Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1424 produtos de "Autofagia"
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Norswertianin
CAS:<p>Norswertianin, a xanthone, induces GBM cell differentiation and autophagy via oxidative stress and Akt/mTOR.</p>Fórmula:C13H8O6Cor e Forma:SolidPeso molecular:260.2ICT5040
CAS:<p>ICT5040 is a CXCR4 antagonist.</p>Fórmula:C10H8F3N3OSCor e Forma:SolidPeso molecular:275.25SB-332235
CAS:<p>SB-332235 is an effective specific CXCR2 antagonist. And it is effectively inhibited CS-induced neutrophilia in a dose-dependent manner.</p>Fórmula:C13H10Cl3N3O4SCor e Forma:SolidPeso molecular:410.66Autophagy-IN-C1
CAS:<p>Autophagy-IN-C1 is a cinchona alkaloid derivative containing urea.</p>Fórmula:C29H28F6N4O2Cor e Forma:SolidPeso molecular:578.55Olacaftor
CAS:<p>Olacaftor, also known as VX-440, is a protein modulator of cystic fibrosis transmembrane regulator (CFTR).</p>Fórmula:C29H34FN3O4SCor e Forma:SolidPeso molecular:539.66PF 750
CAS:<p>PF 750 (ZINC27647189) is a selective and covalent inhibitor of FAAH. PF 750 shows IC50s varying from 16.2 to 595 nM in different incubation times.</p>Fórmula:C22H23N3OPureza:99.87%Cor e Forma:SolidPeso molecular:345.44AMD 3465
CAS:<p>AMD 3465 (GENZ-644494) blocks CXCR4, hinders X4 HIV replication (IC50: 1-10 nM), ineffective against R5 viruses, IC50: 0.75 nM (12G5 mAb), 18 nM (CXCL12AF647).</p>Fórmula:C24H38N6Pureza:98%Cor e Forma:SolidPeso molecular:410.60VUF11211
CAS:<p>VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains.</p>Fórmula:C26H35Cl2N5OPureza:98%Cor e Forma:SolidPeso molecular:504.49AUTEN-67
CAS:<p>AUTEN-67 inhibits MTMR14, boosts autophagy, has antiaging/neuroprotective properties, and combats Huntington's disease onset/severity.</p>Fórmula:C23H14N4O6SCor e Forma:SolidPeso molecular:474.45LV-320
CAS:<p>LV-320, potent ATG4B inhibitor; IC50: 24.5 μM, Kd: 16 μM. Blocks autophagy, stable, non-toxic, active in vivo. Useful for ATG4B research in cancer.</p>Fórmula:C29H26ClNO2S2Pureza:98%Cor e Forma:SolidPeso molecular:520.11Antiproliferative agent-5
CAS:<p>Compound 4o inhibits gastric cancer growth, blocks G2/M cell cycle, induces ROS, and triggers autophagy. Used in anti-cancer studies.</p>Fórmula:C28H21BrN8OSCor e Forma:SolidPeso molecular:597.49CXCR4 antagonist 9
CAS:<p>CXCR4 antagonist 9, with IC50s of 15 nM & 1.3 nM against CXCR4 & Ca²⁺ rise by CXCL12 respectively.</p>Fórmula:C21H27FN6Cor e Forma:SolidPeso molecular:382.48SA 47
CAS:<p>SA 47 is a selective and effective inhibitor of fatty acid amide hydrolase and carbamate.</p>Fórmula:C17H26N4O3Pureza:98%Cor e Forma:SolidPeso molecular:334.41CXCR4 antagonist 8
CAS:<p>CXCR4 antagonist 8 (Compound 3) blocks CXCR4, IC50 of 57 nM; stops CXCL12-induced Ca2+ increase, IC50 of 0.24 nM; hinders cell migration.</p>Fórmula:C21H26N6Cor e Forma:SolidPeso molecular:362.47ALLO-1
CAS:<p>ALLO-1, vital for autophagy, aids in engulfing paternal organelles by binding to worm LC3, LGG-1, via its LIR motif.</p>Fórmula:C17H15ClN2O2Pureza:98%Cor e Forma:SolidPeso molecular:314.77Obatoclax
CAS:<p>Obatoclax (GX15-070), a pan-BCL-2 inhibitor (Ki 220 nM) induces autophagy, degrades cyclin D1, and has anti-cancer/antiparasitic properties.</p>Fórmula:C20H19N3OPureza:99.44%Cor e Forma:SolidPeso molecular:317.38Nicodicosapent
CAS:<p>Nicodicosapent is a fatty acid niacin conjugate that inhibits SREBP, a regulator of cholesterol metabolism.</p>Fórmula:C28H39N3O2Pureza:98%Cor e Forma:SolidPeso molecular:449.63STK683963
CAS:<p>STK683963 activates ATG4B, mediates redox regulation, and aids cancer research.</p>Fórmula:C12H8FN3O2SCor e Forma:SolidPeso molecular:277.27LS2265
CAS:<p>LS2265, a fenofibrate derivative with a taurine modification, effectively induces the proliferation of peroxisomes in rat liver cells.</p>Fórmula:C19H20ClNO6SPureza:98%Cor e Forma:SolidPeso molecular:425.88AGN 205327
CAS:<p>AGN 205327 is a potent synthetic RAR agonist,showing selective RAR activation without RXR inhibition for retinoid research.</p>Fórmula:C24H26N2O3Pureza:99.45% - 99.71%Cor e Forma:SolidPeso molecular:390.47HF51116
CAS:<p>HF51116 blocks XCR4, hinders SDF-1α cell effects & HIV-1; potential for HIV, stem cells, cancer spread.</p>Fórmula:C29H46N8OCor e Forma:SolidPeso molecular:522.73CC214-2
CAS:<p>CC214-2: strong dual mTORC1/2 inhibitor, blocks autophagy, may shorten TB duration.</p>Fórmula:C20H25N5O3Cor e Forma:SolidPeso molecular:383.44AS1708727
CAS:<p>AS1708727 inhibits Foxo1, reducing blood sugar and triglycerides by altering gene expression.</p>Fórmula:C24H24Cl2N2O2Cor e Forma:SolidPeso molecular:443.37Aliskiren fumarate
CAS:<p>Oral renin inhibitor Aliskiren fumarate treats hypertension; IC50: 1.5 nM. Useful for cardiovascular and cancer cachexia research.</p>Fórmula:C34H57N3O10Cor e Forma:SolidPeso molecular:667.83Rimacalib
CAS:<p>Rimacalib is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (IC50s: ~1 μM for CaMKIIα and ~30 μM for CaMKIIγ).</p>Fórmula:C22H23FN4O2Pureza:98%Cor e Forma:SolidPeso molecular:394.44Elliptinium acetate
