DUB
Os inibidores de DUB (desubiquitinases) são compostos que têm como alvo as enzimas que removem moléculas de ubiquitina das proteínas, regulando assim a estabilidade, localização e atividade das proteínas dentro da célula. As desubiquitinases desempenham papéis essenciais em vários processos celulares, incluindo a regulação do ciclo celular, a reparação do DNA e as respostas imunológicas. A desregulação da atividade das DUB está associada ao câncer, distúrbios neurodegenerativos e infecções virais. Inibidores de DUB podem modular esses processos, oferecendo abordagens terapêuticas potenciais para essas condições. Na CymitQuimica, oferecemos inibidores de DUB para apoiar sua pesquisa em homeostase proteica, câncer e neurobiologia.
Foram encontrados 88 produtos de "DUB"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
C527
CAS:C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).Fórmula:C17H8FNO3Pureza:97.22%Cor e Forma:SolidPeso molecular:293.25IU1-47
CAS:IU1-47 是一种特异性 USP14抑制剂，IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5， IC50为 20 μM。Fórmula:C19H23ClN2OPureza:98.94%Cor e Forma:SolidPeso molecular:330.85Ref: TM-T15604
1mg35,00€5mg67,00€10mg115,00€25mg235,00€50mg378,00€100mg627,00€200mg875,00€1mL*10mM (DMSO)73,00€HBX 19818
CAS:<p>HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).</p>Fórmula:C25H28ClN3OPureza:97.71%Cor e Forma:SolidPeso molecular:421.96MF-094
CAS:MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.Fórmula:C30H37N3O4SPureza:99.93%Cor e Forma:SolidPeso molecular:535.7Ref: TM-T12024
1mg43,00€5mg87,00€10mg144,00€25mg283,00€50mg454,00€100mg655,00€200mg934,00€1mL*10mM (DMSO)104,00€GK13S
G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.Fórmula:C21H22N6O2Cor e Forma:SolidPeso molecular:390.44USP7-IN-10 hydrochloride
USP7-IN-10 hydrochloride, also known as compound 1, is a potent inhibitor of the enzyme ubiquitin-specific protease 7 (USP7), exhibiting an IC50 value of 13.39Fórmula:C26H30Cl2N4O3SCor e Forma:SolidPeso molecular:549.51OTUB1/USP8-IN-1 HCl
OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8 for leukaemiaFórmula:C22H17Cl2FN2O4Pureza:99.92%Cor e Forma:SolidPeso molecular:463.29UBD1031
UBD1031 exhibits strong affinity for the ubiquitin-binding domain (UBD) of USP16, with a dissociation constant (KD) of 48 nM. It inhibits the interaction between USP16 and ISG15, displaying an effective concentration (EC50) of 1.7 nM. UBD1031 can serve as a chemical probe for investigating USP16 UBD.Cor e Forma:Odour SolidOTUB2-IN-1
OTUB2-IN-1 is an OTUB2 inhibitor with antitumor activity and can be used to study skin cancer and non-small cell lung cancer (NSCLC).Fórmula:C19H18N2O6S2Pureza:98.19%Cor e Forma:SolidPeso molecular:434.49EN523
CAS:EN523 targets non-catalytic allosteric cysteine C23 in K48 ubiquitin-specific deuquitinase OTUB1.Fórmula:C12H14N2O3Pureza:99.5%Cor e Forma:SolidPeso molecular:234.25Ref: TM-T9884
1mg35,00€5mg70,00€10mg104,00€25mg235,00€50mg376,00€100mg602,00€200mg845,00€1mL*10mM (DMSO)71,00€USP7-IN-16
CAS:USP7-IN-16 (Compound 61) is a selective inhibitor of USP7, with IC50 values of 5.5 nM in the FLINT assay and 2.1 nM in MM.1S cells. This compound exhibits antitumor activity in mice and holds potential for research in the field of oncology.Fórmula:C43H45N7O6SCor e Forma:SolidPeso molecular:787.93USP7-IN-15
USP7-IN-15 (compound J21) is an inhibitor of USP7, exhibiting an IC50 value of 41.35 ± 2.16 nM.Cor e Forma:Odour SolidUSP7 Ligand-Linker Conjugates 1
USP7Ligand-Linker Conjugates 1 is a Target Protein Ligand-Linker Conjugate comprising a USP7 ligand and a PROTAC linker, capable of recruiting E3 ligase. It is utilized in the synthesis of PROTACUSP7 Degrader-1.Cor e Forma:Odour SolidBAY-728
