Receptor opioide
Os receptores opioides são um grupo de receptores acoplados à proteína G que mediam os efeitos dos opioides endógenos e exógenos. Estes receptores desempenham um papel central na modulação da dor, regulação do humor e comportamentos aditivos. Agonistas e antagonistas dos receptores opioides são amplamente utilizados no manejo da dor e tratamento de dependências, bem como em pesquisas sobre distúrbios neurológicos e psiquiátricos. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores de receptores opioides de alta qualidade para apoiar sua pesquisa em neurobiologia, manejo da dor e terapia de dependência.
Foram encontrados 330 produtos para "Receptor opioide".
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CJ-15208
CAS:CJ-15208: κ-opioid antagonist, IC50: 47 nM kappa, 260 nM mu, 2600 nM delta, reverses asimadoline effects in rabbits (ED50 1.3 µM).Fórmula:C34H35N5O4Cor e Forma:SolidPeso molecular:577.67Ac-RYYRIK-NH2
CAS:NOP site high affinity ligand (Ki=1.5 nM); blocks nociceptin effects in rat brain/heart; agonist in vivo, reduces mouse movement.Fórmula:C44H70N14O9Pureza:98%Cor e Forma:SolidPeso molecular:939.12Kentsin
CAS:Kentsin, as a contraceptive polypeptide, has central opiate properties on gastrointestinal motility.Fórmula:C21H40N8O6Cor e Forma:SolidPeso molecular:500.59Ac-RYYRWK-NH2 TFA
CAS:Ac-RYYRWK-NH2: potent, specific NOP receptor partial agonist with 0.071 nM affinity; no affinity for μ/κ/δ-opioid receptors.Fórmula:C51H70F3N15O11Cor e Forma:SolidPeso molecular:1126.21BPR1M97
CAS:BPR1M97 is a mu opioid receptor (MOP) and neuropeptide-orphin FQ (NOP) receptor agonist with blood-brain barrier permeability and potency, with Kis values of 1.Fórmula:C18H18Cl2N2OPureza:98.78% - 99.95%Cor e Forma:SolidPeso molecular:349.25MT-7716 hydrochloride
CAS:MT-7716 hydrochloride is a selective agonist of non-peptide nociceptin receptor (NOP)Fórmula:C27H29ClN4O2Pureza:98%Cor e Forma:SolidPeso molecular:477Axelopran
CAS:Axelopran (TD-1211) treats opioid constipation; it's a potent, selective peripheral opioid blocker.Fórmula:C26H39N3O4Cor e Forma:SolidPeso molecular:457.61DAMGO (TFA)
CAS:DAMGO is a selective peptide agonist of the µ-opioid receptor .Fórmula:C28H36F3N5O8Pureza:98%Cor e Forma:SolidPeso molecular:627.61[DPro10] Dynorphin A (1-11)acetate,porcine
[DPro10] Dynorphin A (1-11)acetate,porcine is a highly potent κ-opioid receptor agonist with a Ki value of 0.13 nM.Fórmula:C65H107N21O15Pureza:99.59%Cor e Forma:SolidPeso molecular:1422.7KOR agonist 5
KOR agonist 5 (Compound 10a) is both a KOR/MOR modulator, exhibiting agonistic effects on KOR and antagonistic effects on MOR. It effectively blocks morphine-induced antinociception and gastrointestinal motility inhibition. KOR agonist 5 is applicable in research related to substance use disorder (SUD).Fórmula:C38H38N2O5Cor e Forma:SolidPeso molecular:602.72β-Endorphin, equine
CAS:Endorphin Beta is A substance produced in the brain, especially in the pituitary gland, Endorphin Beta blocks the sensation of pain.Fórmula:C154H248N42O44SPureza:98%Cor e Forma:SolidPeso molecular:3423.94Morphiceptin
CAS:Morphiceptin is a synthetic tetrapeptide with morphinelike activities, highly specific for morphine receptors, but not for enkephalin receptors.Fórmula:C28H35N5O5Cor e Forma:SolidPeso molecular:521.61Ro 64-6198
CAS:Ro 64-6198: Nonpeptide, selective NOP agonist, high brain uptake, EC50=25.6 nM, 100x NOP>opioid affinity.Fórmula:C26H31N3OPureza:98%Cor e Forma:SolidPeso molecular:401.54[Nphe1]Nociceptin(1-13)NH2 TFA
[Nphe1]Nociceptin(1-13)NH2 is a selective nociceptin receptor antagonist with potential analgesic properties, pKi=8.4, pA2=6.0.Fórmula:C63H101F3N22O17Cor e Forma:SolidPeso molecular:1495.61SB 205607 dihydrobromide
CAS:non-peptide δ1 opioid receptor agonistFórmula:C23H24N2OPureza:98%Cor e Forma:SolidPeso molecular:344.45N-terminally acetylated Endomorphin-1