CAS:<p>Elliptinium acetate (NSC 264137), a cytotoxic DNA intercalator for cancer research, targets L1210 cells.</p>Fórmula:C20H20N2O3Cor e Forma:SolidPeso molecular:336.38SA72
CAS:<p>SA72 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH).</p>Fórmula:C21H26N2O6Pureza:98%Cor e Forma:SolidPeso molecular:402.44SX-517
CAS:<p>SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects, inhibits CXCL-1-induced Ca²⁺ flux.</p>Fórmula:C19H16BFN2O3SCor e Forma:SolidPeso molecular:382.22TN-14003
CAS:<p>TN-14003 is a synthetic antagonist 14-mer peptide inhibiting metastasis in an animal model.</p>Fórmula:C90H141N33O18S2Cor e Forma:SolidPeso molecular:2037.42RNF5 inhibitor inh-02
CAS:<p>RNF5 inhibitor inh-02 is a selective inhibitor of the ubiquitin ligase RNF5/RMA1, which can significantly rescue F508del-CFTR cystic fibrosis (CF).</p>Fórmula:C23H20N4SPureza:99.23%Cor e Forma:SolidPeso molecular:384.5(S)-Hydroxychloroquine
CAS:<p>(S)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine. Hydroxychloroquine shows efficiently inhibits SARS-CoV-2 infection in vitro.</p>Fórmula:C18H26ClN3OPureza:98%Cor e Forma:SolidPeso molecular:335.87IZCZ-3
CAS:<p>IZCZ-3,antitumor activity. is a potent c-MYC transcription inhibitor.</p>Fórmula:C46H49N7OPureza:98%Cor e Forma:SolidPeso molecular:715.93KRH-1636
CAS:<p>KRH-1636: potent, selective CXCR4 antagonist; orally active; inhibits X4 HIV-1 by blocking viral entry and membrane fusion.</p>Fórmula:C32H37N7O2Cor e Forma:SolidPeso molecular:551.68Autophagy inducer 4
CAS:<p>Autophagy inducer 4, a Magnolol-based Mannich derivative, is an anticancer agent that blocks cancer cell migration & is 76x more toxic to T47D cells.</p>Fórmula:C32H37NO6Cor e Forma:SolidPeso molecular:531.64PX20606 trans racemate
CAS:<p>PX20606 trans racemate is an agonist of FXR (EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively).</p>Fórmula:C29H22Cl3NO4Pureza:98%Cor e Forma:SolidPeso molecular:554.85Antitumor agent-81
CAS:<p>Antitumor agent-81, a P62-RNF168 agonist, reduces H2A ubiquitination, hinders DNA repair, and inhibits tumor growth.</p>Fórmula:C19H19N7O3Cor e Forma:SolidPeso molecular:393.4MPM-1
<p>MPM-1, a marine mimic, induces rapid necrotic-like death in cancer cells, disrupts autophagy, and causes lysosomal swelling.</p>Fórmula:C34H44F6N4O7Cor e Forma:SolidPeso molecular:734.73IT1t
CAS:<p>IT1t inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. is a potent CXCR4 antagonist.</p>Fórmula:C21H34N4S2Pureza:98%Cor e Forma:SolidPeso molecular:406.65Amsacrine
CAS:<p>Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.</p>Fórmula:C21H19N3O3SPureza:99.2%Cor e Forma:Yellow Crystalline Powder SolidPeso molecular:393.46CUR5g
CAS:<p>CUR5g is an autophagy inhibitor that inhibits migration and colony formation in A549 cells.</p>Fórmula:C22H20N2O2Pureza:98.92%Cor e Forma:SolidPeso molecular:344.41Evogliptin
CAS:<p>Evogliptin (DA-1229) is an oral DPP4 inhibitor effective in reducing blood sugar and liver inflammation.</p>Fórmula:C19H26F3N3O3Cor e Forma:SolidPeso molecular:401.42ATG7-IN-3
CAS:<p>ATG7-IN-3, or compound 18, is an ATG7 inhibitor with a 0.048 μM IC50, blocking autophagy and LC3B puncta in H4 cells.</p>Fórmula:C11H16N6O5S2Pureza:99.88%Cor e Forma:SolidPeso molecular:376.41Xantocillin
CAS:<p>Xanthocillin is a marine agent. Xanthocillin also induces autophagy through inhibition of the MEK/ERK pathway.</p>Fórmula:C18H12N2O2Pureza:98%Cor e Forma:SolidPeso molecular:288.3YM-155 hydrochloride
CAS:<p>Sepantronium hydrochloride (YM-155 hydrochloride) is a novel survivin suppressant that inhibits survivin promoter with an IC 50 of 0.54 nM[1].</p>Fórmula:C20H19ClN4O3Cor e Forma:SolidPeso molecular:398.85OSU-53
CAS:<p>OSU-53 is an AMPK activator, inhibiting mTOR signaling and autophagy stimulation. OSU-53 also activates mutations in RAS or BRAF.</p>Fórmula:C25H24F3N3O6S2Cor e Forma:SolidPeso molecular:583.6CCT128930
CAS:<p>'CCT128930, potent Akt2 inhibitor (IC50=6 nM), 28x more selective over PKA.'</p>Fórmula:C18H20ClN5Pureza:99.07% - 99.18%Cor e Forma:SolidPeso molecular:341.84FAAH inhibitor 1
CAS:<p>FAAH inhibitor 1 (Benzothiazole analog 3) is an effective FAAH inhibitor with an IC50 of 18 nM.</p>Fórmula:C24H23N3O3S3Pureza:99.6%Cor e Forma:SolidPeso molecular:497.65(Rac)-BL-918
CAS:<p>(Rac)-BL-918 is the racemic form of BL-918. BL-918 is an effective activator of UNC-51-like kinase 1 (ULK1) (EC₅₀ = 24.14 nM), Parkinson's disease.</p>Fórmula:C23H15F8N3OSPureza:98%Cor e Forma:SolidPeso molecular:533.44YOK-2204
CAS:<p>YOK-2204 is a ligand for the p62-ZZ domain and activates p62-dependent selective autophagy. It is also applicable in the design of AUTOTACs.</p>Fórmula:C28H35NO4Cor e Forma:SolidPeso molecular:449.58MRT-68601 HCl
CAS:<p>MRT-68601 HCl, a potent TBK1 (TANK-binding kinase-1), inhibits the formation of autophagosomes in lung cancer cells.</p>Fórmula:C25H34N6O2Pureza:98%Cor e Forma:SolidPeso molecular:450.58FKBP51F67V-selective antagonist Ligand2
