Receptor Sigma
Os receptores sigma são sítios de ligação únicos que, ao contrário dos GPCRs tradicionais, não se enquadram nas categorias clássicas de proteínas receptoras. Eles estão envolvidos na modulação dos sistemas de neurotransmissores e têm sido implicados em vários distúrbios neurológicos e psiquiátricos. Os receptores sigma também estão associados à sobrevivência celular, e seus ligantes estão sendo explorados para aplicações terapêuticas em neuroproteção, câncer e manejo da dor. Na CymitQuimica, oferecemos uma seleção de moduladores de receptores sigma de alta qualidade para apoiar sua pesquisa em neurociência, oncologia e biologia de receptores.
Foram encontrados 46 produtos de "Receptor Sigma"
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Roluperidone
CAS:<p>Roluperidone (CYR-101) is a novel cyclic amide derivative.</p>Fórmula:C22H23FN2O2Pureza:96.46% - 97.77%Cor e Forma:SolidPeso molecular:366.43Glycerol phenylbutyrate
CAS:<p>Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).</p>Fórmula:C33H38O6Pureza:98.54% - 99.74%Cor e Forma:SolidPeso molecular:530.65Blonanserin
CAS:<p>Blonanserin (AD-5423), approved in Japan (2008), is an atypical antipsychotic with fewer side effects like EPS, sedation, or hypotension.</p>Fórmula:C23H30FN3Pureza:99.85%Cor e Forma:SolidPeso molecular:367.5PD 144418 oxalate
CAS:<p>PD 144418 oxalate: σ1 receptor ligand, Ki=0.08 nM; 1377 nM for σ2, minimal affinity elsewhere; potential antipsychotic.</p>Fórmula:C20H24N2O5Pureza:98.76%Cor e Forma:SolidPeso molecular:372.42KB-5492 FA
<p>KB-5492 FA is a selective sigma receptor inhibitor with antiulcerogenic effects.CAS 번호128-52-56-8</p>Fórmula:C24H32N2O8Pureza:98.12%Cor e Forma:SolidPeso molecular:476.52Sigma-1 receptor antagonist 4
<p>Sigma-1 receptor antagonist 4 (Compound 32) is a potent σ1R antagonist that significantly enhances morphine's analgesic effects and reverses morphine-induced</p>Fórmula:C22H26N2OCor e Forma:SolidPeso molecular:334.45AB21 HCl
<p>AB21 HCl: σ1 receptor antagonist, Ki 13 nM; less potent at σ2 (102 nM). Reduces mechanical hypersensitivity.</p>Fórmula:C23H29ClN2OPureza:99.91%Cor e Forma:SolidPeso molecular:384.2AD186
<p>AD186, a potent and selective S1R agonist, exhibits dissociation constants (Kis) of 2.7 nM for S1R and 27 nM for S2R.</p>Fórmula:C22H28N2Pureza:98%Cor e Forma:SolidPeso molecular:320.47UKH-1114
CAS:<p>UKH-1114 is a potent σ2 receptor/Tmem97 agonist with a Ki value of 46 nM, demonstrating antinociceptive effects against mechanical hypersensitivity. This compound alleviates mechanical hypersensitivity in mice caused by nerve injury without inducing motor impairment and is a promising candidate for neuropathic pain research.</p>Fórmula:C22H24F3NOCor e Forma:SolidPeso molecular:375.43S1R agonist 2 hydrochloride
<p>Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R.</p>Fórmula:C21H28ClNOPureza:98%Cor e Forma:SolidPeso molecular:345.91AB21 oxalate
<p>AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM and 102 nM for S1R and S2R, respectively.</p>Fórmula:C25H30N2O5Pureza:98%Cor e Forma:SolidPeso molecular:438.52σ1 Receptor ligand 1
<p>σ1 Receptor ligand 1 (compound 5I) is a σ1 receptor ligand with a Ki value of 3.9 nM. It demonstrates a high plasma protein binding rate (89%) and exhibits good metabolic stability in the presence of mouse liver microsomes and NADPH. σ1 Receptor ligand 1 is applicable in neuroscience and cancer research.</p>Fórmula:C22H28N2O2Cor e Forma:SolidPeso molecular:352.47AD353
