Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1489 produtos de "Autofagia"
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CXCR2 antagonist 4
CXCR2 antagonist 4 inhibits CXCR2 (IC50: 0.13 μM) and CXCL8-induced calcium rise (IC50: 27 μM), promising for cancer research.Fórmula:C15H14F2N4OS2Cor e Forma:SolidPeso molecular:368.42DQ661
CAS:DQ661 is a potent inhibitor of PPT1 and a dimeric quinacrine autophagy (autophagy) inhibitor. It effectively suppresses the activity of mTORC1 and reduces protein expression levels of pS6K T389 and pS6 S240-244. Additionally, DQ661 exhibits anticancer properties.Fórmula:C41H47Cl2N5O2Cor e Forma:SolidPeso molecular:712.75SRI-31255
CAS:SRI-31255 is an orally active LRRK2 inhibitor, with IC50 values of 520 nM for human wild-type (WT) and 427 nM for the G2019S mutant. It inhibits kinase activity by binding to the ATP-binding pocket of LRRK2, providing neuroprotective effects. SRI-31255 serves as a lead compound for developing LRRK2-targeted therapies for Parkinson’s disease research.Fórmula:C15H14N4Cor e Forma:SolidPeso molecular:250.30LRRK2-IN-6
LRRK2-IN-6 is an oral, selective LRRK2 inhibitor crossing the blood-brain barrier, targeting GS (IC50: 4.6μM) and WT LRRK2 (IC50: 49μM).Fórmula:C23H24F2N4O2SCor e Forma:SolidPeso molecular:458.52Anle138b-F105
CAS:<p>Anle138b-F105 is an autophagy-targeting chimera (AUTOTAC) with a DC50 value of 3 nM. It targets tauP301L for lysosomal degradation.</p>Fórmula:C36H37FN4O5Cor e Forma:SolidPeso molecular:624.7SH498
CAS:<p>SH498 is a novel Bmi-1-mediated anti-tumor agent with significant anti-proliferative effects.</p>Fórmula:C27H25F3N2O4Cor e Forma:SolidPeso molecular:498.49LRRK2-IN-3
CAS:LRRK2-IN-3: potent, selective oral LRRK2 blocker, BBB-penetrant, IC50 of 0.6 nM in hPBMCs, for Parkinson's research.Fórmula:C25H29ClF2N6O2Cor e Forma:SolidPeso molecular:518.99Hesperadin hydrochloride
Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.Fórmula:C29H33ClN4O3SCor e Forma:SolidPeso molecular:553.12LRRK2-IN-4
CAS:LRRK2-IN-4: Potent, selective LRRK2 inhibitor, oral, BBB-penetrating, IC50=2.6 nM, potential for Parkinson's.Fórmula:C25H29ClF2N6O2Cor e Forma:SolidPeso molecular:518.99YW3-56 (hydrochloride) (technical grade)
CAS:YW3-56: PAD2 & PAD4 inhibitor (IC50 = 0.5-5 μM), halts U2OS cell growth (IC50 ~2.5 μM), reduces S-180 & MDA-MB-231 tumor growth in mice.Fórmula:C27H33Cl2N5O2Cor e Forma:SolidPeso molecular:530.49BRD5631
CAS:BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway.Fórmula:C30H35N3O4Pureza:98%Cor e Forma:SolidPeso molecular:501.62LRRK2-IN-19
CAS:LRRK2-IN-19 is a PROTAC-targeted protein ligand utilized in the synthesis of PROTAC JH-XII-03-02. JH-XII-03-02 acts as an effective and selective LRRK2 PROTAC degrader, which is applicable for research in Parkinson's disease.Fórmula:C19H22N6OCor e Forma:SolidPeso molecular:350.42LRRK2-IN-5
LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.Fórmula:C24H26F2N4O2SCor e Forma:SolidPeso molecular:472.55LRRK2-IN-20
CAS:LRRK2-IN-20 (EX. 4.64) is a selective inhibitor of LRRK2 with a potency of pIC50 at 0.7921 nM. This compound is applicable in research studies focused on Parkinson's Disease (PD).Fórmula:C24H32ClN7OCor e Forma:SolidPeso molecular:470.01CXCR2 antagonist 5