CAS:<p>FKBP51F67V-selective antagonist Ligand2 (example 3-3), a potent ligand, selectively binds to the FKBP51 F67V variant, with no affinity for wild-type FKBP51 or</p>Fórmula:C43H56N2O10Pureza:98%Cor e Forma:SolidPeso molecular:760.91TUN-92046
CAS:<p>TUN-92046 is a permeable alpha-ketoglutarate analog that blocks harmful autophagy in cardiomyopathy.</p>Fórmula:C7H10O5Pureza:95.48% - 98.58%Cor e Forma:SolidPeso molecular:174.15Glaucocalyxin B
CAS:<p>Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM).</p>Fórmula:C22H30O5Pureza:99.13% - 99.35%Cor e Forma:SolidPeso molecular:374.47GPR35 agonist 1
CAS:<p>GPR35 agonist 1 is a highly effective and specific GPR35/CXCR8 agonist (EC50: 5.8 nM).</p>Fórmula:C10H4BrN5O5Pureza:98%Cor e Forma:SolidPeso molecular:354.07VUF5834
CAS:<p>VUF5834 is a full inverse agonist of CXCR3 N3.35A.</p>Fórmula:C31H41N5O2Pureza:98%Cor e Forma:SolidPeso molecular:515.69LRRK2-IN-10
CAS:<p>LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2</p>Fórmula:C20H15N5OPureza:98%Cor e Forma:SolidPeso molecular:341.37PS372424
CAS:<p>PS372424 is a specific agonist of human CXCR3, with anti-inflammatory activity.</p>Fórmula:C33H44N6O4Pureza:98%Cor e Forma:SolidPeso molecular:588.74AZ10397767
CAS:<p>AZ10397767: Potent CXCR2 blocker (IC50=1nM); lowers neutrophil infiltration in tumors in vitro/in vivo.</p>Fórmula:C15H14ClFN4O2S2Cor e Forma:SolidPeso molecular:400.88FR 167653 free base
CAS:<p>FR 167653 is an oral p38 MAPK inhibitor for inflammation, trauma, ischemia relief; it suppresses TNF-α, IL-1β.</p>Fórmula:C24H18FN5O2Pureza:98%Cor e Forma:SolidPeso molecular:427.43ROC-325
CAS:<p>ROC-325: orally active autophagy inhibitor with anticancer effects, induces kidney cancer cell death; selective action.</p>Fórmula:C28H27ClN4OSPureza:99.26%Cor e Forma:SolidPeso molecular:503.06Sulfosuccinimidyl oleate
CAS:<p>Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells.</p>Fórmula:C22H37NO7SPureza:98%Cor e Forma:SolidPeso molecular:459.6SRT3190
CAS:<p>SRT3190 is an antagonist of CXCR2.</p>Fórmula:C18H23F2N5O4S2Pureza:98%Cor e Forma:SolidPeso molecular:475.53Ipsalazide
CAS:<p>Ipsalazide is a novel salicylazosulfapyridine analog for the treatment of inflammatory bowel disease.</p>Fórmula:C16H11N3Na2O6Pureza:99.43%Cor e Forma:SolidPeso molecular:387.25SCH 546738
CAS:<p>SCH 546738 is an orally available, selective and potent CXCR3 antagonist that attenuates the development of autoimmune diseases and delays graft rejection.</p>Fórmula:C23H31Cl2N7OPureza:98.67%Cor e Forma:SolidPeso molecular:492.45AL 8697
CAS:<p>AL 8697 is a selective p38α MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38β (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases.</p>Fórmula:C21H21F3N4OPureza:99.55% - 99.89%Cor e Forma:SolidPeso molecular:402.41(-)-Talarozole
CAS:<p>(-)-Talarozole is a potent retinoic acid metabolism inhibitor.</p>Fórmula:C21H23N5SCor e Forma:SolidPeso molecular:377.51AGN 205728
CAS:<p>AGN 205728 is a potent and selective RARγ antagonist (Ki: 3 nM; IC95: 0.6 nM) and has no inhibition on RARα and RARβ.</p>Fórmula:C29H27NO3Pureza:98%Cor e Forma:SolidPeso molecular:437.53GSK3-IN-3
CAS:<p>GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy.</p>Fórmula:C24H35N3O4Pureza:99.37%Cor e Forma:SolidPeso molecular:429.55Dinoprost
CAS:<p>Dinoprost (Prostaglandin F2a) is a naturally occurring prostaglandin. It is used in medicine to induce labor and as an abortifacient.</p>Fórmula:C20H34O5Pureza:97.94% - 98.04%Cor e Forma:White To Off-White Crystalline SolidPeso molecular:354.48ABTL-0812
CAS:<p>ABTL-0812 induces endoplasmic reticulum (ER) stress-mediated autophagy, and with anti-cancer activity.</p>Fórmula:C18H32O3Cor e Forma:SolidPeso molecular:296.44K67
CAS:<p>K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1 and can be used to study cancer.</p>Fórmula:C29H30N2O7S2Pureza:98.43%Cor e Forma:SolidPeso molecular:582.69(Rac)-AZD 6482
CAS:<p>(Rac)-AZD 6482 is the racemate of AZD 6482. AZD 6482 is a potent and selective inhibitor of p110β (IC50 of 0.69 nM).</p>Fórmula:C22H24N4O4Cor e Forma:SolidPeso molecular:408.45SR-17398
CAS:<p>SR-17398 is an inhibitor of Unc-51-Like Kinase 1 (ULK1) (IC50 = 22.4 uM).</p>Fórmula:C14H18N4OPureza:98%Cor e Forma:SolidPeso molecular:258.32Autophagy inducer 3
CAS:<p>Autophagy Inducer 3 triggers selective cancer cell death via autophagy, sparing healthy cells.</p>Fórmula:C24H43NO2Cor e Forma:SolidPeso molecular:377.6Evogliptin tartrate
CAS:<p>Evogliptin tartrate: Oral DPP-4 inhibitor, may treat atherosclerosis and diabetes.</p>Fórmula:C23H32F3N3O9Cor e Forma:SolidPeso molecular:551.51AC-55649
CAS:<p>AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.</p>Fórmula:C21H26O2Pureza:99.98%Cor e Forma:SolidPeso molecular:310.43MDK-6983
CAS:<p>MDK-6983 (MDK-6983) is an inhibitor of autophagy and disrupts the dynamics of actin cytoskeleton in human melanoma cells.</p>Fórmula:C22H18Cl2N2O3Pureza:99.68%Cor e Forma:SolidPeso molecular:429.3AMDE-1
