CaSR
O receptor sensível ao cálcio (CaSR) é um GPCR que desempenha um papel vital na manutenção da homeostase do cálcio, regulando a secreção do hormônio paratireoideano e a reabsorção de cálcio nos rins. O CaSR também está envolvido em vários outros processos fisiológicos, incluindo o metabolismo ósseo e a função vascular. Moduladores de CaSR são usados no tratamento de condições como hiperparatireoidismo, osteoporose e doenças cardiovasculares. Na CymitQuimica, oferecemos uma seleção de moduladores de CaSR de alta qualidade para apoiar sua pesquisa em metabolismo do cálcio, endocrinologia e saúde óssea.
Foram encontrados 33 produtos de "CaSR"
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Poly-D-lysine hydrobromide (MW 30000-70000)
CAS:Poly-D-lysine hydrobromide (MW 30000-70000) (Poly-D-lysine HBr) is a peptide CaSR agonist that removes proteinase K-resistant PrP from SN56 neuroblastoma cells.Fórmula:(C6H14N2O2)x·xHBrCor e Forma:SolidPeso molecular:227.102Calhex 231 hydrochloride
CAS:Calhex 231 hydrochloride a potent CaSR negative-conversion modulator that blocks the increase in [3H]inositol phosphate, inhibits mir-208a-mediated .Fórmula:C25H28Cl2N2OPureza:99.36%Cor e Forma:SolidPeso molecular:443.41Tecalcet Hydrochloride
CAS:<p>Tecalcet Hydrochloride, an allosteric CaSR modulator, enhances extracellular Ca2+ sensitivity.</p>Fórmula:C18H23Cl2NOPureza:99.97%Cor e Forma:SolidPeso molecular:340.29GSK3004774
CAS:<p>GSK3004774 is a nonabsorbable agonist of CaSR (pEC50: 7.3, 6.6, and 6.5 for human, mouse, and rat CaSR). GSK3004774 shows an EC50 of 50 nM for human CaSR.</p>Fórmula:C32H40N4O3Pureza:98%Cor e Forma:SolidPeso molecular:528.68(Rac)-Upacicalcet
CAS:<p>(Rac)-Upacicalcet, a racemate, is an IV calcimimetic targeting parathyroid receptors to lower PTH, possibly treating SHPT.</p>Fórmula:C11H14ClN3O6SCor e Forma:SolidPeso molecular:351.76NPS-2143
CAS:NPS-2143 (SB 262470A) is a novel potent and selective antagonist of Ca(2+) receptor.Fórmula:C24H25ClN2O2Pureza:99.56%Cor e Forma:SolidPeso molecular:408.92Ronacaleret HCl
CAS:Ronacaleret HCl (SB-751689) is a small molecule CaSR antagonist for the treatment of endocrine and metabolic diseases, skin and musculoskeletal disorders.Fórmula:C25H32ClF2NO4Pureza:99.97%Cor e Forma:SolidPeso molecular:483.98Encaleret
CAS:Encaleret( JIT-305) is an antagonist of oral calcium-sensing receptor (CaSR), it is used for the treatment of osteoporosis.Fórmula:C29H33ClFNO4Cor e Forma:SolidPeso molecular:514.03CaSR antagonist-1
CAS:CaSR Antagonist-1 is a potent inhibitor of the calcium-sensing receptor (CaSR) with an inhibitory concentration (IC50) of 50 nM, suitable for the investigationFórmula:C29H24FN3O2SPureza:98%Cor e Forma:SolidPeso molecular:497.58Calindol hydrochloride
CAS:<p>Calindol (hydrochloride) is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM.</p>Fórmula:C21H21ClN2Pureza:99.47%Cor e Forma:SolidPeso molecular:336.86H-Glu-Thr-OH
CAS:H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide composed of two amino acids—glutamic acid (Glu) and threonine (Thr)—linked by a peptide bond and functions as an agonist of the extracellular calcium-sensing receptor (CaSR).Fórmula:C9H16N2O6Cor e Forma:SolidPeso molecular:248.23TAK-075
CAS:<p>TAK-075 is an orally active CaSR antagonist with an IC50 value of 0.94 nM. It transiently stimulates parathyroid hormone (PTH) secretion in rats and effectively prevents significant reduction in PTH secretion due to the accumulation of active metabolites, thereby maintaining a normal secretion pattern. TAK-075 is applicable in research related to metabolic diseases and osteoporosis.</p>Fórmula:C36H46N4O4SCor e Forma:SolidPeso molecular:630.84SB-423562
CAS:SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.Fórmula:C26H32N2O4Pureza:99.22%Cor e Forma:SolidPeso molecular:436.54
