Receptor de Dopamina
Os receptores de dopamina são um grupo de GPCRs que respondem ao neurotransmissor dopamina, desempenhando um papel fundamental na regulação do movimento, motivação, recompensa e várias funções cognitivas. Esses receptores são divididos em famílias semelhantes a D1 e D2, cada uma com funções e perfis farmacológicos distintos. Moduladores de receptores de dopamina são amplamente estudados por suas aplicações no tratamento da doença de Parkinson, esquizofrenia, dependência e outros transtornos neuropsiquiátricos. Na CymitQuimica, oferecemos uma ampla gama de moduladores de receptores de dopamina de alta qualidade para apoiar sua pesquisa em neurociência, saúde mental e sinalização GPCR.
Foram encontrados 435 produtos de "Receptor de Dopamina"
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Naxagolide free base
CAS:Naxagolide is a sustained release formulation. It is a dopamine agonist.Fórmula:C15H21NO2Pureza:98%Cor e Forma:SolidPeso molecular:247.33Quinpirole dihydrochloride
CAS:<p>Quinpirole dihydrochloride is an agonist of the D2-like dopamine receptor.</p>Fórmula:C13H23Cl2N3Pureza:98%Cor e Forma:SolidPeso molecular:292.25AJ-76 hydrochloride
CAS:AJ-76 hydrochloride ((+)-AJ 76 hydrochloride) serves as a dopamine autoreceptor antagonist, exhibiting pK i values of 6.95 for hD3, 6.67 for hD4, 6.37 for hD2S, 6.21 for hD2L, and 6.07 for rD2 receptors, indicating its binding affinity strength across these receptor types.Fórmula:C15H24ClNOCor e Forma:SolidPeso molecular:269.81Carbidine dihydrochloride
CAS:Carbidine, a gamma-carboline derivative, is an atypical antipsychotic that modulates dopamine release and tyrosine hydroxylase activity.Fórmula:C13H20Cl2N2Pureza:98.59%Cor e Forma:SolidPeso molecular:275.217Timiperone
CAS:Timiperone exhibits a high affinity for cerebral dopamine D2 receptors, demonstrating antipsychotic activity as it mitigates stereotyped behavior.Fórmula:C22H24FN3OSPureza:98%Cor e Forma:SolidPeso molecular:397.51SKF 81297 hydrobromide
CAS:SKF 81297 hydrobromide, a selective agonist of the dopamine D1-like receptor，exhibits central activity and is widely used to study the neuromodulatory effects.Fórmula:C16H17BrClNO2Pureza:99.52%Cor e Forma:SolidPeso molecular:370.67Dihydrexidine
CAS:<p>Dihydrexidine is a full efficacy D1-like dopamine receptor (D1/D5) agonist (IC50: 10 nM for D1 receptor). It also shows potent antiparkinsonian activity.</p>Fórmula:C17H17NO2Pureza:98%Cor e Forma:SolidPeso molecular:267.32NMI 8739
CAS:<p>NMI 8739 (n-docosahexaenoyl dopamine) is an agonist of D2 autoreceptor.</p>Fórmula:C30H41NO3Pureza:98.51%Cor e Forma:SolidPeso molecular:463.65PAOPA
CAS:dopamine D2 receptor modulatorFórmula:C11H18N4O3Pureza:>99.99%Cor e Forma:SolidPeso molecular:254.29Lumateperone
CAS:<p>Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).</p>Fórmula:C24H28FN3OPureza:99.68% - 99.91%Cor e Forma:SolidPeso molecular:393.5Dopamine D3 receptor antagonist-2
Dopamine D3 receptor antagonist-2 is a dopamine D3 receptor selective (Ki=2.16 nM) or multi-targeting dual ligand that shows potential effects in CNS disorders.Fórmula:C23H27Cl2N3O3Cor e Forma:SolidPeso molecular:464.389-Methyl-β-carboline
CAS:9-Methyl-β-carboline is a cognitive enhancer with neuroprotective, neurorestorative, and anti-inflammatory properties. Its behavioral effects may be linked to hippocampal dopamine levels and the stimulation of dendritic and synaptic proliferation.Fórmula:C12H10N2Cor e Forma:SolidPeso molecular:182.221Dopamine D3 receptor antagonist-1
Dopamine D3 receptor antagonist-1 is a dopamine D3 receptor selective or multi-targeting ligand with a Ki value of 1.58 nM that has demonstrated therapeuticFórmula:C31H35Cl2N3O3Cor e Forma:SolidPeso molecular:568.53RS 12254
CAS:RS 12254 is a dopamine agonist and antihypertensive agent.Fórmula:C28H40N2O4Pureza:98%Cor e Forma:SolidPeso molecular:468.63CM699
CAS:<p>CM699 is an effective dual inhibitor of the dopamine transporter (DAT) and Sigma receptor (σR), with IC50 values of 311 nM and 14.1 nM, respectively.</p>Fórmula:C24H29N3O2Cor e Forma:SolidPeso molecular:391.51UNC10099984A
CAS:UNC10099984A (Compound 6) is a functionally selective ligand for the dopamine D2 receptor, exhibiting a Ki value of 4.6 nM and an EC50 of 6.2 nM for β-arrestin. This compound is useful for research into central nervous system diseases related to the D2 receptor.Fórmula:C24H29Cl2N3O2Cor e Forma:SolidPeso molecular:462.41D4R antagonist-1
<p>Potent, selective D4R antagonist; IC50 = 6.87 µM; potential in Parkinson’s disease research.</p>Fórmula:C21H25F2NO2Cor e Forma:SolidPeso molecular:361.43Neflumozide
