DUB
Os inibidores de DUB (desubiquitinases) são compostos que têm como alvo as enzimas que removem moléculas de ubiquitina das proteínas, regulando assim a estabilidade, localização e atividade das proteínas dentro da célula. As desubiquitinases desempenham papéis essenciais em vários processos celulares, incluindo a regulação do ciclo celular, a reparação do DNA e as respostas imunológicas. A desregulação da atividade das DUB está associada ao câncer, distúrbios neurodegenerativos e infecções virais. Inibidores de DUB podem modular esses processos, oferecendo abordagens terapêuticas potenciais para essas condições. Na CymitQuimica, oferecemos inibidores de DUB para apoiar sua pesquisa em homeostase proteica, câncer e neurobiologia.
Foram encontrados 100 produtos para "DUB".
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HBX 19818
CAS:HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).Fórmula:C25H28ClN3OPureza:97.71%Cor e Forma:SolidPeso molecular:421.96Ref: TM-T15464
1mg35,00€5mg80,00€1mL*10mM (DMSO)89,00€10mg111,00€25mg177,00€50mg253,00€100mg353,00€200mg502,00€MF-094
CAS:MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.Fórmula:C30H37N3O4SPureza:99.93%Cor e Forma:White SolidPeso molecular:535.7Ref: TM-T12024
1mg40,00€5mg93,00€1mL*10mM (DMSO)99,00€10mg137,00€25mg268,00€50mg430,00€100mg620,00€200mg884,00€GRL0617
CAS:GRL0617 is a selective and competitive SARS-CoVPLpro and deubiquitinase noncovalent inhibitor(IC50 : 0.6 μM, Ki : 0.49 μM).Fórmula:C20H20N2OPureza:99.31%Cor e Forma:SolidPeso molecular:304.39Ref: TM-T11464
1mg34,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg105,00€25mg178,00€50mg313,00€100mg500,00€500mg1.063,00€C527
CAS:C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).Fórmula:C17H8FNO3Pureza:97.22%Cor e Forma:SolidPeso molecular:293.25IU1-47
CAS:IU1-47 是一种特异性 USP14抑制剂，IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5， IC50为 20 μM。Fórmula:C19H23ClN2OPureza:98.94%Cor e Forma:White SolidPeso molecular:330.85Ref: TM-T15604
1mg34,00€5mg64,00€1mL*10mM (DMSO)70,00€10mg109,00€25mg222,00€50mg358,00€100mg593,00€200mg830,00€UBD1031
UBD1031 exhibits strong affinity for the ubiquitin-binding domain (UBD) of USP16, with a dissociation constant (KD) of 48 nM. It inhibits the interaction between USP16 and ISG15, displaying an effective concentration (EC50) of 1.7 nM. UBD1031 can serve as a chemical probe for investigating USP16 UBD.Cor e Forma:Odour SolidGK16S
GK16S, a UCHL1 chemogenomic probe, serves as a complementary tool to GK13S for the investigation of UCHL1 function in cellular studies [1].Fórmula:C11H15N3OCor e Forma:SolidPeso molecular:205.12151Subquinocin
Subquinocin is a CYLD inhibitor that suppresses deubiquitinating enzymes (DUB) of the USP family. By inhibiting CYLD, Subquinocin enhances the activation of the NF-κB and IFN pathways. Additionally, Subquinocin facilitates the activation of IRF3 and/or IRF7 in the RIG-I-mediated interferon pathway.Fórmula:C20H27N3O4SCor e Forma:SolidPeso molecular:405.17223USP7-055
CAS:USP7-055 is an inhibitor of USP7, utilized in cancer research.Fórmula:C27H29ClN4O2SCor e Forma:SolidPeso molecular:509.06Ubiquitination Compound Library
