Receptor Sigma
Os receptores sigma são sítios de ligação únicos que, ao contrário dos GPCRs tradicionais, não se enquadram nas categorias clássicas de proteínas receptoras. Eles estão envolvidos na modulação dos sistemas de neurotransmissores e têm sido implicados em vários distúrbios neurológicos e psiquiátricos. Os receptores sigma também estão associados à sobrevivência celular, e seus ligantes estão sendo explorados para aplicações terapêuticas em neuroproteção, câncer e manejo da dor. Na CymitQuimica, oferecemos uma seleção de moduladores de receptores sigma de alta qualidade para apoiar sua pesquisa em neurociência, oncologia e biologia de receptores.
Foram encontrados 48 produtos para "Receptor Sigma".
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Blarcamesine
CAS:Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.Fórmula:C19H23NOPureza:99.87%Cor e Forma:White SolidPeso molecular:281.39BD1063 dhydrochloride
CAS:BD1063 dhydrochloride is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).Fórmula:C13H20Cl4N2Pureza:99.52% - ≥95%Cor e Forma:SolidPeso molecular:346.12Ref: TM-T7488
2mg46,00€5mg69,00€10mg95,00€25mg177,00€50mg321,00€100mg472,00€200mg665,00€500mg1.018,00€Ditolylguanidine
CAS:Ditolylguanidine (Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor).Fórmula:C15H17N3Pureza:98.42%Cor e Forma:White To Pinkish Solid PowderPeso molecular:239.32EST64454 hydrochloride
CAS:EST64454 hydrochloride (EST64454) is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.Fórmula:C18H23ClF2N4O2Pureza:99.28%Cor e Forma:Yellow SolidPeso molecular:400.85Siramesine hydrochloride
CAS:Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibitFórmula:C30H32ClFN2OPureza:99.67% - 99.82%Cor e Forma:SolidPeso molecular:491.04Ref: TM-T1885
1mg57,00€2mg84,00€5mg105,00€1mL*10mM (DMSO)114,00€10mg170,00€25mg334,00€50mg500,00€100mg705,00€PRE-084 hydrochloride
CAS:PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).Fórmula:C19H28ClNO3Pureza:99.54%Cor e Forma:White SolidPeso molecular:353.88Ref: TM-T3198L
5mg42,00€1mL*10mM (DMSO)46,00€10mg62,00€25mg114,00€50mg197,00€100mg350,00€200mg535,00€BD 1008 dihydrobromide
CAS:BD 1008 dihydrobromide: selective σ1 receptor antagonist (Ki=2 nM), high σ1 and moderate σ2 affinity.Fórmula:C15H24Br2Cl2N2Pureza:97.81%Cor e Forma:SolidPeso molecular:463.08Dimemorfan phosphate
CAS:Dimemorfan phosphate (3,17-dimethylmorphinan) is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a potent antitussive.Fórmula:C18H25N·H3O4PPureza:99.65%Cor e Forma:SolidPeso molecular:353.4Blarcamesine hydrochloride
CAS:Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).Fórmula:C19H24ClNOPureza:99.57% - 99.9%Cor e Forma:White SolidPeso molecular:317.85Ref: TM-T4111
1mg34,00€2mg46,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg99,00€25mg197,00€50mg340,00€100mg557,00€200mg790,00€σ1 Receptor antagonist-1
CAS:σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.Fórmula:C21H23NOSPureza:99.8%Cor e Forma:SolidPeso molecular:337.48KB-5492 free base
CAS:KB-5492 free base is an antiulcer agent that inhibits sigma receptors and can be used to study gastric lesions and gastric secretion.Fórmula:C23H30N2O6Pureza:97.10% - 97.94%Cor e Forma:SolidPeso molecular:430.49Ref: TM-T62396
2mg39,00€5mg58,00€1mL*10mM (DMSO)64,00€10mg82,00€25mg119,00€50mg168,00€100mg249,00€500mg613,00€S1RA
CAS:S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2Fórmula:C20H23N3O2Pureza:99.45%Cor e Forma:SolidPeso molecular:337.42Opipramol
CAS:Opipramol (Ensidon) is a compound with antidepressant activity, a sigma (σ) receptor agonist, and anxiolytic activity.Fórmula:C23H29N3OPureza:99.81% - 99.98%Cor e Forma:Yellow SolidPeso molecular:363.5DuP 734
CAS:DuP 734 is a potent and selective sigma receptor antagonist, functioning as a ligand for both sigma and 5-HT2 receptors, and exhibiting weak affinity towards D2 receptors. It possesses potential antipsychotic activity, potentially devoid of the motor side effects commonly observed with neuroleptics[1][2][3].Fórmula:C17H23BrFNOCor e Forma:SolidPeso molecular:356.279PD 144418
CAS:PD 144418 displays potential antipsychotic activity.Fórmula:C18H22N2OPureza:98%Cor e Forma:SolidPeso molecular:282.38Sigma-LIGAND-1
CAS:Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively.Fórmula:C27H33NO4Pureza:99.89%Cor e Forma:SolidPeso molecular:435.56Ref: TM-T13510
1mg46,00€5mg99,00€1mL*10mM (DMSO)113,00€10mg147,00€25mg222,00€50mg299,00€100mg411,00€200mg553,00€NE-100 hydrochloride
CAS:NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity.Fórmula:C23H34ClNO2Pureza:99.76%Cor e Forma:White SolidPeso molecular:391.98Ref: TM-T20797
1mg43,00€2mg54,00€5mg87,00€10mg130,00€25mg210,00€50mg313,00€100mg465,00€200mg662,00€500mg982,00€S1R agonist 1 hydrochloride
CAS:S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstratedFórmula:C20H26ClNOPureza:98%Cor e Forma:SolidPeso molecular:331.88WLB-89462
CAS:WLB-89462 (Compound 20c) is a selective σ2 receptor ligand with a K i of 13 nM, exhibiting neuroprotective properties and the ability to ameliorate Aβ peptide-Fórmula:C21H29N5O3Pureza:98%Cor e Forma:SolidPeso molecular:399.49Sigma-1 receptor antagonist 1
CAS:Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor.Fórmula:C19H23Cl2N3OPureza:99.92%Cor e Forma:SolidPeso molecular:380.31
