Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1424 produtos de "Autofagia"
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Vps34-IN-1
CAS:<p>Vps34-IN-1: potent, selective Vps34 inhibitor, 25 nM IC50, spares class I/II PI3Ks.</p>Fórmula:C21H24ClN7OPureza:97.04%Cor e Forma:SolidPeso molecular:425.91SAR405
CAS:<p>SAR-405 inhibits PIK3C3/Vps34 (IC50: 1.2 nM, Kd: 1.5 nM), blocks autophagy, and enhances MTOR inhibitor effects on cancer cells.</p>Fórmula:C19H21ClF3N5O2Pureza:99.42% - 99.79%Cor e Forma:SolidPeso molecular:443.85Galangin
CAS:<p>Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.</p>Fórmula:C15H10O5Pureza:98.24% - 99.93%Cor e Forma:Yellowish Needle-Like CrystalPeso molecular:270.24CZC-25146
CAS:<p>CZC-25146, a stable LRRK2 inhibitor, IC50: 4.76 nM (wild-type), 6.87 nM (G2019S).</p>Fórmula:C22H25FN6O4SPureza:97.68%Cor e Forma:SolidPeso molecular:488.54AZ304
CAS:<p>AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).</p>Fórmula:C27H25N5O2Pureza:99.82%Cor e Forma:SolidPeso molecular:451.52KB-R7943 mesylate
CAS:<p>KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 μM.</p>Fórmula:C17H21N3O6S2Pureza:99.88% - ≥95%Cor e Forma:SolidPeso molecular:427.5Briciclib
CAS:<p>Briciclib (ON 014185) is a small molecule that suppresses cyclin D1 accumulation in Y cells.</p>Fórmula:C19H23O10PSPureza:98% - 99.84%Cor e Forma:SolidPeso molecular:474.42JNJ-42165279
CAS:<p>JNJ-42165279 selectively inactivates FAAH without notably affecting other enzymes, ion channels, receptors, or CYPs/hERG at 10 μM.</p>Fórmula:C18H17ClF2N4O3Pureza:99.67% - 99.88%Cor e Forma:SolidPeso molecular:410.8Hoechst 33342
CAS:<p>Hoechst 33342 (bisBenzimide H 33342) is a benzimidazole fluorescent dye and a cell-permeable fluorescent DNA dye. High-Quality, Low-Cost!</p>Fórmula:C27H28N6OPureza:98.12% - 99.75%Cor e Forma:Yellow-Green PowderPeso molecular:452.55Brevilin A
CAS:<p>Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.</p>Fórmula:C20H26O5Pureza:99.97% - >99.99%Cor e Forma:SolidPeso molecular:346.42Ponatinib
CAS:<p>Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively</p>Fórmula:C29H27F3N6OPureza:98% - 99.60%Cor e Forma:SolidPeso molecular:532.56Actein
CAS:<p>Actein stimulates bone formation, counters osteoporosis and oxidative damage, and may treat lipid disorders and cancer, inhibiting breast cancer cell growth.</p>Fórmula:C37H56O11Pureza:≥98%Cor e Forma:Brown PowderPeso molecular:676.83Tempol
CAS:<p>Tempol (Tanol) is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.</p>Fórmula:C9H18NO2Pureza:97% - 99.74%Cor e Forma:4-Hydroxy-Tempo Appears As Orange Flakes Solid FlakesPeso molecular:172.25N-Benzyllinolenamide
CAS:<p>N-Benzyllinolenamide is a natural product. It is an inhibitor of fatty acid amide hydrolase (FAAH, IC50 of 41.8 μM).</p>Fórmula:C25H37NOPureza:98.7% - 99.92%Cor e Forma:SolidPeso molecular:367.57Peretinoin
CAS:<p>Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.</p>Fórmula:C20H30O2Pureza:97.23%Cor e Forma:SolidPeso molecular:302.45LC3-mHTT-IN-AN2
CAS:<p>LC3-mHTT-IN-AN2 (5,7-Dihydroxy-4-phenylcoumarin) is found in the plant Passiflora serratodigitata with the antibacterial activity.</p>Fórmula:C15H10O4Pureza:98.82% - ≥98%Cor e Forma:SolidPeso molecular:254.24Rabusertib