CAS:<p>AMDE-1, an autophagy modulator, triggers Atg5-dependent autophagy, recruits Atg16, and induces LC3 lipidation.</p>Fórmula:C18H8ClF6N3Pureza:90%Cor e Forma:SolidPeso molecular:415.72SB02024
CAS:<p>SB02024 inhibits VPS34, boosts cGAS-STING, hinders autophagy, and shrinks breast cancer xenografts; enhances Sunitinib/Erlotinib efficacy.</p>Fórmula:C16H22F3N3O2Cor e Forma:SolidPeso molecular:345.36FAAH-IN-1
CAS:<p>FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.</p>Fórmula:C20H19ClN4OSPureza:98%Cor e Forma:SolidPeso molecular:398.91GPP78
CAS:<p>GPP78: Strong Nampt inhibitor, IC50 3.0 nM, depletes NAD. Kills SH-SY5Y cells, IC50 3.8 nM via autophagy. Anti-cancer and anti-inflammatory.</p>Fórmula:C27H29N5OPureza:98%Cor e Forma:SolidPeso molecular:439.553HOI-BA-01
CAS:<p>3HOI-BA-01 is a mammalian targeting effective rapamycin activation inhibitor.</p>Fórmula:C19H15NO5Pureza:98%Cor e Forma:SolidPeso molecular:337.33rac-NBI-74330
CAS:<p>rac-NBI-74330 is an effective and selective CXCR3 antagonist.</p>Fórmula:C32H27F4N5O3Pureza:99.6%Cor e Forma:SolidPeso molecular:605.58ACT-660602
CAS:<p>ACT-660602: Oral CXCR3 blocker, T-cell migration inhibitor, effective in acute lung injury models, potential for autoimmune research. IC50: 204 nM.</p>Fórmula:C20H20F6N8OSCor e Forma:SolidPeso molecular:534.48DK-1-49
CAS:<p>DK-1-49 is an autophagonizer. It causes accumulation of autophagy-associated LC3-II and enhanced levels of autophagosomes and acidic vacuoles.</p>Fórmula:C28H31N5O3S2Pureza:98%Cor e Forma:SolidPeso molecular:549.71AMG 487 (S-enantiomer)
CAS:<p>AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an CXCR3 antagonist.</p>Fórmula:C32H28F3N5O4Pureza:98%Cor e Forma:SolidPeso molecular:603.59SR12418
CAS:<p>SR12418 is a specific synthetic ligand for REV-ERBα (IC50 = 68 nM) and REV-ERBβ (IC50 = 119 nM) in TR-FRET assays. inhibits IL-17A expression in EL4 cells.</p>Fórmula:C31H30FNO3Pureza:99.96%Cor e Forma:SolidPeso molecular:483.57VUF10132
CAS:<p>VUF10132 is a full inverse CXCR3 N3.35A agonist.</p>Fórmula:C19H13BrCl4N2O2Pureza:98%Cor e Forma:SolidPeso molecular:523.03(R)-Hydroxychloroquine
CAS:<p>(R)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine. Hydroxychloroquine is an agent of synthetic antimalarial.</p>Fórmula:C18H26ClN3OPureza:98%Cor e Forma:SolidPeso molecular:335.87AC-73
CAS:<p>AC-73, an oral CD147 inhibitor, blocks ERK1/2/STAT3/MMP-2 pathway, reducing liver cancer progression and leukemia cell growth.</p>Fórmula:C21H21NO2Pureza:98.95%Cor e Forma:SolidPeso molecular:319.4Atg4B-IN-2
CAS:<p>Atg4B-IN-2 is an Atg4B inhibitor with anticancer activity that inhibits Atg4B and PLA2 and resists the anticancer activity of resistant prostate cancer drugs.</p>Fórmula:C21H30O3Pureza:98.86%Cor e Forma:SolidPeso molecular:330.46GC7 Sulfate
CAS:<p>GC7 Sulfate blocks DHS, the sole enzyme activating eIF5A2, thus preventing eIF5A2 activation.</p>Fórmula:C8H22N4O4SPureza:99.85% - >99.99%Cor e Forma:SolidPeso molecular:270.35NUCC-390
CAS:<p>NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100.</p>Fórmula:C23H33N5OPureza:97.08%Cor e Forma:SolidPeso molecular:395.54Rosolutamide
CAS:<p>Rosolutamide (ALZ-003) is a curcumin analog, an Nrf1 and Nrf2 activator.</p>Fórmula:C28H32O6Pureza:95.48% - 99.15%Cor e Forma:SolidPeso molecular:464.55Apostatin-1
CAS:<p>Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.</p>Fórmula:C19H27N3OSPureza:99.31%Cor e Forma:SolidPeso molecular:345.5CCT020312
CAS:<p>CCT020312 (0-9 µM, 24 h) treatment of medium HT29 cells for 24 h resulted in a concentration-dependent loss of P-S608-pRB.Cost-effective and quality-assured.</p>Fórmula:C31H30Br2N4O2Pureza:98.63%Cor e Forma:SolidPeso molecular:650.4CP-312
CAS:<p>CP-312 activates antioxidant defense, induces HMOX1, and shields human iPSC-derived cardiomyocytes from oxidative stress.</p>Fórmula:C16H12ClN3OS2Pureza:99.61%Cor e Forma:SolidPeso molecular:361.87Acetazolamide sodium
CAS:<p>Acetazolamide sodium (OT-302 sodium) is a potent carbonic anhydrase (CA) IX inhibitor used for indications such as epilepsy and altitude sickness.</p>Fórmula:C4H5N4NaO3S2Pureza:99.71% - 99.87%Cor e Forma:SolidPeso molecular:244.23MAPK13-IN-1
CAS:<p>MAPK13-IN-1 is a potent MAPK13 (p38δ) inhibitor (IC50: 620 nM).</p>Fórmula:C20H23N5O2Pureza:99.62%Cor e Forma:SolidPeso molecular:365.43IT1t dihydrochloride
CAS:<p>IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.</p>Fórmula:C21H36Cl2N4S2Pureza:99.91%Cor e Forma:SolidPeso molecular:479.57Cysmethynil
CAS:<p>Cysmethynil is an indole-based Icmt inhibitor with antitumor activity, induces cell cycle arrest in G1 phase, and can be used for the study of solid tumors.</p>Fórmula:C25H32N2OPureza:99%Cor e Forma:SolidPeso molecular:376.53Laduviglusib trihydrochloride
CAS:<p>Laduviglusib trihydrochloride, a GSK-3α/β inhibitor (IC50: 10/6.7 nM), activates Wnt/β-catenin signaling and induces autophagy.</p>Fórmula:C22H20Cl5N8Pureza:99.34%Cor e Forma:SolidPeso molecular:573.71Elubrixin