BAY-728 serves as a negative control for BAY-805, a potent and selective inhibitor of USP21 [1].Fórmula:C24H28F3N5O2SCor e Forma:SolidPeso molecular:507.57Subquinocin
Subquinocin is a CYLD inhibitor that suppresses deubiquitinating enzymes (DUB) of the USP family. By inhibiting CYLD, Subquinocin enhances the activation of the NF-κB and IFN pathways. Additionally, Subquinocin facilitates the activation of IRF3 and/or IRF7 in the RIG-I-mediated interferon pathway.Fórmula:C20H27N3O4SCor e Forma:SolidPeso molecular:405.17223GK16S
GK16S, a UCHL1 chemogenomic probe, serves as a complementary tool to GK13S for the investigation of UCHL1 function in cellular studies [1].Fórmula:C11H15N3OCor e Forma:SoildPeso molecular:205.12151Ubiquitination Compound Library
A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；Cor e Forma:Odour SolidRef: TM-L8600
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarMS7131
MS7131 is a DUBTAC inhibitor that recruits USP1. It effectively reduces histone H3 lysine 27 trimethylation and significantly inhibits the proliferation and colony-forming ability of cancer cells.Cor e Forma:Odour SolidT20-M
T20-M is a precursor peptide with strong binding affinity for UBE2C.Fórmula:C87H140N22O26SCor e Forma:SolidPeso molecular:1942.24USP8-IN-2
CAS:<p>USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.</p>Fórmula:C19H20ClF3N4OSPureza:99.92%Cor e Forma:SolidPeso molecular:444.9USP8-IN-3
CAS:USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.Fórmula:C18H18F3N5O2SPureza:99.79%Cor e Forma:SolidPeso molecular:425.43Ref: TM-T67873
1mg35,00€5mg64,00€10mg97,00€25mg207,00€50mg329,00€100mg475,00€500mg938,00€1mL*10mM (DMSO)84,00€JAMM protein inhibitor 2
CAS:JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.Fórmula:C21H26N2O2Pureza:98.57%Cor e Forma:SolidPeso molecular:338.44STD1T
CAS:STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.Fórmula:C19H19N3O4S2Pureza:98.77%Cor e Forma:SolidPeso molecular:417.5USP8-IN-1
CAS:USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].Fórmula:C18H21N5O3SPureza:99.07%Cor e Forma:SoildPeso molecular:387.46Ref: TM-T60146
1mg88,00€5mg187,00€10mg264,00€25mg464,00€50mg655,00€100mg944,00€1mL*10mM (DMSO)207,00€P005091
CAS:P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.Fórmula:C12H7Cl2NO3S2Pureza:99.53% - 99.87%Cor e Forma:SolidPeso molecular:348.22ML-323
CAS:ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay and in orthogonal gel-based assays using K63-linked di-Ub and Ub-PCNA as substrates.Fórmula:C23H24N6Pureza:99.87% - 99.96%Cor e Forma:SolidPeso molecular:384.48EOAI3402143
CAS:EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis.Fórmula:C25H28Cl2N4O3Pureza:99.6%Cor e Forma:SolidPeso molecular:503.42Ref: TM-T11209
1mg66,00€5mg144,00€10mg227,00€25mg445,00€50mg717,00€100mg1.064,00€1mL*10mM (DMSO)160,00€XL177A
CAS:XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.Fórmula:C48H57ClN8O5Pureza:98.75%Cor e Forma:SolidPeso molecular:861.47USP25/28 inhibitor AZ1
CAS:USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor.Cost-effective and quality-assured.Fórmula:C17H16BrF4NO2Pureza:99.79% - 99.86%Cor e Forma:SolidPeso molecular:422.21Ref: TM-T7685
1mg35,00€5mg70,00€10mg97,00€25mg210,00€50mg321,00€100mg472,00€500mg1.035,00€1mL*10mM (DMSO)78,00€USP7-IN-8
CAS:Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.Fórmula:C21H21N3O2Pureza:99.31%Cor e Forma:SolidPeso molecular:347.41Ref: TM-T9217
1mg46,00€5mg92,00€10mg147,00€25mg269,00€50mg389,00€100mg532,00€200mg705,00€1mL*10mM (DMSO)100,00€SJB2-043
CAS:SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).Fórmula:C17H9NO3Pureza:98.44%Cor e Forma:SolidPeso molecular:275.26TCID
