Receptor de Histamina
Os receptores de histamina são GPCRs que mediam os efeitos da histamina, uma amina biogênica envolvida em respostas imunológicas, secreção de ácido gástrico e neurotransmissão. Existem quatro subtipos de receptores de histamina (H1, H2, H3 e H4), cada um desempenhando papéis distintos em reações alérgicas, função gástrica e atividade do sistema nervoso central. Antagonistas dos receptores de histamina são amplamente utilizados no tratamento de alergias, úlceras pépticas e enjoo de movimento. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores de receptores de histamina de alta qualidade para apoiar sua pesquisa em imunologia, gastroenterologia e neurofarmacologia.
Foram encontrados 390 produtos para "Receptor de Histamina".
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Nedocromil sodium
CAS:Nedocromil sodium is a pharmacologic stabilizer of mast cells, has been shown to normalize cytokine levels and attenuate cardiac remodeling.Fórmula:C19H17NNaO7Pureza:98%Cor e Forma:SolidPeso molecular:394.335H3R antagonist 5
CAS:H3R antagonist 5 (Compound 1b) is a selective inverse agonist of the histamine H3 receptor that can penetrate the blood-brain barrier, with an IC50 of 0.54 nM. It is applicable for research related to the central nervous system.Fórmula:C23H32N2O4Cor e Forma:SolidPeso molecular:400.511Sitamaquine hydrochloride
CAS:Sitamaquine hydrochloride (WR 6026) is an orally active 8-aminoquinoline analog with antileishmanial activity. This compound inhibits mitochondrial complex II (succinate dehydrogenase) and is characterized by its lipophilic weak base properties. It rapidly accumulates in the acidic compartments of Leishmania parasites, predominantly localizing within the acidocalcisomes.Fórmula:C21H35Cl2N3OCor e Forma:SolidPeso molecular:416.43CI-624
CAS:CI-624 reduces the secretion and output of hydrogen ions, sodium ions, potassium ions, and pepsin. This compound may be utilized in research focusing on cancer and autoimmune diseases.Fórmula:C8H8N2SCor e Forma:SolidPeso molecular:164.228Histamine H3 antagonist-1
CAS:Compound 10o, a histamine H3 antagonist-1, functions as both a histamine H3 antagonist and a serotonin reuptake inhibitor, making it useful for research in depression [1].
Fórmula:C24H28F3N3O2Cor e Forma:SolidPeso molecular:447.49Tixanox sodium
CAS:Tixanox sodium effectively blocks histamine release in the lungs triggered by anti-IgE. It has also been demonstrated that when administered orally, Tixanox sodium can successfully counteract exercise-induced asthma.Fórmula:C15H9NaO5SCor e Forma:SolidPeso molecular:324.28KF-17625
CAS:KF-17625 is an orally active bronchodilator. It inhibits bronchoconstriction induced by Carbachol, Histamine, or Leukotriene D4. Additionally, KF-17625 suppresses phosphodiesterase (PDE) IV in canine trachea with an IC50 of 12 μM and reduces histamine release from rat mast cells induced by Concanavalin-A at a 10 μM concentration with a 44% inhibition rate. This compound is applicable in research related to immunology and inflammation.Fórmula:C15H10N4OPeso molecular:262.27H1R ligand-1
CAS:H1R ligand-1 (Compound fragment 1) is a high-affinity ligand for the human histamine H1 receptor (H1R). It can serve as a scaffold for synthesizing a series of derivatives to investigate H1R binding kinetics.Fórmula:C19H23NOCor e Forma:SolidPeso molecular:281.392H3R antagonist 1
CAS:H3R-IN-1 is an effective inverse agonist of the histamine receptor 3 (H3R).Fórmula:C19H23N3O3Cor e Forma:SolidPeso molecular:341.4Arpromidine
CAS:Arpromidine (BU-E-50) acts as an agonist for the histamine H2 receptor and an antagonist for the histamine H1 receptor. It demonstrates positive inotropic effects with a lower risk of inducing arrhythmias. Arpromidine can be utilized in studies related to congestive heart failure.Fórmula:C21H25FN6Cor e Forma:SolidPeso molecular:380.462