CAS:<p>Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM).</p>Fórmula:C17H17Cl2FN4O4SPureza:98.65% - 99.78%Cor e Forma:SolidPeso molecular:463.31Dactolisib Tosylate
CAS:<p>Dactolisib Tosylate (BEZ235 Tosylate) is a dual kinase inhibitor that targets PI3K and mTOR.</p>Fórmula:C37H31N5O4SPureza:99.91%Cor e Forma:SolidPeso molecular:641.74XRK3F2
CAS:<p>XRK3F2 inhibits p62-ZZ, counters MM's Runx2 suppression in vitro, and prompts bone growth and remodeling in vivo with tumors.</p>Fórmula:C23H24ClF2NO3Pureza:98.75% - 98.91%Cor e Forma:SolidPeso molecular:435.89Tin-protoporphyrin IX dichloride
CAS:<p>Tin-protoporphyrin IX inhibits HO-1, enhancing chemo efficacy in mouse PDAC.</p>Fórmula:C34H32Cl2N4O4SnPureza:98%Cor e Forma:SolidPeso molecular:750.26CHIR-99021 HCl
CAS:<p>CHIR-99021 HCl is a selective GSK-3α/β inhibitor (IC50: 10/6.7 nM), 500x selective over other kinases, boosts Wnt pathway, and enhances stem cell renewal.</p>Fórmula:C22H19Cl3N8Pureza:98.07% - 98.14%Cor e Forma:SolidPeso molecular:501.8Cytarabine hydrochloride
CAS:<p>Cytarabine hydrochloride (Ara-C hydrochloride) is a nucleoside analog that causes S phase cell cycle arrest and inhibits DNA polymerase.</p>Fórmula:C9H14ClN3O5Pureza:98.46%Cor e Forma:White PowderPeso molecular:279.68ITX5061
CAS:<p>ITX5061 is a type II inhibitor of p38 MAPK and scavenger receptor B1 (SRB1) antagonist for the study of hepatitis C virus infection.</p>Fórmula:C30H38ClN3O7SPureza:98.35%Cor e Forma:SolidPeso molecular:620.16LRRK2-IN-7
CAS:<p>LRRK2-IN-7: potent, selective CNS-active LRRK2 inhibitor, IC50 0.9 nM, >1000x selectivity vs kinases/channels/CYPs.</p>Fórmula:C24H26N6OPureza:99.26%Cor e Forma:SolidPeso molecular:414.5AZD8797
CAS:<p>AZD8797 (KAND567) is a CX3CR1 antagonist with potential protective effects against neuronal damage and prevents nociceptive hypersensitivity in rats.</p>Fórmula:C19H25N5OS2Pureza:98.73% - 99.68%Cor e Forma:SolidPeso molecular:403.56Mavorixafor
CAS:<p>Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.</p>Fórmula:C21H27N5Pureza:98.56%Cor e Forma:SolidPeso molecular:349.47AZD8309
CAS:<p>AZD8309 is an oral CXCR2 antagonist, curbing neutrophil movement, lowering MPO in lungs/pancreas, and trypsin/elastase activity.</p>Fórmula:C15H14F2N4O2S2Pureza:98.35% - 99.67%Cor e Forma:SolidPeso molecular:384.42FMK 9a
CAS:<p>FMK 9a is an irreversible inhibitor of ATG4B with IC50 values of 80 and 73 nM in the TR-FRET and cellular-based LRA assays.</p>Fórmula:C23H21FN2O3Pureza:98.97%Cor e Forma:SolidPeso molecular:392.42MTK458
CAS:<p>MTK458 (EP-0035985) is a PINK1 activator with antidepressant activity for the study of Parkinson;s disease.</p>Fórmula:C17H15F3N4Pureza:98.36%Cor e Forma:SolidPeso molecular:332.32Cosalane
CAS:<p>Cosalane (NSC 658586) is an HIV replication inhibitor and an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice.</p>Fórmula:C45H60Cl2O6Pureza:99.53% - 99.78%Cor e Forma:SolidPeso molecular:767.86DCAP
CAS:<p>DCAP, a broad-spectrum antibiotic, disrupts the membranes of both Gram-positive and Gram-negative bacteria. Additionally, it inhibits late-stage autophagy by blocking autophagolysosome maturation and interrupting autophagic flux [1].</p>Fórmula:C19H22Cl2N2O4Cor e Forma:SolidPeso molecular:413.3XIE62-1004
CAS:<p>XIE62-1004 is a chemical compound that induces the interaction between p62 and LC3 by binding to the ZZ domain of p62.</p>Fórmula:C23H25NO3·HClCor e Forma:SolidPeso molecular:399.91p38-α MAPK-IN-1
CAS:<p>p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM in EFC displacement assay and HTRF assay,respectively.</p>Fórmula:C27H35N5O3Pureza:99.93%Cor e Forma:SolidPeso molecular:477.66CEPN
CAS:<p>6CEPN is a Cyclooxygenase-1 inhibitor that acts by suppressing colorectal cancer growth.</p>Fórmula:C23H18O5Cor e Forma:SolidPeso molecular:374.39CXCR4 antagonist 6
CAS:<p>CXCR4 antagonist 6 blocks CXCR4 (IC50: 79 nM), hinders calcium flux (IC50: 0.25 nM), reduces cell migration, and is effective in cancer metastasis mice.</p>Fórmula:C21H30N6Cor e Forma:SolidPeso molecular:366.5Calmidazolium chloride
CAS:<p>Calmidazolium chloride blocks calmodulin, hinders phosphodiesterase (IC50=0.15µM), Ca2+-ATPase (IC50=0.35µM), and can induce cancer cell apoptosis.</p>Fórmula:C31H23Cl7N2OPureza:98.53%Cor e Forma:SolidPeso molecular:687.7AEW541 HCl
CAS:<p>AEW541 (CAS# 475489-16-8) is a selective IGF-IR kinase inhibitor (IC50: IGF-IR=0.086μM, InsR=2.3μM), blocking IGF-I effects and colony formation.</p>Fórmula:C27H31Cl2N5OCor e Forma:SolidPeso molecular:512.47Antitumor agent-82
<p>Antitumor agent-82: potent, anti-proliferative, induces autophagy via ATG5/ATG7.</p>Fórmula:C32H42N6Cor e Forma:SolidPeso molecular:510.72KN-93 Phosphate
CAS:<p>KN-93 (Phosphate) can competitively block the binding of calmodulin to the corresponding kinase.Cost-effective and quality-assured.</p>Fórmula:C26H32ClN2O8PSPureza:99.58% - 99.93%Cor e Forma:SolidPeso molecular:599.03RK-682
CAS:<p>RK-682 is a natural selective inhibitor of protein tyrosine phosphatases (PTPases).</p>Fórmula:C21H36O5Cor e Forma:SolidPeso molecular:368.51AGN-195183