<p>AD353 is a selective sigma-1 receptor ligand. It demonstrates high efficacy in models of capsaicin-induced allodynia and PGE2-induced mechanical hyperalgesia. Additionally, AD353 exhibits favorable pharmacokinetic properties.</p>Fórmula:C23H30N2O2Cor e Forma:SolidPeso molecular:366.5σ1R-IN-1
<p>σ1R-IN-1 ((R,R)-1a) is an effective σ-1R inhibitor with an IC50 of 110 nM. It shows promising potential for use in research related to neuropsychiatric disorders.</p>Fórmula:C15H22N2Cor e Forma:SolidPeso molecular:230.35BD1063 dhydrochloride
CAS:<p>BD1063 dhydrochloride is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).</p>Fórmula:C13H20Cl4N2Pureza:99.52% - ≥95%Cor e Forma:SolidPeso molecular:346.12Siramesine
CAS:<p>Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent</p>Fórmula:C30H31FN2OPureza:98%Cor e Forma:SolidPeso molecular:454.58σ1 Receptor antagonist-1
CAS:<p>σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.</p>Fórmula:C21H23NOSPureza:99.8%Cor e Forma:SolidPeso molecular:337.48Cutamesine dihydrochloride
CAS:<p>Cutamesine dihydrochloride is a σ1 receptor agonist, selective over σ2, combating cardiomyocyte hypertrophy and improving stroke recovery.</p>Fórmula:C23H32N2O2·2HClPureza:99.96%Cor e Forma:SolidPeso molecular:441.434-IBP
CAS:<p>4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .</p>Fórmula:C19H21IN2OPureza:98.99%Cor e Forma:SolidPeso molecular:420.29EST64454 hydrochloride
CAS:<p>EST64454 hydrochloride (EST64454) is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.</p>Fórmula:C18H23ClF2N4O2Pureza:99.15%Cor e Forma:SolidPeso molecular:400.85Siramesine hydrochloride
CAS:<p>Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit</p>Fórmula:C30H32ClFN2OPureza:99.72% - >99.99%Cor e Forma:SolidPeso molecular:491.04PRE-084 hydrochloride
CAS:<p>PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).</p>Fórmula:C19H28ClNO3Pureza:99.54%Cor e Forma:SolidPeso molecular:353.88BD 1008 dihydrobromide
CAS:<p>BD 1008 dihydrobromide: selective σ1 receptor antagonist (Ki=2 nM), high σ1 and moderate σ2 affinity.</p>Fórmula:C15H24Br2Cl2N2Pureza:97.81%Cor e Forma:SolidPeso molecular:463.08Dimemorfan phosphate
CAS:<p>Dimemorfan phosphate (3,17-dimethylmorphinan) is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a potent antitussive.</p>Fórmula:C18H25N·H3O4PPureza:99.65%Cor e Forma:SolidPeso molecular:353.4Blarcamesine hydrochloride
CAS:<p>Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).</p>Fórmula:C19H24ClNOPureza:99.57% - 99.9%Cor e Forma:SolidPeso molecular:317.85BD-1047 dihydrobromide
CAS:<p>BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy</p>Fórmula:C13H22Br2Cl2N2Pureza:98.13% - 99.39%Cor e Forma:SolidPeso molecular:437.04Blarcamesine
CAS:<p>Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.</p>Fórmula:C19H23NOPureza:99.87%Cor e Forma:SolidPeso molecular:281.39Ditolylguanidine
CAS:<p>Ditolylguanidine (Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor).</p>Fórmula:C15H17N3Pureza:98.42%Cor e Forma:White To Pinkish Solid PowderPeso molecular:239.32S1RA hydrochloride
CAS:<p>S1RA hydrochloride (E-52862 hydrochloride) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki ></p>Fórmula:C20H24ClN3O2Pureza:98% - 99.84%Cor e Forma:SolidPeso molecular:373.87KB-5492 free base
CAS:<p>KB-5492 free base is an antiulcer agent that inhibits sigma receptors and can be used to study gastric lesions and gastric secretion.</p>Fórmula:C23H30N2O6Pureza:97.10% - 97.94%Cor e Forma:SolidPeso molecular:430.49Opipramol
CAS:<p>Opipramol (Ensidon) is a compound with antidepressant activity, a sigma (σ) receptor agonist, and anxiolytic activity.</p>Fórmula:C23H29N3OPureza:99.84% - 99.98%Cor e Forma:SolidPeso molecular:363.5S1RA