N-terminally acetylated Endomorphin-1 is a modified Endomorphin-1.Fórmula:C36H40N6O6Pureza:98%Cor e Forma:SolidPeso molecular:652.74Dermorphin Analog
Dermorphin Analog, a heptapeptide from amphibian skin, binds μ-opioid receptors selectively and strongly.Fórmula:C44H59N11O10Pureza:98%Cor e Forma:SolidPeso molecular:901.43Nociceptin(1-7)
CAS:Bioactive metabolite of nociceptin, antagonist of nociceptin-induced hyperalgesiaFórmula:C31H41N7O9Pureza:98%Cor e Forma:SolidPeso molecular:655.709[(pF)Phe4]Nociceptin(1-13)NH2
CAS:Potent, selective OP4 agonist; pKi=10.68, pEC50=9.80. >8000x selectivity vs other opioid receptors; long-lasting in vivo effects.Fórmula:C61H99FN22O15Pureza:98%Cor e Forma:SolidPeso molecular:1399.6Dynorphin B (1-13) (TFA)
Dynorphin B (1-13) TFA acts as an agonist on opioid κ-receptor .Fórmula:C76H116N21F3O19Cor e Forma:SolidPeso molecular:1684.86Akuammicine
CAS:Akuammicine, as an indole alkaloid from Catharanthus roseus, can be used in cancer cell eradication.Fórmula:C20H22N2O2Cor e Forma:SolidPeso molecular:322.408PL-017
CAS:μ opioid receptor agonist; IC50: 5.5 nM (μ), >10,000 nM (δ). Induces reversible analgesia, catalepsy, hyperthermia in rats.Fórmula:C29H37N5O5Pureza:98%Cor e Forma:SolidPeso molecular:535.64Neurotransmitter Receptor Compound Library
A unique collection of 1513 neurotransmitter receptor compounds, can be used for HTS and HCS screening；
Cor e Forma:Odour SolidOrphanin FQ(1-11)
CAS:Nociceptin peptide fragment (1-11) with potent ORL1/KOR-3 receptor agonism (Ki = 55 nM), no opioid receptor affinity, and analgesic in mice.Fórmula:C49H75N15O14Pureza:98%Cor e Forma:SolidPeso molecular:1098.2β-Endorphin, equine TFA
β-Endorphin, equine TFA, an endogenous opioid peptide, demonstrates high affinity binding to μ/δ opioid receptors and possesses analgesic properties [1] [2] [3Fórmula:C156H249F3N42O46SCor e Forma:SolidPeso molecular:3537.96KOR agonist 6
KOR agonist 6 is a KOR agonist with a Ki value of 0.25 pM. In CHO cells, it exhibits agonistic activity on MOR and DOR and inhibits forskolin-stimulated cAMP accumulation. The compound stimulates KOR-mediated [35S]GTPγS binding in HEK293 cells expressing KOR and effectively suppresses cAMP accumulation as a potent agonist, showing lower β-arrestin recruitment efficacy. Additionally, KOR agonist 6 demonstrates analgesic effects in mice and can be employed in the study of analgesics with reduced central nervous system (CNS) side effects.Cor e Forma:Odour Solid[Nphe1]Nociceptin(1-13)NH2
CAS:Competitive nociceptin receptor antagonist with pKi=8.4; no agonist activity; blocks nociceptin effects in vitro/in vivo.Fórmula:C61H100N22O15Pureza:98%Cor e Forma:SolidPeso molecular:1381.6Frakefamide TFA
Frakefamide TFA: potent, peripherally active μ-opioid agonist; doesn't cross blood-brain barrier.Fórmula:C32H35F4N5O7Cor e Forma:SolidPeso molecular:677.64U-54494A hydrochloride
CAS:U-54494A hydrochloride is a benzamide derivative related to kappa opioid receptor agonists. U-54494A hydrochloride has anticonvulsant activity.Fórmula:C18H25Cl3N2OCor e Forma:SolidPeso molecular:391.76DPDPE
CAS:DPDPE is selective δ-opioid receptor agonist peptide.Fórmula:C30H39N5O7S2Pureza:98%Cor e Forma:SolidPeso molecular:645.79Gluten Exorphin B5
CAS:Gluten exorphin B5 (GE-B5) is a food-derived opioid peptide identified in digests of wheat gluten.Fórmula:C30H38N6O7Pureza:98%Cor e Forma:SolidPeso molecular:594.66Herkinorin
CAS:Herkinorin: μ-opioid agonist with 100x μ-affinity, 50x less κ-affinity than Salvinorin A, from Salvia divinorum. Semi-synthetic from Salvinorin B.Fórmula:C28H30O8Cor e Forma:SolidPeso molecular:494.53NP-5497-KA
NP-5497-KA is a κ-opioid receptor agonist with oral bioavailability.Fórmula:C26H39Cl3N4O2Cor e Forma:SolidPeso molecular:544.21386TAN67
CAS:TAN67 is the first effective selective non-peptide delta1 opioid receptor.Fórmula:C23H26Br2N2OCor e Forma:SolidPeso molecular:506.282Dynorphin B (1-13)
CAS:Dynorphin B (1-13) acts as an agonist on opioid κ-receptor.Fórmula:C74H115N21O17Pureza:98%Cor e Forma:SolidPeso molecular:1570.84Neuropeptide AF (human)
