PKA
A proteína quinase A (PKA) é uma enzima chave na cascata de sinalização GPCR, ativada pelo AMP cíclico (cAMP) em resposta a vários sinais extracelulares. A PKA regula uma ampla gama de processos celulares, incluindo metabolismo, expressão gênica e crescimento celular. A desregulação da atividade da PKA está associada a várias doenças, incluindo câncer, distúrbios metabólicos e condições cardiovasculares. Moduladores de PKA são ferramentas valiosas na pesquisa destinada a compreender as vias de sinalização GPCR e desenvolver novas estratégias terapêuticas. Na CymitQuimica, oferecemos uma seleção de moduladores de PKA de alta qualidade para apoiar sua pesquisa em transdução de sinal, regulação celular e mecanismos de doenças.
Foram encontrados 48 produtos de "PKA"
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MR-L2
CAS:<p>MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).</p>Fórmula:C19H16Cl3FN4OPureza:98.09% - 98.94%Cor e Forma:SolidPeso molecular:441.71A-3 hydrochloride
CAS:<p>A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.</p>Fórmula:C12H14Cl2N2O2SPureza:99.32%Cor e Forma:SolidPeso molecular:321.22Bucladesine sodium
CAS:<p>Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties.</p>Fórmula:C18H23N5NaO8PPureza:96.56% - 99.76%Cor e Forma:White PowderPeso molecular:491.37JAK1/2/3 Inhibitor 1
CAS:<p>JAK1/2/3 Inhibitor 1 is a potent protein kinase inhibitor.JAK1/2/3 Inhibitor 1 has antitumor activity that inhibits the growth of a variety of cancer cell lines</p>Fórmula:C6H2Cl2N2SPureza:99.32%Cor e Forma:SolidPeso molecular:205.06Vasonatrin Peptide (VNP)
CAS:<p>Vasonatrin peptide (VNP) is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) with potent venodilating and natriuretic activity</p>Fórmula:C123H198N36O36S3Pureza:98%Cor e Forma:SolidPeso molecular:2865.37Fasudil
CAS:<p>Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.</p>Fórmula:C14H17N3O2SPureza:99.79% - 99.84%Cor e Forma:SolidPeso molecular:291.37KT5720
CAS:<p>KT5720 is a cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase A (PKA) (Ki: 60 nM).</p>Fórmula:C32H31N3O5Pureza:98%Cor e Forma:SolidPeso molecular:537.61PKG inhibitor peptide
CAS:<p>PKG inhibitor; mimics H2B phosphorylation site; Ki=86mM; blocks synthetic substrates, not histone phosphorylation; stops PKA activity on histones.</p>Fórmula:C38H74N18O10Pureza:98%Cor e Forma:SolidPeso molecular:943.12PKI(5-24)
CAS:<p>High affinity PKA inhibitor (Ki = 2.3 nM).</p>Fórmula:C76H129N31O28Pureza:98%Cor e Forma:SolidPeso molecular:1925.057Gliotoxin
CAS:<p>Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.</p>Fórmula:C13H14N2O4S2Pureza:98%Cor e Forma:SolidPeso molecular:326.39Malantide
CAS:<p>Malantide, a synthetic dodecapeptide, boosts and measures PKA activity by undergoing PKA-induced phosphorylation.</p>Fórmula:C72H124N22O21Pureza:98%Cor e Forma:SolidPeso molecular:1633.89Calcineurin substrate
CAS:<p>Calcineurin Substrate is a Peptide from the regulatory RII subunit of cAMP-dependent protein kinase.</p>Fórmula:C92H150N28O29Pureza:98%Cor e Forma:SolidPeso molecular:2112.35CREBtide
CAS:<p>CREBtide is a synthetic substrate for PKA (Km=3.9 µM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).</p>Fórmula:C73H129N29O19Pureza:98%Cor e Forma:SolidPeso molecular:1716.99Kemptide Phospho-Ser5
<p>Kemptide (Phospho-Ser5) is a phosphoreceptor peptide that is a specific substrate for camp-dependent protein kinase (PKA).</p>Fórmula:C32H62N13O12PPureza:98%Cor e Forma:SolidPeso molecular:851.89PKG Substrate
CAS:<p>PKG Substrate is selective for PKG, favors PKG Iα (Km=59µM) over PKG II (Km=305µM).</p>Fórmula:C35H67N17O11Pureza:98%Cor e Forma:SolidPeso molecular:902.01Malantide TFA