A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；Cor e Forma:Odour SolidRef: TM-L8600
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarUCHL1-IN-1
UCHL1-IN-1 (Compound 46) is an inhibitor of ubiquitin C-terminal hydrolase L1 (UCHL1), with an IC50 of 5.1 μM. This compound is applicable in cancer research.Fórmula:C11H13Cl2N3O2Cor e Forma:SolidPeso molecular:289.03848USP1-IN-9
USP1-IN-9 (Compound 1m) is a reversible and non-competitive inhibitor of ubiquitin-specific protease (USP1) with an IC50 value of 8.8 nM. It is synthesized based on the structures of ML323 and KSQ-4279 as a pyrido[2,3-d]pyrimidin-7(8H)-one derivative. USP1-IN-9 exhibits excellent inhibition of USP1/UAF and demonstrates strong antiproliferative effects on breast cancer cells. When combined with the PARP inhibitor olaparib, USP1-IN-9 enhances the cytotoxic effect on MDA-MB-436/OP cells. USP1-IN-9 holds potential for research in the field of cancer.Cor e Forma:Odour Solid(R)-CMPD-39
(R)-CMPD-39 is the R-enantiomer of CMPD-39. CMPD-39 acts as a selective non-covalent inhibitor of the ubiquitin-specific protease USP30 with an IC50 of approximately 20 nM and demonstrates high selectivity for other DUB family members at concentrations ranging from 1-100 μM. By inhibiting USP30's deubiquitination activity, CMPD-39 enhances the ubiquitination of mitochondrial proteins TOMM20 and SYNJ2BP and promotes the accumulation of phosphorylated ubiquitin. This process accelerates both mitophagy and pexophagy. Additionally, CMPD-39 significantly restores impaired mitochondrial function in dopaminergic neurons derived from Parkinson’s disease patients.OTUB2-IN-1
OTUB2-IN-1 is an OTUB2 inhibitor with antitumor activity and can be used to study skin cancer and non-small cell lung cancer (NSCLC).Fórmula:C19H18N2O6S2Pureza:98.19%Cor e Forma:Red SolidPeso molecular:434.49OTUB1/USP8-IN-1 HCl
OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8 for leukaemiaFórmula:C22H17Cl2FN2O4Pureza:99.92%Cor e Forma:SolidPeso molecular:463.29USP8-IN-2
CAS:USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.Fórmula:C19H20ClF3N4OSPureza:99.92%Cor e Forma:SolidPeso molecular:444.9Ref: TM-T67876
1mg94,00€5mg200,00€1mL*10mM (DMSO)233,00€10mg313,00€25mg520,00€50mg740,00€100mg982,00€USP8-IN-3
CAS:USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.Fórmula:C18H18F3N5O2SPureza:99.79%Cor e Forma:SolidPeso molecular:425.43Ref: TM-T67873
1mg34,00€5mg60,00€1mL*10mM (DMSO)79,00€10mg92,00€25mg195,00€50mg311,00€100mg449,00€500mg888,00€Ga-CY03
Ga-CY03 (compound) is a FAP-tracing molecule designed based on the FAP inhibitor QI-18 and labeled with [Ga].Fórmula:C53H63F2GaN13O15Cor e Forma:SolidPeso molecular:1229.87USP7-IN-16
CAS:USP7-IN-16 (Compound 61) is a selective inhibitor of USP7, with IC50 values of 5.5 nM in the FLINT assay and 2.1 nM in MM.1S cells. This compound exhibits antitumor activity in mice and holds potential for research in the field of oncology.Fórmula:C43H45N7O6SCor e Forma:SolidPeso molecular:787.93GK13S
G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.Fórmula:C21H22N6O2Cor e Forma:SolidPeso molecular:390.44USP7-IN-10 hydrochloride