CAS:Neflumozide (HRP 913) is an orally effective derivative of benzisoxazole, characterized by its potent dopamine antagonist properties and antipsychotic activity. It is utilized in research related to psychiatric disorders.Fórmula:C22H23FN4O2Cor e Forma:SolidPeso molecular:394.44Quinagolide Free Base
CAS:Quinagolide Free Base is a non-ergot dopamine D(2)-agonist.Fórmula:C20H33N3O3SCor e Forma:SolidPeso molecular:395.56Lisuride
CAS:Lisuride: an oral D2 dopamine agonist, ergot derivative, used in Parkinson's, migraine, and high prolactin research.Fórmula:C20H26N4OCor e Forma:SolidPeso molecular:338.45LY3154207
CAS:LY3154207: selective, potent oral human dopamine D1 receptor PAM, low agonist activity, EC50=3 nM.Fórmula:C24H29Cl2NO3Cor e Forma:SolidPeso molecular:450.4D1R antagonist 1
CAS:Compound 12a (D1R antagonist 1) is a D1R antagonist that participates in both G-protein-coupled and β-arrestin-mediated signaling pathways [1].Fórmula:C22H26BrNO4Pureza:98%Cor e Forma:SolidPeso molecular:448.35Cendifensine
CAS:Cendifensine functions as a monoamine reuptake inhibitor, targeting the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT).Fórmula:C14H17Cl2NOCor e Forma:SolidPeso molecular:286.197PD-147693
CAS:PD-147693 (compound II) is an active metabolite of the presynaptic dopamine autoreceptor agonist CI-1007, and it exhibits antipsychotic activity similar to CI-1007.Fórmula:C24H27NOPeso molecular:345.477D4R antagonis-2
Potent D4R antagonist-2: selective, IC50=6.52 μM, good in vitro PK and brain penetration, potential for Parkinson's research.Fórmula:C21H23ClF2N2O2Cor e Forma:SolidPeso molecular:408.87NMDAR antagonist 5
CAS:NMDAR antagonist 5 (Compound A17) is a multi-target antagonist that acts on NMDAR and monoamine transporters (SERT, DAT, and NET). It demonstrates strong NMDAR antagonistic efficacy (IC50= 0.3 μM) and effective activity on monoamine transporters (SERT IC50= 1.1 μM, DAT IC50= 0.7 μM, NET IC50= 2.7 μM). NMDAR antagonist 5 exhibits high safety with low toxicity (hepatic and renal toxicity IC50> 100 μM; cardiac toxicity IC50= 24.5 μM). It has antidepressant properties and is useful for depression research.Fórmula:C17H21N3Cor e Forma:SolidPeso molecular:267.369Dopamine D4 receptor ligand 3
CAS:Dopamine D4 receptor ligand 3 (Compound 16) functions as a dopamine D4 receptor (D4R) antagonist with a pKi of 8.86. In HEK-293T cells, it shows pIC50 values of 5.78, 5.55, and 6.17 for Go, Gi, and βArr2 sensors, respectively. This compound inhibits the activity of human glioma cell lines U87 MG, T98G, and U251 MG, and it induces ROS production and mitochondrial dysfunction in these glioma cells.Fórmula:C28H31N3O5Cor e Forma:SolidPeso molecular:489.56U91356
CAS:U91356 is an agonist of the dopamine receptors.Fórmula:C13H17N3OPureza:98%Cor e Forma:SolidPeso molecular:231.29RG-15
CAS:RG-15 is an orally active dopamine receptor antagonist with high affinity for the human D2 receptor (pKi of 8.23) and human D3 receptor (pKi of 10.49). It inhibits dopamine-stimulated [35S]GTPγS binding with IC50 values of 21.2 nM in rat striatal membranes, 36.7 nM in mouse A9 cells expressing human D2L receptors, and 7.2 nM in CHO cells expressing human D3 receptors. RG-15 enhances dopamine turnover and synthesis in the striatum and olfactory bulb of mice, exhibiting antipsychotic activity.Fórmula:C25H32Cl2F3N5O2SCor e Forma:SolidPeso molecular:594.52Dinoxyline
CAS:<p>Dinoxyline is a potent dopamine receptor agonist, with dissociation constants (Ki values) for D1, D2, D3, and D4 receptors being 7 nM, 6 nM, 5 nM, and 43 nM, respectively. It is utilized in neuroscience research.</p>Fórmula:C15H13NO3Cor e Forma:SolidPeso molecular:255.27Disulergine
CAS:Disulergine is a dopamine receptor agonist. It also prolactin release-inhibiting 8 alpha-amino-ergoline.Fórmula:C17H24N4O2SPureza:98%Cor e Forma:SolidPeso molecular:348.46Dopamine D3 receptor ligand-1
Dopamine D 3 receptor ligand is a potent, selective, high-affinity dopamine D3 receptor ligand that is 89 times more selective for D3 (Ki: 8 nM) than D2 (Ki:Fórmula:C27H29N5OCor e Forma:SolidPeso molecular:439.556-Chloro-5-(2-chloroethyl)indolin-2-one
CAS:6-Chloro-5-(2-chloroethyl)indolin-2-one is a useful organic compound for research related to life sciences. The catalog number is T64862 and the CAS number is 118289-55-7.Fórmula:C10H9Cl2NOCor e Forma:SolidPeso molecular:230.093-Hydroxybenzylamine
CAS:<p>3-Hydroxybenzylamine is a useful organic compound for research related to life sciences. The catalog number is T124305 and the CAS number is 73604-31-6.</p>Fórmula:C7H9NOCor e Forma:SolidPeso molecular:123.155GR 218,231
CAS:GR 218,231 is a selective antagonist of D3 dopamine receptor.Fórmula:C24H33NO3SPureza:98%Cor e Forma:SolidPeso molecular:415.59