<p>Malantide TFA: synthetic dodecapeptide, PKA-specific with Km 15 μM, >90% PKI blockage, also PKC substrate, Km 16 μM.</p>Fórmula:C74H125F3N22O23Cor e Forma:SolidPeso molecular:1747.91H1-7 (histone H1 phosphorylation site), PKA Substrate
CAS:<p>H1-7 (histone H1 phosphorylation site), a synthetic polypeptide serving as a PKA substrate, demonstrates utility in PKA substrate applications [1] [2].</p>Fórmula:C31H58N14O9Cor e Forma:SolidPeso molecular:770.88PKI (5-24),amide
CAS:<p>PKI (5-24),amide is a 20-residue peptide, a potent PKA inhibitor with a Ki of 2.3 nM, derived from a cAMP inhibitor protein.</p>Fórmula:C94H149N33O30Cor e Forma:SolidPeso molecular:2221.4STAD 2
CAS:<p>STAD-2 is a cell permeable akap disruptor, selectively binding to pka-rii and blocking the interaction of pka-ri with akap</p>Fórmula:C102H182N24O22Cor e Forma:SolidPeso molecular:2096.724Kemptide
CAS:<p>Kemptide is a synthetic heptapeptide, acting as a substrate for cAMP-dependent protein kinase (PK).</p>Fórmula:C32H61N13O9Pureza:98%Cor e Forma:SolidPeso molecular:771.91Kiss2 peptide acetate
<p>Kiss2 peptide acetate is the acetate form of Kiss2 peptide, serving as a positive regulator of reproduction. It binds to its homologous receptor Kiss2R (GPR54) in COS-7 cells, activating the PKA and PKC signaling pathways through Gas and Gaq proteins. This activation enhances the activity of both cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc).</p>Fórmula:C63H84N16O12·xC2H4O2Cor e Forma:SolidPeso molecular:1257.44 (free base)PKA-IN-1
CAS:<p>PKA-IN-1 is a selective and potent cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor (IC50: 0.03 μM).PKA-IN-1 can be used to study</p>Fórmula:C13H11N3OPureza:97.52%Cor e Forma:SolidPeso molecular:225.25AP-C2
CAS:<p>AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.</p>Fórmula:C18H16N4SPureza:99.87%Cor e Forma:SoildPeso molecular:320.41PKA/AKAP-IN-2
CAS:<p>PKA/AKAP-IN-2 (WAY-298350) is a PKA and AKAP interaction inhibitor, used in metabolic disease research.</p>Fórmula:C17H17NO3Pureza:99.82%Cor e Forma:SoildPeso molecular:283.32Aplithianines A
<p>Aplithianines A effectively inhibits J-PKAcα with an IC50 value of 1 μM and displays higher potency against wild-type PKA, achieving an IC50 of 84 nM by</p>Pureza:98%Cor e Forma:Odour SolidDT-3 acetate
<p>DT-3 acetate is a cell-permeable peptide that acts as an inhibitor of protein kinase G (PKGIα), effectively blocking the cGMP-PKG signaling pathway.</p>Fórmula:C152H258N52O28S·xC2H4O2Cor e Forma:SolidPeso molecular:3294.07 (free acid)CCG215022
CAS:<p>CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.</p>Fórmula:C26H22FN7O3Pureza:97.63% - 99.69%Cor e Forma:SolidPeso molecular:499.5Metadoxine
CAS:<p>Metadoxine (Metadoxil) is a neurotransmitter stimulant.</p>Fórmula:C8H11NO3·C5H7NO3Pureza:99.19%Cor e Forma:Off-White PowderPeso molecular:298.29AT7867
CAS:<p>AT7867 inhibits Akt1/2/3 & p70S6K/PKA (IC50: 32/17/47 nM & 85/20 nM), minimal effect beyond AGC kinases.</p>Fórmula:C20H20ClN3Pureza:99.63%Cor e Forma:SolidPeso molecular:337.85Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Fórmula:C9H6O4Pureza:97.47% - 99.8%Cor e Forma:SolidPeso molecular:178.14HA-100
CAS:<p>HA-100 is an inhibitor of protein kinase</p>Fórmula:C13H15N3O2SPureza:99.44%Cor e Forma:Pale Yellow Crystalline SolidPeso molecular:277.34Iso-H7 dihydrochloride
CAS:<p>Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7.</p>Fórmula:C14H19Cl2N3O2SPureza:99.53%Cor e Forma:White Crystalline SolidPeso molecular:364.29Bilobetin
CAS:<p>Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.</p>Fórmula:C31H20O10Pureza:97.74% - 99.69%Cor e Forma:SolidPeso molecular:552.48Fasudil hydrochloride