CAS:<p>AGN 195183: RARα agonist, Kd=3 nM, selective, no RARβ/γ effect, inhibits breast cancer cells, in Phase I/II clinical trials, non-irritant.</p>Fórmula:C22H22ClF2NO4Cor e Forma:SolidPeso molecular:437.86Di-N-desethyl amiodarone hydrochloride
CAS:<p>Di-N-desethyl Amiodarone hydrochloride, a metabolite of Amiodarone, functions as a potent inhibitor of the respiratory chain [1].</p>Fórmula:C21H22ClI2NO3Pureza:98%Cor e Forma:SolidPeso molecular:625.67LY2955303
CAS:<p>LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).</p>Fórmula:C36H42N4O3Pureza:98.56% - 99.85%Cor e Forma:SolidPeso molecular:578.74E6130
CAS:<p>E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.</p>Fórmula:C28H37ClF3N3O3Cor e Forma:SolidPeso molecular:556.06(3R,5R)-Rosuvastatin
CAS:<p>(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).</p>Fórmula:C22H28FN3O6SPureza:98%Cor e Forma:SolidPeso molecular:481.544E2RCat
CAS:<p>4E2RCat is an inhibitor of eIF4E-eIF4G interaction (IC50 = 13.5 μM) and is capable of blocking coronavirus replication as monitored by viral protein expression</p>Fórmula:C22H14ClNO4S2Pureza:98.44%Cor e Forma:SolidPeso molecular:455.93Beclin1-ATG14L interaction inhibitor 1
CAS:<p>Beclin1-ATG14L Interaction Inhibitor 1 (COM 19) is a selective inhibitor targeting the specific interaction between Beclin1 and ATG14L.</p>Fórmula:C23H24N4O5SPureza:98%Cor e Forma:SolidPeso molecular:468.53INT-767
CAS:<p>INT-767 is a highly potent farneson X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral fat brown lipogenesis and mitochondrial function</p>Fórmula:C25H43NaO6SPureza:98%Cor e Forma:SolidPeso molecular:494.66CXCR4 antagonist 7
CAS:<p>Compound PARA-B, a CXCR4 antagonist with IC50 = 9.3 nM, targets HIV, cancer, inflammatory diseases, and WHIM syndrome.</p>Fórmula:C15H17N5O3Cor e Forma:SolidPeso molecular:315.33Ruxolitinib sulfate
CAS:<p>Ruxolitinib sulfate, a potent JAK1/2 inhibitor (IC50: 3.3/2.8 nM), is >130x more selective for JAK1/2 than JAK3.</p>Fórmula:C17H20N6O4SCor e Forma:SolidPeso molecular:404.45Gly-β-MCA
CAS:<p>Gly-β-MCA is an orally bioactive, entero inhibitor of the farnesoid X receptor (FXR), a bile acid, used in the study of obesity and diabetes.</p>Fórmula:C26H43NO6Pureza:≥98.0%Cor e Forma:SolidPeso molecular:465.62Butylate
CAS:<p>Butylate is a herbicide of thiocarbamate.</p>Fórmula:C11H23NOSCor e Forma:Less Liquid Which Darkens Upon Exposure To Light Air And Moisture Colorless Liquid Which Darkens Upon Exposure To Light Air And MoisturePeso molecular:217.37CXCR2-IN-2
CAS:<p>CXCR2-IN-2: A selective, brain-penetrant, oral CXCR2 inhibitor (IC50: 5.2 nM/1 nM). ~730x selectivity vs CXCR1, >1900x vs other chemokine receptors.</p>Fórmula:C18H23ClN2O5SCor e Forma:SolidPeso molecular:414.9(R,R)-CXCR2-IN-2
CAS:<p>'(R,R)-CXCR2-IN-2 is a brain-penetrating diastereoisomer and CXCR2 antagonist with pIC50 of 9 (Tango) and 6.8 (HWB Gro-α/CD11b).'</p>Fórmula:C18H23ClN2O5SCor e Forma:SolidPeso molecular:414.9TIQ-15
CAS:<p>TIQ-15 is an effective and selective CXCR4 antagonist. It has good drug-like properties.</p>Fórmula:C23H32N4Pureza:98%Cor e Forma:SolidPeso molecular:364.53p38 MAPK-IN-1
CAS:<p>p38 MAPK-IN-1 is a novel selective p38 MAPK inhibitor with high potency, which reduces inflammatory responses by inhibiting LPS-induced TNF-α production.</p>Fórmula:C21H14F2N2OPureza:98%Cor e Forma:SolidPeso molecular:348.35CXCR2 antagonist 3
CAS:<p>Compound 11h, a CXCR2 antagonist, inhibits neutrophil/MDSCs and boosts CD3+ T cells in Pan02 tumors.</p>Fórmula:C17H15FN2O4SCor e Forma:SolidPeso molecular:362.38(±)-AMG 487
<p>AMG 487 is an effective and selective antagonist of chemokine receptor 3.</p>Fórmula:C32H28F3N5O4Pureza:98%Cor e Forma:SolidPeso molecular:603.59BPO-27 racemate
CAS:<p>BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.</p>Fórmula:C26H18BrN3O6Pureza:97.67% - 98.86%Cor e Forma:SolidPeso molecular:548.34Ladarixin Sodium
CAS:<p>Ladarixin Sodium, an Chemokine CXCR antagonist, is used potentially for the treatment of type I diabetes.</p>Fórmula:C11H12F3NNaO6S2Cor e Forma:SolidPeso molecular:398.32SR10067
CAS:<p>SR10067 is a potent, selective and brain penetrant agonist of Rev-Erbβ(IC50 = 160 nM) and Rev-Erbα(IC50 = 170 nM) with anxiolytic activity.</p>Fórmula:C31H31NO3Pureza:99.57%Cor e Forma:SolidPeso molecular:465.58Acitretin sodium
CAS:<p>Acitretin sodium is a second-generation, systemic retinoid. It is also has been used in the treatment of psoriasis.</p>Fórmula:C21H26NaO3Pureza:98%Cor e Forma:SolidPeso molecular:349.42AGN 194078
CAS:<p>AGN 194078 is a selective RARα agonist (Kd: 3 nM; EC50: 112 nM).</p>Fórmula:C22H23F2NO4Cor e Forma:SolidPeso molecular:403.42Pentixafor
CAS:<p>Pentixafor is a peptide that selectively targets the CXCR4 receptor and can be labeled with Gallium-68 (68Ga) for visualization using positron emission</p>Fórmula:C60H80N14O14Pureza:98%Cor e Forma:SolidPeso molecular:1221.36Cisd2 agonist 1
