Receptor Sigma
Os receptores sigma são sítios de ligação únicos que, ao contrário dos GPCRs tradicionais, não se enquadram nas categorias clássicas de proteínas receptoras. Eles estão envolvidos na modulação dos sistemas de neurotransmissores e têm sido implicados em vários distúrbios neurológicos e psiquiátricos. Os receptores sigma também estão associados à sobrevivência celular, e seus ligantes estão sendo explorados para aplicações terapêuticas em neuroproteção, câncer e manejo da dor. Na CymitQuimica, oferecemos uma seleção de moduladores de receptores sigma de alta qualidade para apoiar sua pesquisa em neurociência, oncologia e biologia de receptores.
Foram encontrados 46 produtos de "Receptor Sigma"
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Siramesine hydrochloride
CAS:<p>Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit</p>Fórmula:C30H32ClFN2OPureza:99.72% - >99.99%Cor e Forma:SolidPeso molecular:491.04PRE-084 hydrochloride
CAS:<p>PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).</p>Fórmula:C19H28ClNO3Pureza:99.54%Cor e Forma:SolidPeso molecular:353.88BD 1008 dihydrobromide
CAS:<p>BD 1008 dihydrobromide: selective σ1 receptor antagonist (Ki=2 nM), high σ1 and moderate σ2 affinity.</p>Fórmula:C15H24Br2Cl2N2Pureza:97.81%Cor e Forma:SolidPeso molecular:463.08Dimemorfan phosphate
CAS:<p>Dimemorfan phosphate (3,17-dimethylmorphinan) is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a potent antitussive.</p>Fórmula:C18H25N·H3O4PPureza:99.65%Cor e Forma:SolidPeso molecular:353.4Blarcamesine hydrochloride
CAS:<p>Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).</p>Fórmula:C19H24ClNOPureza:99.57% - 99.9%Cor e Forma:SolidPeso molecular:317.85BD-1047 dihydrobromide
CAS:<p>BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy</p>Fórmula:C13H22Br2Cl2N2Pureza:98.13% - 99.39%Cor e Forma:SolidPeso molecular:437.04Blarcamesine
CAS:<p>Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.</p>Fórmula:C19H23NOPureza:99.87%Cor e Forma:SolidPeso molecular:281.39Ditolylguanidine
CAS:<p>Ditolylguanidine (Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor).</p>Fórmula:C15H17N3Pureza:98.42%Cor e Forma:White To Pinkish Solid PowderPeso molecular:239.32S1RA hydrochloride
CAS:<p>S1RA hydrochloride (E-52862 hydrochloride) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki ></p>Fórmula:C20H24ClN3O2Pureza:98% - 99.84%Cor e Forma:SolidPeso molecular:373.87KB-5492 free base
CAS:<p>KB-5492 free base is an antiulcer agent that inhibits sigma receptors and can be used to study gastric lesions and gastric secretion.</p>Fórmula:C23H30N2O6Pureza:97.10% - 97.94%Cor e Forma:SolidPeso molecular:430.49Opipramol
CAS:<p>Opipramol (Ensidon) is a compound with antidepressant activity, a sigma (σ) receptor agonist, and anxiolytic activity.</p>Fórmula:C23H29N3OPureza:99.84% - 99.98%Cor e Forma:SolidPeso molecular:363.5S1RA
CAS:<p>S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2</p>Fórmula:C20H23N3O2Pureza:99.45%Cor e Forma:SolidPeso molecular:337.42PD 144418
CAS:<p>PD 144418 displays potential antipsychotic activity.</p>Fórmula:C18H22N2OPureza:98%Cor e Forma:SolidPeso molecular:282.38Sigma-LIGAND-1
CAS:<p>Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively.</p>Fórmula:C27H33NO4Pureza:99.89%Cor e Forma:SolidPeso molecular:435.56DuP 734
CAS:<p>DuP 734 is a potent and selective sigma receptor antagonist, functioning as a ligand for both sigma and 5-HT2 receptors, and exhibiting weak affinity towards D2 receptors. It possesses potential antipsychotic activity, potentially devoid of the motor side effects commonly observed with neuroleptics[1][2][3].</p>Fórmula:C17H23BrFNOCor e Forma:SolidPeso molecular:356.279NE-100 hydrochloride
CAS:<p>NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity.</p>Fórmula:C23H34ClNO2Pureza:99.76%Cor e Forma:SolidPeso molecular:391.98Sigma-1 receptor antagonist 3
CAS:<p>Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor (Ki = 1.14 nM) than σ2 receptor(Ki = 1239 nM).</p>Fórmula:C19H23ClFN3OPureza:99.95%Cor e Forma:SolidPeso molecular:363.86WLB-89462
CAS:<p>WLB-89462 (Compound 20c) is a selective σ2 receptor ligand with a K i of 13 nM, exhibiting neuroprotective properties and the ability to ameliorate Aβ peptide-</p>Fórmula:C21H29N5O3Pureza:98%Cor e Forma:SolidPeso molecular:399.49Sigma-1 receptor antagonist 2
CAS:<p>Sigma-1 receptor antagonist 2 is a more potent and selective antagonist of sigma 1 receptor (σ1 R, Ki = 3.88 nM) than σ2 receptor (Ki = 1288 nM).</p>Fórmula:C20H26ClN3O2Pureza:99.6%Cor e Forma:SolidPeso molecular:375.89S1R agonist 1 hydrochloride
CAS:<p>S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstrated</p>Fórmula:C20H26ClNOPureza:98%Cor e Forma:SolidPeso molecular:331.88
