Receptor de Histamina
Os receptores de histamina são GPCRs que mediam os efeitos da histamina, uma amina biogênica envolvida em respostas imunológicas, secreção de ácido gástrico e neurotransmissão. Existem quatro subtipos de receptores de histamina (H1, H2, H3 e H4), cada um desempenhando papéis distintos em reações alérgicas, função gástrica e atividade do sistema nervoso central. Antagonistas dos receptores de histamina são amplamente utilizados no tratamento de alergias, úlceras pépticas e enjoo de movimento. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores de receptores de histamina de alta qualidade para apoiar sua pesquisa em imunologia, gastroenterologia e neurofarmacologia.
Foram encontrados 390 produtos para "Receptor de Histamina".
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Immethridine dihydrobromide
CAS:Immethridine dihydrobromide is a histamine H3 receptor agonist.Fórmula:C9H11Br2N3Pureza:97.61% - 99.61%Cor e Forma:SolidPeso molecular:321.01Enerisant hydrochloride
CAS:Enerisant HCl is a novel potent and selective histamine H3 receptor antagonist, a substrate for P-gp, mediated by cytochrome P450 (CYP) and transporter proteinsFórmula:C22H31ClN4O3Pureza:99.95%Cor e Forma:White OilPeso molecular:434.96Efletirizine
CAS:Efletirizine (UCB-28754), a histamine blocker and 5-LO inhibitor, aids in topical allergy treatment.Fórmula:C21H24F2N2O3Pureza:99.39%Cor e Forma:SolidPeso molecular:390.42Elbanizine
CAS:Elbanizine showed antiallergic, antiasthmatic, antihistaminic, and spasmolytic activity.Fórmula:C26H31N5O2Pureza:99.97% - 99.98%Cor e Forma:SolidPeso molecular:445.56Ref: TM-T67953
1mg71,00€5mg147,00€1mL*10mM (DMSO)161,00€10mg212,00€25mg288,00€50mg421,00€100mg600,00€200mg812,00€DF-1111301
CAS:DF-1111301 is a novel anti-allergic compound with anti-histamine H1 and anti-PAF activity.Fórmula:C15H25Cl2N3OPureza:99.17%Cor e Forma:SolidPeso molecular:334.29KP136
CAS:KP136 is an orally effective antiallergic compound (IC50: 76.1 μg/mL for histamine release and 63 ug/mL for degranulation).Fórmula:C16H18N4O3Pureza:98.61% - 99.96%Cor e Forma:SolidPeso molecular:314.34Linetastine
CAS:Linetastine (TMK-688) inhibits 5-LOX, blocks leukotrienes, counters histamine; researched for asthma, atherosclerosis, ulcers.Fórmula:C35H40N2O6Pureza:99.99%Cor e Forma:SolidPeso molecular:584.7Quinotolast sodium
CAS:Quinotolast sodium inhibits histamine, LTC4 and PGD2 release in a concentration-dependent manner in the concentration range of 1-100 μg/mL.Fórmula:C17H12N6NaO3Pureza:98%Cor e Forma:SolidPeso molecular:371.312CI-949
CAS:CI-949 inhibits LTC4/D4, histamine, TXB2 release (IC50: 0.5, 11.4, 0.1 μM).Fórmula:C20H20N6O3Pureza:98%Cor e Forma:SolidPeso molecular:392.41Minocromil
CAS:Minocromil is a new agent of Anti-asthmatic.Fórmula:C18H16N2O6Pureza:98%Cor e Forma:SolidPeso molecular:356.33JNJ-28583867
CAS:JNJ-28583867 is an inhibitor of histamine H(3) receptor antagonist and serotonin reuptake.Fórmula:C24H32N2O2SCor e Forma:SolidPeso molecular:412.59GSK-1004723
CAS:GSK-1004723 is a novel antagonist of histamine H(1) and H(3) receptor. It represents a potential novel therapy for allergic rhinitis.Fórmula:C39H49ClN4O2Cor e Forma:SolidPeso molecular:641.28Ebrotidine
CAS:Ebrotidine (FI3542) is a competitive H2-receptor antagonist with Ki of 127.5 nM. Ebrotidine has a potent antisecretory activity and evidenced gastroprotection.Fórmula:C14H17BrN6O2S3Pureza:97.51%Cor e Forma:SolidPeso molecular:477.42GT-2331