CAS:TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.Fórmula:C9H2Cl4O2Pureza:99.34%Cor e Forma:SolidPeso molecular:283.92DUB-IN-2
CAS:Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.Fórmula:C15H9N5OPureza:98.96%Cor e Forma:SolidPeso molecular:275.26Ref: TM-T11111
1mg74,00€5mg163,00€10mg245,00€25mg494,00€50mg720,00€100mg1.045,00€1mL*10mM (DMSO)172,00€GNE-6776
CAS:GNE-6776 is a selective USP7 inhibitor.Fórmula:C20H20N4O2Pureza:96.59% - 98.2%Cor e Forma:SolidPeso molecular:348.4Ref: TM-T4634
1mg81,00€5mg170,00€10mg273,00€25mg525,00€50mg753,00€100mg1.026,00€1mL*10mM (DMSO)187,00€P 22077
CAS:P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.Fórmula:C12H7F2NO3S2Pureza:97.9% - 99.64%Cor e Forma:SolidPeso molecular:315.32STAMBP-IN-1
CAS:STAMBP-IN-1 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release afterFórmula:C27H28N4O4SPureza:99.64%Cor e Forma:SolidPeso molecular:504.6Ref: TM-T8706
1mg71,00€5mg160,00€10mg250,00€25mg535,00€50mg772,00€100mg1.074,00€1mL*10mM (DMSO)A consultarNSC632839
CAS:NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2Fórmula:C21H22ClNOPureza:99.74% - 99.88%Cor e Forma:SolidPeso molecular:339.86IU1-248
CAS:IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].Fórmula:C20H23N3O2Pureza:99.3%Cor e Forma:SolidPeso molecular:337.42Ref: TM-T9375
1mg50,00€5mg97,00€10mg160,00€25mg319,00€50mg449,00€100mg640,00€200mg893,00€1mL*10mM (DMSO)107,00€ML364
CAS:ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.Fórmula:C24H18F3N3O3S2Pureza:99.35% - >99.99%Cor e Forma:SolidPeso molecular:517.54DUB-IN-1
CAS:DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).Fórmula:C20H11N5OPureza:98.33% - 98.96%Cor e Forma:SolidPeso molecular:337.33Ref: TM-T11110
1mg65,00€5mg116,00€10mg183,00€25mg353,00€50mg495,00€100mg652,00€200mg895,00€1mL*10mM (DMSO)128,00€USP7/USP47 inhibitor
CAS:USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM,Fórmula:C18H11Cl2N3O3S3Pureza:98.5% - 98.71%Cor e Forma:SolidPeso molecular:484.4Ref: TM-T4338
1mg43,00€5mg92,00€10mg160,00€25mg283,00€50mg452,00€100mg742,00€200mg1.008,00€1mL*10mM (DMSO)99,00€DUB-IN-3
CAS:DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.Fórmula:C16H9N5OPureza:99.34%Cor e Forma:SolidPeso molecular:287.28Ref: TM-T11112
1mg137,00€2mg188,00€5mg325,00€10mg465,00€25mg743,00€50mg1.035,00€100mg1.406,00€500mg2.802,00€1mL*10mM (DMSO)341,00€GNE-6640
CAS:GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).Fórmula:C20H18N4OPureza:98.64%Cor e Forma:SolidPeso molecular:330.38Ref: TM-T5461
1mg70,00€2mg92,00€5mg153,00€10mg250,00€25mg535,00€50mg772,00€100mg1.074,00€1mL*10mM (DMSO)166,00€VLX1570
CAS:VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.Fórmula:C23H17F2N3O6Pureza:98.53% - 99.91%Cor e Forma:SolidPeso molecular:469.39Ref: TM-T4067
1mg96,00€2mg155,00€5mg259,00€10mg406,00€25mg680,00€50mg938,00€100mg1.301,00€1mL*10mM (DMSO)265,00€USP1-IN-2
CAS:USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.Fórmula:C26H22F4N6OPureza:99.69% - 99.88%Cor e Forma:SolidPeso molecular:510.486POSH-IN-1
CAS:POSH-IN-1 (Compound 108) is an inhibitor of the POSH polypeptide （e3 ligase) and has antiviral, anticancer, and neurodegenerative disease potential.Fórmula:C14H8FNO3SPureza:99.29%Cor e Forma:SolidPeso molecular:289.28USP28-IN-3
CAS:USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Fórmula:C23H20Cl2N2O3SPureza:99.92%Cor e Forma:SolidPeso molecular:475.39FT827
CAS:FT827 is a covalent inhibitor of USP7 that targets the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.Fórmula:C27H28N6O5SPureza:98.76%Cor e Forma:SolidPeso molecular:548.61MF-095
