Receptor OX
Os receptores de orexina (OX1 e OX2) são GPCRs que se ligam às orexinas, neuropeptídeos envolvidos na regulação da vigília, apetite e homeostase energética. A desregulação da sinalização da orexina está ligada a distúrbios do sono, como a narcolepsia, bem como a condições metabólicas, como a obesidade. Moduladores dos receptores de orexina estão sendo investigados por seu potencial terapêutico no tratamento de distúrbios do sono, ansiedade e dependência. Na CymitQuimica, oferecemos uma gama de moduladores de receptores de orexina de alta qualidade para apoiar sua pesquisa em biologia do sono, metabolismo e neurofarmacologia.
Foram encontrados 40 produtos de "Receptor OX"
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Filorexant
CAS:<p>Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).</p>Fórmula:C24H25FN4O2Pureza:98.88%Cor e Forma:SolidPeso molecular:420.48Seltorexant
CAS:<p>Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain.</p>Fórmula:C21H22FN7OPureza:99.79% - >99.99%Cor e Forma:SolidPeso molecular:407.44EMPA
CAS:<p>EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM</p>Fórmula:C23H26N4O4SPureza:99.11%Cor e Forma:SolidPeso molecular:454.54YNT-185
CAS:<p>YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R,</p>Fórmula:C33H37N5O5SPureza:99.67%Cor e Forma:SolidPeso molecular:615.74SB-408124
CAS:SB408124: Non-peptide, OX1 receptor antagonist, Ki 57 nM (whole cell) and 27 nM (membrane), 50x more selective than OX2.Fórmula:C19H18F2N4OPureza:99.81%Cor e Forma:SolidPeso molecular:356.37Suntinorexton
CAS:<p>Suntinorexton (TAK 861) is an orexin type 2 receptor (OX2R) agonist used in the study of neurologic disorders.</p>Fórmula:C23H28F2N2O4SPureza:99.89%Cor e Forma:SolidPeso molecular:466.54OXA(17-33)
CAS:Potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). Truncated form of orexin A.Fórmula:C79H125N23O22Pureza:98%Cor e Forma:SolidPeso molecular:1749Orexin A (human, rat, mouse) acetate
<p>Orexin A (human, rat, mouse) acetate (Hypocretin-1 (human, rat, mouse) acetate) is an excitatory neuropeptide with analgesic properties.</p>Fórmula:C154H247N47O46S4Cor e Forma:SolidPeso molecular:3621.15[Ala11,D-Leu15]-Orexin B acetate
<p>[Ala11,D-Leu15]-Orexin B acetate is a selective agonist of orexin-2 receptor (OX2) with an EC50 of 0.13 nM, showing 400-fold selectivity over OX1 (52 nM).</p>Fórmula:C122H210N44O37SPureza:98.18%Cor e Forma:SolidPeso molecular:2917.31Orexin B, rat, mouse
CAS:<p>Orexin B, rat, mouse is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.</p>Fórmula:C126H215N45O34SPureza:98%Cor e Forma:SolidPeso molecular:2936.45[Ala11,D-Leu15]-Orexin B(human)
CAS:<p>OX2 receptor agonist with 400x selectivity vs OX1. EC50: 0.13 nM (OX2), 52 nM (OX1).</p>Fórmula:C120H206N44O35SPureza:98%Cor e Forma:SolidPeso molecular:2857.28Orexin B, rat, mouse TFA
<p>Orexin B, rat/mouse TFA, activates OX1-R & OX2-R receptors, influencing food intake, energy, and sleep regulation.</p>Fórmula:C128H216F3N45O36SCor e Forma:SolidPeso molecular:3050.42ZL-1101
<p>ZL-1101 is a human monoclonal antibody (mAb) targeting TNFRSF4/OX40/CD134.</p>Cor e Forma:Odour LiquidXenopus orexin B
CAS:Xenopus orexin B, a neuropeptide identified as an endogenous ligand for an orphan G-protein-coupled receptor, acts as a potent agonist of OX2R [1].Fórmula:C130H219N45O40S2Cor e Forma:SolidPeso molecular:3116.54Orexin A (human, rat, mouse)
CAS:Orexin A, a 33 AA neuropeptide in humans, rats, mice, influences various processes, studied in pancreatic function and as an OX1R antagonist.Fórmula:C152H243N47O44S4Pureza:98%Cor e Forma:SolidPeso molecular:3561.1OXA(17-33) TFA
<p>OXA(17-33) TFA: Potent OX1 agonist, ~23x more selective for OX1 (EC50=8.29nM) than OX2 (187nM).</p>Fórmula:C81H126F3N23O24Cor e Forma:SolidPeso molecular:1863Orexin A (human, rat, mouse) (TFA)
Endogenous orexin receptor agonist with Ki of 20 nM (OX1) and 38 nM (OX2), promotes feeding, may regulate sleep-wake cycle.Fórmula:C154H244N47F3O46S4Pureza:98%Cor e Forma:SolidPeso molecular:3675.12Orexin B, human
CAS:Orexin B, human agonizes Orexin receptors (OX1 Ki=420 nM, OX2 Ki=36 nM), promotes feeding in rats, and is a neuropeptide.Fórmula:C123H212N44O35SPureza:98%Cor e Forma:SolidPeso molecular:2899.34SB-674042
