DUB
Os inibidores de DUB (desubiquitinases) são compostos que têm como alvo as enzimas que removem moléculas de ubiquitina das proteínas, regulando assim a estabilidade, localização e atividade das proteínas dentro da célula. As desubiquitinases desempenham papéis essenciais em vários processos celulares, incluindo a regulação do ciclo celular, a reparação do DNA e as respostas imunológicas. A desregulação da atividade das DUB está associada ao câncer, distúrbios neurodegenerativos e infecções virais. Inibidores de DUB podem modular esses processos, oferecendo abordagens terapêuticas potenciais para essas condições. Na CymitQuimica, oferecemos inibidores de DUB para apoiar sua pesquisa em homeostase proteica, câncer e neurobiologia.
Foram encontrados 84 produtos de "DUB"
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P22074
CAS:<p>P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.</p>Fórmula:C12H9NO3S2Pureza:>99.99%Cor e Forma:SolidPeso molecular:279.33USP22-IN-1
CAS:<p>USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.</p>Fórmula:C22H18N4Pureza:98.2%Cor e Forma:SolidPeso molecular:338.41OTUB1/USP8-IN-1
CAS:<p>OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.</p>Fórmula:C22H16ClFN2O4Pureza:98.59%Cor e Forma:SoildPeso molecular:426.83USP1-IN-3
CAS:<p>USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50<30 nM). USP1-IN-3 can be used to study cancer.</p>Fórmula:C27H24F3N7OCor e Forma:SolidPeso molecular:519.52USP1-IN-5
CAS:<p>USP1-IN-5 (compound 10) is a potent inhibitor of both USP1, with an IC50 of less than 50 nM, and MDA-MB-436 cells, where it also exhibits an IC50 of less than</p>Fórmula:C27H23F3N8OCor e Forma:SolidPeso molecular:532.52USP7-IN-12
CAS:<p>USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].</p>Fórmula:C29H28ClFN4O2SCor e Forma:SolidPeso molecular:551.07FT206
CAS:<p>FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].</p>Fórmula:C25H29N5OSCor e Forma:SolidPeso molecular:447.6USP7-IN-1
CAS:<p>USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).</p>Fórmula:C23H24ClN3O3Pureza:99.82%Cor e Forma:SolidPeso molecular:425.91DUB-IN-7
CAS:<p>DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].</p>Fórmula:C17H19N5OCor e Forma:SolidPeso molecular:309.37FT671
CAS:<p>FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).</p>Fórmula:C24H23F4N7O3Pureza:98%Cor e Forma:SolidPeso molecular:533.48USP7-IN-3
CAS:<p>USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).</p>Fórmula:C29H31F3N6O3Pureza:98%Cor e Forma:SolidPeso molecular:568.59LDN-91946
CAS:<p>LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).</p>Fórmula:C15H10N2O4SPureza:97.12%Cor e Forma:SolidPeso molecular:314.32USP30 inhibitor 18
CAS:<p>USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.</p>Fórmula:C26H28FN3O4SPureza:99.85%Cor e Forma:SolidPeso molecular:497.58USP1-IN-6
CAS:<p>USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.</p>Fórmula:C29H27F3N8OCor e Forma:SolidPeso molecular:560.57CT1113
CAS:<p>CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDX</p>Fórmula:C25H29N5O2SCor e Forma:SolidPeso molecular:463.6USP7-IN-13
CAS:<p>USP7-IN-13 (Compound 101), a USP7 inhibitor, exhibits an IC50 range of 0.2-1 μM and is applicable in researching multiple myeloma [1].</p>Fórmula:C24H28N4O3Cor e Forma:SolidPeso molecular:420.5IMP-1710
CAS:<p>IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.</p>Fórmula:C23H19N5OPureza:99.3%Cor e Forma:SolidPeso molecular:381.43USP7-IN-10
CAS:<p>USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.</p>Fórmula:C26H29ClN4O3SCor e Forma:SolidPeso molecular:513.05FT709
CAS:<p>FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.</p>Fórmula:C23H22N4O7SCor e Forma:SolidPeso molecular:498.51FT3967385
<p>FT3967385: New USP30 inhibitor boosts mitochondrial ubiquitylation via PINK1-PARKIN.</p>Fórmula:C21H19N5O2Cor e Forma:SolidPeso molecular:373.41
