Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1483 produtos de "Autofagia"
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FIPI
CAS:<p>FIPI, a halopemide derivative, strongly blocks PLD1 and PLD2 (IC50s: 25 nM, 20 nM) and hinders PLD-mediated cell activity.</p>Fórmula:C23H24FN5O2Pureza:97.21% - 98.68%Cor e Forma:SolidPeso molecular:421.47BX795
CAS:BX795 selectively inhibits PDK1 (IC50: 6 nM), 140x over PKA, 1600x over PKC, 100x over GSK3β in cell-free assays.Fórmula:C23H26IN7O2SPureza:98% - 99.57%Cor e Forma:SolidPeso molecular:591.47PI-103
CAS:PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Fórmula:C19H16N4O3Pureza:97.79% - 99.3%Cor e Forma:SolidPeso molecular:348.36Rasagiline Mesylate
CAS:Rasagiline Mesylate (AGN1135) is a novel MAO-B inhibitor, which can treat idiopathic Parkinson's disease.Fórmula:C13H17NO3SPureza:99.33%Cor e Forma:White PowderPeso molecular:267.34Nordihydroguaiaretic acid
CAS:<p>Nordihydroguaiaretic acid (NDGA) is a natural lipoxygenase (5-LOX) inhibitor. Nordihydroguaiaretic acid has antioxidant effect. Cost-effective and quality-assured.</p>Fórmula:C18H22O4Pureza:97.82% - 99.91%Cor e Forma:SolidPeso molecular:302.36Elubrixin HCl
CAS:Elubrixin is a interleukin 8 inhibitor and CXCR2 selective antagonist.Fórmula:C17H18Cl3FN4O4SCor e Forma:SolidPeso molecular:499.77Piperlongumine
CAS:Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L.Fórmula:C17H19NO5Pureza:97.03% - 99.90%Cor e Forma:SolidPeso molecular:317.34AS-605240
CAS:AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).Fórmula:C12H7N3O2SPureza:97% - 99.91%Cor e Forma:SolidPeso molecular:257.27LC3-mHTT-IN-AN1
CAS:LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B.Fórmula:C15H9Br2NO3Pureza:97.26%Cor e Forma:SolidPeso molecular:411.04Oxyresveratrol
CAS:1.Fórmula:C14H12O4Pureza:98.09% - 99.69%Cor e Forma:Yellow SolidPeso molecular:244.24Tezacaftor
CAS:Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.Fórmula:C26H27F3N2O6Pureza:98.84% - >99.99%Cor e Forma:SolidPeso molecular:520.5Quercitrin
CAS:Quercitrin (3-rhamnosyl quercetin) is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities.Fórmula:C21H20O11Pureza:98.89% - 99.66%Cor e Forma:Yellow Crystals From Dil Methanol Or Ethanol SolidPeso molecular:448.38Alisertib
CAS:Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.Fórmula:C27H20ClFN4O4Pureza:98.31% - >99.99%Cor e Forma:SolidPeso molecular:518.92Rac-Belinostat
CAS:<p>Rac-Belinostat (PX-105684) is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.</p>Fórmula:C15H14N2O4SPureza:99.67% - 99.96%Cor e Forma:SolidPeso molecular:318.35NS1643
CAS:NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM.Fórmula:C15H10F6N2O3Pureza:98.37% - 99.31%Cor e Forma:SolidPeso molecular:380.24Polydatin
CAS:Polydatin, a resveratrol glycoside from Polygonum cuspidatum, inhibits platelet aggregation, alters lipid ratios, and modulates cell functions.Fórmula:C20H22O8Pureza:97.2% - 98.94%Cor e Forma:White Fine PowderPeso molecular:390.38Tubastatin A
CAS:Tubastatin A: Selective HDAC6 inhibitor, IC50 of 15 nM, 1000x less effective on other isozymes except HDAC8.Fórmula:C20H21N3O2Pureza:97.22% - 99.51%Cor e Forma:SolidPeso molecular:335.4NVP-AEW541
CAS:NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-basedFórmula:C27H29N5OPureza:98.7% - 99.86%Cor e Forma:SolidPeso molecular:439.55Lys05
CAS:Lys05, a potent autophagy inhibitor, outperforms HCQ in cancer treatment, showing promise for drug development.Fórmula:C23H26Cl5N5Pureza:99.13% - 99.55%Cor e Forma:SolidPeso molecular:549.75MK-2206 dihydrochloride
CAS:MK-2206 dihydrochloride (MK-2206 2HCl) is a variant Akt inhibitor that inhibits Akt1, Akt2, and Akt3 (IC50=8/12/65 nM) with orally active, highly potent andFórmula:C25H23Cl2N5OPureza:99.228% - 99.94%Cor e Forma:SolidPeso molecular:480.39