CAS:<p>S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2</p>Fórmula:C20H23N3O2Pureza:99.45%Cor e Forma:SolidPeso molecular:337.42PD 144418
CAS:<p>PD 144418 displays potential antipsychotic activity.</p>Fórmula:C18H22N2OPureza:98%Cor e Forma:SolidPeso molecular:282.38Sigma-LIGAND-1
CAS:<p>Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively.</p>Fórmula:C27H33NO4Pureza:99.89%Cor e Forma:SolidPeso molecular:435.56DuP 734
CAS:<p>DuP 734 is a potent and selective sigma receptor antagonist, functioning as a ligand for both sigma and 5-HT2 receptors, and exhibiting weak affinity towards D2 receptors. It possesses potential antipsychotic activity, potentially devoid of the motor side effects commonly observed with neuroleptics[1][2][3].</p>Fórmula:C17H23BrFNOCor e Forma:SolidPeso molecular:356.279NE-100 hydrochloride
CAS:<p>NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity.</p>Fórmula:C23H34ClNO2Pureza:99.76%Cor e Forma:SolidPeso molecular:391.98Sigma-1 receptor antagonist 3
CAS:<p>Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor (Ki = 1.14 nM) than σ2 receptor(Ki = 1239 nM).</p>Fórmula:C19H23ClFN3OPureza:99.95%Cor e Forma:SolidPeso molecular:363.86WLB-89462
CAS:<p>WLB-89462 (Compound 20c) is a selective σ2 receptor ligand with a K i of 13 nM, exhibiting neuroprotective properties and the ability to ameliorate Aβ peptide-</p>Fórmula:C21H29N5O3Pureza:98%Cor e Forma:SolidPeso molecular:399.49Sigma-1 receptor antagonist 2
CAS:<p>Sigma-1 receptor antagonist 2 is a more potent and selective antagonist of sigma 1 receptor (σ1 R, Ki = 3.88 nM) than σ2 receptor (Ki = 1288 nM).</p>Fórmula:C20H26ClN3O2Pureza:99.6%Cor e Forma:SolidPeso molecular:375.89S1R agonist 1 hydrochloride
CAS:<p>S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstrated</p>Fórmula:C20H26ClNOPureza:98%Cor e Forma:SolidPeso molecular:331.88Sigma-1 receptor antagonist 1
CAS:<p>Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor.</p>Fórmula:C19H23Cl2N3OPureza:99.92%Cor e Forma:SolidPeso molecular:380.31BD-1047
CAS:<p>BD-1047 is a selective functional antagonist of sigma receptors. It can alleviate climbing behavior induced by Apomorphine and head twitching caused by Phencyclidine.</p>Fórmula:C13H20Cl2N2Cor e Forma:SolidPeso molecular:275.217UMB24
CAS:<p>UMB24 is an effective antagonist of the σ2 receptor, exhibiting dissociation constants (Ki values) of 170 nM for the σ2 receptor and 322 nM for the σ1 receptor. This compound mitigates cocaine-induced convulsions and hyperactivity without causing mortality.</p>Fórmula:C17H21N3Cor e Forma:SolidPeso molecular:267.37Sigma-2 Radioligand 2
CAS:<p>Sigma-2 Radioligand 2 (compound 4) exhibits low nanomolar affinity for the σ2 receptor (Ki=2.30 nM) and high subtype selectivity (Ki(σ1)/Ki(σ2) > 1500).</p>Fórmula:C23H28FN3O3Cor e Forma:SolidPeso molecular:413.49Sigma-1 receptor antagonist 6
CAS:<p>Sigma-1 receptor antagonist 6 (Compound 12), a σ1R antagonist, demonstrates significant antiallodynic effects by targeting the Sigma-1 receptor (σ1R). This compound is effective in animal models for neuropathic pain, particularly for reducing mechanical allodynia caused by paclitaxel.</p>Fórmula:C32H34N6Cor e Forma:SolidPeso molecular:502.65Opipramol dihydrochloride
CAS:<p>Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) primarily functioning as a sigma (σ) receptor agonist. It interacts effectively with sigma recognition sites, having a Ki value of 50 nM. Opipramol is applicable in the study of generalized anxiety disorder (GAD).</p>Fórmula:C23H31Cl2N3OCor e Forma:SolidPeso molecular:436.418