CAS:GT-2331 is a histamine H3 receptor antagonist.Fórmula:C14H20N2Cor e Forma:SolidPeso molecular:216.32A-349821
CAS:A-349821 is an H3 receptor agonist radioligand.Fórmula:C28H35F3N2O5Cor e Forma:SolidPeso molecular:536.59Cipralisant maleate
CAS:Cipralisant maleate is a potent, selective Histamine H3 receptor antagonist.Fórmula:C18H24N2O4Cor e Forma:SolidPeso molecular:332.39Levocabastine
CAS:Levocarbastine: 2nd-gen H1 antagonist, treats allergic conjunctivitis, selective NTS2 neurotensin inhibitor.Fórmula:C26H29FN2O2Cor e Forma:SolidPeso molecular:420.52UCB-35440
CAS:UCB-35440, a 5-lipoxygenase inhibitor and a histamine H1 receptor antagonist, is used potentially for the treatment of dermatitis.Fórmula:C31H34ClN5O4Cor e Forma:SolidPeso molecular:576.09H3 receptor antagonist 1
CAS:H3 receptor antagonist 1 is used in the study of neurological diseases, histamine H3 receptor antagonist.Fórmula:C20H28F2N2OPureza:98%Cor e Forma:SolidPeso molecular:350.45Meclizine N-oxide
CAS:Meclizine N-oxide, a metabolite of the histamine H1 receptor antagonist meclizine (1), also acts as a degradation product and potential impurity in commercial meclizine preparations (2).Fórmula:C25H27ClN2OCor e Forma:SolidPeso molecular:407Cipralisant
CAS:Cipralisant: H3 receptor antagonist (in vivo), agonist (in vitro, pKi 9.9), Ki 0.47 nM in rats, may treat ADHD.Fórmula:C14H20N2Pureza:98%Cor e Forma:SolidPeso molecular:216.32Levocabastine hydrochloride
CAS:Levocabastine HCl is an agent with antihistaminic activity.Fórmula:C26H30ClFN2O2Cor e Forma:SolidPeso molecular:456.98Hydroxydione
CAS:Hydroxydione, a neuroactive steroid with general anesthetic properties, is utilized in anesthesia-related research [1] [2].Fórmula:C21H32O3Cor e Forma:SolidPeso molecular:332.48Embramine hydrochloride
CAS:Embramine hydrochloride is a monoethanolamine derivative utilized for its antihistaminic and anticholinergic properties [1].Fórmula:C18H23BrClNOCor e Forma:SolidPeso molecular:384.74APD-916
CAS:APD-916, an H3 receptor antagonist, exhibits favorable pharmacokinetic properties. Oral administration of APD-916 has been demonstrated to enhance wakefulness in various animal models.Fórmula:C23H31NO3SCor e Forma:SolidPeso molecular:401.56H4R antagonist 2
CAS:H4R Antagonist 2, a potent Furo[3,2-d]pyrimidine derivative, serves as a histamine H4 receptor antagonist and holds potential for research into rheumatoidFórmula:C13H17N5OPureza:98%Cor e Forma:SolidPeso molecular:259.31Enerisant
CAS:Enerisant (TS-091) is a histamine H3 receptor antagonist that promotes pro-cognitive effects and reverses scopolamine-induced cognitive deficits.Fórmula:C22H30N4O3Pureza:99.97%Cor e Forma:SolidPeso molecular:398.50Ref: TM-T67828
1mg49,00€2mg67,00€5mg102,00€1mL*10mM (DMSO)111,00€10mg166,00€25mg339,00€50mg439,00€100mg610,00€200mg827,00€ST-1006
CAS:ST-1006: histamine H4 agonist, pKi 7.94, anti-inflammatory, anti-pruritic, promotes basophil migration.Fórmula:C16H20Cl2N6Pureza:99.96% - 99.98%Cor e Forma:SolidPeso molecular:367.28Ref: TM-T34709
1mg86,00€1mL*10mM (DMSO)187,00€5mg188,00€10mg299,00€25mg487,00€50mg600,00€100mg743,00€200mg990,00€ONO-8809
CAS:ONO-8809: Thromboxane A2 antagonist, reduces airway hyperresponse, macrophage accumulation, and MMP-9 in SHRSP brains.Fórmula:C30H46BrNO4SPureza:98%Cor e Forma:SolidPeso molecular:596.66Dimephosphon
