Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1486 produtos de "Autofagia"
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PTC-209 hydrobromide
CAS:<p>PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in</p>Fórmula:C17H13Br2N5OS·HBrPureza:99.91%Cor e Forma:SolidPeso molecular:576.1NSC 185058
CAS:NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.Fórmula:C11H9N3SPureza:99.27%Cor e Forma:SolidPeso molecular:215.27PF-543 hydrochloride
CAS:PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2Fórmula:C27H32ClNO4SPureza:98.9% - 99.93%Cor e Forma:SolidPeso molecular:502.1XL388
CAS:XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.Fórmula:C23H22FN3O4SPureza:99.39% - 99.53%Cor e Forma:SolidPeso molecular:455.5Autocamtide-2-related inhibitory peptide
CAS:Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.Fórmula:C64H116N22O19Pureza:>99.99%Cor e Forma:SolidPeso molecular:1497.74PF-06447475
CAS:PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.Fórmula:C17H15N5OPureza:98.61% - 99.62%Cor e Forma:SolidPeso molecular:305.33Onjisaponin B
CAS:Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-Fórmula:C75H112O35Pureza:99.20% - 99.972%Cor e Forma:SolidPeso molecular:1573.67URMC-099
CAS:URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 – MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.Fórmula:C27H27N5Pureza:99.32% - 99.98%Cor e Forma:SolidPeso molecular:421.54A-867744
CAS:A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).Fórmula:C20H19ClN2O3SPureza:95.66%Cor e Forma:SolidPeso molecular:402.89LYS01
CAS:LYS01 free base is a new lysosomal autophagy inhibitor.Fórmula:C23H23Cl2N5Pureza:98.28%Cor e Forma:SolidPeso molecular:440.37Spautin-1
CAS:Spautin-1 is an autophagy inhibitor that can suppress the deubiquitination activity of ubiquitin-specific peptidase USP10 and USP13. Cost-effective and quality-assured.Fórmula:C15H11F2N3Pureza:97.69% - 98.99%Cor e Forma:SolidPeso molecular:271.26TA-01
CAS:TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.Fórmula:C20H12F3N3Pureza:99.55% - 99.94%Cor e Forma:SolidPeso molecular:351.32PI3Kδ-IN-15
CAS:CAL-101 (Idelalisib) is a selective inhibitor of p110δ; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ.Fórmula:C21H16FN7OPureza:99.61%Cor e Forma:SolidPeso molecular:401.4Lanatoside C
CAS:Lanatoside C, a cardiac glycoside, treats heart failure and arrhythmia; taken orally or IV.Fórmula:C49H76O20Pureza:98.3% - >99.99%Cor e Forma:SolidPeso molecular:985.12Sofalcone
CAS:Sofalcone (SU-88), a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.Fórmula:C27H30O6Pureza:97.55%Cor e Forma:SolidPeso molecular:450.52Hesperadin
CAS:Hesperadin(IC50=250 nM) effectively inhibits Aurora B.Fórmula:C29H32N4O3SPureza:98.04% - 99.44%Cor e Forma:SolidPeso molecular:516.65Nitroprusside disodium dihydrate
CAS:Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) is a potent vasodilator working through releasing NO spontaneously in blood.Fórmula:C5H4FeN6Na2O3Pureza:98%Cor e Forma:Bright RedPeso molecular:297.95UNC1999
CAS:UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).Fórmula:C33H43N7O2Pureza:99.19% - >99.99%Cor e Forma:SolidPeso molecular:569.74α-Thujone
CAS:α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.Fórmula:C10H16OPureza:97.02% - 98.41%Cor e Forma:Less Or Almost Colorless Liquid With A Menthol- Like Odor (Albert-Puleo 1978; Budavari 1996) Colorless Or Almost Colorless Liquid With A Menthol- Like Odor (Albert-Puleo 1978; Budavari 1996)Peso molecular:152.23Ivacaftor
CAS:Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells,Fórmula:C24H28N2O3Pureza:99% - 99.98%Cor e Forma:SolidPeso molecular:392.49
