Receptor opioide
Os receptores opioides são um grupo de receptores acoplados à proteína G que mediam os efeitos dos opioides endógenos e exógenos. Estes receptores desempenham um papel central na modulação da dor, regulação do humor e comportamentos aditivos. Agonistas e antagonistas dos receptores opioides são amplamente utilizados no manejo da dor e tratamento de dependências, bem como em pesquisas sobre distúrbios neurológicos e psiquiátricos. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores de receptores opioides de alta qualidade para apoiar sua pesquisa em neurobiologia, manejo da dor e terapia de dependência.
Foram encontrados 327 produtos de "Receptor opioide"
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Moguisteine
CAS:Moguisteine (BBR-2173) is a new-type peripheral non-narcotic antitussive drug.Fórmula:C16H21NO5SPureza:99.98%Cor e Forma:SolidPeso molecular:339.41Apitegromab
CAS:Apitegromab (SRK-015) is a new myostatin inhibitor, an antibody targeting myostatin precursor, which can be used to study neuromuscular diseases includingPureza:97.59% (SDS-PAGE); 99.78% (SEC-HPLC) - >95.0% (SDS-PAGE); 99.62% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:145.06 kDaSinomenine hydrochloride
CAS:Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.Fórmula:C19H24ClNO4Pureza:99.43%Cor e Forma:SolidPeso molecular:365.85Alvimopan
CAS:Alvimopan is a potent opioid antagonist targeting gut receptors to reverse opioid effects on motility.Fórmula:C25H32N2O4Pureza:99.47% - 99.78%Cor e Forma:SolidPeso molecular:424.53Ref: TM-T1242
1mg44,00€2mg57,00€5mg93,00€1mL*10mM (DMSO)94,00€10mg120,00€25mg220,00€50mg356,00€100mg530,00€200mg755,00€Naltrexone hydrochloride
CAS:Naltrexone hydrochloride (Naltrexone HCl) is a synthetic opioid antagonist used in the prevention of relapse of opiate addiction and alcoholism.Fórmula:C20H24ClNO4Pureza:98.72% - 99.65%Cor e Forma:White Crystalline PowderPeso molecular:377.862CP 866087
CAS:CP 866087 is an opioid receptor antagonist for the study of female sexual dysfunction.Fórmula:C24H30N2O3SPureza:99.22% - 99.74%Cor e Forma:SolidPeso molecular:426.57ZT 52656A hydrochloride
CAS:ZT 52656A is a selective agonist of kappa opioid, and used for the prevention or alleviation of pain in the eye.Fórmula:C19H26ClF3N2OPureza:98.78%Cor e Forma:SolidPeso molecular:390.87Loperamide hydrochloride
CAS:Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.Fórmula:C29H34Cl2N2O2Pureza:99.91% - >99.99%Cor e Forma:Crystals Practically Insoluble In WaterPeso molecular:513.50Matrine
CAS:Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.Fórmula:C15H24N2OPureza:99.77% - >99.99%Cor e Forma:SolidPeso molecular:248.36LY2940094
CAS:LY2940094 (LY-2940094) decreases ethanol self-administration in animal models.Fórmula:C22H23ClF2N4O2SPureza:99.4%Cor e Forma:SolidPeso molecular:480.96Ref: TM-T15799
1mg77,00€2mg101,00€5mg155,00€1mL*10mM (DMSO)170,00€10mg259,00€25mg513,00€50mg737,00€100mg1.018,00€BTRX-335140
CAS:BTRX-335140 (CYM-53093) is a potent and selective orally active κ-opioid receptor (KOR) antagonist with antagonistic activity.Cost-effective and quality-assured.Fórmula:C25H32FN5O2Pureza:98% - 99.89%Cor e Forma:SolidPeso molecular:453.55Ref: TM-T14835
1mg100,00€2mg146,00€5mg236,00€1mL*10mM (DMSO)268,00€10mg385,00€25mg797,00€50mg1.305,00€100mg1.783,00€200mg2.493,00€Meptazinol hydrochloride
CAS:Meptazinol hydrochloride (Meptazinol HCl) , a unique centrally opioid analgesic, is used as a narcotic antagonist with analgesic properties.Fórmula:C15H23NO·HClPureza:99.75%Cor e Forma:White SolidPeso molecular:269.81Trimebutine maleate
CAS:Trimebutine maleate (Polibutin) is a weak mu-opioid agonist and has antimuscarinic effects.
