Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1424 produtos de "Autofagia"
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IT1t dihydrochloride
CAS:<p>IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.</p>Fórmula:C21H36Cl2N4S2Pureza:99.91%Cor e Forma:SolidPeso molecular:479.57Cysmethynil
CAS:<p>Cysmethynil is an indole-based Icmt inhibitor with antitumor activity, induces cell cycle arrest in G1 phase, and can be used for the study of solid tumors.</p>Fórmula:C25H32N2OPureza:99%Cor e Forma:SolidPeso molecular:376.53Laduviglusib trihydrochloride
CAS:<p>Laduviglusib trihydrochloride, a GSK-3α/β inhibitor (IC50: 10/6.7 nM), activates Wnt/β-catenin signaling and induces autophagy.</p>Fórmula:C22H20Cl5N8Pureza:99.34%Cor e Forma:SolidPeso molecular:573.71Elubrixin
CAS:<p>Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM).</p>Fórmula:C17H17Cl2FN4O4SPureza:98.65% - 99.78%Cor e Forma:SolidPeso molecular:463.31Dactolisib Tosylate
CAS:<p>Dactolisib Tosylate (BEZ235 Tosylate) is a dual kinase inhibitor that targets PI3K and mTOR.</p>Fórmula:C37H31N5O4SPureza:99.91%Cor e Forma:SolidPeso molecular:641.74XRK3F2
CAS:<p>XRK3F2 inhibits p62-ZZ, counters MM's Runx2 suppression in vitro, and prompts bone growth and remodeling in vivo with tumors.</p>Fórmula:C23H24ClF2NO3Pureza:98.75% - 98.91%Cor e Forma:SolidPeso molecular:435.89Tin-protoporphyrin IX dichloride
CAS:<p>Tin-protoporphyrin IX inhibits HO-1, enhancing chemo efficacy in mouse PDAC.</p>Fórmula:C34H32Cl2N4O4SnPureza:98%Cor e Forma:SolidPeso molecular:750.26CHIR-99021 HCl
CAS:<p>CHIR-99021 HCl is a selective GSK-3α/β inhibitor (IC50: 10/6.7 nM), 500x selective over other kinases, boosts Wnt pathway, and enhances stem cell renewal.</p>Fórmula:C22H19Cl3N8Pureza:98.07% - 98.14%Cor e Forma:SolidPeso molecular:501.8Cytarabine hydrochloride
CAS:<p>Cytarabine hydrochloride (Ara-C hydrochloride) is a nucleoside analog that causes S phase cell cycle arrest and inhibits DNA polymerase.</p>Fórmula:C9H14ClN3O5Pureza:98.46%Cor e Forma:White PowderPeso molecular:279.68ITX5061
CAS:<p>ITX5061 is a type II inhibitor of p38 MAPK and scavenger receptor B1 (SRB1) antagonist for the study of hepatitis C virus infection.</p>Fórmula:C30H38ClN3O7SPureza:98.35%Cor e Forma:SolidPeso molecular:620.16LRRK2-IN-7
CAS:<p>LRRK2-IN-7: potent, selective CNS-active LRRK2 inhibitor, IC50 0.9 nM, >1000x selectivity vs kinases/channels/CYPs.</p>Fórmula:C24H26N6OPureza:99.26%Cor e Forma:SolidPeso molecular:414.5AZD8797
CAS:<p>AZD8797 (KAND567) is a CX3CR1 antagonist with potential protective effects against neuronal damage and prevents nociceptive hypersensitivity in rats.</p>Fórmula:C19H25N5OS2Pureza:98.73% - 99.68%Cor e Forma:SolidPeso molecular:403.56Mavorixafor
CAS:<p>Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.</p>Fórmula:C21H27N5Pureza:98.56%Cor e Forma:SolidPeso molecular:349.47AZD8309
CAS:<p>AZD8309 is an oral CXCR2 antagonist, curbing neutrophil movement, lowering MPO in lungs/pancreas, and trypsin/elastase activity.</p>Fórmula:C15H14F2N4O2S2Pureza:98.35% - 99.67%Cor e Forma:SolidPeso molecular:384.42FMK 9a
CAS:<p>FMK 9a is an irreversible inhibitor of ATG4B with IC50 values of 80 and 73 nM in the TR-FRET and cellular-based LRA assays.</p>Fórmula:C23H21FN2O3Pureza:98.97%Cor e Forma:SolidPeso molecular:392.42MTK458
CAS:<p>MTK458 (EP-0035985) is a PINK1 activator with antidepressant activity for the study of Parkinson;s disease.</p>Fórmula:C17H15F3N4Pureza:98.36%Cor e Forma:SolidPeso molecular:332.32Cosalane