CAS:<p>Cisd2 agonist 1 is a CISD2) agonist (EC50: 34 nM) with potential anticancer activity and can be used to study non-alcoholic fatty liver disease (NAFLD).</p>Fórmula:C14H13FN2O3SPureza:99.06%Cor e Forma:SolidPeso molecular:308.33AGN 194310
CAS:<p>AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].</p>Fórmula:C28H24O2SCor e Forma:SolidPeso molecular:424.55ATG12-ATG3 inhibitor 1
CAS:<p>ATG12-ATG3 Inhibitor 1 (compound 189) serves as a potent inhibitor of autophagy [1].</p>Fórmula:C18H17NO3SCor e Forma:SolidPeso molecular:327.4EACC
CAS:<p>EACC inhibits Stx17, blocking autophagosome-lysosome fusion, and is a reversible autophagy inhibitor.</p>Fórmula:C13H11N3O6S2Pureza:99.8%Cor e Forma:SolidPeso molecular:369.37NUCC-390 dihydrochloride (1060524-97-1 free base)
<p>NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.</p>Fórmula:C23H35Cl2N5OPureza:98%Cor e Forma:SolidPeso molecular:468.46SLLN-15
CAS:<p>SLLN-15: oral, potent autophagy enhancer; targets macroautophagy in TNBC.</p>Fórmula:C19H23N7Se2Pureza:98%Cor e Forma:SolidPeso molecular:507.35CXCR2 antagonist 2
CAS:<p>CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.</p>Fórmula:C17H17FN2O4SCor e Forma:SolidPeso molecular:364.39SAFit2
CAS:<p>SAFit2 is a highly potent and selective inhibitor of fk506 binding protein 51 (FKBP51).Cost-effective and quality-assured</p>Fórmula:C46H62N2O10Pureza:98.16% - >99.99%Cor e Forma:SolidPeso molecular:802.99PHY34
CAS:<p>PHY34 inhibits autophagy at nanomolar potency, with anti-tumor effects on HGSOC in vivo.</p>Fórmula:C30H30O12Pureza:98.71%Cor e Forma:SolidPeso molecular:582.55AZ PFKFB3 26
CAS:<p>AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.</p>Fórmula:C24H26N4O2Pureza:99.85%Cor e Forma:SolidPeso molecular:402.49CXCR2-IN-1
CAS:<p>CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.</p>Fórmula:C19H20Cl2FN3O4SPureza:99.89%Cor e Forma:SolidPeso molecular:476.35GDC-0349
CAS:<p>GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.</p>Fórmula:C24H32N6O3Pureza:96.00% - 98.17%Cor e Forma:SolidPeso molecular:452.55SW063058
CAS:<p>SW063058 is an autophagy inducer that specifically disrupts the interaction between Beclin 1 and Bcl-2 without affecting the interactions of Bcl-2 with pro-apoptotic members (such as Bax and BIM). By inhibiting the negative regulation of Beclin 1 (key to autophagy initiation) by Bcl-2, SW063058 enhances autophagic activity without inducing cytotoxicity, apoptosis, or other forms of cell death in vitro.</p>Fórmula:C22H15BrFIN2O2Cor e Forma:SolidPeso molecular:565.17CXCR7 modulator 2
CAS:<p>CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM.</p>Fórmula:C29H42N6O3Cor e Forma:SolidPeso molecular:522.68SCH 563705
CAS:<p>SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.</p>Fórmula:C23H27N3O5Pureza:98.03%Cor e Forma:SolidPeso molecular:425.48SORT1-IN-2
CAS:<p>SORT1-IN-2 (compound 6) is an inhibitor of SORT1.</p>Fórmula:C21H29N3O4Cor e Forma:SolidPeso molecular:387.47CXCR2 antagonist 7
<p>CXCR2 antagonist 7 is a powerful blocker with IC50s: 0.044 μM for binding, 0.66 μM for calcium mobilization.</p>Fórmula:C14H14F2N6OSCor e Forma:SolidPeso molecular:352.36Autophagy-IN-7
CAS:<p>Autophagy-IN-7 is an autophagy inhibitor for use in studying solid tumours.</p>Fórmula:C15H11N7Pureza:98.47%Cor e Forma:SolidPeso molecular:289.29ATG12-IN-1
CAS:<p>ATG12-IN-1 (compound 4) acts as an autophagy inhibitor targeting the ATG12-ATG3 protein-protein interaction (IC50= 9 μM), suitable for research in cancer studies.</p>Fórmula:C23H15ClN4O2Cor e Forma:SolidPeso molecular:414.84CXCR2/CCR7 antagonist-1
CAS:<p>CXCR2/CCR7 antagonist-1 (compound 6) is a potent dual antagonist of CXCR2 and CCR7, with IC50 values of 0.0046 μM and 0.0014 μM, respectively. It is valuable for research in tumor metastasis and autoimmune diseases.</p>Fórmula:C23H27N3O5Cor e Forma:SolidPeso molecular:425.48SHS206
<p>SHS206 (compound 6n) is an orally active mitochondrial uncoupler that decreases triglyceride levels in the liver. Demonstrating in vivo efficacy in a GAN mouse model, SHS206 also exhibits inhibitory effects on metabolic dysfunction-associated steatohepatitis (MASH).</p>Fórmula:C14H7F6N3OCor e Forma:SolidPeso molecular:347.22YOK-1304
CAS:<p>YOK-1304, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62.</p>Fórmula:C28H35NO4Cor e Forma:SolidPeso molecular:449.58LRRK2-IN-4
CAS:<p>LRRK2-IN-4: Potent, selective LRRK2 inhibitor, oral, BBB-penetrating, IC50=2.6 nM, potential for Parkinson's.</p>Fórmula:C25H29ClF2N6O2Cor e Forma:SolidPeso molecular:518.99ST-539
CAS:<p>ST-539 is an inhibitor of the deubiquitinating enzyme USP30, with an IC50 of 0.37 μM. It enhances the ubiquitination of mitochondrial proteins and induces mitophagy (autophagy), thereby regulating mitochondrial homeostasis. ST-539 is applicable for research in neurodegenerative diseases.</p>Fórmula:C30H31N3O4SCor e Forma:SolidPeso molecular:529.65SH498
CAS:<p>SH498 is a novel Bmi-1-mediated anti-tumor agent with significant anti-proliferative effects.</p>Fórmula:C27H25F3N2O4Cor e Forma:SolidPeso molecular:498.49Anle138b-F105
