Aurora Quinase
Os inibidores da quinase Aurora têm como alvo as quinasas Aurora, uma família de quinasas serina/treonina que desempenham um papel crucial na regulação da mitose. Essas quinasas são essenciais para o alinhamento adequado dos cromossomos, segregação e citocinese durante a divisão celular. A atividade anormal da quinase Aurora pode levar à proliferação celular descontrolada e ao câncer. Ao inibir as quinasas Aurora, esses compostos podem induzir a parada do ciclo celular e a apoptose em células cancerígenas, tornando-os ferramentas valiosas na pesquisa e terapia do câncer. Na CymitQuimica, oferecemos uma ampla gama de inibidores de quinasas Aurora de alta qualidade para apoiar sua pesquisa em regulação do ciclo celular, mitose e oncologia.
Foram encontrados 112 produtos de "Aurora Quinase"
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Aurora/LIM kinase-IN-1
Aurora/LIM kinase-IN-1 (Compound F114) is a dual inhibitor targeting aurora and lim kinases, potentially useful in GBM cancer treatment efforts.Fórmula:C16H20N6OCor e Forma:SolidPeso molecular:312.37Glycyl H-1152 hydrochloride
CAS:Glycyl-H-1152 is a potent ROCK-II inhibitor (IC50=11.8 nM) with high selectivity over CaMKII, PKG, Aurora A, PKA, and PKC. Better than Y-27632 and HA-1077.Fórmula:C18H26Cl2N4O3SCor e Forma:SolidPeso molecular:449.39TY-011
CAS:TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.Fórmula:C18H16ClN5Cor e Forma:SolidPeso molecular:337.81Aurora A inhibitor 1
CAS:Aurora A inhibitor 1: potent, selective, targets cancer-linked Aurora A overexpression, potential for cancer research. (WO2021147974A1, 49)Fórmula:C25H28ClF2N5O2Cor e Forma:SolidPeso molecular:503.97Aurora inhibitor 1
CAS:Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase).Fórmula:C23H25N9SPureza:98%Cor e Forma:SolidPeso molecular:459.57Aurora B inhibitor 1
CAS:Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki <0.010 uM) with potential anticancer activity for cancer research.Fórmula:C25H26ClF2N7O2Pureza:98.37%Cor e Forma:SolidPeso molecular:529.97BRD-7880
CAS:BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C.Fórmula:C32H38N4O7Cor e Forma:SolidPeso molecular:590.67Hesperadin hydrochloride
Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.Fórmula:C29H33ClN4O3SCor e Forma:SolidPeso molecular:553.126K465
CAS:6K465 is a potent Aurora A kinase inhibitor that reduces c-MYC and N-MYC oncoproteins, showing antiproliferative effects in SCLC and breast cancer cell lines.Fórmula:C26H33ClFN9OPureza:99.78%Cor e Forma:SolidPeso molecular:542.05BET/Aurora kinase-IN-1
CAS:BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.Fórmula:C25H30FN7OCor e Forma:SolidPeso molecular:463.55SCH-1473759
CAS:SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).Fórmula:C20H26N8OSPureza:98%Cor e Forma:SolidPeso molecular:426.54PF-03814735
CAS:PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.Fórmula:C23H25F3N6O2Pureza:98%Cor e Forma:SolidPeso molecular:474.48