CAS:<p>Cosalane (NSC 658586) is an HIV replication inhibitor and an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice.</p>Fórmula:C45H60Cl2O6Pureza:99.53% - 99.78%Cor e Forma:SolidPeso molecular:767.86DCAP
CAS:<p>DCAP, a broad-spectrum antibiotic, disrupts the membranes of both Gram-positive and Gram-negative bacteria. Additionally, it inhibits late-stage autophagy by blocking autophagolysosome maturation and interrupting autophagic flux [1].</p>Fórmula:C19H22Cl2N2O4Cor e Forma:SolidPeso molecular:413.3XIE62-1004
CAS:<p>XIE62-1004 is a chemical compound that induces the interaction between p62 and LC3 by binding to the ZZ domain of p62.</p>Fórmula:C23H25NO3·HClCor e Forma:SolidPeso molecular:399.91p38-α MAPK-IN-1
CAS:<p>p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM in EFC displacement assay and HTRF assay,respectively.</p>Fórmula:C27H35N5O3Pureza:99.93%Cor e Forma:SolidPeso molecular:477.66CEPN
CAS:<p>6CEPN is a Cyclooxygenase-1 inhibitor that acts by suppressing colorectal cancer growth.</p>Fórmula:C23H18O5Cor e Forma:SolidPeso molecular:374.39CXCR4 antagonist 6
CAS:<p>CXCR4 antagonist 6 blocks CXCR4 (IC50: 79 nM), hinders calcium flux (IC50: 0.25 nM), reduces cell migration, and is effective in cancer metastasis mice.</p>Fórmula:C21H30N6Cor e Forma:SolidPeso molecular:366.5Calmidazolium chloride
CAS:<p>Calmidazolium chloride blocks calmodulin, hinders phosphodiesterase (IC50=0.15µM), Ca2+-ATPase (IC50=0.35µM), and can induce cancer cell apoptosis.</p>Fórmula:C31H23Cl7N2OPureza:98.53%Cor e Forma:SolidPeso molecular:687.7AEW541 HCl
CAS:<p>AEW541 (CAS# 475489-16-8) is a selective IGF-IR kinase inhibitor (IC50: IGF-IR=0.086μM, InsR=2.3μM), blocking IGF-I effects and colony formation.</p>Fórmula:C27H31Cl2N5OCor e Forma:SolidPeso molecular:512.47Antitumor agent-82
<p>Antitumor agent-82: potent, anti-proliferative, induces autophagy via ATG5/ATG7.</p>Fórmula:C32H42N6Cor e Forma:SolidPeso molecular:510.72KN-93 Phosphate
CAS:<p>KN-93 (Phosphate) can competitively block the binding of calmodulin to the corresponding kinase.Cost-effective and quality-assured.</p>Fórmula:C26H32ClN2O8PSPureza:99.58% - 99.93%Cor e Forma:SolidPeso molecular:599.03RK-682
CAS:<p>RK-682 is a natural selective inhibitor of protein tyrosine phosphatases (PTPases).</p>Fórmula:C21H36O5Cor e Forma:SolidPeso molecular:368.51AGN-195183
CAS:<p>AGN 195183: RARα agonist, Kd=3 nM, selective, no RARβ/γ effect, inhibits breast cancer cells, in Phase I/II clinical trials, non-irritant.</p>Fórmula:C22H22ClF2NO4Cor e Forma:SolidPeso molecular:437.86Di-N-desethyl amiodarone hydrochloride
CAS:<p>Di-N-desethyl Amiodarone hydrochloride, a metabolite of Amiodarone, functions as a potent inhibitor of the respiratory chain [1].</p>Fórmula:C21H22ClI2NO3Pureza:98%Cor e Forma:SolidPeso molecular:625.67LY2955303
CAS:<p>LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).</p>Fórmula:C36H42N4O3Pureza:98.56% - 99.85%Cor e Forma:SolidPeso molecular:578.74E6130
CAS:<p>E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.</p>Fórmula:C28H37ClF3N3O3Cor e Forma:SolidPeso molecular:556.06(3R,5R)-Rosuvastatin
CAS:<p>(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).</p>Fórmula:C22H28FN3O6SPureza:98%Cor e Forma:SolidPeso molecular:481.544E2RCat
CAS:<p>4E2RCat is an inhibitor of eIF4E-eIF4G interaction (IC50 = 13.5 μM) and is capable of blocking coronavirus replication as monitored by viral protein expression</p>Fórmula:C22H14ClNO4S2Pureza:98.44%Cor e Forma:SolidPeso molecular:455.93Beclin1-ATG14L interaction inhibitor 1