Fórmula:C26H33NO9Pureza:99.76% - 99.98%Cor e Forma:White SolidPeso molecular:503.55Samidorphan HCl
CAS:Samidorphan HCl is an orally active and highly potent modulator of the opioid system that binds to μ‐opioid, κ‐opioid, and delta-opioid receptors.Fórmula:C21H27ClN2O4Pureza:96.79% - 97.85%Cor e Forma:SoildPeso molecular:406.9[(pF)Phe4]Nociceptin(1-13)NH2
CAS:Potent, selective OP4 agonist; pKi=10.68, pEC50=9.80. >8000x selectivity vs other opioid receptors; long-lasting in vivo effects.Fórmula:C61H99FN22O15Pureza:98%Cor e Forma:SolidPeso molecular:1399.6Ro 64-6198
CAS:Ro 64-6198: Nonpeptide, selective NOP agonist, high brain uptake, EC50=25.6 nM, 100x NOP>opioid affinity.Fórmula:C26H31N3OPureza:98%Cor e Forma:SolidPeso molecular:401.54Boc-ypgflt(O-tbu)
CAS:Boc-ypgflt(O-tbu) is a delta-receptor-selective opioid antagonist.Fórmula:C44H64N6O11Cor e Forma:SolidPeso molecular:853.01BAM-22P
CAS:Bovine adrenal medulla docosapeptide (BAM-22P) is a potent opioid agonist, derived from the proenkephalin A gene, which is present in the adrenal medulla.Fórmula:C130H184N38O31S2Pureza:98%Cor e Forma:SolidPeso molecular:2839.22Orphanin FQ(1-11)
CAS:Nociceptin peptide fragment (1-11) with potent ORL1/KOR-3 receptor agonism (Ki = 55 nM), no opioid receptor affinity, and analgesic in mice.Fórmula:C49H75N15O14Pureza:98%Cor e Forma:SolidPeso molecular:1098.2TAN67
CAS:TAN67 is the first effective selective non-peptide delta1 opioid receptor.
Fórmula:C23H26Br2N2OCor e Forma:SolidPeso molecular:506.282(Rac)-SNC80
CAS:(Rac)-SNC80, a racemic δ-opioid agonist (K i 1.78 nM), shows potential for treating various headache disorders.Fórmula:C28H39N3O2Cor e Forma:SolidPeso molecular:449.63HINT1-IN-1
HINT1-IN-1 (compound 8) is an inhibitor of histidine triad nucleotide-binding protein 1 (HINT1) with a Ki of 1.14 μM. It influences the cross-regulation between μ-opioid receptors (MOR) and NMDA receptors (NMDAR).Fórmula:C23H24N8O5Cor e Forma:SolidPeso molecular:492.49Akuammicine
CAS:Akuammicine, as an indole alkaloid from Catharanthus roseus, can be used in cancer cell eradication.Fórmula:C20H22N2O2Cor e Forma:SolidPeso molecular:322.408Dermorphin Analog
Dermorphin Analog, a heptapeptide from amphibian skin, binds μ-opioid receptors selectively and strongly.Fórmula:C44H59N11O10Pureza:98%Cor e Forma:SolidPeso molecular:901.43β-Naltrexamine dihydrochloride
CAS:β-Naltrexamine dihydrochloride is an orally administered, irreversible opioid receptor antagonist. Its derivatives exhibit optimised subtype selectivity and can be used for pain research.Fórmula:C20H28Cl2N2O3Pureza:95.98%Cor e Forma:SoildPeso molecular:415.35β-Endorphin, equine TFA
β-Endorphin, equine TFA, an endogenous opioid peptide, demonstrates high affinity binding to μ/δ opioid receptors and possesses analgesic properties [1] [2] [3Fórmula:C156H249F3N42O46SCor e Forma:SolidPeso molecular:3537.96Frakefamide TFA
Frakefamide TFA: potent, peripherally active μ-opioid agonist; doesn't cross blood-brain barrier.Fórmula:C32H35F4N5O7Cor e Forma:SolidPeso molecular:677.64DPDPE
CAS:DPDPE is selective δ-opioid receptor agonist peptide.Fórmula:C30H39N5O7S2Pureza:98%Cor e Forma:SolidPeso molecular:645.79CTOP
CAS:Potent μ-receptor antagonist, Ki=0.96nM, ineffective at δ (>10,000nM). Alters behavior in vivo, boosts K+ currents in rat neurons in vitro, μ-independent.Fórmula:C50H67N11O11S2Pureza:98%Cor e Forma:SolidPeso molecular:1062.28Nociceptin(1-7)
CAS:Bioactive metabolite of nociceptin, antagonist of nociceptin-induced hyperalgesiaFórmula:C31H41N7O9Pureza:98%Cor e Forma:SolidPeso molecular:655.709Gluten Exorphin B5
CAS:Gluten exorphin B5 (GE-B5) is a food-derived opioid peptide identified in digests of wheat gluten.Fórmula:C30H38N6O7Pureza:98%Cor e Forma:SolidPeso molecular:594.66Biphalin TFA
CAS:Biphalin TFA is an opioid peptide analog that penetrates the blood-brain barrier (BBB) and encompasses two active enkephalin pharmacophores.Fórmula:C46H56N10O10·xC2HF3O2Pureza:98%Cor e Forma:SolidPeso molecular:909.00 (free base)Cebranopadol hemicitrate
