Receptor de Histamina
Os receptores de histamina são GPCRs que mediam os efeitos da histamina, uma amina biogênica envolvida em respostas imunológicas, secreção de ácido gástrico e neurotransmissão. Existem quatro subtipos de receptores de histamina (H1, H2, H3 e H4), cada um desempenhando papéis distintos em reações alérgicas, função gástrica e atividade do sistema nervoso central. Antagonistas dos receptores de histamina são amplamente utilizados no tratamento de alergias, úlceras pépticas e enjoo de movimento. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores de receptores de histamina de alta qualidade para apoiar sua pesquisa em imunologia, gastroenterologia e neurofarmacologia.
Foram encontrados 385 produtos de "Receptor de Histamina"
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Bamirastine
CAS:Bamirastine inhibits ligand binding to recombinant human histamine H1 receptor (rhH1R) with an IC50 value of 17.3 nM.Bamirastine has an inhibitory effect onFórmula:C31H37N5O3Pureza:96.68%Cor e Forma:SolidPeso molecular:527.66CP-66948
CAS:CP-66948 is a potent histamine H2 receptor antagonist with inhibitory effect on gastric acid secretion and can be used to protect gastric and intestinal mucosa.Fórmula:C13H20N6SPureza:99.14%Cor e Forma:SolidPeso molecular:292.4PF-03654764
CAS:PF-03654764, an oral H3 receptor blocker, Ki: human 1.2 nM, rat 7.9 nM, used with Fexofenadine for allergic rhinitis.Fórmula:C20H28F2N2OPureza:>99.99%Cor e Forma:SolidPeso molecular:350.45Lavoltidine
CAS:Lavoltidine (Loxtidine) is potent and selective H2 receptor antagonist, oral and irreversible,inhibits gastric acid secretion, gastroesophageal reflux disease.Fórmula:C19H29N5O2Pureza:98.30% - 98.36%Cor e Forma:SolidPeso molecular:359.47H3R-IN-1 Hydrochloride
CAS:H3R-IN-1 Hydrochloride is an inverse agonist of histamine receptor 3( H3R ) .Fórmula:C19H24ClN3O3Pureza:98%Cor e Forma:SolidPeso molecular:377.86Propiomazine HCl
CAS:Propiomazine HCl is an analgesia adjunct.Fórmula:C20H25ClN2OSCor e Forma:SolidPeso molecular:376.94Vapitadine dihydrochloride
CAS:Vapitadine dihydrochloride(R-129160 2HCl) is a novel, potent, selective and non-sedating compound with inhibitory effects on histamine H1.Fórmula:C17H22Cl2N4OPureza:98.28% - 99.30%Cor e Forma:SolidPeso molecular:369.29JNJ 10191584 maleate
CAS:JNJ 10191584 maleate (VUF6002 maleate) is an orally active and selective antagonist of H4 receptor (Ki = 26 nM).Fórmula:C17H19ClN4O5Pureza:99.37%Cor e Forma:SolidPeso molecular:394.81Azatadine
CAS:Azatadine is histamine and cholinergic inhibitor (IC50: 6.5 nM and 10 nM, respectively).Fórmula:C20H22N2Pureza:98%Cor e Forma:SolidPeso molecular:290.4Impromidine
CAS:Impromidine is a highly potent and specific agonist of the histamine H2 receptor.Fórmula:C14H23N7SPureza:98%Cor e Forma:SolidPeso molecular:321.44VUF14862
CAS:VUF14862 is a robust and fatigue-resistant photoswitchable GPCR antagonist.Fórmula:C26H32N4O2Cor e Forma:SolidPeso molecular:432.56Sch 44643
CAS:Sch 44643 is an antagonist of platelet activating factor with oral activity.Fórmula:C25H22ClN3O2Cor e Forma:SolidPeso molecular:431.91UR-PI376