CAS:<p>Beclin1-ATG14L Interaction Inhibitor 1 (COM 19) is a selective inhibitor targeting the specific interaction between Beclin1 and ATG14L.</p>Fórmula:C23H24N4O5SPureza:98%Cor e Forma:SolidPeso molecular:468.53INT-767
CAS:<p>INT-767 is a highly potent farneson X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral fat brown lipogenesis and mitochondrial function</p>Fórmula:C25H43NaO6SPureza:98%Cor e Forma:SolidPeso molecular:494.66CXCR4 antagonist 7
CAS:<p>Compound PARA-B, a CXCR4 antagonist with IC50 = 9.3 nM, targets HIV, cancer, inflammatory diseases, and WHIM syndrome.</p>Fórmula:C15H17N5O3Cor e Forma:SolidPeso molecular:315.33Ruxolitinib sulfate
CAS:<p>Ruxolitinib sulfate, a potent JAK1/2 inhibitor (IC50: 3.3/2.8 nM), is >130x more selective for JAK1/2 than JAK3.</p>Fórmula:C17H20N6O4SCor e Forma:SolidPeso molecular:404.45Gly-β-MCA
CAS:<p>Gly-β-MCA is an orally bioactive, entero inhibitor of the farnesoid X receptor (FXR), a bile acid, used in the study of obesity and diabetes.</p>Fórmula:C26H43NO6Pureza:≥98.0%Cor e Forma:SolidPeso molecular:465.62Butylate
CAS:<p>Butylate is a herbicide of thiocarbamate.</p>Fórmula:C11H23NOSCor e Forma:Less Liquid Which Darkens Upon Exposure To Light Air And Moisture Colorless Liquid Which Darkens Upon Exposure To Light Air And MoisturePeso molecular:217.37CXCR2-IN-2
CAS:<p>CXCR2-IN-2: A selective, brain-penetrant, oral CXCR2 inhibitor (IC50: 5.2 nM/1 nM). ~730x selectivity vs CXCR1, >1900x vs other chemokine receptors.</p>Fórmula:C18H23ClN2O5SCor e Forma:SolidPeso molecular:414.9(R,R)-CXCR2-IN-2
CAS:<p>'(R,R)-CXCR2-IN-2 is a brain-penetrating diastereoisomer and CXCR2 antagonist with pIC50 of 9 (Tango) and 6.8 (HWB Gro-α/CD11b).'</p>Fórmula:C18H23ClN2O5SCor e Forma:SolidPeso molecular:414.9TIQ-15
CAS:<p>TIQ-15 is an effective and selective CXCR4 antagonist. It has good drug-like properties.</p>Fórmula:C23H32N4Pureza:98%Cor e Forma:SolidPeso molecular:364.53p38 MAPK-IN-1
CAS:<p>p38 MAPK-IN-1 is a novel selective p38 MAPK inhibitor with high potency, which reduces inflammatory responses by inhibiting LPS-induced TNF-α production.</p>Fórmula:C21H14F2N2OPureza:98%Cor e Forma:SolidPeso molecular:348.35CXCR2 antagonist 3
CAS:<p>Compound 11h, a CXCR2 antagonist, inhibits neutrophil/MDSCs and boosts CD3+ T cells in Pan02 tumors.</p>Fórmula:C17H15FN2O4SCor e Forma:SolidPeso molecular:362.38(±)-AMG 487
<p>AMG 487 is an effective and selective antagonist of chemokine receptor 3.</p>Fórmula:C32H28F3N5O4Pureza:98%Cor e Forma:SolidPeso molecular:603.59BPO-27 racemate
CAS:<p>BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.</p>Fórmula:C26H18BrN3O6Pureza:97.67% - 98.86%Cor e Forma:SolidPeso molecular:548.34Ladarixin Sodium
CAS:<p>Ladarixin Sodium, an Chemokine CXCR antagonist, is used potentially for the treatment of type I diabetes.</p>Fórmula:C11H12F3NNaO6S2Cor e Forma:SolidPeso molecular:398.32SR10067
CAS:<p>SR10067 is a potent, selective and brain penetrant agonist of Rev-Erbβ(IC50 = 160 nM) and Rev-Erbα(IC50 = 170 nM) with anxiolytic activity.</p>Fórmula:C31H31NO3Pureza:99.57%Cor e Forma:SolidPeso molecular:465.58Acitretin sodium
CAS:<p>Acitretin sodium is a second-generation, systemic retinoid. It is also has been used in the treatment of psoriasis.</p>Fórmula:C21H26NaO3Pureza:98%Cor e Forma:SolidPeso molecular:349.42AGN 194078
CAS:<p>AGN 194078 is a selective RARα agonist (Kd: 3 nM; EC50: 112 nM).</p>Fórmula:C22H23F2NO4Cor e Forma:SolidPeso molecular:403.42
