Autofagia

<p>Fluvastatin (XU-62320) is an HMG-CoA reductase inhibitor used to lower plasma cholesterol levels and prevent cardiovascular disease.</p>

<p>Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.</p>

<p>mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer with antiviral and antitumor activity for the study of non-small cell lung cancer.</p>

<p>ML 145 is a selective antagonist of GPR35/CXCR8 (IC50/EC50 of 20.1 nM)</p>

<p>SB 203580 hydrochloride (Adezmapimod hydrochloride) is a p38 MAPK inhibitor that induces mitochondrial autophagy and cytosolic autophagy.</p>

<p>Ketanserin tartrate (KJK-945 tartrate) is a 5-HT2A receptor and α1-adrenergic receptor antagonist for the study of systemic sclerosis.</p>

<p>Chenodeoxycholic Acid sodium salt (CDCA sodium salt) is a bile acid in humans that activates the nuclear receptor FXR, rescues axonal degeneration of induced pluripotent stem cell-derived neurons in patients with spastic paraplegia type 5 and cerebral xanthomatosis, and can be used to study pancreatic necrosis.</p>

<p>Meloxicam (Metacam) is a Nonsteroidal Anti-inflammatory Drug.</p>

<p>740 Y-P (740YPDGFR) is a PI3K activator with cell permeability,binds GST fusion proteins containing the N-and C-terminal SH2 domains of p85. Low-Cost!</p>

<p>H-89 is a PKA inhibitor, a candidate cardioprotectant, induces spatial learning impairment in rats, and can be used to study myocardial infarction.</p>

<p>Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.</p>

<p>Latrepirdine dihydrochloride (Dimebolin dihydrochloride) is an orally active, and neuroactive antagonist of multiple drug targets.</p>

<p>Irinotecan-d10 Hydrochloride is a deuterated compound of Irinotecan Hydrochloride. Irinotecan Hydrochloride has a CAS number of 100286-90-6. Irinotecan Hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.</p>

<p>Tigecycline-d9 is a deuterated compound of Tigecycline. Tigecycline has a CAS number of 220620-09-7. Tigecycline is a broad-spectrum glycylcycline antibiotic derived from tetracycline. Tigecycline binds to the 30S ribosomal subunit, thereby interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome complex.</p>

<p>Rosuvastatin-d6 Sodium Salt is a deuterated compound of Rosuvastatin Sodium Salt. Rosuvastatin Sodium Salt has a CAS number of 1007871-86-4.</p>

<p>Lovastatin-d3 is a deuterated compound of Lovastatin. Lovastatin has a CAS number of 75330-75-5. Lovastatin is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.</p>

<p>Alisol A: induces autophagy, anti-cancer, inhibits HepG2, MDA-MB-231, MCF-7 cells.</p>

<p>MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.</p>

<p>Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).</p>

<p>Brivanib Alaninate (BMS-582664) is an alaninate salt of a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic effect.</p>