CAS:MF-095 is a control probe for MF-094, which is a potent inhibitor of ubiquitin specific protease 30.Fórmula:C27H31N3O4SCor e Forma:SolidPeso molecular:493.62LCAHA
CAS:LCAHA is a USP2a inhibitor. LCAHA inhibits growth of cyclin D1-dependent cells.Fórmula:C24H41NO3Cor e Forma:SolidPeso molecular:391.59Capzimin
CAS:Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.Fórmula:C30H24N6O2S4Pureza:98.31% - 99.32%Cor e Forma:SolidPeso molecular:628.81Ref: TM-T10672
1mg48,00€2mgA consultar5mg95,00€10mg150,00€25mg300,00€50mg515,00€1mL*10mM (DMSO)131,00€XL-188
CAS:XL-188: Potent, selective USP7 inhibitor, IC50 = 193 nM (domain), 90 nM (full). Boosts p53, p21; degrades HDM2. Unique among DUB inhibitors.Fórmula:C32H42N6O4Cor e Forma:SolidPeso molecular:574.71USP7-IN-4
CAS:USP7-IN-4 is a non-competitive, potent and selective inhibitor of USP7, up-regulates p53 and p21, down-regulates MDM2,anti-proliferativity RS4;11 (leukemia) .Fórmula:C29H34N6O3Pureza:98.27% - 99.09%Cor e Forma:SolidPeso molecular:514.628RK64
CAS:8RK64 is a covalent UCHL1 inhibitor ( IC 50 : 0.32 μM) .Fórmula:C14H16N8O2SCor e Forma:SolidPeso molecular:360.4USP28-IN-2
CAS:USP28-IN-2 selectively inhibits USP28 (IC50=0.3 μM), degrades c-Myc, kills cancer cells, lowers ankyrin-1/2, and enhances Regorafenib effects.Fórmula:C23H20Cl2N2O3SCor e Forma:SolidPeso molecular:475.39HBX28258
CAS:HBX28258, a human USP7 inhibitor, binds covalently and selectively deactivates USP7 in colon cancer and kidney cells.Fórmula:C26H30ClN3OPureza:98%Cor e Forma:SolidPeso molecular:435.99BAP1-IN-1
CAS:BAP1-IN-1 is an inhibitor of the catalytic activity of BRCA1-associated protein 1 (BAP1), which is related to cancer and can be used to study cancer.Fórmula:C18H16N2O2Pureza:98.11%Cor e Forma:SolidPeso molecular:292.33I-138
CAS:I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.Fórmula:C26H23F3N6OPureza:99.41%Cor e Forma:SolidPeso molecular:492.5Ref: TM-T73560
1mg180,00€5mg369,00€10mg518,00€25mg747,00€50mg1.035,00€100mg1.549,00€200mg2.262,00€1mL*10mM (DMSO)405,00€USP28-IN-4
CAS:USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Fórmula:C22H18Cl2N2O3SPureza:98.48%Cor e Forma:SolidPeso molecular:461.36GSK2643943A
CAS:GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.Fórmula:C17H12FN3Pureza:97.09%Cor e Forma:SolidPeso molecular:277.3Ref: TM-T11485
1mg42,00€2mg52,00€5mg87,00€10mg127,00€25mg250,00€50mg376,00€100mg567,00€200mg805,00€1mL*10mM (DMSO)95,00€6RK73
CAS:6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM).Fórmula:C13H17N5O2SPureza:99.91%Cor e Forma:SolidPeso molecular:307.37Ref: TM-T10188
1mg144,00€5mg298,00€10mg510,00€25mg825,00€50mg1.130,00€100mg1.510,00€500mg3.060,00€1mL*10mM (DMSO)328,00€SJB3-019A
CAS:SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 timesFórmula:C16H8N2O3Pureza:99.72%Cor e Forma:SolidPeso molecular:276.25Ref: TM-T12926
1mg81,00€2mg106,00€5mg172,00€10mg266,00€25mg439,00€50mg612,00€100mg827,00€200mg1.111,00€P22074
CAS:P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.Fórmula:C12H9NO3S2Pureza:>99.99%Cor e Forma:SolidPeso molecular:279.33Ref: TM-T28284
1mg144,00€5mg330,00€10mg452,00€25mg633,00€50mg842,00€100mg1.159,00€200mg1.549,00€1mL*10mM (DMSO)251,00€USP30 inhibitor 11
CAS:USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Fórmula:C17H16N6O2SPureza:98.84% - 99.59%Cor e Forma:SolidPeso molecular:368.41OTUB1/USP8-IN-1
CAS:OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.Fórmula:C22H16ClFN2O4Pureza:98.59%Cor e Forma:SoildPeso molecular:426.83USP22-IN-1
CAS:USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.Fórmula:C22H18N4Pureza:99.37%Cor e Forma:SolidPeso molecular:338.41FT206
CAS:FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].Fórmula:C25H29N5OSCor e Forma:SolidPeso molecular:447.6USP1-IN-3