USP7-IN-10 hydrochloride, also known as compound 1, is a potent inhibitor of the enzyme ubiquitin-specific protease 7 (USP7), exhibiting an IC50 value of 13.39Fórmula:C26H30Cl2N4O3SCor e Forma:SolidPeso molecular:549.51MS7131
MS7131 is a DUBTAC inhibitor that recruits USP1. It effectively reduces histone H3 lysine 27 trimethylation and significantly inhibits the proliferation and colony-forming ability of cancer cells.Cor e Forma:Odour SolidUSP7-IN-15
USP7-IN-15 (compound J21) is an inhibitor of USP7, exhibiting an IC50 value of 41.35 ± 2.16 nM.Cor e Forma:Odour SolidQ14
Q14 is a polypeptide derived from the transmembrane (TM) domain of USP30 (ubiquitin specific peptidase30) and is capable of inhibiting the deubiquitination activity of USP30 (IC50=57.2 nM). By hindering the interaction between USP30’s transmembrane and catalytic domains, it lowers USP30 activity. The Q14 polypeptide contains an LC3 interaction region (LIR) motif, enabling it to bind with LC3, thereby accelerating autophagosome formation and promoting mitophagy. Q14 is applicable in the study of neurodegenerative diseases, mitochondrial quality control, and cellular metabolism.Fórmula:C101H168N32O23Cor e Forma:SolidPeso molecular:2197.29601T20-M
T20-M is a precursor peptide with strong binding affinity for UBE2C.Fórmula:C87H140N22O26SCor e Forma:SolidPeso molecular:1942.24EN523
CAS:EN523 targets non-catalytic allosteric cysteine C23 in K48 ubiquitin-specific deuquitinase OTUB1.Fórmula:C12H14N2O3Pureza:99.5%Cor e Forma:White SolidPeso molecular:234.25Ref: TM-T9884
1mg34,00€5mg66,00€1mL*10mM (DMSO)67,00€10mg99,00€25mg222,00€50mg356,00€100mg570,00€200mg800,00€JAMM protein inhibitor 2
CAS:JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.Fórmula:C21H26N2O2Pureza:98.57%Cor e Forma:SolidPeso molecular:338.44USP7 Ligand-Linker Conjugates 1
USP7Ligand-Linker Conjugates 1 is a Target Protein Ligand-Linker Conjugate comprising a USP7 ligand and a PROTAC linker, capable of recruiting E3 ligase. It is utilized in the synthesis of PROTACUSP7 Degrader-1.Cor e Forma:Odour SolidBAY-728
BAY-728 serves as a negative control for BAY-805, a potent and selective inhibitor of USP21 [1].Fórmula:C24H28F3N5O2SCor e Forma:SolidPeso molecular:507.57STD1T
CAS:STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.Fórmula:C19H19N3O4S2Pureza:98.77%Cor e Forma:SolidPeso molecular:417.5USP8-IN-1
CAS:USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].Fórmula:C18H21N5O3SPureza:99.07%Cor e Forma:SoildPeso molecular:387.46Ref: TM-T60146
1mg50,00€5mg110,00€1mL*10mM (DMSO)122,00€10mg156,00€25mg264,00€50mg371,00€100mg537,00€EOAI3402143
CAS:EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis.Fórmula:C25H28Cl2N4O3Pureza:99.6%Cor e Forma:SolidPeso molecular:503.42Ref: TM-T11209
1mg63,00€5mg137,00€1mL*10mM (DMSO)152,00€10mg215,00€25mg423,00€50mg680,00€100mg1.009,00€USP7-IN-8
CAS:Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.Fórmula:C21H21N3O2Pureza:99.31%Cor e Forma:SolidPeso molecular:347.41Ref: TM-T9217
1mg46,00€5mg92,00€1mL*10mM (DMSO)100,00€10mg147,00€25mg269,00€50mg389,00€100mg532,00€200mg705,00€SJB2-043
CAS:SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).Fórmula:C17H9NO3Pureza:98.44%Cor e Forma:SolidPeso molecular:275.26DUB-IN-2