CAS:<p>Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.</p>Fórmula:C14H18ClN3O2SPureza:99.54% - ≥95%Cor e Forma:White SolidPeso molecular:327.83PKG drug G1
CAS:<p>PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.</p>Fórmula:C13H11N3OSPureza:97.57% - 97.67%Cor e Forma:SolidPeso molecular:257.31AT13148
CAS:<p>AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.</p>Fórmula:C17H16ClN3OPureza:98.04% - ≥95%Cor e Forma:SolidPeso molecular:313.78H-89 dihydrochloride
CAS:<p>H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).</p>Fórmula:C20H20BrN3O2S·2HClPureza:98.22% - >99.99%Cor e Forma:SolidPeso molecular:519.28Staurosporine
CAS:<p>Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr</p>Fórmula:C28H26N4O3Pureza:99.24% - 99.82%Cor e Forma:Off-White PowderPeso molecular:466.538-Bromo-cAMP sodium salt
CAS:<p>8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. 8-Bromo-cAMP is an activator of cyclic AMP-dependent protein kinase.</p>Fórmula:C10H10BrN5NaO6PPureza:98% - 99.94%Cor e Forma:Off-White PowderPeso molecular:430.08H-8 hydrochloride
CAS:<p>H-8 hydrochloride is a reversible and ATP-competitive PKA inhibitor. It can be used to study metabolic diseases.</p>Fórmula:C12H17Cl2N3O2SPureza:99.93%Cor e Forma:White To Off-White Crystalline SolidPeso molecular:338.256-Bn-cAMP
CAS:<p>6-Bn-cAMP is a selective activator of cAMP-dependent protein kinase (PKA) that does not activate Epac. Compared to cAMP, 6-Bn-cAMP enhances hydrolytic stability against PDE, esterases, and amidases, and significantly increases membrane permeability.</p>Fórmula:C17H18N5O6PCor e Forma:SolidPeso molecular:419.338-Chloro-cAMP sodium
CAS:<p>8-Chloro-cAMP sodium is a cAMP analog that induces growth arrest and modulates cAMP-dependent PKA activity. This compound also exhibits anticancer activity.</p>Fórmula:C10H10ClN5NaO6PCor e Forma:SolidPeso molecular:385.638-MA-cAMP
CAS:<p>8-MA-cAMP (8-Methylamino-cAMP) is a cyclic adenosine monophosphate analog that acts as a site-selective PKA agonist, exhibiting similar affinity for the B site of both Type I and Type II protein kinase A. When used in conjunction with analogs that preferentially target site A, such as 8-piperidinyl cAMP, 8-MA-cAMP facilitates selective stimulation of Type I enzymes.</p>Fórmula:C11H15N6O6PCor e Forma:SolidPeso molecular:358.25BGC201531
CAS:<p>BGC201531 (AP-1531) is a EP4 antagonist for the treatment of acute migraine.</p>Fórmula:C26H28N2O6SPureza:98.51% - 99.33%Cor e Forma:SolidPeso molecular:496.58Rp-cAMPS triethylammonium salt
CAS:<p>Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinase I and II.</p>Fórmula:C16H27N6O5PSPureza:98%Cor e Forma:SolidPeso molecular:446.46FMP-API-1
CAS:<p>FMP-API-1 is an inhibitor of the A-kinase anchoring protein (AKAP)-PKA interaction. It binds to the allosteric site of the PKAR subunit, enhancing the activity of PKA and AQP2 in PKA knockout cell lines of the renal cortex collecting duct (mpkCCD cells). FMP-API-1 holds potential for studying nephrogenic diabetes insipidus (NDI).</p>Fórmula:C13H14N2O2Cor e Forma:SolidPeso molecular:230.2628-Br-cGMP-AM
CAS:<p>8-Br-cGMP-AM, a derivative of 8-Br-cGMP, acts as an activator of PKG (cGMP-dependent protein kinase), inducing various biological effects such as vasodilation and platelet inhibition. This compound is utilized in the research of cardiovascular diseases.</p>Fórmula:C13H15BrN5O9PCor e Forma:SolidPeso molecular:496.16PET-cGMP
CAS:<p>PET-cGMP is an analogue of cyclic guanosine monophosphate and functions as a potent, selective agonist for PKGI. It exhibits an EC50 of 3.8 nM for PKGIβ and 193 nM for PKGII.</p>Fórmula:C18H16N5O7PCor e Forma:SolidPeso molecular:445.323