CAS:<p>SB-674042 is a nonpeptide dual antagonist of the appetite peptides OX1 and OX2 receptors.SB-674042 is used in the treatment of depression.</p>Fórmula:C24H21FN4O2SPureza:99.9%Cor e Forma:SolidPeso molecular:448.51OXA (17-33) acetate
<p>OXA (17-33) acetate is a more potent agonist of orexin-1 receptor (OX1, EC50 = 8.29 nM)) over OX2 (EC50 = 187 nM).</p>Fórmula:C79H125N23O22Pureza:98.52%Cor e Forma:SolidPeso molecular:1748.98SB-649868
CAS:<p>SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).</p>Fórmula:C26H24FN3O3SPureza:99.53%Cor e Forma:SolidPeso molecular:477.55Orexin 2 Receptor Agonist
CAS:Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.Fórmula:C32H34N4O5SPureza:98.26% - 99.43%Cor e Forma:SolidPeso molecular:586.7MK-1064
CAS:<p>MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).</p>Fórmula:C24H20ClN5O3Pureza:99.19% - 99.82%Cor e Forma:SolidPeso molecular:461.9DORA-22
CAS:<p>DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory</p>Fórmula:C23H22F2N4O2Pureza:97.67%Cor e Forma:SolidPeso molecular:424.44IPSU
CAS:<p>IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.</p>Fórmula:C23H27N5O2Pureza:97.05%Cor e Forma:SolidPeso molecular:405.49PF3274167
CAS:PF3274167 (Cligosiban) is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.Fórmula:C19H19ClFN5O3Pureza:99.67% - 99.88%Cor e Forma:SolidPeso molecular:419.84SB-334867 free base
CAS:<p>SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist.</p>Fórmula:C17H13N5O2Pureza:99.67% - >99.99%Cor e Forma:SolidPeso molecular:319.32MK-3697
CAS:<p>MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).</p>Fórmula:C23H21N5O3SPureza:97.69% - 98.15%Cor e Forma:SolidPeso molecular:447.51TCS-OX2-29
CAS:TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.Fórmula:C23H31N3O3Pureza:99.81%Cor e Forma:SolidPeso molecular:397.51Orexin B, rat, mouse Acetate
Orexin B, rat, mouse Acetate (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.Fórmula:C128H219N45O36SPureza:94.61%Cor e Forma:SolidPeso molecular:2996.45TCS 1102
CAS:TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).Fórmula:C27H26N4O2SPureza:99.35% - 99.52%Cor e Forma:SolidPeso molecular:470.59L-368,899 hydrochloride
CAS:<p>L-368,899 hydrochloride is an OXTR antagonist that prevents oxytocin-induced antiabnormal pain and anti-nausea, and may be used in the study of depression.</p>Fórmula:C26H43ClN4O5S2Pureza:99.59%Cor e Forma:SolidPeso molecular:591.23ACT-462206
CAS:ACT-462206 is a Orexin 1/Orexin 2 receptor antagonist.ACT-462206 is highly potent and can be used to study sleep and anxiety.Fórmula:C20H24N2O4SPureza:99.45%Cor e Forma:SolidPeso molecular:388.48Tebideutorexant
CAS:<p>Tebideutorexant, an orexin-1 receptor antagonist, shows anti-panic effects in rodents and humans, providing a tool for stress response and psychiatric research.</p>Fórmula:C23H16D2F4N4O2Pureza:98.89%Cor e Forma:SolidPeso molecular:460.42Alixorexton
CAS:<p>Alixorexton is an agonist of the orexin-2 receptor (orexin-2 receptor) and is utilized in obesity research.</p>Fórmula:C21H30N2O5SCor e Forma:SolidPeso molecular:422.538YNT-3708
CAS:<p>YNT-3708 is an orexin receptor (OXR) agonist, exhibiting EC50 values of 14.6 nM for OX1R and 277 nM for OX2R.</p>Fórmula:C35H36N4O6SCor e Forma:SolidPeso molecular:640.749(S)-YNT-3708
CAS:<p>(S)-YNT-3708 is the S-isomer of YNT-3708, demonstrating relatively low activity against OX1R and OX2R receptors, with EC50 values of 3595 nM and 1661 nM, respectively.</p>Fórmula:C35H36N4O6SCor e Forma:SolidPeso molecular:640.749Rocavorexant
CAS:<p>Rocavorexant is an antagonist of the orexin-1 receptor (orexin-1 receptor), exhibiting a pIC50 value of 9.1 for human OX1 and a pIC50 of 6.0 for human OX2.</p>Fórmula:C18H19F3N8OCor e Forma:SolidPeso molecular:420.392RTIOXA-43
CAS:<p>RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.</p>Fórmula:C37H37N5O5SPureza:99.17%Cor e Forma:SolidPeso molecular:663.79CVN766
CAS:<p>CVN766 is an orally active orexin 1 receptor antagonist with blood-brain permeability, demonstrating IC50 values of 8 nM for OX1R and >10 μM for OX2R. CVN766 can be used to study schizophrenia [1].</p>Fórmula:C20H21F3N8OCor e Forma:SolidPeso molecular:446.43
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