CaSR
O receptor sensível ao cálcio (CaSR) é um GPCR que desempenha um papel vital na manutenção da homeostase do cálcio, regulando a secreção do hormônio paratireoideano e a reabsorção de cálcio nos rins. O CaSR também está envolvido em vários outros processos fisiológicos, incluindo o metabolismo ósseo e a função vascular. Moduladores de CaSR são usados no tratamento de condições como hiperparatireoidismo, osteoporose e doenças cardiovasculares. Na CymitQuimica, oferecemos uma seleção de moduladores de CaSR de alta qualidade para apoiar sua pesquisa em metabolismo do cálcio, endocrinologia e saúde óssea.
Foram encontrados 32 produtos de "CaSR"
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AC265347
CAS:<p>AC265347 is a potent calcium-sensitive receptor (CaSR) agonist and ago-PAM orthosteric modulator with antitumour activity for the study of neuroblastoma.</p>Fórmula:C17H17NOSPureza:>99.99%Cor e Forma:SolidPeso molecular:283.39Strontium ranelate
CAS:<p>Strontium ranelate (S12911), a strontium (II) salt of the ranelic acid, is a medication for osteoporosis and can slow the course of osteoarthritis of the knee.</p>Fórmula:C12H6N2O8S·2SrPureza:98.97%Cor e Forma:Crystalline SolidPeso molecular:513.49Evocalcet
CAS:<p>Evocalcet (KHK7580) has an activating effect on the calcium-sensing receptor (CaSR).</p>Fórmula:C24H26N2O2Pureza:98.88% - 99.68%Cor e Forma:SolidPeso molecular:374.48G-Glu-Val
CAS:<p>G-Glu-Val (γ-glutamyl-L-valine, H-Glu-Val -OH), a flavour-regulating dipeptide, is a major contributor to "mellow".</p>Fórmula:C10H18N2O5Cor e Forma:SolidPeso molecular:246.26Upacicalcet HCl
<p>Upacicalcet HCl, a calcium mimetic, reduces blood PTH by targeting parathyroid receptors; treats secondary hyperparathyroidism.</p>Fórmula:C11H15Cl2N3O6SPureza:98.56%Cor e Forma:SoildPeso molecular:388.22Etelcalcetide
CAS:<p>Etelcalcetide (AMG 416), a synthetic peptide CaSR activator, treats secondary hyperparathyroidism in hemodialysis patients.</p>Fórmula:C38H73N21O10S2Pureza:98%Cor e Forma:SolidPeso molecular:1048.26Poly-D-lysine hydrobromide (MW 150000-300000)
<p>Poly-D-lysine hydrobromide (MW 150000-300000) enhances neural cell adhesion in culture and acts as a calcium-sensing receptor agonist peptide in research.</p>Cor e Forma:Odour Solidγ-Glu-Abu TFA
<p>Gamma-Glu-AbuTFA is the TFA salt form of Gamma-Glu-Abu. This compound acts as an agonist for the calcium sensing receptor (CaSR), activating CaSR in HEK-293 cells with an EC50 of 0.21 μM.</p>Fórmula:C11H17F3N2O7Cor e Forma:SolidPeso molecular:346.26Poly-D-lysine hydrobromide (MW 1000-5000)
<p>Poly-D-lysine hydrobromide (PDLHB) (MW 1000-5000) is a synthetically produced polymeric substrate widely used in neural cell culture. Additionally, Poly-D-lysine hydrobromide acts as a CaSR agonist peptide.</p>Cor e Forma:Odour SolidCalcium-Sensing Receptor Antagonists I
CAS:<p>Calcium-Sensing Receptor Antagonists I functions as an antagonist to the parathyroid hormone receptors that sense calcium.</p>Fórmula:C23H24N2O2Cor e Forma:SolidPeso molecular:360.45NPS-2143 hydrochloride
CAS:<p>NPS-2143 hydrochloride (NPS-2143 HCL) is a selective potent calcium ion-sensing receptor antagonist.</p>Fórmula:C24H25ClN2O2·HClPureza:99.38% - 99.67%Cor e Forma:SolidPeso molecular:445.38Etelcalcetide hydrochloride
CAS:<p>Etelcalcetide HCl, a synthetic peptide modulator of CaSR, lowers PTH in dialysis patients with secondary hyperparathyroidism.</p>Fórmula:C38H73N21O10S2HClPureza:>99.99%Cor e Forma:SolidPeso molecular:1353.33NPS2390
CAS:<p>NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively)</p>Fórmula:C19H21N3OPureza:97.13%Cor e Forma:SolidPeso molecular:307.39Cinacalcet
CAS:<p>Cinacalcet (AMG 073) is an orally active, allosteric Ca receptor (CaR) agonist, treatment of cardiovascular disease .</p>Fórmula:C22H22F3NPureza:99.48%Cor e Forma:Yellow OilPeso molecular:357.41TNCA
CAS:<p>TNCA (Lycoperodine-1) is a high-affinity CaSR ligand (CaSRL) with co-agonist activity.</p>Fórmula:C12H12N2O2Pureza:97.33% - 97.73%Cor e Forma:SolidPeso molecular:216.24Cinacalcet hydrochloride