CAS:Neuropeptide AF (93-110), Human is an endogenous antiopioid peptide.Fórmula:C90H132N26O25Pureza:98%Cor e Forma:SolidPeso molecular:1978.17CTAP
CAS:Potent μ opioid antagonist, IC50 3.5 nM, 1200x selectivity over δ and somatostatin, brain-penetrant, active in vivo.Fórmula:C51H69N13O11S2Pureza:98%Cor e Forma:SolidPeso molecular:1104.32δ opioid receptor antagonist 1
Compound 6-Cy3, a δ-opioid receptor antagonist, serves as a highly selective fluorescent probe for δ-opioid receptors (DOR), showcasing an affinity (Ki=1.7 nM). This compound is used in the study of pain perception mechanisms.Cor e Forma:Odour Solid(Rac)-SNC80
CAS:(Rac)-SNC80, a racemic δ-opioid agonist (K i 1.78 nM), shows potential for treating various headache disorders.Fórmula:C28H39N3O2Cor e Forma:SolidPeso molecular:449.63β-Naltrexamine dihydrochloride
CAS:β-Naltrexamine dihydrochloride is an orally administered, irreversible opioid receptor antagonist. Its derivatives exhibit optimised subtype selectivity and can be used for pain research.Fórmula:C20H28Cl2N2O3Pureza:95.98%Cor e Forma:SolidPeso molecular:415.35ICI 174,864
CAS:Selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.Fórmula:C38H53N5O7Pureza:98%Cor e Forma:White SolidPeso molecular:691.87CTOP
CAS:Potent μ-receptor antagonist, Ki=0.96nM, ineffective at δ (>10,000nM). Alters behavior in vivo, boosts K+ currents in rat neurons in vitro, μ-independent.Fórmula:C50H67N11O11S2Pureza:98%Cor e Forma:SolidPeso molecular:1062.28Cebranopadol hemicitrate
CAS:Cebranopadol hemicitrate is a NOP and opioid receptor agonist that targets human NOP, MOP, KOP, and δ-opioid peptide (DOP) receptors, with Ki/EC50 values of 0.9 nM/13 nM, 0.7 nM/1.2 nM, 2.6 nM/17 nM, and 18 nM/110 nM, respectively. It is used in studies of acute and chronic pain.Cor e Forma:SolidUFP-101
CAS:Strong, selective NOP receptor antagonist with pKi=10.24; >3000x selectivity over δ, μ, κ receptors; blocks nociceptin effects.Fórmula:C82H138N32O21Pureza:98%Cor e Forma:SolidPeso molecular:1908.19Dermorphin
CAS:Dermorphin is agonist of μ-opioid receptor (MOR) agonist.Fórmula:C40H50N8O10Pureza:98.82%Cor e Forma:White SolidPeso molecular:802.87μ/κ/δ opioid receptor agonist 1
μ/κ/δopioid receptor agonist1 is an agonist for the μ opioid receptor (MOR), κ opioid receptor (KOR), and δ opioid receptor (DOR). It produces potent and long-lasting analgesic effects in the tail flick test through peripheral MOR and KOR activation.Fórmula:C35H45FN8O8Cor e Forma:SolidPeso molecular:724.33444N-Formyl-MMYALF TFA
N-Formyl-MMYALF TFA is a mitochondrial N-formyl peptide known for its ability to deplete calcium ions in the endoplasmic reticulum. Additionally, it inhibits the FPR-1-mediated chemotactic response of PMNs to bacterial peptides.Fórmula:C38H54N6O9S2·xC2HF3O2Peso molecular:803.00 (free base)Naldemedine
CAS:Naldemedine (S 297995), developed by Shionogi, is a drug for opioid side effects like constipation. It's well tolerated with minor GI issues.Fórmula:C32H34N4O6Cor e Forma:SolidPeso molecular:570.64KOR agonist 4
KOR agonist 4 (compound 39) is an agonist targeting the κ opioid receptor (Kappa Opioid Receptor) and activates G protein signaling. It has an EC50 of 14 nM and an Emax of 83% for binding to GTPγS. This compound demonstrates moderate to high intrinsic clearance in human liver cells and shows selectivity for the κ opioid receptor over the μ (MOR) and δ (DOR) opioid receptors by factors of 60 and 810, respectively. KOR agonist 4 is useful for research into central nervous system (CNS) disorders.Fórmula:C21H25N3Cor e Forma:SolidPeso molecular:319.44HINT1-IN-1
HINT1-IN-1 (compound 8) is an inhibitor of histidine triad nucleotide-binding protein 1 (HINT1) with a Ki of 1.14 μM. It influences the cross-regulation between μ-opioid receptors (MOR) and NMDA receptors (NMDAR).Fórmula:C23H24N8O5Cor e Forma:SolidPeso molecular:492.49
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