CAS:Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.Fórmula:C15H9N5OPureza:98.96%Cor e Forma:SolidPeso molecular:275.26NSC632839
CAS:NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2Fórmula:C21H22ClNOPureza:99.74% - 99.88%Cor e Forma:SolidPeso molecular:339.86DUB-IN-1
CAS:DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).Fórmula:C20H11N5OPureza:98.33% - 98.96%Cor e Forma:SolidPeso molecular:337.33Ref: TM-T11110
1mg62,00€5mg110,00€1mL*10mM (DMSO)122,00€10mg173,00€25mg334,00€50mg469,00€100mg618,00€200mg848,00€USP7/USP47 inhibitor
CAS:USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM,Fórmula:C18H11Cl2N3O3S3Pureza:98.5% - 98.71%Cor e Forma:SolidPeso molecular:484.4Ref: TM-T4338
1mg40,00€1mL*10mM (DMSO)94,00€5mg96,00€10mg152,00€25mg268,00€50mg429,00€100mg703,00€200mg954,00€XL177A
CAS:XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.Fórmula:C48H57ClN8O5Pureza:98.75% - 99.49%Cor e Forma:Yellow SolidPeso molecular:861.47USP25/28 inhibitor AZ1
CAS:USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor.Cost-effective and quality-assured.Fórmula:C17H16BrF4NO2Pureza:99.81% - 99.86%Cor e Forma:White SolidPeso molecular:422.21P 22077
CAS:P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.Fórmula:C12H7F2NO3S2Pureza:97.9% - 99.64%Cor e Forma:Yellow SolidPeso molecular:315.32STAMBP-IN-1
CAS:STAMBP-IN-1 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release afterFórmula:C27H28N4O4SPureza:99.64%Cor e Forma:SolidPeso molecular:504.6Ref: TM-T8706
1mg67,00€5mg152,00€1mL*10mM (DMSO)192,00€10mg236,00€25mg507,00€50mg730,00€100mg1.018,00€P005091
CAS:P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.Fórmula:C12H7Cl2NO3S2Pureza:99.53% - 99.87%Cor e Forma:SolidPeso molecular:348.22VLX1570
CAS:VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.Fórmula:C23H17F2N3O6Pureza:98.53% - 99.91%Cor e Forma:SolidPeso molecular:469.39Ref: TM-T4067
1mg90,00€2mg146,00€5mg245,00€1mL*10mM (DMSO)251,00€10mg385,00€25mg645,00€50mg888,00€100mg1.234,00€ML-323
CAS:ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay and in orthogonal gel-based assays using K63-linked di-Ub and Ub-PCNA as substrates.Fórmula:C23H24N6Pureza:99.87% - 99.96%Cor e Forma:SolidPeso molecular:384.48GNE-6640
CAS:GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).Fórmula:C20H18N4OPureza:98.64%Cor e Forma:SolidPeso molecular:330.38Ref: TM-T5461
1mg66,00€2mg96,00€5mg144,00€1mL*10mM (DMSO)158,00€10mg236,00€25mg507,00€50mg730,00€100mg1.018,00€DUB-IN-3
CAS:DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.Fórmula:C16H9N5OPureza:99.34%Cor e Forma:SolidPeso molecular:287.28Ref: TM-T11112
1mg130,00€2mg178,00€5mg309,00€1mL*10mM (DMSO)324,00€10mg442,00€25mg705,00€50mg982,00€100mg1.333,00€500mg2.655,00€ML364
CAS:ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.Fórmula:C24H18F3N3O3S2Pureza:99.35% - >99.99%Cor e Forma:SolidPeso molecular:517.54IU1-248
CAS:IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].Fórmula:C20H23N3O2Pureza:99.3%Cor e Forma:SolidPeso molecular:337.42Ref: TM-T9375
1mg48,00€5mg92,00€1mL*10mM (DMSO)102,00€10mg152,00€25mg301,00€50mg424,00€100mg605,00€200mg845,00€GNE-6776
CAS:GNE-6776 is a selective USP7 inhibitor.Fórmula:C20H20N4O2Pureza:96.59% - 98.2%Cor e Forma:SolidPeso molecular:348.4
