Forma:SolidPeso molecular:267.35Fenretinide
CAS:<p>Fenretinide (4-HPR) is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.</p>Fórmula:C26H33NO2Pureza:98% - 99.68%Cor e Forma:Yellow PowderPeso molecular:391.55CD437
CAS:<p>CD437 (AHPN) is a specifc Retinoic Acid Receptor γ (RARγ) agonist.</p>Fórmula:C27H26O3Pureza:98.92% - 99.63%Cor e Forma:SolidPeso molecular:398.49Ixazomib
CAS:<p>Ixazomib (MLN2238) is a boron-based peptide proteasome inhibitor targeting β5 site (IC50: 3.4 nM), also affecting β1 and β2 sites.</p>Fórmula:C14H19BCl2N2O4Pureza:98% - 98.92%Cor e Forma:SolidPeso molecular:361.03FERULIC ACID METHYL ESTER
CAS:<p>FERULIC ACID METHYL ESTER (Methyl ferulate) is a hydroxycinnamic acid that is abundant in plants. FERULIC ACID METHYL ESTER has antioxidant activities.</p>Fórmula:C11H12O4Pureza:99.66% - 99.95%Cor e Forma:SolidPeso molecular:208.21SBE13 Hydrochloride
CAS:<p>SBE13 Hydrochloride (SBE 13 HCl) is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3.</p>Fórmula:C24H28Cl2N2O4Pureza:99.00% - ≥95%Cor e Forma:SolidPeso molecular:479.4Oxyphenisatin acetate
CAS:<p>Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468.</p>Fórmula:C24H19NO5Pureza:98% - 99.35%Cor e Forma:SolidPeso molecular:401.41LRRK2-IN-1
CAS:<p>LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.</p>Fórmula:C31H38N8O3Pureza:98% - 98.82%Cor e Forma:SolidPeso molecular:570.69Tenovin-6 Hydrochloride
CAS:<p>Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.</p>Fórmula:C25H35ClN4O2SPureza:99.36%Cor e Forma:SolidPeso molecular:491.09Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Fórmula:C9H6O4Pureza:97.47% - 99.8%Cor e Forma:SolidPeso molecular:178.14H-89 dihydrochloride
CAS:<p>H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).</p>Fórmula:C20H20BrN3O2S·2HClPureza:98.22% - >99.99%Cor e Forma:SolidPeso molecular:519.28PD98059
CAS:<p>PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.</p>Fórmula:C16H13NO3Pureza:98.63% - >99.99%Cor e Forma:Yellow SolidPeso molecular:267.28