CAS:<p>Cinacalcet hydrochloride (AMG-073 hydrochloride) is a naphthalene derivative and CALCIMIMETIC AGENT that increases the sensitivity of PARATHYROID GLAND calcium-</p>Fórmula:C22H23ClF3NPureza:99.96% - >99.99%Cor e Forma:Off-White To Tan SolidPeso molecular:393.87γ-L-Glutamyl-L-alanine
CAS:<p>γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is the substrate of CRF21 (gamma-Glutamylcyclotransferase, GGCT).</p>Fórmula:C8H14N2O5Pureza:99.49%Cor e Forma:SolidPeso molecular:218.21Ligustroflavone
CAS:<p>Ligustroflavone (Nuezhenoside) has anti-inflammatory activity.</p>Fórmula:C33H40O18Pureza:98% - 99.92%Cor e Forma:SolidPeso molecular:724.66Gadolinium chloride
CAS:<p>Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist</p>Fórmula:Cl3GdPureza:98%Cor e Forma:White Crystalline SolidPeso molecular:263.61Poly-D-lysine hydrobromide (MW 30000-70000)
CAS:<p>Poly-D-lysine hydrobromide (MW 30000-70000) (Poly-D-lysine HBr) is a peptide CaSR agonist that removes proteinase K-resistant PrP from SN56 neuroblastoma cells.</p>Fórmula:(C6H14N2O2)x·xHBrCor e Forma:SolidPeso molecular:227.102Calhex 231 hydrochloride
CAS:<p>Calhex 231 hydrochloride a potent CaSR negative-conversion modulator that blocks the increase in [3H]inositol phosphate, inhibits mir-208a-mediated .</p>Fórmula:C25H28Cl2N2OPureza:99.36%Cor e Forma:SolidPeso molecular:443.41Tecalcet Hydrochloride
CAS:<p>Tecalcet Hydrochloride, an allosteric CaSR modulator, enhances extracellular Ca2+ sensitivity.</p>Fórmula:C18H23Cl2NOPureza:99.97%Cor e Forma:SolidPeso molecular:340.29GSK3004774
CAS:<p>GSK3004774 is a nonabsorbable agonist of CaSR (pEC50: 7.3, 6.6, and 6.5 for human, mouse, and rat CaSR). GSK3004774 shows an EC50 of 50 nM for human CaSR.</p>Fórmula:C32H40N4O3Pureza:98%Cor e Forma:SolidPeso molecular:528.68(Rac)-Upacicalcet
CAS:<p>(Rac)-Upacicalcet, a racemate, is an IV calcimimetic targeting parathyroid receptors to lower PTH, possibly treating SHPT.</p>Fórmula:C11H14ClN3O6SCor e Forma:SolidPeso molecular:351.76NPS-2143
CAS:<p>NPS-2143 (SB 262470A) is a novel potent and selective antagonist of Ca(2+) receptor.</p>Fórmula:C24H25ClN2O2Pureza:99.56%Cor e Forma:SolidPeso molecular:408.92Ronacaleret HCl
CAS:<p>Ronacaleret HCl (SB-751689) is a small molecule CaSR antagonist for the treatment of endocrine and metabolic diseases, skin and musculoskeletal disorders.</p>Fórmula:C25H32ClF2NO4Pureza:99.97%Cor e Forma:SolidPeso molecular:483.98Encaleret
CAS:<p>Encaleret( JIT-305) is an antagonist of oral calcium-sensing receptor (CaSR), it is used for the treatment of osteoporosis.</p>Fórmula:C29H33ClFNO4Cor e Forma:SolidPeso molecular:514.03CaSR antagonist-1
CAS:<p>CaSR Antagonist-1 is a potent inhibitor of the calcium-sensing receptor (CaSR) with an inhibitory concentration (IC50) of 50 nM, suitable for the investigation</p>Fórmula:C29H24FN3O2SPureza:98%Cor e Forma:SolidPeso molecular:497.58Calindol hydrochloride
CAS:<p>Calindol (hydrochloride) is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM.</p>Fórmula:C21H21ClN2Pureza:99.47%Cor e Forma:SolidPeso molecular:336.86H-Glu-Thr-OH
CAS:<p>H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide composed of two amino acids—glutamic acid (Glu) and threonine (Thr)—linked by a peptide bond and functions as an agonist of the extracellular calcium-sensing receptor (CaSR).</p>Fórmula:C9H16N2O6Cor e Forma:SolidPeso molecular:248.23TAK-075
CAS:<p>TAK-075 is an orally active CaSR antagonist with an IC50 value of 0.94 nM. It transiently stimulates parathyroid hormone (PTH) secretion in rats and effectively prevents significant reduction in PTH secretion due to the accumulation of active metabolites, thereby maintaining a normal secretion pattern. TAK-075 is applicable in research related to metabolic diseases and osteoporosis.</p>Fórmula:C36H46N4O4SCor e Forma:SolidPeso molecular:630.84SB-423562
CAS:<p>SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.</p>Fórmula:C26H32N2O4Pureza:99.22%Cor e Forma:SolidPeso molecular:436.54