CAS:Dimephosphon is an anti-inflammatory agent exhibiting both antihistamine and antiserotonin activities. It aids in maintaining spinal cord conduction function and reduces the excitability of motor neurons around lesion areas. Additionally, Dimephosphon directly stimulates lymph vessel movement, enhancing lymph circulation. This compound is useful for studying inflammatory edema, acute spinal cord injuries, and lymphatic circulation disorders.Fórmula:C8H17O4PCor e Forma:SolidPeso molecular:208.19Nedocromil sodium
CAS:Nedocromil sodium is a pharmacologic stabilizer of mast cells, has been shown to normalize cytokine levels and attenuate cardiac remodeling.Fórmula:C19H17NNaO7Pureza:98%Cor e Forma:SolidPeso molecular:394.335H3R antagonist 5
CAS:H3R antagonist 5 (Compound 1b) is a selective inverse agonist of the histamine H3 receptor that can penetrate the blood-brain barrier, with an IC50 of 0.54 nM. It is applicable for research related to the central nervous system.Fórmula:C23H32N2O4Cor e Forma:SolidPeso molecular:400.511Sitamaquine hydrochloride
CAS:Sitamaquine hydrochloride (WR 6026) is an orally active 8-aminoquinoline analog with antileishmanial activity. This compound inhibits mitochondrial complex II (succinate dehydrogenase) and is characterized by its lipophilic weak base properties. It rapidly accumulates in the acidic compartments of Leishmania parasites, predominantly localizing within the acidocalcisomes.Fórmula:C21H35Cl2N3OCor e Forma:SolidPeso molecular:416.43CI-624
CAS:CI-624 reduces the secretion and output of hydrogen ions, sodium ions, potassium ions, and pepsin. This compound may be utilized in research focusing on cancer and autoimmune diseases.Fórmula:C8H8N2SCor e Forma:SolidPeso molecular:164.228Histamine H3 antagonist-1
CAS:Compound 10o, a histamine H3 antagonist-1, functions as both a histamine H3 antagonist and a serotonin reuptake inhibitor, making it useful for research in depression [1].
Fórmula:C24H28F3N3O2Cor e Forma:SolidPeso molecular:447.49Tixanox sodium
CAS:Tixanox sodium effectively blocks histamine release in the lungs triggered by anti-IgE. It has also been demonstrated that when administered orally, Tixanox sodium can successfully counteract exercise-induced asthma.Fórmula:C15H9NaO5SCor e Forma:SolidPeso molecular:324.28KF-17625
CAS:KF-17625 is an orally active bronchodilator. It inhibits bronchoconstriction induced by Carbachol, Histamine, or Leukotriene D4. Additionally, KF-17625 suppresses phosphodiesterase (PDE) IV in canine trachea with an IC50 of 12 μM and reduces histamine release from rat mast cells induced by Concanavalin-A at a 10 μM concentration with a 44% inhibition rate. This compound is applicable in research related to immunology and inflammation.Fórmula:C15H10N4OPeso molecular:262.27H1R ligand-1
CAS:H1R ligand-1 (Compound fragment 1) is a high-affinity ligand for the human histamine H1 receptor (H1R). It can serve as a scaffold for synthesizing a series of derivatives to investigate H1R binding kinetics.Fórmula:C19H23NOCor e Forma:SolidPeso molecular:281.392H3R antagonist 1
CAS:H3R-IN-1 is an effective inverse agonist of the histamine receptor 3 (H3R).Fórmula:C19H23N3O3Cor e Forma:SolidPeso molecular:341.4Arpromidine
CAS:Arpromidine (BU-E-50) acts as an agonist for the histamine H2 receptor and an antagonist for the histamine H1 receptor. It demonstrates positive inotropic effects with a lower risk of inducing arrhythmias. Arpromidine can be utilized in studies related to congestive heart failure.Fórmula:C21H25FN6Cor e Forma:SolidPeso molecular:380.462
