GRK
As cinases de receptores acoplados à proteína G (GRKs) são uma família de enzimas que fosforilam GPCRs ativados, levando à dessensibilização dos receptores e à regulação da sinalização dos receptores. As GRKs desempenham papéis críticos no controle da intensidade e duração da sinalização dos GPCRs, sendo importantes na regulação de vários processos fisiológicos, incluindo função cardiovascular, resposta imunológica e neurotransmissão. Inibidores e ativadores de GRK são estudados por suas potenciais aplicações terapêuticas em insuficiência cardíaca, câncer e distúrbios neurológicos. Na CymitQuimica, oferecemos uma gama de moduladores de GRK de alta qualidade para apoiar sua pesquisa em transdução de sinal, regulação de receptores e desenvolvimento terapêutico.
Foram encontrados 41 produtos para "GRK".
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CMPD101
CAS:CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).Fórmula:C24H21F3N6OPureza:99.01% - 99.04%Cor e Forma:SolidPeso molecular:466.46Endothelin-3, human, mouse, rabbit, rat
CAS:Endothelin-3, human, mouse, rabbit, rat , is a cyclic 21 amino acid peptide. It is an endogenous neuropeptide and potent vasoconstrictor.Fórmula:C121H168N26O33S4Pureza:98%Cor e Forma:SolidPeso molecular:2643.04Crustacean Cardioactive Peptide (CCAP)
CAS:Crustacean Cardioactive Peptide (CCAP) is a conserved modified cyclic nonapeptide primary structure of PFCNAFTGC-NH2, a disulfide bridge between Cys3 and Cys9.Fórmula:C42H58N10O12S2Pureza:95.40%Cor e Forma:SolidPeso molecular:959.1Corazonin
CAS:Corazonin, a neuropeptide in insects, regulates caste identity and behavior, mainly in workers/foragers.Fórmula:C62H83N17O19Cor e Forma:SolidPeso molecular:1370.42GRK2i TFA
GRK2i TFA inhibits Gβγ-activated GRK2, mimicking its binding domain and acts as a Gβγ antagonist.Fórmula:C152H257F3N50O43SPeso molecular:3598.1GRL-03022
GRL-03022 is a potent and highly selective non-covalent inhibitor of G protein-coupled receptor kinase 5 (GRK5), with an IC50 of 60 nM. It demonstrates over 16,000-fold selectivity for GRK5 compared to GRK2 (IC50 > 1000 μM). GRL-03022 is applicable in research related to heart failure and cancer.GRK2 degrader-1
CAS:GRK2 degrader-1 (compound 1) is a potent and orally active GRK2 degrader. It facilitates the degradation of GRK2 via the ubiquitin-proteasome pathway. In a pulmonary arterial hypertension (PAH) mouse model, GRK2 degrader-1 inhibits right ventricular remodeling and the increase in pulmonary arterial pressure. This compound is suitable for research in pulmonary arterial hypertension (PAH).Fórmula:C25H22N4O4SPeso molecular:474.54GSK270822A
CAS:GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively.Fórmula:C24H20N4O2Pureza:98.64% - 99.78%Cor e Forma:SolidPeso molecular:396.44Ref: TM-T27467
1mg133,00€5mg314,00€1mL*10mM (DMSO)323,00€10mg416,00€25mg632,00€50mg847,00€100mg1.134,00€200mg1.513,00€E3 Ligase Ligand-linker Conjugate 139
CAS:E3 Ligase Ligand-linker Conjugate 139 is an E3 ubiquitin ligase ligand and linker for PROTACKB03-SLF, used in cancer research.Fórmula:C20H25ClF3N3O7Peso molecular:511.88GRK2i
CAS:GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. Corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.Fórmula:C153H256N50O41SPureza:98%Cor e Forma:SolidPeso molecular:3484.08GRL018-21
GRL018-21 is a potent, highly selective inhibitor of G protein-coupled receptor kinase 5 (GRK5), exhibiting an IC50 of 10 nM [1].Cor e Forma:Odour SolidGRK2-IN-1 hydrochloride (2055990-90-2 free base)
GRKs-IN-1 hydrochloride has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).Fórmula:C24H26ClFN4O4Pureza:98%Cor e Forma:SolidPeso molecular:488.94GRK-IN-1
CAS:4-Amino-5-(bromomethyl)-2-methylpyrimidine used in vitamin B1 analogs and esters synthesis.Fórmula:C6H10Br3N3Cor e Forma:SolidPeso molecular:363.879GRL-098-22
GRL-098-22 (Compound 6t) is a potent inhibitor of G protein-coupled receptor kinase 5 (GRK5) and GRK6, with IC50 values of 0.6 μM and 0.19 μM, respectively. GRL-098-22 shows potential for research in diseases such as heart failure and multiple myeloma.CCG258208 hydrochloride
CCG258208 hydrochloride is a potent, selective GRK2 inhibitor that enhances cardiomyocyte contractility and shows excellent in vivo pharmacokinetic properties.Fórmula:C24H26ClFN4O4Cor e Forma:Transparent LiquidPeso molecular:488.94GRL093-22
GRL093-22 is an effective and selective inhibitor of G protein-coupled receptor kinases (GRK), with IC50 values of 60 nM for GRK5 and 40 nM for GRK6. It shows potential for research in heart failure and multiple myeloma.Fórmula:C33H29FN6O3Cor e Forma:SolidPeso molecular:576.62GRK2 Inhibitor
CAS:GRK2 Inhibitor; prevents receptor desensitization; enhances signaling; cardiovascular and inflammation research.Fórmula:C12H9NO6Pureza:98.46%Cor e Forma:SolidPeso molecular:263.2Ref: TM-T25464
1mgA consultar5mgA consultar10mgA consultar25mgA consultar50mgA consultar1mL*10mM (DMSO)126,00€1-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-5-oxo-pyrrolidine-3-carboxylic acid
CAS:1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID targets GRK2.Fórmula:C13H13NO5Pureza:99.55%Cor e Forma:SolidPeso molecular:263.25GSK180736A
CAS:GSK180736A: GRK2 inhibitor (IC50 0.77µM), >100x selectivity vs GRKs, weak at PKA (IC50 30µM), strong vs ROCK1 (IC50 100nM).Fórmula:C19H16FN5O2Pureza:98.98% - 99.51%Cor e Forma:SolidPeso molecular:365.36Ref: TM-T3513
1mg39,00€2mg50,00€1mL*10mM (DMSO)62,00€5mg70,00€10mg94,00€25mg161,00€50mg290,00€100mg538,00€500mg1.161,00€Takeda103A
CAS:Takeda103A (CMPD103A) is the GRK2-dependent bovine tubulin oxidation effective inhibitor.Fórmula:C24H23F2N7OPureza:97.17%Cor e Forma:White SolidPeso molecular:463.48Ref: TM-T24850
1mg80,00€2mg100,00€5mg156,00€1mL*10mM (DMSO)177,00€10mg244,00€25mg401,00€50mg532,00€100mg745,00€200mg982,00€
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