CAS:UR-PI376 is a selective histamine H4 receptor agonist with low H1/H2 activity and moderate H3 affinity.Fórmula:C17H22N6SCor e Forma:SolidPeso molecular:342.46Brl 22321
CAS:Brl 22321 is a mast cell stabilizer.Fórmula:C12H9N3O2Cor e Forma:SolidPeso molecular:227.22BL 6341A
CAS:BL 6341A is related to Tumor data and H2-antagonists or anti-histaminsFórmula:C9H14N8OS3Cor e Forma:SolidPeso molecular:346.46(R)-Azelastine
CAS:(R)-Azelastine, an antihistamine, reduces H1R, M1R, M3R levels and inhibits HNEpC growth.Fórmula:C22H24ClN3OCor e Forma:SolidPeso molecular:381.9Aceprometazine
CAS:Aceprometazine (1664CB) is an antipsychotic which is orally active. Aceprometazine can be used in psychiatric disorders research, for example, depression [1].Fórmula:C19H22N2OSCor e Forma:SolidPeso molecular:326.46Noberastine maleate
CAS:Noberastine maleate, a fast-acting furan-derived H1 antagonist, peaks at 4 hours with minimal CNS effects and maximal efficacy at 30 mg/day.Fórmula:C25H29N5O9Cor e Forma:SolidPeso molecular:543.53ROS 234 dioxalate
CAS:ROS 234 dioxalate is a potent antagonist of H3(pKB of 9.46 for Guinea-pig ileum H3-receptor)Fórmula:C17H19N5O8Pureza:98%Cor e Forma:SolidPeso molecular:421.37Fenspiride-d5
CAS:Fenspiride-d5: internal standard for GC/LC-MS quantification, H1 antagonist, NSAID, anti-inflammatory, selective PDE4,5,3 inhibitor.Fórmula:C15H15D5N2O2Cor e Forma:SolidPeso molecular:265.36GSK-239512
CAS:GSK-239512 is an antagonist of H3 receptor and can be used in studies about the treatment of cognitive dysfunction in neurodegenerative disorders.Fórmula:C23H27N3O2Pureza:99.62% - 99.74%Cor e Forma:SolidPeso molecular:377.48S-1-Propenyl-L-cysteine
CAS:S-1-Propenyl-L-cysteine, a stereoisomer of S-allyl-l-cysteine, exhibits immunomodulatory effects and has been shown to decrease blood pressure in hypertensiveFórmula:C6H11NO2SPureza:98%Cor e Forma:SolidPeso molecular:161.22Dacemazine
CAS:Dacemazine is used to treat depression.Fórmula:C16H16N2OSCor e Forma:SolidPeso molecular:284.38VUF14738
CAS:VUF14738 is a robust and fatigue-resistant photoswitchable GPCR antagonist.Fórmula:C25H32N4O2Cor e Forma:SolidPeso molecular:420.55Nedocromil
CAS:Nedocromil (FPL 59002) inhibits the action or formation of multiple mediators. Which including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).Fórmula:C19H17NO7Pureza:95% - 97.34%Cor e Forma:SolidPeso molecular:371.34Dothiepin HCl
CAS:Dothiepin HCl: TCA, SNRI, with antihistamine, antiadrenergic, anticholinergic, and sodium block properties.Fórmula:C19H22ClNSCor e Forma:SolidPeso molecular:331.9FR-A 19
CAS:FR-A 19: Histamine H2 agonist, nanomolar inhibition of basophil histamine release; potent anti-allergic.Fórmula:C25H34Cl3F2N5Cor e Forma:SolidPeso molecular:548.93KY 234
CAS:KY 234 is a thromboxane synthetase antagonist.Fórmula:C33H35N5O2Cor e Forma:SolidPeso molecular:533.676(S)-Azelastine
CAS:(S)-Azelastine is an antihistamine reducing receptors H1R, M1R, M3R, and inhibiting HNEpC cell growth.Fórmula:C22H24ClN3OCor e Forma:SolidPeso molecular:381.9VUF 8328