<p>CXCR2 antagonist 5 (compound 25) binds strongly (IC50=0.013μM) and mobilizes calcium (IC50=0.1μM).</p>Fórmula:C15H14F2N4O2SCor e Forma:SolidPeso molecular:352.36DC-LC3in-D5
CAS:DC-LC3in-D5 is a potent and selective covalent inhibitor of LC3A/B that disrupts autophagy by covalently binding to Lys49 on LC3B.Fórmula:C19H22Cl2N2O3Pureza:99.79%Cor e Forma:SolidPeso molecular:397.3Ref: TM-T61871
1mg99,00€5mg235,00€10mg376,00€25mg753,00€50mg1.169,00€100mg1.833,00€200mg2.460,00€1mL*10mM (DMSO)259,00€Rosiglitazone sodium
CAS:Rosiglitazone sodium is an effective and selective PPARγ activator, with EC50 values of 30 nM for PPARγ1, 100 nM for PPARγ2, and 60 nM for PPARγ. It also has an approximate Kd of 40 nM for PPARγ. Additionally, Rosiglitazone sodium acts as a regulator of TRP channels, inhibiting the activities of TRPM2 and TRPM3, while activating TRPC5.Fórmula:C18H18N3NaO3SCor e Forma:SolidPeso molecular:379.41HDAC1-IN-8
CAS:HDAC1-IN-8 (compound 5c) is a potent and selective HDAC1 inhibitor, with IC50 values of 11.94 µM for HDAC1, 22.95 µM for HDAC6, and greater than 500 µM for HDAC8. It exhibits antiproliferative activity, induces cell cycle arrest in G1 and G2/M phases, and triggers autophagy (autophagy). Additionally, HDAC1-IN-8 demonstrates anticancer properties and holds potential for lung cancer research.Fórmula:C22H24N2O4Cor e Forma:SolidPeso molecular:380.437BRD1991
CAS:BRD1991 is a chemical compound that specifically disrupts the interaction between Beclin 1 and Bcl-2, thereby inducing autophagy.Fórmula:C33H35Cl2N3O4Cor e Forma:SolidPeso molecular:608.55Acetylpepstatin
CAS:Acetylpepstatin is an inhibitor of HIV-1 protease, HIV-2 protease, aspartyl protease.Fórmula:C33H61N5O11Pureza:98%Cor e Forma:SolidPeso molecular:703.875Stauprimide
CAS:Stauprimide inhibits MYC by blocking NME2, reducing MYC transcription in ESCs.Fórmula:C35H28N4O5Pureza:98%Cor e Forma:SolidPeso molecular:584.62HDAC10-IN-2
HDAC10-IN-2, a selective HDAC10 inhibitor (IC50=20nM), modulates autophagy in FLT3-ITD+ acute myeloid leukemia.Fórmula:C19H22N2O2Cor e Forma:SolidPeso molecular:310.39CXCR2 antagonist 6
CXCR2 antagonist 6: strong CXCR2 affinity (IC50=0.044 μM), hinders calcium mobilization (IC50=0.66 μM).Fórmula:C17H16F2N4OSCor e Forma:SolidPeso molecular:362.4CXCR4 modulator-1
CAS:CXCR4 modulator-1 (ZINC72372983) is potent (EC50=100nM) with uses in anti-inflammatory, anticancer, and anti-HIV research.Fórmula:C23H27N5O2Cor e Forma:SolidPeso molecular:405.49SW063058
CAS:SW063058 is an autophagy inducer that specifically disrupts the interaction between Beclin 1 and Bcl-2 without affecting the interactions of Bcl-2 with pro-apoptotic members (such as Bax and BIM). By inhibiting the negative regulation of Beclin 1 (key to autophagy initiation) by Bcl-2, SW063058 enhances autophagic activity without inducing cytotoxicity, apoptosis, or other forms of cell death in vitro.Fórmula:C22H15BrFIN2O2Cor e Forma:SolidPeso molecular:565.17CXCR7 modulator 2
CAS:CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM.Fórmula:C29H42N6O3Cor e Forma:SolidPeso molecular:522.68Z-FY-CHO
