Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1427 produtos de "Autofagia"
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Glaucocalyxin B
CAS:<p>Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM).</p>Fórmula:C22H30O5Pureza:99.13% - 99.35%Cor e Forma:SolidPeso molecular:374.47FKBP51F67V-selective antagonist Ligand2
CAS:<p>FKBP51F67V-selective antagonist Ligand2 (example 3-3), a potent ligand, selectively binds to the FKBP51 F67V variant, with no affinity for wild-type FKBP51 or</p>Fórmula:C43H56N2O10Pureza:98%Cor e Forma:SolidPeso molecular:760.91VUF5834
CAS:<p>VUF5834 is a full inverse agonist of CXCR3 N3.35A.</p>Fórmula:C31H41N5O2Pureza:98%Cor e Forma:SolidPeso molecular:515.69PS372424
CAS:<p>PS372424 is a specific agonist of human CXCR3, with anti-inflammatory activity.</p>Fórmula:C33H44N6O4Pureza:98%Cor e Forma:SolidPeso molecular:588.74ATG7-IN-2
CAS:<p>ATG7-IN-2 inhibits ATG7 protein with 0.089 μM IC50 and suppresses autophagy marker LC3B.</p>Fórmula:C11H16N6O7SCor e Forma:SolidPeso molecular:376.35LRRK2-IN-10
CAS:<p>LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2</p>Fórmula:C20H15N5OPureza:98%Cor e Forma:SolidPeso molecular:341.37AZ10397767
CAS:<p>AZ10397767: Potent CXCR2 blocker (IC50=1nM); lowers neutrophil infiltration in tumors in vitro/in vivo.</p>Fórmula:C15H14ClFN4O2S2Cor e Forma:SolidPeso molecular:400.88(R)-Hydroxychloroquine
CAS:<p>(R)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine. Hydroxychloroquine is an agent of synthetic antimalarial.</p>Fórmula:C18H26ClN3OPureza:98%Cor e Forma:SolidPeso molecular:335.87AGN 205728
CAS:<p>AGN 205728 is a potent and selective RARγ antagonist (Ki: 3 nM; IC95: 0.6 nM) and has no inhibition on RARα and RARβ.</p>Fórmula:C29H27NO3Pureza:98%Cor e Forma:SolidPeso molecular:437.53SCH 546738
CAS:<p>SCH 546738 is an orally available, selective and potent CXCR3 antagonist that attenuates the development of autoimmune diseases and delays graft rejection.</p>Fórmula:C23H31Cl2N7OPureza:98.67%Cor e Forma:SolidPeso molecular:492.45AC-55649
CAS:<p>AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.</p>Fórmula:C21H26O2Pureza:99.98%Cor e Forma:SolidPeso molecular:310.43AL 8697
CAS:<p>AL 8697 is a selective p38α MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38β (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases.</p>Fórmula:C21H21F3N4OPureza:99.55% - 99.89%Cor e Forma:SolidPeso molecular:402.41FR 167653 free base
CAS:<p>FR 167653 is an oral p38 MAPK inhibitor for inflammation, trauma, ischemia relief; it suppresses TNF-α, IL-1β.</p>Fórmula:C24H18FN5O2Pureza:98%Cor e Forma:SolidPeso molecular:427.43Sulfosuccinimidyl oleate
CAS:<p>Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells.</p>Fórmula:C22H37NO7SPureza:98%Cor e Forma:SolidPeso molecular:459.6SRT3190
CAS:<p>SRT3190 is an antagonist of CXCR2.</p>Fórmula:C18H23F2N5O4S2Pureza:98%Cor e Forma:SolidPeso molecular:475.53Ipsalazide
CAS:<p>Ipsalazide is a novel salicylazosulfapyridine analog for the treatment of inflammatory bowel disease.</p>Fórmula:C16H11N3Na2O6Pureza:99.43%Cor e Forma:SolidPeso molecular:387.25GLPG2451
CAS:<p>GLPG2451 potentiates F508del CFTR at low temp (EC50: 11.1 nM), aiding cystic fibrosis treatment.</p>Fórmula:C16H16F3N3O5SCor e Forma:SolidPeso molecular:419.38ACT-660602
CAS:<p>ACT-660602: Oral CXCR3 blocker, T-cell migration inhibitor, effective in acute lung injury models, potential for autoimmune research. IC50: 204 nM.</p>Fórmula:C20H20F6N8OSCor e Forma:SolidPeso molecular:534.48Omeprazole Sodium
CAS:<p>Omeprazole Sodium is a proton pump inhibitor(PPI) and suppresses gastric acid secretion.</p>Fórmula:C17H18N3NaO3SPureza:99.84%Cor e Forma:Clear In WaterPeso molecular:367.4SMER18
CAS:<p>SMER18, a small molecule enhancer of rapamycin, acts as an mTOR-independent inducer of autophagy and can be used to study neurodegenerative diseases.</p>Fórmula:C16H14ClNO2Pureza:97.27%Cor e Forma:SolidPeso molecular:287.74