CAS:VUF 8328 is an agonist of histamine H(3) receptor.Fórmula:C7H12N4SPureza:98%Cor e Forma:SolidPeso molecular:184.26ReN-1869
CAS:ReN-1869 is a novel selective histamine H(1) receptor antagonist with anti-neurogenic pain and anti-inflammatory activity for the study of neurological diseasesFórmula:C24H27NO2Pureza:99.83% - 99.98%Cor e Forma:SolidPeso molecular:361.48Immethridine dihydrobromide
CAS:Immethridine dihydrobromide is a histamine H3 receptor agonist.Fórmula:C9H11Br2N3Pureza:97.61% - 98.14%Cor e Forma:SolidPeso molecular:321.01Proxyfan
CAS:Proxyfan is a high-affinity protean antagonist/agonist of H3 receptors from full agonist to full inverse agonist, depending on given tissue or brain region.Fórmula:C13H16N2OPureza:99.68%Cor e Forma:SolidPeso molecular:216.28DF-1111301
CAS:DF-1111301 is a novel anti-allergic compound with anti-histamine H1 and anti-PAF activity.Fórmula:C15H25Cl2N3OPureza:99.17%Cor e Forma:SolidPeso molecular:334.29Noberastine
CAS:Noberastine (R 64947) is a novel histamine H1 antagonist with potent and specific peripheral antihistamine activity.Fórmula:C17H21N5OPureza:99.72% - >99.99%Cor e Forma:SolidPeso molecular:311.38KP136
CAS:KP136 is an orally effective antiallergic compound (IC50: 76.1 μg/mL for histamine release and 63 ug/mL for degranulation).Fórmula:C16H18N4O3Pureza:98.3% - 98.61%Cor e Forma:SolidPeso molecular:314.34JZP-361
CAS:JZP-361: selective MAGL inhibitor (IC50 = 46 nM); weaker on FAAH, hABHD6; anti-histamine; for asthma research.Fórmula:C22H20ClN5OPureza:99.82%Cor e Forma:SolidPeso molecular:405.88Pitolisant
CAS:Pitolisant is a potent and selective nonimidazole inverse agonist that acts on the recombinant human histamine H3 receptor with Ki of 0.16 nM.Fórmula:C17H26ClNOPureza:99.84%Cor e Forma:SolidPeso molecular:295.85Ref: TM-T60636
5mg48,00€10mg70,00€25mg120,00€50mg188,00€100mg311,00€500mg747,00€1mL*10mM (DMSO)52,00€KSK94
CAS:KSK94 is an H3 receptor antagonist that inhibits sigma-2 receptors , with a Ki value of 75.2 nM, and can be used to study injurious pain.Fórmula:C25H26N4OPureza:99.60%Cor e Forma:SolidPeso molecular:398.5Impromidine hydrochloride
CAS:Impromidine hydrochloride is a very potent and specific histamine H2 receptor agonist for conducting cardiovascular studies.Fórmula:C14H26Cl3N7SPureza:99.82%Cor e Forma:SolidPeso molecular:430.83NP10679
CAS:NP10679 is a N-methyl-D-aspartate (NMDA) receptor inhibitor of the GluN2B subunit that inhibits histamine H1, hERG channels, and CYPase.Fórmula:C23H26F3N3O3Pureza:99.43%Cor e Forma:SolidPeso molecular:449.47Clemastine
CAS:Clemastine (Meclastin) is an antagonist of the H1 receptor and exhibits anti-inflammatory effects.Fórmula:C21H26ClNOPureza:99.21%Cor e Forma:SolidPeso molecular:343.89Bavisant
CAS:Bavisant (JNJ-31001074) is a selective and orally active Human H3 receptor antagonist.Fórmula:C19H27N3O2Pureza:99.21% - 99.65%Cor e Forma:SolidPeso molecular:329.44Ref: TM-TQ0046
1mg43,00€5mg96,00€10mg134,00€25mg221,00€50mg325,00€100mg465,00€500mgA consultar1mL*10mM (DMSO)94,00€Linetastine