CAS:<p>Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.</p>Fórmula:C18H22BrN5O3Pureza:98.86% - 99.87%Cor e Forma:SolidPeso molecular:436.3SN-38
CAS:<p>SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).</p>Fórmula:C22H20N2O5Pureza:98% - 99.97%Cor e Forma:Light-Yellow SolidPeso molecular:392.4Ethyl 3,4-dihydroxybenzoate
CAS:<p>Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.</p>Fórmula:C9H10O4Pureza:99.88%Cor e Forma:White Crystal Or PowderPeso molecular:182.17AS1842856
CAS:<p>AS1842856 is a Foxo1 inhibitor that blocks the transcriptional activity of Foxo1. AS1842856 has autophagy inhibitory activity. Cost-effective and quality-assured.</p>Fórmula:C18H22FN3O3Pureza:99.36% - >99.99%Cor e Forma:SolidPeso molecular:347.38DMH-1
CAS:<p>DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.</p>Fórmula:C24H20N4OPureza:98% - 99.92%Cor e Forma:SolidPeso molecular:380.44SP600125
CAS:<p>SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitive</p>Fórmula:C14H8N2OPureza:97.63% - 99.82%Cor e Forma:SolidPeso molecular:220.23Pexmetinib
CAS:<p>Pexmetinib (ARRY-614) is an orally bioavailable dual p38 MAPK/Tie-2 inhibitor.Cost-effective and quality-assured.</p>Fórmula:C31H33FN6O3Pureza:99.07% - 99.66%Cor e Forma:SolidPeso molecular:556.63Vps34-IN-4
CAS:<p>VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)</p>Fórmula:C21H25N7OPureza:98.6%Cor e Forma:SolidPeso molecular:391.473BDO
CAS:<p>3BDO is a new mTOR activator. 3BDO inhibits autophagy.</p>Fórmula:C18H17NO5Pureza:97.76%Cor e Forma:SolidPeso molecular:327.33XCT790
CAS:<p>XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).</p>Fórmula:C23H13F9N4O3SPureza:99% - 99.61%Cor e Forma:SolidPeso molecular:596.4220-DEOXYINGENOL
CAS:<p>20-DEOXYINGENOL is a natual product.</p>Fórmula:C20H28O4Pureza:99.98% - ≥95%Cor e Forma:SolidPeso molecular:332.43Pseudolaric Acid B
CAS:<p>Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi.</p>Fórmula:C23H28O8Pureza:98.91% - 99.84%Cor e Forma:SolidPeso molecular:432.46U0126
CAS:<p>U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively.</p>Fórmula:C18H16N6S2Pureza:99.61%Cor e Forma:White SolidPeso molecular:380.49Torin 1
CAS:<p>Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.</p>Fórmula:C35H28F3N5O2Pureza:98.3% - 99.33%Cor e Forma:SolidPeso molecular:607.62Clinofibrate
CAS:<p>Clinofibrate lowers lipids, blocks HMGCR (IC50: 0.47 mM), and controls cholesterol/triacylglycerides.</p>Fórmula:C28H36O6Pureza:>99.99%Cor e Forma:White Crystalline PowderPeso molecular:468.58Alginic acid
CAS:<p>Alginic acid, a polysaccharide from brown seaweed, has anti-anaphylactic and anti-inflammatory properties and is used in food industry.</p>Fórmula:C14H22O13Pureza:≥98%Cor e Forma:SolidPeso molecular:398.317Oleanolic Acid
CAS:<p>Oleanolic Acid (Caryophyllin) is a natural compound with anti-tumor activities, which are widely distributed in plants.</p>Fórmula:C30H48O3Pureza:97.04% - 98.51%Cor e Forma:SolidPeso molecular:456.7Tetrahydrocurcumin