CAS:Cebranopadol hemicitrate is a NOP and opioid receptor agonist that targets human NOP, MOP, KOP, and δ-opioid peptide (DOP) receptors, with Ki/EC50 values of 0.9 nM/13 nM, 0.7 nM/1.2 nM, 2.6 nM/17 nM, and 18 nM/110 nM, respectively. It is used in studies of acute and chronic pain.Cor e Forma:SolidNaldemedine
CAS:Naldemedine (S 297995), developed by Shionogi, is a drug for opioid side effects like constipation. It's well tolerated with minor GI issues.Fórmula:C32H34N4O6Cor e Forma:SolidPeso molecular:570.64Dermorphin
CAS:Dermorphin is agonist of μ-opioid receptor (MOR) agonist.Fórmula:C40H50N8O10Pureza:98.82%Cor e Forma:SolidPeso molecular:802.87[Nphe1]Nociceptin(1-13)NH2
CAS:Competitive nociceptin receptor antagonist with pKi=8.4; no agonist activity; blocks nociceptin effects in vitro/in vivo.Fórmula:C61H100N22O15Pureza:98%Cor e Forma:SolidPeso molecular:1381.6PL-017
CAS:μ opioid receptor agonist; IC50: 5.5 nM (μ), >10,000 nM (δ). Induces reversible analgesia, catalepsy, hyperthermia in rats.Fórmula:C29H37N5O5Pureza:98%Cor e Forma:SolidPeso molecular:535.64Neuropeptide AF (human)
CAS:Neuropeptide AF (93-110), Human is an endogenous antiopioid peptide.Fórmula:C90H132N26O25Pureza:98%Cor e Forma:SolidPeso molecular:1978.17CTAP
CAS:Potent μ opioid antagonist, IC50 3.5 nM, 1200x selectivity over δ and somatostatin, brain-penetrant, active in vivo.Fórmula:C51H69N13O11S2Pureza:98%Cor e Forma:White Solid/PowderPeso molecular:1104.32Ac-RYYRIK-NH2
CAS:NOP site high affinity ligand (Ki=1.5 nM); blocks nociceptin effects in rat brain/heart; agonist in vivo, reduces mouse movement.Fórmula:C44H70N14O9Pureza:98%Cor e Forma:SolidPeso molecular:939.12ICI 174,864
CAS:Selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.Fórmula:C38H53N5O7Pureza:98%Cor e Forma:White SolidPeso molecular:691.87[DPro10] Dynorphin A (1-11)acetate,porcine
[DPro10] Dynorphin A (1-11)acetate,porcine is a highly potent κ-opioid receptor agonist with a Ki value of 0.13 nM.Fórmula:C65H107N21O15Pureza:99.59%Cor e Forma:SoildPeso molecular:1422.7Neurotransmitter Receptor Compound Library
A unique collection of 1513 neurotransmitter receptor compounds, can be used for HTS and HCS screening；
Cor e Forma:Odour SolidKOR agonist 4
KOR agonist 4 (compound 39) is an agonist targeting the κ opioid receptor (Kappa Opioid Receptor) and activates G protein signaling. It has an EC50 of 14 nM and an Emax of 83% for binding to GTPγS. This compound demonstrates moderate to high intrinsic clearance in human liver cells and shows selectivity for the κ opioid receptor over the μ (MOR) and δ (DOR) opioid receptors by factors of 60 and 810, respectively. KOR agonist 4 is useful for research into central nervous system (CNS) disorders.Fórmula:C21H25N3Cor e Forma:SolidPeso molecular:319.44UFP-101
CAS:Strong, selective NOP receptor antagonist with pKi=10.24; >3000x selectivity over δ, μ, κ receptors; blocks nociceptin effects.
Fórmula:C82H138N32O21Pureza:98%Cor e Forma:SolidPeso molecular:1908.19Axelopran
CAS:Axelopran (TD-1211) treats opioid constipation; it's a potent, selective peripheral opioid blocker.Fórmula:C26H39N3O4Cor e Forma:SolidPeso molecular:457.61Herkinorin
CAS:Herkinorin: μ-opioid agonist with 100x μ-affinity, 50x less κ-affinity than Salvinorin A, from Salvia divinorum. Semi-synthetic from Salvinorin B.Fórmula:C28H30O8Cor e Forma:SolidPeso molecular:494.53DAMGO (TFA)
CAS:DAMGO is a selective peptide agonist of the µ-opioid receptor .Fórmula:C28H36F3N5O8Pureza:98%Cor e Forma:SolidPeso molecular:627.61KOR agonist 5
KOR agonist 5 (Compound 10a) is both a KOR/MOR modulator, exhibiting agonistic effects on KOR and antagonistic effects on MOR. It effectively blocks morphine-induced antinociception and gastrointestinal motility inhibition. KOR agonist 5 is applicable in research related to substance use disorder (SUD).Fórmula:C38H38N2O5Cor e Forma:SolidPeso molecular:602.72U-54494A hydrochloride
CAS:U-54494A hydrochloride is a benzamide derivative related to kappa opioid receptor agonists. U-54494A hydrochloride has anticonvulsant activity.Fórmula:C18H25Cl3N2OCor e Forma:SolidPeso molecular:391.76
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