CAS:Linetastine (TMK-688) inhibits 5-LOX, blocks leukotrienes, counters histamine; researched for asthma, atherosclerosis, ulcers.Fórmula:C35H40N2O6Pureza:99.99%Cor e Forma:SolidPeso molecular:584.7D18024
CAS:<p>D18024 is a phthalazinonderivat with anti-allergic and anti-histamine effect.</p>Fórmula:C29H31ClFN3OPureza:99.86%Cor e Forma:SolidPeso molecular:492.03Enerisant hydrochloride
CAS:Enerisant HCl is a novel potent and selective histamine H3 receptor antagonist, a substrate for P-gp, mediated by cytochrome P450 (CYP) and transporter proteinsFórmula:C22H31ClN4O3Pureza:99.95%Cor e Forma:SolidPeso molecular:434.96Abt-288
CAS:ABT-288 is a selective and potent H3 antagonist for the treatment of mild to moderate Alzheimer's dementia.Fórmula:C23H24N4OPureza:98.17% - 98.49%Cor e Forma:SolidPeso molecular:372.46KSK68
CAS:KSK68 is a sigma-1 and histamine H3 receptor antagonist with analgesic activity, inhibits H3 receptors and can be used to study pain.Fórmula:C23H28N2O2Pureza:99.11%Cor e Forma:SolidPeso molecular:364.48Efletirizine
CAS:Efletirizine (UCB-28754), a histamine blocker and 5-LO inhibitor, aids in topical allergy treatment.Fórmula:C21H24F2N2O3Pureza:99.39%Cor e Forma:SolidPeso molecular:390.42Antihistamine-1
CAS:Antihistamine-1 是能够渗透血脑屏障的 H1-抗组胺药 (Ki=6.9 nM), 它也是 CYP2D6 和 hERG 通道的抑制剂，其 IC50 值分别为 5.4 和 0.8 μM。Fórmula:C23H24FN5Pureza:99.69%Cor e Forma:SolidPeso molecular:389.47Eclazolast
CAS:<p>Eclazolast (RHC 2871), a lipophilic anti-allergic, inhibits mast cell mediator release by affecting Fc(epsilon)RI-related processes, dose-dependently.</p>Fórmula:C12H12ClNO4Pureza:98.36% - 98.58%Cor e Forma:SolidPeso molecular:269.68Irdabisant
CAS:Irdabisant (CEP-26401) is an H3R antagonist/inverse agonist, BBB permeable, with cognition-enhancing effects for schizophrenia/cognitive research.Fórmula:C18H23N3O2Pureza:99.96%Cor e Forma:SolidPeso molecular:313.39UCB-35440
CAS:UCB-35440, a 5-lipoxygenase inhibitor and a histamine H1 receptor antagonist, is used potentially for the treatment of dermatitis.Fórmula:C31H34ClN5O4Cor e Forma:SolidPeso molecular:576.09Meclizine N-oxide
CAS:Meclizine N-oxide, a metabolite of the histamine H1 receptor antagonist meclizine (1), also acts as a degradation product and potential impurity in commercial meclizine preparations (2).Fórmula:C25H27ClN2OCor e Forma:SolidPeso molecular:407Levocabastine hydrochloride
CAS:Levocabastine HCl is an agent with antihistaminic activity.Fórmula:C26H30ClFN2O2Cor e Forma:SolidPeso molecular:456.98Quinotolast sodium
CAS:Quinotolast sodium inhibits histamine, LTC4 and PGD2 release in a concentration-dependent manner in the concentration range of 1-100 μg/mL.Fórmula:C17H12N6NaO3Pureza:98%Cor e Forma:SolidPeso molecular:371.312A-349821
CAS:A-349821 is an H3 receptor agonist radioligand.Fórmula:C28H35F3N2O5Cor e Forma:SolidPeso molecular:536.59CI-949
CAS:CI-949 inhibits LTC4/D4, histamine, TXB2 release (IC50: 0.5, 11.4, 0.1 μM).Fórmula:C20H20N6O3Pureza:98%Cor e Forma:SolidPeso molecular:392.41Ebrotidine
CAS:Ebrotidine (FI3542) is a competitive H2-receptor antagonist with Ki of 127.5 nM. Ebrotidine has a potent antisecretory activity and evidenced gastroprotection.Fórmula:C14H17BrN6O2S3Pureza:97.519%Cor e Forma:SolidPeso molecular:477.42Minocromil