CAS:<p>Tetrahydrocurcumin (HZIV 81-2), a major metabolite of curcumin, has strong antioxidant and cardioprotective properties.</p>Fórmula:C21H24O6Pureza:97.81% - 98.82%Cor e Forma:Solid PowderPeso molecular:372.41Salbutamol hemisulfate
CAS:<p>Salbutamol hemisulfate (Albuterol Sulfate) is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 μM.</p>Fórmula:C13H21NO3H2O4SPureza:99.35%Cor e Forma:White Or Almost White Odourless PowderPeso molecular:576.70JZL195
CAS:<p>JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.</p>Fórmula:C24H23N3O5Pureza:99.81%Cor e Forma:SolidPeso molecular:433.46Acumapimod
CAS:<p>Acumapimod (BCT-197) is an orally active inhibitor of p38α MAPK (IC50 <1 μM).</p>Fórmula:C22H19N5O2Pureza:≥95%Cor e Forma:SolidPeso molecular:385.42Lithocholic acid
CAS:<p>Lithocholic acid (3α-Hydroxy-5β-cholanic acid) is a toxic secondary bile acid, They were FXR antagonists (IC50=0.7, 1.4 μM). High-Quality, Low-Cost!</p>Fórmula:C24H40O3Pureza:99.69% - 99.93%Cor e Forma:Hexagonal Leaflets From Alc Prisms From Acetic Acid Powder (Ntp 1992)Peso molecular:376.57Scutellarein
CAS:<p>Scutellarein (6-Hydroxyapigenin) reduces inflammatory responses by inhibiting Src kinase activity.</p>Fórmula:C15H10O6Pureza:98.02% - 99.63%Cor e Forma:SolidPeso molecular:286.24Vancomycin
CAS:<p>Vancomycin is a glycopeptide antibiotic that exerts its antimicrobial activity by altering the permeability of cell membranes and selectively inhibiting</p>Fórmula:C66H75Cl2N9O24Pureza:98.76% - 99.35%Cor e Forma:Almost White PowderPeso molecular:1449.25URB-597
CAS:<p>URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.</p>Fórmula:C20H22N2O3Pureza:97.20% - 98.24%Cor e Forma:SolidPeso molecular:338.4Tropifexor
CAS:<p>Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.</p>Fórmula:C29H25F4N3O5SPureza:99.3% - 99.85%Cor e Forma:SolidPeso molecular:603.58Obeticholic Acid
CAS:<p>Obeticholic Acid (6-ECDCA, INT-747) is a high-affinity, semisynthetic, bile acid-derived FXR agonist.Cost-effective and quality-assured.</p>Fórmula:C26H44O4Pureza:99.88% - 99.97%Cor e Forma:SolidPeso molecular:420.63TG101209
CAS:<p>TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.</p>Fórmula:C26H35N7O2SPureza:99% - >99.99%Cor e Forma:SolidPeso molecular:509.67Pifithrin-μ
CAS:<p>Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.</p>Fórmula:C8H7NO2SPureza:99.33% - 99.79%Cor e Forma:SolidPeso molecular:181.21Valinomycin
CAS:<p>Valinomycin (NSC-122023) is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes Parkin</p>Fórmula:C54H90N6O18Pureza:95.37% - 97.16%Cor e Forma:White SolidPeso molecular:1111.32Eupatilin
CAS:<p>Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.</p>Fórmula:C18H16O7Pureza:98.53% - 99%Cor e Forma:SolidPeso molecular:344.32LYN-1604
CAS:<p>LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.</p>Fórmula:C33H43Cl2N3O2Pureza:98%Cor e Forma:SolidPeso molecular:584.62SR9009
CAS:<p>SR9009, a REV-ERB agonist, modulates genes and circadian rhythms, reducing fat mass and improving metabolism in obese mice.</p>Fórmula:C20H24ClN3O4SPureza:99.94% - >99.99%Cor e Forma:SolidPeso molecular:437.94BC1618
CAS:<p>BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling.</p>Fórmula:C24H24F3NO2Pureza:99.95%Cor e Forma:SolidPeso molecular:415.45