CAS:<p>Anle138b-F105 is an autophagy-targeting chimera (AUTOTAC) with a DC50 value of 3 nM. It targets tauP301L for lysosomal degradation.</p>Fórmula:C36H37FN4O5Cor e Forma:SolidPeso molecular:624.7SYUIQ-5
CAS:<p>SYUIQ-5 is a ligand for G-quadruplex structures. It plays a role in stabilizing G-quadruplexes and inducing senescence. Additionally, SYUIQ-5 inhibits the activity of the c-myc gene promoter. By displacing TRF2 from telomeres, SYUIQ-5 induces telomeric damage, which triggers autophagy (autophagy) in cancer cells.</p>Fórmula:C20H22N4Cor e Forma:SolidPeso molecular:318.415LRRK2-IN-16
CAS:<p>LRRK2-IN-16 (compound 25) is an inhibitor of the LRRK2 kinase with an IC50 value of less than 5 μM. It is applicable for research in neurodegenerative and autoimmune diseases.</p>Fórmula:C18H19N5OSCor e Forma:SolidPeso molecular:353.441Hesperadin hydrochloride
<p>Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.</p>Fórmula:C29H33ClN4O3SCor e Forma:SolidPeso molecular:553.12(R)-SCH 546738
CAS:<p>(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.</p>Fórmula:C23H31Cl2N7OCor e Forma:SolidPeso molecular:492.45CXCR2 antagonist 4
<p>CXCR2 antagonist 4 inhibits CXCR2 (IC50: 0.13 μM) and CXCL8-induced calcium rise (IC50: 27 μM), promising for cancer research.</p>Fórmula:C15H14F2N4OS2Cor e Forma:SolidPeso molecular:368.42CXCR7 antagonist-1 hydrochloride
CAS:<p>CXCR7 antagonist-1 hydrochloride blocks SDF-1 and I-TAC from CXCR7; may prevent cancer and inflammation.</p>Fórmula:C21H20ClFN6OCor e Forma:SolidPeso molecular:426.87HDAC10-IN-2
<p>HDAC10-IN-2, a selective HDAC10 inhibitor (IC50=20nM), modulates autophagy in FLT3-ITD+ acute myeloid leukemia.</p>Fórmula:C19H22N2O2Cor e Forma:SolidPeso molecular:310.39LRRK2-IN-6
<p>LRRK2-IN-6 is an oral, selective LRRK2 inhibitor crossing the blood-brain barrier, targeting GS (IC50: 4.6μM) and WT LRRK2 (IC50: 49μM).</p>Fórmula:C23H24F2N4O2SCor e Forma:SolidPeso molecular:458.52CXCR2 antagonist 6
<p>CXCR2 antagonist 6: strong CXCR2 affinity (IC50=0.044 μM), hinders calcium mobilization (IC50=0.66 μM).</p>Fórmula:C17H16F2N4OSCor e Forma:SolidPeso molecular:362.4Autophagy activator-1
CAS:<p>Autophagyactivator-1 (Compound B2) is an autophagy activator that induces autophagy by downregulating key members of the HSP70 family and activating the unfolded protein response.</p>Fórmula:C25H32O8Cor e Forma:SolidPeso molecular:460.517DC-LC3in-D5
CAS:<p>DC-LC3in-D5 is a potent and selective covalent inhibitor of LC3A/B that disrupts autophagy by covalently binding to Lys49 on LC3B.</p>Fórmula:C19H22Cl2N2O3Pureza:99.79%Cor e Forma:SolidPeso molecular:397.3LC3B recruiter 1
CAS:<p>LC3B recruiter 1 (compound 33R) is an LC3B recruiting fragment. It directly interacts with LC3B, exhibiting a Kd value of 2.87 µM.</p>Fórmula:C14H10ClN3O2Cor e Forma:SolidPeso molecular:287.701ACT-672125
CAS:<p>ACT-672125: Potent CXCR3 blocker, may treat autoimmunity, safe with dose-dependent efficacy in lung inflammation.</p>Fórmula:C25H25F3N10O2SCor e Forma:SolidPeso molecular:586.59CXCR4 antagonist 10
CAS:<p>CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.</p>Fórmula:C18H18N4O4Cor e Forma:SolidPeso molecular:354.36PARL-IN-1
<p>PARL-IN-1: Strong PARL blocker, IC50 28 nM, boosts PINK1/Parkin mitophagy.</p>Fórmula:C40H58N6O7Cor e Forma:SolidPeso molecular:734.92ACT-777991
CAS:<p>ACT-777991: oral CXCR3 blocker, stable in microsomes/hepatocytes, inhibits T-cell migration to CXCL11.</p>Fórmula:C20H20F6N8O2SCor e Forma:SolidPeso molecular:550.48LRRK2-IN-2
CAS:<p>LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.</p>Fórmula:C23H23Cl2F3N6O2Cor e Forma:SolidPeso molecular:543.37HMG499
CAS:<p>HMG499 inhibits HMG-CoA reductase (IC50: 0.41μM), reduces statin-induced HMGCR, lowers cholesterol, and lessens atherosclerosis.</p>Fórmula:C33H54O3Pureza:98%Cor e Forma:SolidPeso molecular:498.78HDAC10-IN-1
<p>HDAC10-IN-1 is a potent, selective HDAC10 inhibitor (IC50=58 nM) affecting autophagy in FLT3-ITD+ acute myeloid leukemia cells.</p>Fórmula:C18H23N3O2Cor e Forma:SolidPeso molecular:313.39Stauprimide
CAS:<p>Stauprimide inhibits MYC by blocking NME2, reducing MYC transcription in ESCs.</p>Fórmula:C35H28N4O5Pureza:98%Cor e Forma:SolidPeso molecular:584.62DQ661
CAS:<p>DQ661 is a potent inhibitor of PPT1 and a dimeric quinacrine autophagy (autophagy) inhibitor. It effectively suppresses the activity of mTORC1 and reduces protein expression levels of pS6K T389 and pS6 S240-244. Additionally, DQ661 exhibits anticancer properties.</p>Fórmula:C41H47Cl2N5O2Cor e Forma:SolidPeso molecular:712.75BRD1991
CAS:<p>BRD1991 is a chemical compound that specifically disrupts the interaction between Beclin 1 and Bcl-2, thereby inducing autophagy.</p>Fórmula:C33H35Cl2N3O4Cor e Forma:SolidPeso molecular:608.55Z-FY-CHO
CAS:<p>Pyridoxal (Pyridoxaldehyde), a component of vitamin B6, is an aldehyde obtained by oxidizing pyridoxine and is widely found in plants and animals.</p>Fórmula:C26H26N2O5Pureza:95.88%Cor e Forma:SolidPeso molecular:446.5