CAS:Minocromil is a new agent of Anti-asthmatic.Fórmula:C18H16N2O6Pureza:98%Cor e Forma:SolidPeso molecular:356.33GT-2331
CAS:GT-2331 is a histamine H3 receptor antagonist.Fórmula:C14H20N2Cor e Forma:SolidPeso molecular:216.32APD-916
CAS:APD-916, an H3 receptor antagonist, exhibits favorable pharmacokinetic properties. Oral administration of APD-916 has been demonstrated to enhance wakefulness in various animal models.Fórmula:C23H31NO3SCor e Forma:SolidPeso molecular:401.56Embramine hydrochloride
CAS:Embramine hydrochloride is a monoethanolamine derivative utilized for its antihistaminic and anticholinergic properties [1].Fórmula:C18H23BrClNOCor e Forma:SolidPeso molecular:384.74JNJ-28583867
CAS:JNJ-28583867 is an inhibitor of histamine H(3) receptor antagonist and serotonin reuptake.Fórmula:C24H32N2O2SCor e Forma:SolidPeso molecular:412.59GSK-1004723
CAS:GSK-1004723 is a novel antagonist of histamine H(1) and H(3) receptor. It represents a potential novel therapy for allergic rhinitis.Fórmula:C39H49ClN4O2Cor e Forma:SolidPeso molecular:641.28Cipralisant
CAS:Cipralisant: H3 receptor antagonist (in vivo), agonist (in vitro, pKi 9.9), Ki 0.47 nM in rats, may treat ADHD.Fórmula:C14H20N2Pureza:98%Cor e Forma:SolidPeso molecular:216.32Hydroxydione
CAS:Hydroxydione, a neuroactive steroid with general anesthetic properties, is utilized in anesthesia-related research [1] [2].Fórmula:C21H32O3Cor e Forma:SolidPeso molecular:332.48Cipralisant maleate
CAS:Cipralisant maleate is a potent, selective Histamine H3 receptor antagonist.Fórmula:C18H24N2O4Cor e Forma:SolidPeso molecular:332.39H3 receptor antagonist 1
CAS:H3 receptor antagonist 1 is used in the study of neurological diseases, histamine H3 receptor antagonist.Fórmula:C20H28F2N2OPureza:98%Cor e Forma:SolidPeso molecular:350.45Levocabastine
CAS:Levocarbastine: 2nd-gen H1 antagonist, treats allergic conjunctivitis, selective NTS2 neurotensin inhibitor.Fórmula:C26H29FN2O2Cor e Forma:SolidPeso molecular:420.52H4R antagonist 2
CAS:H4R Antagonist 2, a potent Furo[3,2-d]pyrimidine derivative, serves as a histamine H4 receptor antagonist and holds potential for research into rheumatoidFórmula:C13H17N5OPureza:98%Cor e Forma:SolidPeso molecular:259.31ST-1006
CAS:ST-1006: histamine H4 agonist, pKi 7.94, anti-inflammatory, anti-pruritic, promotes basophil migration.Fórmula:C16H20Cl2N6Pureza:99.96% - 99.98%Cor e Forma:SolidPeso molecular:367.28Ref: TM-T34709
1mg90,00€5mg198,00€10mg316,00€25mg513,00€50mg633,00€100mg785,00€200mg1.045,00€1mL*10mM (DMSO)A consultarEnerisant
CAS:Enerisant (TS-091) is a histamine H3 receptor antagonist that promotes pro-cognitive effects and reverses scopolamine-induced cognitive deficits.Fórmula:C22H30N4O3Pureza:99.7%Cor e Forma:SoildPeso molecular:398.50Ref: TM-T67828
1mg52,00€2mg71,00€5mg107,00€10mg170,00€25mg359,00€50mg462,00€100mg645,00€200mg873,00€1mL*10mM (DMSO)117,00€H3R antagonist 1
CAS:H3R-IN-1 is an effective inverse agonist of the histamine receptor 3 (H3R).Fórmula:C19H23N3O3Cor e Forma:SolidPeso molecular:341.4Tixanox sodium