CAS:Pyridoxal (Pyridoxaldehyde), a component of vitamin B6, is an aldehyde obtained by oxidizing pyridoxine and is widely found in plants and animals.Fórmula:C26H26N2O5Pureza:95.88%Cor e Forma:SolidPeso molecular:446.5SCH 563705
CAS:SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.Fórmula:C23H27N3O5Pureza:98.03%Cor e Forma:SolidPeso molecular:425.48DCC-3116
CAS:DCC-3116 is an orally active, selective and potent ULK1/2 inhibitor with anticancer activity.DCC-3116 inhibits autophagy and can be used in cancer research.Fórmula:C26H36F3N7O2Pureza:98.55%Cor e Forma:SoildPeso molecular:535.61Gepotidacin mesylate dihydrate
CAS:Gepotidacin mesylate dihydrate (GSK2140944 mesylate dihydrate) is an antibiotic and an inhibitor of bacterial type II topoisomerase.Fórmula:C25H36N6O8SPureza:99.85%Cor e Forma:SolidPeso molecular:580.65VUF11207 trifluoroacetate salt
CAS:VUF11207 trifluoroacetate salt is a useful organic compound for research related to life sciences. The catalog number is T66657 and the CAS number is 1378524-41-4.Fórmula:C29H36F4N2O6Cor e Forma:SolidPeso molecular:584.609Dihydrocelastrol
CAS:Dihydrocelastrol is synthesized by hydrogenation of celastrol, a treterpene isolated from Chinese medicinal plant Tripterygium regelii. Dihydrocelastrol could inhibit cell proliferation and promote apoptosis through caspase-dependent way in vitro. DHCE coFórmula:C29H40O4Cor e Forma:SolidPeso molecular:452.63Pepstatin Ammonium
Pepstatin Ammonium is a specific inhibitor of aspartic proteaseproduced by actinomycetes(hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nMFórmula:C34H66N6O9Pureza:98%Cor e Forma:SolidPeso molecular:702.92Dusquetide
CAS:Dusquetide is a first-in-class innate defense regulator. Dusquetide displays activity in both reducing inflammation and increasing the clearance of bacterial infection.Fórmula:C25H47N9O5Pureza:98%Cor e Forma:SolidPeso molecular:553.709Salvianolic acid B
CAS:<p>Salvianolic acid B (Dan Shen Suan B) is a water-soluble antioxidant from Salvia miltiorrhiza extract with antiplatelet aggregation and antithrombotic effects.</p>Fórmula:C36H30O16Pureza:99.75% - 99.86%Cor e Forma:Yellow SolidPeso molecular:718.61CXCR4-IN-1
CAS:<p>CXCR4-IN-1 (Example C5), with an IC50 of 20 nM, is a potent inhibitor of CXCR4, applicable for the research of various conditions such as cancer, HIV, diabetic</p>Fórmula:C23H32N6Pureza:98%Cor e Forma:SolidPeso molecular:392.54Ref: TM-T79059
Produto descontinuadoEIPA hydrochloride
CAS:EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM.Fórmula:C11H19Cl2N7OPureza:98%Cor e Forma:SolidPeso molecular:336.22FR 167653
CAS:FR 167653 sulfate, an orally active and selective inhibitor of p38 MAPK, is effective in treating inflammation, trauma, and ischemia-reperfusion injury in vivo. It acts as a potent suppressor of TNF-α and IL-1β production through specific inhibition of p38 MAPK activity.Fórmula:C24H20FN5O6SPureza:98%Cor e Forma:SolidPeso molecular:525.51VISTA-IN-2
CAS:<p>VISTA-IN-2 (Compound 1) is a V-domain Ig suppressor of T-cell activation (VISTA) inhibitor that promotes the degradation of VISTA in cells via autophagy,</p>Fórmula:C23H23N3OPureza:98%Cor e Forma:SolidPeso molecular:357.45Ref: TM-T79653
Produto descontinuado