CAS:USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50<30 nM). USP1-IN-3 can be used to study cancer.Fórmula:C27H24F3N7OCor e Forma:SolidPeso molecular:519.52DUB-IN-7
CAS:DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].Fórmula:C17H19N5OCor e Forma:SolidPeso molecular:309.37USP1-IN-5
CAS:USP1-IN-5 (compound 10) is a potent inhibitor of both USP1, with an IC50 of less than 50 nM, and MDA-MB-436 cells, where it also exhibits an IC50 of less thanFórmula:C27H23F3N8OCor e Forma:SolidPeso molecular:532.52USP1-IN-6
CAS:USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.Fórmula:C29H27F3N8OCor e Forma:SolidPeso molecular:560.57CT1113
CAS:CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDXFórmula:C25H29N5O2SCor e Forma:SolidPeso molecular:463.6USP7-IN-1
CAS:USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).Fórmula:C23H24ClN3O3Pureza:99.82%Cor e Forma:SolidPeso molecular:425.91Ref: TM-T13268
1mg97,00€5mg188,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.130,00€1mL*10mM (DMSO)217,00€USP7-IN-3
CAS:USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).Fórmula:C29H31F3N6O3Pureza:98%Cor e Forma:SolidPeso molecular:568.59LDN-91946
CAS:LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).Fórmula:C15H10N2O4SPureza:97.12%Cor e Forma:SolidPeso molecular:314.32USP30 inhibitor 18
CAS:USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.Fórmula:C26H28FN3O4SPureza:99.85%Cor e Forma:SolidPeso molecular:497.58Ref: TM-T36682
1mg144,00€5mg298,00€10mg472,00€25mg753,00€50mg1.074,00€100mg1.444,00€500mg2.822,00€1mL*10mM (DMSO)325,00€USP7-IN-12
CAS:USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].Fórmula:C29H28ClFN4O2SCor e Forma:SolidPeso molecular:551.07USP7-IN-13
CAS:USP7-IN-13 (Compound 101), a USP7 inhibitor, exhibits an IC50 range of 0.2-1 μM and is applicable in researching multiple myeloma [1].Fórmula:C24H28N4O3Cor e Forma:SolidPeso molecular:420.5FT671
CAS:FT671 is a non-covalent, selective USP7 inhibitor, disrupts the stability of USP7 substrates including MDM2, elevates p53, induces p21, inhibits tumor growth.Fórmula:C24H23F4N7O3Pureza:99.76%Cor e Forma:SolidPeso molecular:533.48IMP-1710
CAS:IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.Fórmula:C23H19N5OPureza:99.3%Cor e Forma:SolidPeso molecular:381.43USP7-IN-6
CAS:USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).Fórmula:C41H43N7O4SPureza:98%Cor e Forma:SolidPeso molecular:729.89FT709
CAS:FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.Fórmula:C23H22N4O7SCor e Forma:SolidPeso molecular:498.51USP7-IN-10
CAS:USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.Fórmula:C26H29ClN4O3SCor e Forma:SolidPeso molecular:513.05FT3967385
FT3967385: New USP30 inhibitor boosts mitochondrial ubiquitylation via PINK1-PARKIN.Fórmula:C21H19N5O2Cor e Forma:SolidPeso molecular:373.41USP7-797
CAS:USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency properties.Fórmula:C27H28ClN3O3SPureza:95.90%Cor e Forma:SolidPeso molecular:510.05USP15-IN-1
CAS:<p>USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).</p>Fórmula:C22H23N3O3Pureza:99.509% - 99.81%Cor e Forma:SolidPeso molecular:377.44USP5-IN-1
<p>USP5-IN-1, a powerful USP5 deubiquitinase inhibitor, selectively binds with 2.8 μM affinity, blocking USP5's di-ubiquitin cleavage.</p>Fórmula:C19H20ClN3O5SPureza:99.76%Cor e Forma:SoildPeso molecular:437.9VCPIP1-IN-1
CAS:VCPIP1-IN-1 is a VCPIP1 inhibitor used in cancer research.Fórmula:C13H15ClN2O2Pureza:99.3%Cor e Forma:SolidPeso molecular:266.72Ref: TM-T88664
1mg49,00€5mg97,00€10mg154,00€25mg298,00€50mg472,00€100mg755,00€200mg1.017,00€1mL*10mM (DMSO)106,00€