CAS:Tixanox sodium effectively blocks histamine release in the lungs triggered by anti-IgE. It has also been demonstrated that when administered orally, Tixanox sodium can successfully counteract exercise-induced asthma.Fórmula:C15H9NaO5SCor e Forma:SolidPeso molecular:324.28H3R antagonist 5
CAS:H3R antagonist 5 (Compound 1b) is a selective inverse agonist of the histamine H3 receptor that can penetrate the blood-brain barrier, with an IC50 of 0.54 nM. It is applicable for research related to the central nervous system.Fórmula:C23H32N2O4Cor e Forma:SolidPeso molecular:400.511CI-624
CAS:CI-624 reduces the secretion and output of hydrogen ions, sodium ions, potassium ions, and pepsin. This compound may be utilized in research focusing on cancer and autoimmune diseases.Fórmula:C8H8N2SCor e Forma:SolidPeso molecular:164.228H1R ligand-1
CAS:<p>H1R ligand-1 (Compound fragment 1) is a high-affinity ligand for the human histamine H1 receptor (H1R). It can serve as a scaffold for synthesizing a series of derivatives to investigate H1R binding kinetics.</p>Fórmula:C19H23NOCor e Forma:SolidPeso molecular:281.392Sitamaquine hydrochloride
CAS:Sitamaquine hydrochloride (WR 6026) is an orally active 8-aminoquinoline analog with antileishmanial activity. This compound inhibits mitochondrial complex II (succinate dehydrogenase) and is characterized by its lipophilic weak base properties. It rapidly accumulates in the acidic compartments of Leishmania parasites, predominantly localizing within the acidocalcisomes.Fórmula:C21H35Cl2N3OCor e Forma:SolidPeso molecular:416.43Arpromidine
CAS:Arpromidine (BU-E-50) acts as an agonist for the histamine H2 receptor and an antagonist for the histamine H1 receptor. It demonstrates positive inotropic effects with a lower risk of inducing arrhythmias. Arpromidine can be utilized in studies related to congestive heart failure.Fórmula:C21H25FN6Cor e Forma:SolidPeso molecular:380.462Nedocromil sodium
CAS:Nedocromil sodium is a pharmacologic stabilizer of mast cells, has been shown to normalize cytokine levels and attenuate cardiac remodeling.Fórmula:C19H17NNaO7Pureza:98%Cor e Forma:SolidPeso molecular:394.335Histamine H3 antagonist-1
CAS:<p>Compound 10o, a histamine H3 antagonist-1, functions as both a histamine H3 antagonist and a serotonin reuptake inhibitor, making it useful for research in depression [1].</p>Fórmula:C24H28F3N3O2Cor e Forma:SolidPeso molecular:447.49ONO-8809
CAS:ONO-8809: Thromboxane A2 antagonist, reduces airway hyperresponse, macrophage accumulation, and MMP-9 in SHRSP brains.Fórmula:C30H46BrNO4SPureza:98%Cor e Forma:SolidPeso molecular:596.66(R)-(-)-α-Methylhistamine dihydrochloride
CAS:R(-)-alpha-Methylhistamine 2HCl is an effective and selective agonist of the H3 histamine receptor.Fórmula:C6H13Cl2N3Cor e Forma:SolidPeso molecular:198.09Imetit dihydrobromide
CAS:Imetit dihydrobromide is a high affinity and effective agonist of histamine H3 and H4 receptors (Ki: 0.3 and 2.7 nM). Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50: 25 nM).Fórmula:C6H12Br2N4SPureza:98%Cor e Forma:SolidPeso molecular:332.06
